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Mitogen-activated protein kinase dependent presynaptic potentiation in the lateral habenula mediates depressive-like behaviors in rats
Mitogen-activated protein kinase dependent presynaptic potentiation in the lateral habenula mediates depressive-like behaviors in rats
Emerging evidence suggests that the enhanced activity of lateral habenula (LHb) is involved in depressive disorders. This ...
A sleepy cannabis constituent: cannabinol and its active metabolite influence sleep architecture in rats
A sleepy cannabis constituent: cannabinol and its active metabolite influence sleep architecture in rats
Medicinal cannabis is being used worldwide and there is increasing use of novel cannabis products in the community. Cannab...
Chronic Δ9-tetrahydrocannabinol exposure in adolescent nonhuman primates: persistent abnormalities in economic demand and brain functional connectivity
Chronic Δ9-tetrahydrocannabinol exposure in adolescent nonhuman primates: persistent abnormalities in economic demand and brain functional connectivity
Although chronic cannabis use during adolescence can alter brain function and impair complex behavioral processes, it is u...
Anterior piriform cortex dysfunction underlies autism spectrum disorders-related olfactory deficits in Fmr1 conditional deletion mice
Anterior piriform cortex dysfunction underlies autism spectrum disorders-related olfactory deficits in Fmr1 conditional deletion mice
Previous studies indicated that ASD-related olfactory dysfunctions are rooted in the piriform cortex. However, the direct ...
In memoriam – George R. Breese, Ph.D
In memoriam – George R. Breese, Ph.D
George R. Breese, PhD, was a longtime faculty at the University of North Carolina School of Medicine and the Bowles Center...
Decoding threat neurocircuitry representations during traumatic memory recall in PTSD
Decoding threat neurocircuitry representations during traumatic memory recall in PTSD
The neurocircuitry mechanisms underlying recall of traumatic memories remain unclear. This study investigated whether trau...
Endocannabinoid interference blocks post-global cerebral ischemia depression through prefrontal cortico-amygdala projections
Endocannabinoid interference blocks post-global cerebral ischemia depression through prefrontal cortico-amygdala projections
Up to 45% of patients surviving from transient global cerebral ischemia (GCI) after cardiac arrest develop post-global cer...
Longevity, enhanced memory, and altered density of dendritic spines in hippocampal CA3 and dentate gyrus after hemizygous deletion of Pde2a in mice
Longevity, enhanced memory, and altered density of dendritic spines in hippocampal CA3 and dentate gyrus after hemizygous deletion of Pde2a in mice
Studies using acute or subchronic pharmacological inhibition of phosphodiesterase 2 A (PDE2A) have led to its propos...
Prevalence and correlates of irritability among U.S. adults
Prevalence and correlates of irritability among U.S. adults
This study aimed to characterize the prevalence of irritability among U.S. adults, and the extent to which it co-occurs wi...
Acute sleep disruption reduces fear memories in male and female mice
Acute sleep disruption reduces fear memories in male and female mice
Sleep problems are a prominent feature of mental health conditions including post-traumatic stress disorder (PTSD). Despit...
What can neuroimaging of neuromodulation reveal about the basis of circuit therapies for psychiatry?
What can neuroimaging of neuromodulation reveal about the basis of circuit therapies for psychiatry?
Neuromodulation is increasingly becoming a therapeutic option for treatment resistant psychiatric disorders. These non-inv...
Replicability and generalizability in population psychiatric neuroimaging
Replicability and generalizability in population psychiatric neuroimaging
Studies linking mental health with brain function in cross-sectional population-based association studies have historicall...
Kappa opioid receptor availability predicts severity of anhedonia in schizophrenia
Kappa opioid receptor availability predicts severity of anhedonia in schizophrenia
The kappa opioid receptor (KOR) and its endogenous agonist dynorphin have been implicated in multiple psychiatric conditio...
Therapeutic efficacy of the BKCa channel opener chlorzoxazone in a mouse model of Fragile X syndrome
Therapeutic efficacy of the BKCa channel opener chlorzoxazone in a mouse model of Fragile X syndrome
Fragile X syndrome (FXS) is an X-linked neurodevelopmental disorder characterized by several behavioral abnormalities, inc...
GLP-1 receptor agonist exenatide uncouples food intake from hedonic and anticipatory regulation in non-human primates: insights from an operant meal schedule paradigm
GLP-1 receptor agonist exenatide uncouples food intake from hedonic and anticipatory regulation in non-human primates: insights from an operant meal schedule paradigm
Glucagon-like peptide 1 (GLP-1), a neuroendocrine signal of energy balance and satiety, has a major role in regulating foo...
Prenatal exposure to the mineralocorticoid receptor antagonist spironolactone disrupts hippocampal area CA2 connectivity and alters behavior in mice
Prenatal exposure to the mineralocorticoid receptor antagonist spironolactone disrupts hippocampal area CA2 connectivity and alters behavior in mice
In the brain, the hippocampus is enriched with mineralocorticoid receptors (MR; Nr3c2), a ligand-dependent transcription f...
Efficacy and safety of aticaprant, a kappa receptor antagonist, adjunctive to oral SSRI/SNRI antidepressant in major depressive disorder: results of a phase 2 randomized, double-blind, placebo-controlled study
Efficacy and safety of aticaprant, a kappa receptor antagonist, adjunctive to oral SSRI/SNRI antidepressant in major depressive disorder: results of a phase 2 randomized, double-blind, placebo-controlled study
This was a double-blind, randomized, phase 2 study of adults (18–64 years) with DSM−5 diagnosis of major depre...
Substance P in the medial amygdala regulates aggressive behaviors in male mice
Substance P in the medial amygdala regulates aggressive behaviors in male mice
Behavioral and clinical studies have revealed a critical role of substance P (SP) in aggression; however, the neural circu...
Side-effects of mdma-assisted psychotherapy: a systematic review and meta-analysis
Side-effects of mdma-assisted psychotherapy: a systematic review and meta-analysis
Evidence suggests that MDMA-assisted psychotherapy (MDMA-AP) has therapeutic potential for treatment of psychiatric illnes...
Dopamine D1 receptor in medial prefrontal cortex mediates the effects of TAAR1 activation on chronic stress-induced cognitive and social deficits
Dopamine D1 receptor in medial prefrontal cortex mediates the effects of TAAR1 activation on chronic stress-induced cognitive and social deficits
Trace amine-associated receptor 1 (TAAR1) is an intracellular expressed G-protein-coupled receptor that is widely expresse...
Effects of diazepam on hippocampal blood flow in people at clinical high risk for psychosis
Effects of diazepam on hippocampal blood flow in people at clinical high risk for psychosis
Elevated hippocampal perfusion has been observed in people at clinical high risk for psychosis (CHR-P). Preclinic...
A large-scale c-Fos brain mapping study on extinction of cocaine-primed reinstatement
A large-scale c-Fos brain mapping study on extinction of cocaine-primed reinstatement
Individuals with cocaine addiction can experience many craving episodes and subsequent relapses, which represents the main...
Alterations in adolescent brain serotonin (5HT)1A, 5HT2A, and dopamine (D)2 receptor systems in a nonhuman primate model of early life adversity
Alterations in adolescent brain serotonin (5HT)1A, 5HT2A, and dopamine (D)2 receptor systems in a nonhuman primate model of early life adversity
Stress affects brain serotonin (5HT) and dopamine (DA) function, and the effectiveness of 5HT and DA to regulate stress an...
Enhanced cognitive flexibility and phasic striatal dopamine dynamics in a mouse model of low striatal tonic dopamine
Enhanced cognitive flexibility and phasic striatal dopamine dynamics in a mouse model of low striatal tonic dopamine
The catecholamine neuromodulators dopamine and norepinephrine are implicated in motor function, motivation, and cognition....
Factors influencing JUUL e-cigarette nicotine vapour-induced reward, withdrawal, pharmacokinetics and brain connectivity in rats: sex matters
Factors influencing JUUL e-cigarette nicotine vapour-induced reward, withdrawal, pharmacokinetics and brain connectivity in rats: sex matters
Though vaping likely represents a safer alternative to smoking, it is not without risks, many of which are not well unders...
Activation of prefrontal parvalbumin interneurons ameliorates working memory deficit even under clinically comparable antipsychotic treatment in a mouse model of schizophrenia
Activation of prefrontal parvalbumin interneurons ameliorates working memory deficit even under clinically comparable antipsychotic treatment in a mouse model of schizophrenia
One of the critical unmet medical needs in schizophrenia is the treatment for cognitive deficits. However, the neural circ...
Targeting SIK3 to modulate hippocampal synaptic plasticity and cognitive function by regulating the transcription of HDAC4 in a mouse model of Alzheimer’s disease
Targeting SIK3 to modulate hippocampal synaptic plasticity and cognitive function by regulating the transcription of HDAC4 in a mouse model of Alzheimer’s disease
Cognitive deterioration and memory decline associated with the progression of Alzheimer’s disease (AD) primarily res...
Greater subjective effects of a low dose of LSD in participants with depressed mood
Greater subjective effects of a low dose of LSD in participants with depressed mood
Recent studies and anecdotal reports suggest that psychedelics can improve mood states, even at low doses. However, few pl...
Correction: Voltage-gated potassium channels control extended access cocaine seeking: a role for nucleus accumbens astrocytes
Authors and AffiliationsDepartment of Neuroscience, University of Kentucky, Lexington, KY, USAMengfan Xia, Tanner L. Ander...
ACNP 62nd Annual Meeting: Poster Abstracts P1 – P250
Sanjay Mathew*, Andrew J. Cutler, Nicole C. Visitacion, Michael Gold, Jason Yuan, Bill AuroraBaylor College of Medicine, H...
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