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The Effects of a Novel Supplement Containing Probiotics and Vitamin D as an Adjutant Therapy on sNFL and Th Cell Profiles in Patients with Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial
The Effects of a Novel Supplement Containing Probiotics and Vitamin D as an Adjutant Therapy on sNFL and Th Cell Profiles in Patients with Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial
multiple sclerosis is a chronic autoimmune disease that affects the central nervous system. It damages the myelin sheath t...
Linn. Root Extract-Mediated Synthesis of Zinc Oxide Nanoparticles: a Study of Glucose Uptake Efficiency on 3T3-L1 Adipocytes
Linn. Root Extract-Mediated Synthesis of Zinc Oxide Nanoparticles: a Study of Glucose Uptake Efficiency on 3T3-L1 Adipocytes
Mimosa pudica is a medicinal plant conventionally used to cure various ailments, including diabetes and is a model for syn...
Microemulsion-Based Gel for Skin Delivery of Tacrolimus and Pramoxine Hydrochloride
Microemulsion-Based Gel for Skin Delivery of Tacrolimus and Pramoxine Hydrochloride
Atopic dermatitis (AD) is a chronic, pruritic skin disorder usually treated with topical tacrolimus and corticosteroids, w...
Quality by Design for Cost Effective Production of Pregabalin Extended-Release Tablets: in vitro and in vivo Study
Quality by Design for Cost Effective Production of Pregabalin Extended-Release Tablets: in vitro and in vivo Study
Pregabalin (LYRICA®) is a centrally acting neuromodulating agent for the management of neuropathic pain and fibromyal...
Topical Wound Healing Effects of and Extracts Compared to Povidone-Iodine in Sprague Dawley Rats
Topical Wound Healing Effects of and Extracts Compared to Povidone-Iodine in Sprague Dawley Rats
This study aims to evaluate the wound-healing potential of Bauhinia purpurea Linn (B. purpurea L.) leaf extract and Ficus ...
Efficacy of Drug Delivery Systems in Breast Cancer: A Meta-Analysis of Preclinical Animal Studies
Efficacy of Drug Delivery Systems in Breast Cancer: A Meta-Analysis of Preclinical Animal Studies
Breast cancer remains a leading cause of cancer-related death in women, with conventional chemotherapy facing challenges l...
Advancing Lamotrigine Therapy: Piezoelectric Atomized Cloud Drying-Developed Microparticles in Lyophilized Orally Disintegrating Tablets with Characterization and PBPK Simulation for Enhanced Dissolution, Rapid Absorption, and Faster Onset of Action
Advancing Lamotrigine Therapy: Piezoelectric Atomized Cloud Drying-Developed Microparticles in Lyophilized Orally Disintegrating Tablets with Characterization and PBPK Simulation for Enhanced Dissolution, Rapid Absorption, and Faster Onset of Action
Epilepsy, a prevalent neurological disorder, is predominantly managed by antiepileptic drugs (AEDs) like lamotrigine. Desp...
Enhancing Flowability and Compactibility of Glutinous Rice Starch Through Co-Precipitation: A Central Composite Design Approach
Enhancing Flowability and Compactibility of Glutinous Rice Starch Through Co-Precipitation: A Central Composite Design Approach
Flowability and compactibility are essential properties for excipients in direct compression tablet formulations. Native s...
Design and Evaluation of Compritol-Based Mesalazine Pellets and Tablets for Sustained Release Throughout the Gastrointestinal Tract
Design and Evaluation of Compritol-Based Mesalazine Pellets and Tablets for Sustained Release Throughout the Gastrointestinal Tract
Drug delivery to the gastrointestinal tract (GIT) has become very important for the local treatment of digestive diseases ...
Robust RP-HPLC Method for the Analysis of Domiphen Bromide in Pharmaceuticals with Comprehensive Sustainability Assessment
Robust RP-HPLC Method for the Analysis of Domiphen Bromide in Pharmaceuticals with Comprehensive Sustainability Assessment
Domiphen bromide (DB), a quaternary ammonium compound, is widely used as an antimicrobial preservative in pharmaceutical f...
Development of Sertaconazole Loaded Nanoemulgel Using Quality by Design Approach for Enhanced Antifungal Drug Delivery
Development of Sertaconazole Loaded Nanoemulgel Using Quality by Design Approach for Enhanced Antifungal Drug Delivery
This study focuses on the development and optimization of a sertaconazole-loaded nanoemulgel (SER-NEG) using a quality by ...
Development and Evaluation of Luliconazole-Loaded Microsponge Gel for Improved Topical Retention and Reduced Irritation
Development and Evaluation of Luliconazole-Loaded Microsponge Gel for Improved Topical Retention and Reduced Irritation
Traditional topical therapies often require high drug concentrations, leading to irritation and poor patient compliance. T...
Development and Optimization of Eudragit EPO Coated Solid Dispersion-Based Immediate-Release Pellets of Drotaverine Hydrochloride for Pediatric use
Development and Optimization of Eudragit EPO Coated Solid Dispersion-Based Immediate-Release Pellets of Drotaverine Hydrochloride for Pediatric use
The study aimed to develop a pediatric-friendly, immediate-release pellet formulation of Drotaverine Hydrochloride (DHC) t...
Optimized Transfersomal Hyaluronic Acid/Carboxymethyl Chitosan Hydrogel for Enhanced Ocular Delivery of Fluconazole in Fungal Keratitis
Optimized Transfersomal Hyaluronic Acid/Carboxymethyl Chitosan Hydrogel for Enhanced Ocular Delivery of Fluconazole in Fungal Keratitis
The current research presents the development of transfersomal hydrogel-based formulation for effective ocular administrat...
Evaluating the Impact of Adding Herbal Medicine into Standard Treatment for Patients with Primary Hypertension in Comparison to a Placebo: A Triple-Blinded Randomized Controlled Trial
Evaluating the Impact of Adding Herbal Medicine into Standard Treatment for Patients with Primary Hypertension in Comparison to a Placebo: A Triple-Blinded Randomized Controlled Trial
This research was conducted to assess the impact of Gaznab syrup (aqueous extract of Urtica dioica and Ziziphus jujube) on...
Enhancing Doxorubicin Efficacy with a Novel Lipid-Polymer Nanosystem Containing Melatonin: Formulation, Characterization and in Vitro Study
Enhancing Doxorubicin Efficacy with a Novel Lipid-Polymer Nanosystem Containing Melatonin: Formulation, Characterization and in Vitro Study
Recently, combination therapy for cancer has been shown to be more effective than monotherapy, resulting in reduced side e...
Toxicity Assessment of Oral Liquid Formulations of Novel Ciprofloxacin-Dicarboxylic Acid Salts in Female Albino Rats: Haematological, Biochemical, and Histopathological Parameters
Toxicity Assessment of Oral Liquid Formulations of Novel Ciprofloxacin-Dicarboxylic Acid Salts in Female Albino Rats: Haematological, Biochemical, and Histopathological Parameters
This study aimed to evaluate and compare the systemic toxicity profiles of novel ciprofloxacin salts synthesised using dic...
Development and Optimization of ZnO Nanoparticle-Embedded Fe-Crosslinked pH-Sensitive Carboxymethyl Cellulose/Poly(Vinyl Alcohol) Nanocomposite Beads: in Vitro Release Properties of an Anti-Cancer Drug
Development and Optimization of ZnO Nanoparticle-Embedded Fe-Crosslinked pH-Sensitive Carboxymethyl Cellulose/Poly(Vinyl Alcohol) Nanocomposite Beads: in Vitro Release Properties of an Anti-Cancer Drug
This study aims to design and evaluate a carboxymethyl cellulose (CMC)/poly(vinyl alcohol) (PVA) nanocomposite drug delive...
Development and Evaluation of a PH-Responsive Bovine Serum Albumin-Functionalized Layered Double Hydroxide Nanocarrier for Targeted Therapy of Ovarian Cancer
Development and Evaluation of a PH-Responsive Bovine Serum Albumin-Functionalized Layered Double Hydroxide Nanocarrier for Targeted Therapy of Ovarian Cancer
Ovarian cancer accounts for 4.7% of cancer-related deaths in women, with paclitaxel (PAC) being an effective treatment opt...
Increasing the Stability of Pellets Containing Lycopene by Using Dual-Coating
Increasing the Stability of Pellets Containing Lycopene by Using Dual-Coating
Lycopene (LYC) is a natural carotenoid, which has antioxidant, anti-inflammatory and anti-cancer properties. Nevertheless,...
Formulation, Evaluation and Optimization of Acitretin Loaded Transethosomes for the Management of Psoriasis
Formulation, Evaluation and Optimization of Acitretin Loaded Transethosomes for the Management of Psoriasis
Psoriasis is a chronic inflammatory skin disorder characterized by the development of red, scaly patches (National Psorias...
Insight into Binding and Interaction of Docking, Dynamics and Network Pharmacology to Explore the Target on Cancer Inhibitors
Insight into Binding and Interaction of Docking, Dynamics and Network Pharmacology to Explore the Target on Cancer Inhibitors
The bioefficacy of accessible chemical structures has been established, leading to some optimization to address these cons...
Formulation, Optimization and In Vitro Studies of Flutamide-loaded Nanostructured Lipid Carrier Based Oral Drug Delivery for Enhanced Anticancer Activity
Formulation, Optimization and In Vitro Studies of Flutamide-loaded Nanostructured Lipid Carrier Based Oral Drug Delivery for Enhanced Anticancer Activity
The purpose of this study was to formulate and evaluate nanostructured lipid carriers (NLCs) of the poorly water soluble a...
Accelerated Approval for Cancer Drugs in the United States and the Clinical Evidence Required for Conversion to Regular Approval
Accelerated Approval for Cancer Drugs in the United States and the Clinical Evidence Required for Conversion to Regular Approval
Oncology products often leverage accelerated approval program to seek earlier launches in the United States. Little is kno...
Assessment of the HaLCon® Protein Analyzer for At-Line Titer Measurements in Biomanufacturing Applications
Assessment of the HaLCon® Protein Analyzer for At-Line Titer Measurements in Biomanufacturing Applications
With the increasing demand for intensified processes in biopharmaceutical manufacturing, there is a growing requirement fo...
Development and In-Vitro Characterization of Capsaicin Microsponges Loaded Topical Gels for Management of Arthritis
Development and In-Vitro Characterization of Capsaicin Microsponges Loaded Topical Gels for Management of Arthritis
Arthritis is the one of the leading causes of disability among a large group of population. It is a slowly progressive dis...
Improving Continuous Loss-in-weight Feeding Accuracy by a Novel Hopper Design
Improving Continuous Loss-in-weight Feeding Accuracy by a Novel Hopper Design
Powder feeding is a vital unit operation in the continuous manufacturing of pharmaceutical products. Loss-in-weight twin-s...
Improving the Doxorubicin Loading to PLGA Nanoparticles with TOPSIS-Based Taguchi Design Approach: Effect of the Water Phase
Improving the Doxorubicin Loading to PLGA Nanoparticles with TOPSIS-Based Taguchi Design Approach: Effect of the Water Phase
PLGA nanoparticles are one of the most investigated drug delivery systems among all polymeric nanoparticles. Although ther...
Preparation and Characterization of Electrospun Polyvinylpyrrolidone Nanofiber Mat Containing Phillyrea Latifolia L. Herbal Extract and Evaluation of Antioxidant Mechanism
Preparation and Characterization of Electrospun Polyvinylpyrrolidone Nanofiber Mat Containing Phillyrea Latifolia L. Herbal Extract and Evaluation of Antioxidant Mechanism
Fast-disintegrating dosage forms based on nanofibers hold promise as effective carriers for a diverse array of drugs. In t...
Quality by Design (QbD) Enabled and Central-Composite Design Assisted Approach for Formulation of Oral Herbal Gastro-retentive In-situ Gel
Quality by Design (QbD) Enabled and Central-Composite Design Assisted Approach for Formulation of Oral Herbal Gastro-retentive In-situ Gel
The delivery of herbal medications is currently a growing area in pharmacy. One of the areas of interest for the scientist...
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