Miller GM, Verrico CD, Jassen A, Konar M, Yang H, Panas H, et al. Primate trace amine receptor 1 modulation by the dopamine transporter. J Pharmacol Exp Ther. 2005;313:983–94.

Article  CAS  PubMed  Google Scholar 

Revel FG, Meyer CA, Bradaia A, Jeanneau K, Calcagno E, Andre CB, et al. Brain-specific overexpression of trace amine-associated receptor 1 alters monoaminergic neurotransmission and decreases sensitivity to amphetamine. Neuropsychopharmacology. 2012;37:2580–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dorotenko A, Tur M, Dolgorukova A, Bortnikov N, Belozertseva IV, Zvartau EE, et al. The action of TAAR1 agonist RO5263397 on executive functions in rats. Cell Mol Neurobiol. 2020;40:215–28.

Article  CAS  PubMed  Google Scholar 

Wu R, Liu J, Seaman R Jr, Johnson B, Zhang Y, Li JX. The selective TAAR1 partial agonist RO5263397 promoted novelty recognition memory in mice. Psychopharmacology. 2021;238:3221–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tanaka K, Furuyashiki T, Kitaoka S, Senzai Y, Imoto Y, Segi-Nishida E, et al. Prostaglandin E2-mediated attenuation of mesocortical dopaminergic pathway is critical for susceptibility to repeated social defeat stress in mice. J Neurosci. 2012;32:4319–29.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lupien SJ, McEwen BS, Gunnar MR, Heim C. Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat Rev Neurosci. 2009;10:434–45.

Article  CAS  PubMed  Google Scholar 

Tzschentke TM. The medial prefrontal cortex as a part of the brain reward system. Amino Acids. 2000;19:211–9.

Article  CAS  PubMed  Google Scholar 

Cools R, Arnsten AFT. Neuromodulation of prefrontal cortex cognitive function in primates: the powerful roles of monoamines and acetylcholine. Neuropsychopharmacology. 2022;47:309–28.

Article  PubMed  Google Scholar 

Xu P, Yue YL, Su JT, Sun XQ, Du HF, Liu ZC, et al. Pattern decorrelation in the mouse medial prefrontal cortex enables social preference and requires MeCP2. Nat Commun. 2022;13:3899.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moghaddam B, Adams B, Verma A, Daly D. Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. J Neurosci. 1997;17:2921–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tzschentke TM. Pharmacology and behavioral pharmacology of the mesocortical dopamine system. Prog Neurobiol. 2001;63:241–320.

Article  CAS  PubMed  Google Scholar 

Beaulieu JM, Gainetdinov RR. The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev. 2011;63:182–217.

Article  CAS  PubMed  Google Scholar 

Goldman-Rakic PS, Castner SA, Svensson TH, Siever LJ, Williams GV. Targeting the dopamine D1 receptor in schizophrenia: insights for cognitive dysfunction. Psychopharmacology. 2004;174:3–16.

Article  CAS  PubMed  Google Scholar 

Arnsten AF, Wang MJ, Paspalas CD. Neuromodulation of thought: flexibilities and vulnerabilities in prefrontal cortical network synapses. Neuron. 2012;76:223–39.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xing B, Mack NR, Guo KM, Zhang YX, Ramirez B, Yang SS, et al. A subpopulation of prefrontal cortical neurons is required for social memory. Biol Psychiatry. 2021;89:521–31.

Article  CAS  PubMed  Google Scholar 

Cai XW, Wu M, Zhang ZA, Liu HC, Huang ST, Song J, et al. Electroacupuncture alleviated depression-like behaviors in ventromedial prefrontal cortex of chronic unpredictable mild stress-induced rats: increasing synaptic transmission and phosphorylating dopamine transporter. CNS Neurosci Ther. 2023;29:2608–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shinohara R, Taniguchi M, Ehrlich AT, Yokogawa K, Deguchi Y, Cherasse Y, et al. Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice. Mol Psychiatry. 2018;23:1717–30.

Article  CAS  PubMed  Google Scholar 

Zhang Y, Li JT, Wang H, Niu WP, Zhang CC, Zhang Y, et al. Role of trace amine‑associated receptor 1 in the medial prefrontal cortex in chronic social stress-induced cognitive deficits in mice. Pharmacol Res. 2021;167:105571.

Article  CAS  PubMed  Google Scholar 

Pei Y, Asif-Malik A, Canales JJ. Trace amines and the trace amine-associated receptor 1: pharmacology, neurochemistry, and clinical implications. Front Neurosci. 2016;10:148.

Article  PubMed  PubMed Central  Google Scholar 

Xie ZH, Miller GM. Trace amine-associated receptor 1 as a monoaminergic modulator in brain. Biochem Pharmacol. 2009;78:1095–104.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie Z, Westmoreland SV, Miller GM. Modulation of monoamine transporters by common biogenic amines via trace amine-associated receptor 1 and monoamine autoreceptors in human embryonic kidney 293 cells and brain synaptosomes. J Pharmacol Exp Ther. 2008;325:629–40.

Article  CAS  PubMed  Google Scholar 

Harmeier A, Obermueller S, Meyer CA, Revel FG, Buchy D, Chaboz S, et al. Trace amine-associated receptor 1 activation silences GSK3β signaling of TAAR1 and D2R heteromers. Eur Neuropsychopharm. 2015;25:2049–61.

Article  CAS  Google Scholar 

Espinoza S, Salahpour A, Masri B, Sotnikova TD, Messa M, Barak LS, et al. Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor. Mol Pharmacol. 2011;80:416–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leo D, Mus L, Espinoza S, Hoener MC, Sotnikova TD, Gainetdinov RR. TAAR1-mediated modulation of presynaptic dopaminergic neurotransmission: role of D2 dopamine autoreceptors. Neuropharmacology. 2014;81:283–91.

Article  CAS  PubMed  Google Scholar 

De Gregorio D, Posa L, Ochoa-Sanchez R, McLaughlin R, Maione S, Comai S, et al. The hallucinogen D-lysergic diethylamide (LSD) decreases dopamine firing activity through 5-HT1A, D2 and TAAR1 receptors. Int J Neuropsychoph. 2016;19:181.

Google Scholar 

Grinchii D, Hoener MC, Khoury T, Dekhtiarenko R, Bervanlou RN, Jezova D, et al. Effects of acute and chronic administration of trace amine-associated receptor 1 (TAAR1) ligands on in vivo excitability of central monoamine-secreting neurons in rats. Mol Psychiatry. 2022;27:4861–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Espinoza S, Leou D, Sotnikova TD, Shahid M, Kääriäinen TM, Gainetdinov RR. Biochemical and functional characterization of the trace amine-associated receptor 1 (TAAR1) agonist RO5263397. Front Pharmacol. 2018;9:645.

Article  PubMed  PubMed Central  Google Scholar 

Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, et al. The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. PLoS Biol. 2020;18:e3000410.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wagner KV, Wang XD, Liebl C, Scharf SH, Müller MB, Schmidt MV. Pituitary glucocorticoid receptor deletion reduces vulnerability to chronic stress. Psychoneuroendocrinology. 2011;36:579–87.

Article  CAS  PubMed  Google Scholar 

Haenisch B, Bilkei-Gorzo A, Caron MG, Bönisch H. Knockout of the norepinephrine transporter and pharmacologically diverse antidepressants prevent behavioral and brain neurotrophin alterations in two chronic stress models of depression. J Neurochem. 2009;111:403–16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li JT, Xie XM, Yu JY, Sun YX, Liao XM, Wang XX, et al. Suppressed calbindin levels in hippocampal excitatory neurons mediate stress-induced memory loss. Cell Rep. 2017;21:891–900.

Article  CAS  PubMed  Google Scholar 

Yang XD, Liao XM, Uribe-Marino A, Liu R, Xie XM, Jia J, et al. Stress during a critical postnatal period induces region-specific structural abnormalities and dysfunction of the prefrontal cortex via CRF1. Neuropsychopharmacology. 2015;40:1203–15.

Article  CAS  PubMed  Google Scholar 

Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25:402–8.

Article  CAS  PubMed  Google Scholar 

Waterhouse A, Bertoni M, Bienert S, Studer G, Tauriello G, Gumienny R, et al. SWISS-MODEL: homology modelling of protein structures and complexes. Nucleic Acids Res. 2018;46:W296–W303.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Biasini M,