SCI Abstract

search
+
Unraveling time-dependent genetic components underlying alcohol response
Unraveling time-dependent genetic components underlying alcohol response
While numerous studies have examined the subjective response to alcohol as an intermediate phenotype to understand its var...
Inflammatory pain in mice induces light cycle-dependent effects on sleep architecture
Inflammatory pain in mice induces light cycle-dependent effects on sleep architecture
Pain syndromes include physical, sensory, emotional, and cognitive symptoms such as disability, negative affect, feelings ...
Fatty acid amide hydrolase in major depressive episodes: A [11C]CURB positron emission tomography study
Fatty acid amide hydrolase in major depressive episodes: A [11C]CURB positron emission tomography study
The role of the endocannabinoid system (ECS) in major depressive disorder (MDD) is under-investigated despite reports of i...
The mesolimbic reward pathway is necessary for disruptions in cocaine-seeking behavior following mediated devaluation
The mesolimbic reward pathway is necessary for disruptions in cocaine-seeking behavior following mediated devaluation
We developed an approach to disrupt cocaine-seeking behaviors using mediated devaluation. Male rats underwent cocaine self...
Using causal network mapping to clarify pre-clinical brain stimulation results
Using causal network mapping to clarify pre-clinical brain stimulation results
SHS is primarily supported by public funds from the National Institute of Mental Health, but also has foundation funds fro...
Neurobiology of resilience to early life stress
Neurobiology of resilience to early life stress
The early years of life are a critical period for brain development, encompassing high sensitivity to adverse experiences....
Anti-seizure effects of WS-3, a TRPM8 agonist, on focal onset seizure mouse model via reduction of extracellular glutamate levels
Anti-seizure effects of WS-3, a TRPM8 agonist, on focal onset seizure mouse model via reduction of extracellular glutamate levels
The development of novel anti-seizure drugs targeting novel mechanisms is crucial, especially for patients with intractabl...
Circulating endocannabinoids in children and adolescents: associations with anxiety and the impact of selective serotonin reuptake inhibitors
Circulating endocannabinoids in children and adolescents: associations with anxiety and the impact of selective serotonin reuptake inhibitors
Anxiety disorders are prevalent psychiatric conditions that frequently emerge during adolescence. Among the neurobiologica...
Mitogen-activated protein kinase dependent presynaptic potentiation in the lateral habenula mediates depressive-like behaviors in rats
Mitogen-activated protein kinase dependent presynaptic potentiation in the lateral habenula mediates depressive-like behaviors in rats
Emerging evidence suggests that the enhanced activity of lateral habenula (LHb) is involved in depressive disorders. This ...
A sleepy cannabis constituent: cannabinol and its active metabolite influence sleep architecture in rats
A sleepy cannabis constituent: cannabinol and its active metabolite influence sleep architecture in rats
Medicinal cannabis is being used worldwide and there is increasing use of novel cannabis products in the community. Cannab...
Chronic Δ9-tetrahydrocannabinol exposure in adolescent nonhuman primates: persistent abnormalities in economic demand and brain functional connectivity
Chronic Δ9-tetrahydrocannabinol exposure in adolescent nonhuman primates: persistent abnormalities in economic demand and brain functional connectivity
Although chronic cannabis use during adolescence can alter brain function and impair complex behavioral processes, it is u...
Anterior piriform cortex dysfunction underlies autism spectrum disorders-related olfactory deficits in Fmr1 conditional deletion mice
Anterior piriform cortex dysfunction underlies autism spectrum disorders-related olfactory deficits in Fmr1 conditional deletion mice
Previous studies indicated that ASD-related olfactory dysfunctions are rooted in the piriform cortex. However, the direct ...
In memoriam – George R. Breese, Ph.D
In memoriam – George R. Breese, Ph.D
George R. Breese, PhD, was a longtime faculty at the University of North Carolina School of Medicine and the Bowles Center...
Decoding threat neurocircuitry representations during traumatic memory recall in PTSD
Decoding threat neurocircuitry representations during traumatic memory recall in PTSD
The neurocircuitry mechanisms underlying recall of traumatic memories remain unclear. This study investigated whether trau...
Endocannabinoid interference blocks post-global cerebral ischemia depression through prefrontal cortico-amygdala projections
Endocannabinoid interference blocks post-global cerebral ischemia depression through prefrontal cortico-amygdala projections
Up to 45% of patients surviving from transient global cerebral ischemia (GCI) after cardiac arrest develop post-global cer...
Longevity, enhanced memory, and altered density of dendritic spines in hippocampal CA3 and dentate gyrus after hemizygous deletion of Pde2a in mice
Longevity, enhanced memory, and altered density of dendritic spines in hippocampal CA3 and dentate gyrus after hemizygous deletion of Pde2a in mice
Studies using acute or subchronic pharmacological inhibition of phosphodiesterase 2 A (PDE2A) have led to its propos...
Prevalence and correlates of irritability among U.S. adults
Prevalence and correlates of irritability among U.S. adults
This study aimed to characterize the prevalence of irritability among U.S. adults, and the extent to which it co-occurs wi...
Acute sleep disruption reduces fear memories in male and female mice
Acute sleep disruption reduces fear memories in male and female mice
Sleep problems are a prominent feature of mental health conditions including post-traumatic stress disorder (PTSD). Despit...
What can neuroimaging of neuromodulation reveal about the basis of circuit therapies for psychiatry?
What can neuroimaging of neuromodulation reveal about the basis of circuit therapies for psychiatry?
Neuromodulation is increasingly becoming a therapeutic option for treatment resistant psychiatric disorders. These non-inv...
Replicability and generalizability in population psychiatric neuroimaging
Replicability and generalizability in population psychiatric neuroimaging
Studies linking mental health with brain function in cross-sectional population-based association studies have historicall...
Kappa opioid receptor availability predicts severity of anhedonia in schizophrenia
Kappa opioid receptor availability predicts severity of anhedonia in schizophrenia
The kappa opioid receptor (KOR) and its endogenous agonist dynorphin have been implicated in multiple psychiatric conditio...
Therapeutic efficacy of the BKCa channel opener chlorzoxazone in a mouse model of Fragile X syndrome
Therapeutic efficacy of the BKCa channel opener chlorzoxazone in a mouse model of Fragile X syndrome
Fragile X syndrome (FXS) is an X-linked neurodevelopmental disorder characterized by several behavioral abnormalities, inc...
GLP-1 receptor agonist exenatide uncouples food intake from hedonic and anticipatory regulation in non-human primates: insights from an operant meal schedule paradigm
GLP-1 receptor agonist exenatide uncouples food intake from hedonic and anticipatory regulation in non-human primates: insights from an operant meal schedule paradigm
Glucagon-like peptide 1 (GLP-1), a neuroendocrine signal of energy balance and satiety, has a major role in regulating foo...
Prenatal exposure to the mineralocorticoid receptor antagonist spironolactone disrupts hippocampal area CA2 connectivity and alters behavior in mice
Prenatal exposure to the mineralocorticoid receptor antagonist spironolactone disrupts hippocampal area CA2 connectivity and alters behavior in mice
In the brain, the hippocampus is enriched with mineralocorticoid receptors (MR; Nr3c2), a ligand-dependent transcription f...
Efficacy and safety of aticaprant, a kappa receptor antagonist, adjunctive to oral SSRI/SNRI antidepressant in major depressive disorder: results of a phase 2 randomized, double-blind, placebo-controlled study
Efficacy and safety of aticaprant, a kappa receptor antagonist, adjunctive to oral SSRI/SNRI antidepressant in major depressive disorder: results of a phase 2 randomized, double-blind, placebo-controlled study
This was a double-blind, randomized, phase 2 study of adults (18–64 years) with DSM−5 diagnosis of major depre...
Substance P in the medial amygdala regulates aggressive behaviors in male mice
Substance P in the medial amygdala regulates aggressive behaviors in male mice
Behavioral and clinical studies have revealed a critical role of substance P (SP) in aggression; however, the neural circu...
Side-effects of mdma-assisted psychotherapy: a systematic review and meta-analysis
Side-effects of mdma-assisted psychotherapy: a systematic review and meta-analysis
Evidence suggests that MDMA-assisted psychotherapy (MDMA-AP) has therapeutic potential for treatment of psychiatric illnes...
Dopamine D1 receptor in medial prefrontal cortex mediates the effects of TAAR1 activation on chronic stress-induced cognitive and social deficits
Dopamine D1 receptor in medial prefrontal cortex mediates the effects of TAAR1 activation on chronic stress-induced cognitive and social deficits
Trace amine-associated receptor 1 (TAAR1) is an intracellular expressed G-protein-coupled receptor that is widely expresse...
Effects of diazepam on hippocampal blood flow in people at clinical high risk for psychosis
Effects of diazepam on hippocampal blood flow in people at clinical high risk for psychosis
Elevated hippocampal perfusion has been observed in people at clinical high risk for psychosis (CHR-P). Preclinic...
A large-scale c-Fos brain mapping study on extinction of cocaine-primed reinstatement
A large-scale c-Fos brain mapping study on extinction of cocaine-primed reinstatement
Individuals with cocaine addiction can experience many craving episodes and subsequent relapses, which represents the main...
Load More
format_indent_increase