Fusar-Poli P. Integrated mental health services for the developmental period (0 to 25 Years): a critical review of the evidence. Front Psychiatry. 2019;10:355.

Article  PubMed  PubMed Central  Google Scholar 

Mcgorry PD, Killackey E, Yung A. Early intervention in psychosis: concepts, evidence and future directions. World Psychiatry. 2008;7:148–56.

Article  PubMed  PubMed Central  Google Scholar 

Fusar-Poli P, Davies C, Solmi M, Brondino N, De Micheli A, Kotlicka-Antczak M, et al. Preventive treatments for psychosis: umbrella review (Just the Evidence). Front Psychiatry. 2019;10:764.

Article  PubMed  PubMed Central  Google Scholar 

Bosnjak Kuharic D, Kekin I, Hew J, Rojnic Kuzman M, Puljak L. Interventions for prodromal stage of psychosis. Cochrane Database Syst Rev. 2019. https://doi.org/10.1002/14651858.CD012236.pub2

Article  PubMed  PubMed Central  Google Scholar 

Davies C, Cipriani A, Ioannidis JPA, Radua J, Stahl D, Provenzani U, et al. Lack of evidence to favor specific preventive interventions in psychosis: a network meta-analysis. World Psychiatry. 2018. https://doi.org/10.1002/wps.20526

Article  PubMed  PubMed Central  Google Scholar 

Devoe DJ, Farris MS, Townes P, Addington J. Interventions and transition in youth at risk of psychosis: a systematic review and meta-analyses. J Clin Psychiatry. 2020;81:9326.

Article  Google Scholar 

Lieberman JA, Girgis RR, Brucato G, Moore H, Provenzano F, Kegeles L, et al. Hippocampal dysfunction in the pathophysiology of schizophrenia: a selective review and hypothesis for early detection and intervention. Mol Psychiatry. 2018. https://doi.org/10.1038/mp.2017.249

Article  PubMed  PubMed Central  Google Scholar 

Knight S, McCutcheon R, Dwir D, Grace AA, O’Daly O, McGuire P, et al. Hippocampal circuit dysfunction in psychosis. Transl Psychiatry. 2022;12:344.

Article  PubMed  PubMed Central  Google Scholar 

Guo J, Rothman DL, Small SA. Why hippocampal glutamate levels are elevated in schizophrenia. JAMA Psychiatry. 2023;80:274–5.

Article  PubMed  Google Scholar 

Benes FM, Kwok EW, Vincent SL, Todtenkopf MS. A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives. Biol Psychiatry. 1998;44:88–97.

Article  CAS  PubMed  Google Scholar 

Heckers S, Stone D, Walsh J, Shick J, Koul P, Benes FM. Differential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophrenia. Arch Gen Psychiatry. 2002;59:521–9.

Article  CAS  PubMed  Google Scholar 

Zhang ZJ, Reynolds GP. A selective decrease in the relative density of parvalbumin-immunoreactive neurons in the hippocampus in schizophrenia. Schizophr Res. 2002;55:1–10.

Article  PubMed  Google Scholar 

Konradi C, Yang CK, Zimmerman EI, Lohmann KM, Gresch P, Pantazopoulos H, et al. Hippocampal interneurons are abnormal in schizophrenia. Schizophr Res. 2011;131:165–73.

Article  PubMed  PubMed Central  Google Scholar 

Wang AY, Lohmann KM, Yang CK, Zimmerman EI, Pantazopoulos H, Herring N, et al. Bipolar disorder type 1 and schizophrenia are accompanied by decreased density of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region. Acta Neuropathol. 2011;122:615–26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Singh T, Poterba T, Curtis D, Akil H, Al Eissa M, Barchas JD. Rare coding variants in ten genes confer substantial risk for schizophrenia. Nature. 2022;604:509–16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Trubetskoy V, Pardiñas AF, Qi T, Panagiotaropoulou G, Awasthi S, Bigdeli TB, et al. Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature. 2022;604:502–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heckers S, Konradi C. GABAergic mechanisms of hippocampal hyperactivity in schizophrenia. Schizophr Res. 2015. https://doi.org/10.1016/j.schres.2014.09.041

Article  PubMed  PubMed Central  Google Scholar 

Cenquizca LA, Swanson LW. Spatial organization of direct hippocampal field CA1 axonal projections to the rest of the cerebral cortex. Brain Res Rev. 2007;56:1–26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Groenewegen HJ, der Zee EVV, te Kortschot A, Witter MP. Organization of the projections from the subiculum to the ventral striatum in the rat. A study using anterograde transport of Phaseolus vulgaris leucoagglutinin. Neuroscience. 1987;23:103–20.

Article  CAS  PubMed  Google Scholar 

Herman JP, Mueller NK. Role of the ventral subiculum in stress integration. Behav Brain Res. 2006;174:215–24.

Article  CAS  PubMed  Google Scholar 

Jay TM, Witter MP. Distribution of hippocampal CA1 and subicular efferents in the prefrontal cortex of the rat studied by means of anterograde transport of Phaseolus vulgaris-leucoagglutinin. J Comparat Neurol. 1991;313:574–86.

Article  CAS  Google Scholar 

Grace AA. Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression. Nat Rev Neurosci. 2016. https://doi.org/10.1038/nrn.2016.57

Article  PubMed  PubMed Central  Google Scholar 

O’Donnell P, Grace AA. Synaptic interactions among excitatory afferents to nucleus accumbens neurons: hippocampal gating of prefrontal cortical input. J Neurosci. 1995;15:3622–39.

Article  PubMed  PubMed Central  Google Scholar 

Moore H, Jentsch JD, Ghajarnia M, Geyer MA, Grace AA. A neurobehavioral systems analysis of adult rats exposed to methylazoxymethanol acetate on E17: implications for the neuropathology of schizophrenia. Biol Psychiatry. 2006. https://doi.org/10.1016/j.biopsych.2006.01.003

Article  PubMed  PubMed Central  Google Scholar 

Lodge DJ, Grace AA. Aberrant hippocampal activity underlies the dopamine dysregulation in an animal model of schizophrenia. J Neurosci. 2007. https://doi.org/10.1523/JNEUROSCI.2847-07.2007

Article  PubMed  PubMed Central  Google Scholar 

Lodge DJ, Grace AA. Hippocampal dysfunction and disruption of dopamine system regulation in an animal model of schizophrenia. Neurotox Res. 2008. https://doi.org/10.1007/BF03033801

Article  PubMed  PubMed Central  Google Scholar 

Lodge DJ, Behrens MM, Grace AA. A loss of parvalbumin-containing interneurons is associated with diminished oscillatory activity in an animal model of schizophrenia. J Neurosci. 2009. https://doi.org/10.1523/JNEUROSCI.5419-08.2009

Article  PubMed  PubMed Central  Google Scholar 

Gilani AI, Chohan MO, Inan M, Schobel SA, Chaudhury NH, Paskewitz S, et al. Interneuron precursor transplants in adult hippocampus reverse psychosis-relevant features in a mouse model of hippocampal disinhibition. Proc Natl Acad Sci USA. 2014;111:7450–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kiemes A, Serrano Navacerrada ME, Kim E, Randall K, Simmons C, Rojo Gonzalez L, et al. Erbb4 deletion from inhibitory interneurons causes psychosis-relevant neuroimaging phenotypes. Schizophr Bull. 2022;49:569–80.

Article  PubMed Central  Google Scholar 

Boley AM, Perez SM, Lodge DJ. A fundamental role for hippocampal parvalbumin in the dopamine hyperfunction associated with schizophrenia. Schizophr Res. 2014. https://doi.org/10.1016/j.schres.2014.05.005

Article  PubMed  PubMed Central  Google Scholar 

Lander SS, Khan U, Lewandowski N, Chakraborty D, Provenzano FA, Mingote S, et al. Glutamate dehydrogenase–deficient mice display schizophrenia-like behavioral abnormalities and CA1-specific hippocampal dysfunction. Schizophr Bull. 2019;45:127–37.

Article  PubMed  Google Scholar 

Donegan JJ, Boley AM, Yamaguchi J, Toney GM, Lodge DJ. Modulation of extrasynaptic GABAA alpha 5 receptors in the ventral hippocampus normalizes physiological and behavioral deficits in a circuit specific manner. Nat Commun. 2019;10:2819.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Perez SM, McCoy AM, Prevot TD, Mian MY, Carreno FR, Frazer A, et al. Hippocampal α5-GABAA receptors modulate dopamine neuron activity in the rat ventral tegmental area. Biol Psychiatry Global Open Sci. 2023;3:78–86.

Article  Google Scholar 

Gill KM, Lodge DJ, Cook JM, Aras S, Grace AA. A novel α5GABA a r-positive allosteric modulator reverses hyperactivation of the dopamine system in the MAM model of schizophrenia. Neuropsychopharmacology. 2011. https://doi.org/10.1038/npp.2011.76

Article  PubMed  PubMed Central  Google Scholar 

Du Y, Grace AA. Peripubertal diazepam administration prevents the emergence of dopamine system hyperresponsivity in the MAM developmental disruption model of schizophrenia. Neuropsychopharmacology. 2013. https://doi.org/10.1038/npp.2013.101

Article  PubMed  PubMed Central  Google Scholar