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Correction: Treating Lower Urinary Tract Symptoms in Older Adults: Intravesical Options
Correction: Treating Lower Urinary Tract Symptoms in Older Adults: Intravesical Options
Illustration of intravesical drug delivery via a transurethral catheter in female mice. Combined instillation of paramagne...
Prospective Monitoring of New Drugs in Older Adults with and without Frailty: Near-Real-Time Assessment of Effectiveness and Safety of Oral Anticoagulants in Medicare Data
Prospective Monitoring of New Drugs in Older Adults with and without Frailty: Near-Real-Time Assessment of Effectiveness and Safety of Oral Anticoagulants in Medicare Data
Prospective sequential analyses after a new drug approval allow proactive surveillance of new drugs. In the current study,...
Efficacy and safety of insomnia treatment with lemborexant in older adults: analyses from three clinical trials
Efficacy and safety of insomnia treatment with lemborexant in older adults: analyses from three clinical trials
Insomnia is more common as people age. Several common hypnotics used to treat insomnia often do not adequately alleviate s...
Fall Outcomes in Older Adults Following Benzodiazepine/Z-Drug Discontinuation: A Retrospective Cohort Study in an Academic Health System
Fall Outcomes in Older Adults Following Benzodiazepine/Z-Drug Discontinuation: A Retrospective Cohort Study in an Academic Health System
Benzodiazepines and z-drugs increase the fall risk in older adults. There is a lack of real-world data examining the assoc...
Prevalence of Adverse Drug Reactions in Hospital Among Older Patients with and Without Dementia
Prevalence of Adverse Drug Reactions in Hospital Among Older Patients with and Without Dementia
Older inpatients with dementia are at an increased risk of an adverse drug reaction (ADR) during hospitalization. To quant...
Oral Corticosteroids for Skin Disease in the Older Population: Minimizing Potential Adverse Effects
Oral Corticosteroids for Skin Disease in the Older Population: Minimizing Potential Adverse Effects
Corticosteroids play a crucial role as anti-inflammatory and immunomodulatory agents in dermatology and other medical spec...
Co-Designing a Consult Patient Decision Aid for Continuation Versus Deprescribing Cholinesterase Inhibitors in People Living with Dementia
Co-Designing a Consult Patient Decision Aid for Continuation Versus Deprescribing Cholinesterase Inhibitors in People Living with Dementia
As dementia progresses, people living with dementia may take high-risk, unnecessary, or ineffective medicines. Cholinester...
The Relationship Between Antipsychotics, Cognitive Enhancers, and Major Adverse Cardiovascular/Cerebrovascular Events (MACCE) in Older Adults with Behavioral and Psychological Symptoms of Dementia
The Relationship Between Antipsychotics, Cognitive Enhancers, and Major Adverse Cardiovascular/Cerebrovascular Events (MACCE) in Older Adults with Behavioral and Psychological Symptoms of Dementia
Antipsychotics and cognitive enhancers are often used to treat psychosis and behavioral disturbances in individuals with d...
Minimising Harm and Managing Pain: Deprescribing Opioids in Older Adults
Minimising Harm and Managing Pain: Deprescribing Opioids in Older Adults
Approximately one in three older adults (aged 65 years and over) experience pain, negatively impacting their quality of li...
Pilocarpine in the Treatment of Presbyopia: Progress, Issues, and Future Prospects
Pilocarpine in the Treatment of Presbyopia: Progress, Issues, and Future Prospects
Presbyopia is a common age-related visual impairment. With the aging of the population, the incidence of presbyopia is inc...
Pharmacological Treatment of Obesity in Older Adults
Pharmacological Treatment of Obesity in Older Adults
Obesity is a complex health issue with growing prevalence worldwide. It is also becoming more prevalent in the population ...
Assessing Long-Term Adverse Outcomes in Older Kidney Transplant Recipients: A Propensity Score-Matched Comparison of Early Steroid Withdrawal Versus Continuous Steroid Immunosuppression Using a Large Real-World Database
Assessing Long-Term Adverse Outcomes in Older Kidney Transplant Recipients: A Propensity Score-Matched Comparison of Early Steroid Withdrawal Versus Continuous Steroid Immunosuppression Using a Large Real-World Database
Steroids are widely used in maintenance immunosuppression treatment in kidney transplant recipients. Older individuals und...
Development of a Frailty Screening Tool Using Electronic Community Pharmacy Records
Development of a Frailty Screening Tool Using Electronic Community Pharmacy Records
Frailty is associated with increased susceptibility to medication-related harm, highlighting the importance of medication ...
Safety and Efficacy of Cenobamate for the Treatment of Focal Seizures in Older Patients: Post Hoc Analysis of a Phase III, Multicenter, Open-Label Study
Safety and Efficacy of Cenobamate for the Treatment of Focal Seizures in Older Patients: Post Hoc Analysis of a Phase III, Multicenter, Open-Label Study
Cenobamate is an antiseizure medication (ASM) approved in the US and Europe for the treatment of uncontrolled focal seizur...
Impact of Immunosenescence in Older Kidney Transplant Recipients: Associated Clinical Outcomes and Possible Risk Stratification for Immunosuppression Reduction
Impact of Immunosenescence in Older Kidney Transplant Recipients: Associated Clinical Outcomes and Possible Risk Stratification for Immunosuppression Reduction
The number of older individuals receiving a kidney transplant as replacement therapy has significantly increased in the pa...
The Difficulties of Managing Pain in People Living with Frailty: The Potential for Digital Phenotyping
The Difficulties of Managing Pain in People Living with Frailty: The Potential for Digital Phenotyping
Pain and frailty are closely linked. Chronic pain is a risk factor for frailty, and frailty is a risk factor for pain. Peo...
Cumulative Anticholinergic Burden and its Predictors among Older Adults with Alzheimer’s Disease Initiating Cholinesterase Inhibitors
Cumulative Anticholinergic Burden and its Predictors among Older Adults with Alzheimer’s Disease Initiating Cholinesterase Inhibitors
Cumulative anticholinergic burden refers to the cumulative effect of multiple medications with anticholinergic properties....
Older Canadians’ Perceptions of the Safety, Effectiveness and Accessibility of Cannabis for Medicinal Purposes: A Cross-Sectional Analysis
Older Canadians’ Perceptions of the Safety, Effectiveness and Accessibility of Cannabis for Medicinal Purposes: A Cross-Sectional Analysis
Cannabis use is increasing among older adults, with use primarily for medicinal purposes. Much of the evidence on percepti...
Management of Scleritis in Older Adults
Management of Scleritis in Older Adults
Scleritis, an inflammatory disease of the eye affecting scleral tissue, presents unique challenges in the older adult popu...
Patterns of Comorbidities and Prescribing and Dispensing of Non-steroidal Anti-inflammatory Drugs (NSAIDs) Among Patients with Osteoarthritis in the USA: Real-World Study
Patterns of Comorbidities and Prescribing and Dispensing of Non-steroidal Anti-inflammatory Drugs (NSAIDs) Among Patients with Osteoarthritis in the USA: Real-World Study
Osteoarthritis (OA) is a major cause of chronic pain. Non-steroidal anti-inflammatory drugs (NSAIDs) are analgesics common...
Post-Stroke Depression in Older Adults: An Overview
Post-Stroke Depression in Older Adults: An Overview
Detailed data on post-stroke depression (PSD) in older adults are limited in spite of the high vulnerability of this popul...
Lipid-Lowering Medications are Associated with Reduced Sarcopenia-Related Quality of Life in Older Adults with Hyperlipidemia
Lipid-Lowering Medications are Associated with Reduced Sarcopenia-Related Quality of Life in Older Adults with Hyperlipidemia
Statins medications negatively affect age-associated loss of muscle mass and strength, termed sarcopenia, and neuromuscula...
Association of Tumor Necrosis Factor-α Inhibitors with Incident Dementia: Analysis Based on Population-Based Cohort Studies
Association of Tumor Necrosis Factor-α Inhibitors with Incident Dementia: Analysis Based on Population-Based Cohort Studies
Preliminary evidence suggests a possible preventive effect of tumor necrosis factor-α inhibitors (TNFi) on incident d...
Rosacea in Older Adults and Pharmacologic Treatments
Rosacea in Older Adults and Pharmacologic Treatments
Rosacea is a chronic inflammatory skin condition that is often more severe in older patients. The main clinical features a...
Measuring Quality of Life in Deprescribing Trials: A Scoping Review
Measuring Quality of Life in Deprescribing Trials: A Scoping Review
Quality of life (QoL) is an important outcome to capture in clinical trials evaluating deprescribing interventions. We aim...
Respiratory Syncytial Virus Infection in Older Adults: An Update
Respiratory Syncytial Virus Infection in Older Adults: An Update
Respiratory syncytial virus (RSV) infection represents one of the most common infections during childhood, with significan...
Toxicity in Older Patients with Cancer Receiving Immunotherapy: An Observational Study
Toxicity in Older Patients with Cancer Receiving Immunotherapy: An Observational Study
Checkpoint inhibition has emerged as an effective treatment strategy for a variety of cancers, including in older adults. ...
Associations Between Midlife Anticholinergic Medication Use and Subsequent Cognitive Decline: A British Birth Cohort Study
Associations Between Midlife Anticholinergic Medication Use and Subsequent Cognitive Decline: A British Birth Cohort Study
Anticholinergic medication use is associated with cognitive decline and incident dementia. Our study, a prospective birth&...
Potentially Inappropriate Psychotropic Drugs in Nursing Homes: An Italian Observational Study
Potentially Inappropriate Psychotropic Drugs in Nursing Homes: An Italian Observational Study
Physicians often face difficulties in selecting appropriate medications for older adults with multiple comorbidities. As p...
Cutaneous Lupus Erythematosus: Review and Considerations for Older Populations
Cutaneous Lupus Erythematosus: Review and Considerations for Older Populations
Though more common earlier in life, increasing attention is being focused on the development of cutaneous lupus erythemato...
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