Kapoor DU, Garg R, Gaur M, Patel MB, Minglani VV, Prajapati BG, et al. Pediatric drug delivery challenges: enhancing compliance through age-appropriate formulations and safety measures. J Drug Deliv Sci Technol. 2024;96:105720.

Article  CAS  Google Scholar 

Martir J, Flanagan T, Mann J, Fotaki N. Recommended strategies for the oral administration of paediatric medicines with food and drinks in the context of their biopharmaceutical properties: a review. J Pharm Pharmacol. 2017;69(4):384–97.

Article  PubMed  CAS  Google Scholar 

Martínez-Terán ME, Hoang-Thi TH, Flament MP. Multiparticulate dosage forms for pediatric use. Pediatr Ther. 2017;7(314):2161–0665.

Google Scholar 

Stoltenberg I, Breitkreutz J. Orally disintegrating mini-tablets (ODMTs)–a novel solid oral dosage form for paediatric use. Eur J Pharm Biopharm. 2011;78(3):462–9.

Article  PubMed  CAS  Google Scholar 

Zajicek A, Fossler MJ, Barrett JS, Worthington JH, Ternik R, Charkoftaki G, Lum S, Breitkreutz J, Baltezor M, Macheras P, Khan M, Agharkar S, MacLaren DD. A report from the pediatric formulations task force: perspectives on the state of child-friendly oral dosage forms. AAPS J. 2013;15(4):1072–81.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Moreira M. Pharmaceutics MSI journal of, 2020. How can oral paediatric formulations be improved? A challenge for the XXI century. Int J Pharm. 2020;590–119905.

Wang B, Yang L, Wang B, Luo C, Wang Y, Wang H, Chen F, Xiang X. Development, in vitro and in vivo evaluation of Racecadotril orodispersible films for pediatric use. AAPS PharmSciTech. 2021;22(1):1–13.

Article  Google Scholar 

Ivanovska V, Rademaker C, van Dijk L. Pediatric drug formulations: a review of challenges and progress. Pediatrics. 2014;134(2):361–72.

Article  PubMed  Google Scholar 

Narang M, Shah D, Akhtar H. Efficacy and safety of Drotaverine hydrochloride in children with recurrent abdominal pain: A randomized placebo controlled trial. Indian Pediatr. 2015;52:847–85152.

Article  PubMed  Google Scholar 

Bhise S, Mathure D, Patil MVK. Solubility enhancement of antihypertensive agent by solid dispersion technique. Int J Pharm Life Sci. 2011;2(8):970–5.

CAS  Google Scholar 

Ibrahim M, El-Badry M. Formulation of immediate release pellets containing famotidine solid dispersions. Saudi Pharm J. 2014;22(2):149–56.

Article  PubMed  Google Scholar 

Kumar A, Ghosh M, Bithy M, Khan MRI. Development and evaluation of stable Paracetamol loaded solid dispersion with enhanced analgesic and hepatoprotective property. Pharmacol Pharm. 2023;14(4):123–43.

Article  CAS  Google Scholar 

Kilor VA, Sapkal NP, Awari JG, Shewale BD. Development and characterization of enteric-coated immediate-release pellets of aceclofenac by extrusion/spheronization technique using κ-carrageenan as a pelletizing agent. AAPS PharmSciTech. 2010;11(1):336–43.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Mandal R, Saini P, Pal R, Pandey P. Coating tablets, compositions, recent advancement and current status: a comprehensive review. J Drug Deliv Ther. 2024;14(10):182–95.

Article  CAS  Google Scholar 

Alburyhi M, Saif A, Noman MA. Domperidone-excipient compatibility studies for advanced drug delivery systems development. World J Biomed Pharm Sci. 2025;12(3):250–69.

CAS  Google Scholar 

Vélaz I, Sánchez M, Martín C, Martínez-Ohárriz MC. Effect of PEG 4000 on the dissolution rate of Naproxen. Eur J Drug Metab Pharmacokinet. 1998;23(2):103–8.

Article  PubMed  Google Scholar 

Patel M, Shelke S, Shaikh F, Surti N, Panzade P, Panjwani D. Gastroretentive floating microsponges of mitiglinide: design, preparation, and pharmacokinetic evaluation. J Pharm Innov. 2023;18(3):1500–14.

Article  Google Scholar 

Shaikh F, Patel M, Shelke S, Patel V, Jani D, Shinde G, et al. Formulation, characterization, optimization, and pharmacokinetic evaluation of Cilnidipine-loaded liquisolid compacts with improved dissolution and bioavailability. J Pharm Innov. 2023;18(2):404–25.

Article  Google Scholar 

de Souza Candeo E, Scheufele FB, de Cassia Campos Pena A, Dequigiovanni G, Linde GA, Mata G, Colauto NB, Schaker PDC. Fungal lignocellulolytic enzymes: an in Silico and full factorial design approach. World J Microbiol Biotechnol. 2025;41(2).

Schlick-Hasper E, Bethke J, Vogler N, Goedecke T. Flow properties of powdery or granular filling substances of dangerous goods packagings—comparison of the measurement of the angle of repose and the determination of the Hausner ratio. Packag Technol Sci. 2022;35(10):765–82.

Article  Google Scholar 

Akseli I, Hilden J, Katz JM, Kelly RC, Kramer TT, Mao C, et al. Reproducibility of the measurement of bulk/tapped density of pharmaceutical powders between pharmaceutical laboratories. J Pharm Sci. 2019;108(3):1081–4.

Article  PubMed  CAS  Google Scholar 

Vertomrnen J, industrial, RKD development. and, 1997 undefined. The influence of five selected processing and formulation variables on the particle size, particle size distribution, and friability of pellets produced in a rotary processor. Taylor & FrancisJ Vertomrnen, R KingetDrug development and industrial pharmacy, 1997•Taylor & Francis. 1997;23(1):39–46.

Hill SW, Varker AS, Karlage K, Myrdal PB. Analysis of drug content and weight uniformity for half-tablets of 6 commonly split medications. J Manag Care Pharm. 2015;15(3):253–61.

Google Scholar 

Brniak W, Jachowicz R, Pelka P. The practical approach to the evaluation of methods used to determine the disintegration time of orally disintegrating tablets (ODTs). Saudi Pharm J. 2015;23(4):437–43.

Article  PubMed  PubMed Central  Google Scholar 

Louis MM, Badawy AA, Nessem DI, Abd Elmalak NS. Drotaverine hydrochloride gastroretentive floating mini-tablets: formulation, in-vitro and in-vivo evaluation. J Drug Deliv Sci Technol. 2020;57:101733.

Article  CAS  Google Scholar 

Ekenna IC, Abali SO. Comparison of the use of kinetic model plots and DD solver software to evaluate the drug release from Griseofulvin tablets. J Drug Deliv Ther. 2022;12(s):5–13.

Article  CAS  Google Scholar 

Guo S, Wang G, Wu T, Bai F, Xu J, Zhang X. Solid dispersion of berberine hydrochloride and Eudragit® S100: formulation, physicochemical characterization and cytotoxicity evaluation. J Drug Deliv Sci Technol. 2017;40:21–7.

Article  CAS  Google Scholar 

Pearnchob N, Bodmeier R. Dry powder coating of pellets with micronized Eudragit® RS for extended drug release. Pharm Res. 2003;20(12):1970–6.

Article  PubMed  CAS  Google Scholar 

Thoma K, Bechtold K. Influence of aqueous coatings on the stability of enteric coated pellets and tablets. Eur J Pharm Biopharm. 1999;47(1):39–50.

Article  PubMed  CAS  Google Scholar 

Drotaverin. HCl – Neutral Pharma [Internet]. Available from: https://neutralpharma.com/product/drotaverin-hcl/

Pavel IZ, Heller L, Sommerwerk S, Loesche A, Al-Harrasi A, Csuk R. Drotaverine – Concealed Cytostatic! Arch Pharm (Weinheim). 2017;350(1).

Sarode AL, Sandhu H, Shah N, Malick W, Zia H. Hot melt extrusion (HME) for amorphous solid dispersions: predictive tools for processing and impact of drug–polymer interactions on supersaturation. Eur J Pharm Sci. 2013;48(3):371–84.

Article  PubMed  CAS  Google Scholar 

Patel N, Serajuddin ATM. Moisture sorption by polymeric excipients commonly used in amorphous solid dispersion and its effect on glass transition temperature: I. Polyvinylpyrrolidone and. Int J Pharm. 2022;616:121532.

Article  PubMed  CAS  Google Scholar 

Ambike AA, Mahadik KR, Paradkar A. Spray-dried amorphous solid dispersions of simvastatin, a low Tg drug: in vitro and in vivo evaluations. Pharm Res. 2005;22(6):990–8.

Article  PubMed  CAS  Google Scholar 

Liu C, Desai KG. Characteristics of rofecoxib-polyethylene glycol 4000 solid dispersions and tablets based on solid dispersions. Pharm Dev Technol. 2005;10(4):467–77.

Article  PubMed  CAS  Google Scholar 

Soare AC, Meltzer V, Colbea C, Stanculescu I, Pincu E. Compatibility of Drotaverine hydrochloride with ibuprofen and ketoprofen nonsteroidal anti-inflammatory drugs mixtures. Materials. 2022. https://doi.org/10.3390/ma15031244.

Article  PubMed  PubMed Central  Google Scholar 

Gurram R, Gandra S, Shastri NR. Design and optimization of disintegrating pellets of MCC by non-aqueous extrusion process using statistical tools. Eur J Pharm Sci. 2016;84:146–56.

Article  PubMed  CAS  Google Scholar 

Dash S, Murthy P, Nath L, Chowdhury P. Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol Pharm. 2010;67(3):217–23.

PubMed  CAS  Google Scholar 

Ahsan W, Alam S, Javed S, Alhazmi HA. Study of drug release kinetics of Rosuvastatin calcium immediate-release tablets marketed in Saudi Arabia. Dissolution Technol. 2022;29:GC1.