Development and Evaluation of Luliconazole-Loaded Microsponge Gel for Improved Topical Retention and Reduced Irritation

Kshatriya PJ, Shinde JV, Chavan RS. As review on microsponge gel as topical drug delivery system. JDDT. 2020;10(6):125–33. https://doi.org/10.22270/jddt.v10i6-s.4455.

Article  Google Scholar 

Kumar Jilta R, Prashar D. Pharmaceutical and economical prospective of microsponges drug delivery system, AJPRD. 2025;13(1): 81–3. https://doi.org/10.22270/ajprd.v13i1.1507

Kumar M, Ali S, Gohri S. Microsponge drug delivery systems: advancing methotrexate delivery for rheumatoid arthritis management. CPR. 2025;1(1):15–29.

Article  Google Scholar 

Vyas A, Jain V. Luliconazole promising drug for dermatophytes: a review. Int J Technol. 2023;13(2):79–84. https://doi.org/10.52711/2231-3915.2023.00010.

Article  Google Scholar 

Sharma P, Kaushik P, Sharma SK, Dhankhar S. Exploring Microsponges in Dermatology: Opportunities and Hurdles Ahead: Micro and Nanosystems B.S. 2024;16(2): 65–74. https://doi.org/10.2174/0118764029295903240328054858

Raut AV, Kathar N, Sanap G, Microsponges. The drug delivery system. Int J Pharm Sci. 2024;2(1):328–41. https://doi.org/10.5281/zenodo.10523750.

Article  Google Scholar 

Srinatha N, Sowjanya B, Vishwanath BA. Microsponges: a promising frontier for prolonged release-current perspectives and patents. BENI-SUEF U J BASIC. 2024;13:60: 1–19. https://doi.org/10.1186/s43088-024-00519-4.

Article  Google Scholar 

Halder S, Behera U. Preparation of microsponge drug delivery system (MSDDS) followed by a scale-up approach. AAPS Pharm Sci Tech. 2024;25:162–70. https://doi.org/10.1208/s12249-024-02874-y.

Article  CAS  Google Scholar 

Mohanraj VJ, Chen YJ. Nanoparticles—a review. Trop J Pharm Res. 2006;5(1):561–73.

Google Scholar 

Osmani RA, Aloorkar NH, Thaware BU, Kulkarni PK, Moin A, Hani U, et al. Microsponge-based drug delivery system for augmented gastroparesis therapy: formulation development and evaluation. Asian J Pharm Sci. 2015;10(5):442–51.

Google Scholar 

Walters KA, editor. Dermatological and transdermal formulations. Boca Raton: CRC; 2002.

Google Scholar 

Jain V, Singh R. Dicyclomine-loaded Eudragit®-based microsponge with potential for colonic delivery: preparation and characterization. Trop J Pharm Res. 2010;9(1):67–72.

Article  CAS  Google Scholar 

Patel UB, Chainesh N. Shah 2. Formulation and development of aceclofenac loaded microsponges for topical delivery using quality by design approach int. J Pharm. 2018;7(04):17–32.

Google Scholar 

Dhyani A, Kumar G. Development and characterization of atenolol-based microsponge gel for ophthalmic delivery. Int J Pharm Educ Res. 2025;59(1):114–20. https://doi.org/10.5530/ijper.20255777.

Article  Google Scholar 

Yadav KS, Kale K. High-pressure homogenizer in pharmaceuticals: understanding its critical processing parameters and application. J Pharm Innov. 2019;15(1):1–12. https://doi.org/10.1007/s12247-019-09413-4.

Article  CAS  Google Scholar 

Mandal S, Bhumika K, Kumar M, Hak J. A novel approach on microsponges drug delivery system: p of preparations, application, and its future prospective. Int J Pharm Educ Res. 2024;58(1):45–63. https://doi.org/10.5530/ijper.58.1.

Article  CAS  Google Scholar 

Li M, Gan J, Xu X, Zhang S, Li Y, Bian L, Dong Z. Preparation, characterisation and in vitro anti-inflammatory activity of Baicalin microsponges. Heliyon. 2024;10(7):e29151. https://doi.org/10.1016/j.heliyon.2024.e29151.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Nagula RL, Wairkar S. Cellulose microsponges based gel of naringenin for atopic dermatitis: design, optimization, in vitro and in vivo investigation. Int J Biol Macromol. 2020;164:717–25. https://doi.org/10.1016/j.ijbiomac.2020.07.168.

Article  PubMed  CAS  Google Scholar 

Kumar M, Shanthi N. Qualitative and quantitative methods for determination of drug Luliconazole. Int J Res Advent Technol. 2018;6(10):2764–70.

CAS  Google Scholar 

Oza NA, Sahoo S, Sagara S. 3² full factorial design for topical controlled release Tazarotene microsponge using HPMC gel. Int J Appl Pharm. 2019;11:12–8. https://doi.org/10.22159/ijap.2019v11i5.34496.

Article  CAS  Google Scholar 

He Y, Hussain T. Formulation and characterization of lornoxicam-loaded cellulosic microsponge gel for possible applications in arthritis. Saudi Pharm J. 2020;28:994–1003. https://doi.org/10.1016/j.jsps.2020.06.021.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Balamurugan P, Govardhan P. Microsponges: as a drug delivery system. Pharma Innov J. 2019;8(1):139–43.

CAS  Google Scholar 

Yadav V, Jadhav P, Dombe S. Formulation and evaluation of microsponge gel for topical delivery of antifungal drug. Int J Appl Pharm. 2017;9(4):120–6. https://doi.org/10.22159/ijap.2017v9i4.17760.

Article  CAS  Google Scholar 

Tangri S, Khurana G, Gnanarajan G, Sisodiya V, Rana S. Preparation and in vitro characterization of diacerein microsponges loaded topical gels. Int J Pharm Investig. 2024;14(3):794–805.

Article  CAS  Google Scholar 

Hong J, Chen H, Xiang S, Zuo T, Cao S, Liu L. Toward application of microsponges in transdermal drug delivery system. MOJ Bioequiv. 2015;1:1–7.

Google Scholar 

Amrutiya N, Bajaj A, Madan M. Development of microsponges for topical delivery of mupirocin. AAPS PharmSciTech. 2009;10(2):402–6.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bhatia M, Saini M. Formulation and evaluation of Curcumin microsponges for oral and topical drug delivery. Prog Biomater. 2018;7:239–48. https://doi.org/10.1007/s40204-018-0087-2.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gholap AD. Investigation of Ethyl cellulose microsponge gel for topical delivery of eberconazole nitrate for fungal therapy. Ther Deliv. 2014;5(7):781–94. https://doi.org/10.4155/tde.14.41.

Article  PubMed  CAS  Google Scholar 

Mahaparale PR. Development and evaluation of terbinafine polymeric microsponges for topical drug delivery. Indian J Pharm Sci. 2018;80(6):1086–92. https://doi.org/10.4172/pharmaceutical-sciences.1000462.

Article  CAS  Google Scholar 

Bothiraja C, Gholap AD, Pawar AP. Investigation of ethyl cellulose microsponge gel for topical delivery of eberconazole nitrate for fungal therapy. Ther Deliv. 2014;5(7):781–94. https://doi.org/10.4155/tde.14.43.

Article  PubMed  CAS  Google Scholar 

Kumar PM, Ghosh A. Development and evaluation of silver sulfadiazine loaded microsponge-based gel for partial thickness (second degree) burn wounds. Eur J Pharm Sci. 2017;96:243–54. https://doi.org/10.1016/j.ejps.2016.09.038.

Article  PubMed  CAS  Google Scholar 

Salah S, Awad GEA. Improved vaginal retention and enhanced antifungal activity of miconazole microsponges gel: formulation development and in vivo therapeutic efficacy. Eur J Pharm Sci. 2018;114:255–66. https://doi.org/10.1016/j.ejps.2017.12.023.

Article  PubMed  CAS  Google Scholar 

Ramesh GS, Hussain N, Roy S, Kaity S. Composite polymeric microsponge-based long-acting gel formulation for topical delivery of mupirocin. J Appl Polym Sci. 2023;141(8):121–8. https://doi.org/10.1002/app.54975.

Article  CAS  Google Scholar 

Rizkalla CMZ, Aziz RL, Soliman II. In vitro and in vivo evaluation of hydroxyzine hydrochloride microsponges for topical delivery. AAPS PharmSciTech. 2011;12(3):989–1001. https://doi.org/10.1208/s12249-011-9663-5.

Article  CAS  Google Scholar 

Pandey P, Misra SK, Kapoor A. Tolnaftate microsponges embedded biocompatible gels for controlled and effective antidermatophytic activity. Int Res J Pharm. 2018;9(6):128–33. https://doi.org/10.7897/2230-8407.09694.

Article  CAS  Google Scholar 

Goci E, Haloci E, Dxhulaj S, Mala L. Formulation and in vitro evaluation of diclofenac sodium gel. Int J Pharm Pharm Sci. 2014;6(4):564–6.

Google Scholar 

Patel K, Narola M, Dhameliya P. Formulation and evaluation of ciclopirox olamine microsponge based topical gel. Inventi Rapid NDDS. 2014;3:1.

Google Scholar 

Pawar AP, Gholap AP, Kuchekar AB, Bothiraja C, Mali AJ. Formulation and evaluation of optimized oxybenzone microsponge gel for topical delivery. J Drug Deliv. 2015; 2015:261068. https://doi.org/10.1155/2015/261068

Jain NK, Thakur R. Microsponge delivery system: a novel strategy for controlled drug delivery. Indian J Pharm Sci. 2005;67(2):141–6.

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