Hossain MS, et al. Colorectal cancer: a review of carcinogenesis, global epidemiology, current challenges, risk factors, preventive and treatment strategies. Cancers. 2022;14(7):1732.

Article  PubMed  PubMed Central  Google Scholar 

Syngal S, et al. ACG clinical guideline: genetic testing and management of hereditary gastrointestinal cancer syndromes. Am J Gastroenterol. 2015;110(2):223–62.

Article  PubMed  PubMed Central  Google Scholar 

Nakatsu G, et al. Gut mucosal microbiome across stages of colorectal carcinogenesis. Nat Commun. 2015;6(1):8727.

Article  CAS  PubMed  Google Scholar 

Gao Q, et al. Opportunities and challenges for co-delivery nanomedicines based on combination of phytochemicals with chemotherapeutic drugs in cancer treatment. Adv Drug Deliv Rev. 2022;188:114445.

Article  CAS  PubMed  Google Scholar 

Alven S, Aderibigbe BA. Efficacy of polymer-based nanocarriers for co-delivery of curcumin and selected anticancer drugs. Nanomaterials. 2020;10(8):1556.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Renu K, et al. Molecular mechanism of doxorubicin-induced cardiomyopathy–An update. Eur J Pharmacol. 2018;818:241–53.

Article  CAS  PubMed  Google Scholar 

Wenningmann N, et al. Insights into doxorubicin-induced cardiotoxicity: molecular mechanisms, preventive strategies, and early monitoring. Mol Pharmacol. 2019;96(2):219–32.

Article  CAS  PubMed  Google Scholar 

Sheibani M, et al. Doxorubicin-induced cardiotoxicity: an overview on pre-clinical therapeutic approaches. Cardiovasc Toxicol. 2022;22(4):292–310.

Article  CAS  PubMed  Google Scholar 

Eftekhari RB, et al. Co-delivery nanosystems for cancer treatment: a review. Pharm Nanotechnol. 2019;7(2):90–112.

Article  CAS  PubMed  Google Scholar 

Gurunathan S, et al. Role and therapeutic potential of melatonin in various type of cancers. OncoTargets Ther. 2021. https://doi.org/10.2147/OTT.S298512.

Grant SG, et al. Melatonin and breast cancer: cellular mechanisms, clinical studies and future perspectives. Expert Rev Mol Med. 2009;11:e5.

Article  PubMed  PubMed Central  Google Scholar 

Amaral FGd, Cipolla-Neto J. A brief review about melatonin, a pineal hormone. Arch Endocrinol Metab. 2018;62:472–9.

Article  PubMed  PubMed Central  Google Scholar 

Chenthamara D, et al. Therapeutic efficacy of nanoparticles and routes of administration. Biomater Res. 2019;23(1):20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sainz R, et al. Melatonin and cell death: differential actions on apoptosis in normal and cancer cells. Cellular and Molecular Life Sciences (CMLS). 2003;60:1407–26.

Article  CAS  PubMed  Google Scholar 

Srivastava RK. TRAIL/Apo-2L: mechanisms and clinical applications in cancer. Neoplasia. 2001;3(6):535–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Di Bella G, et al. Melatonin anticancer effects. Int J Mol Sci. 2013;14(2):2410–30.

Article  PubMed  PubMed Central  Google Scholar 

Chuffa LGdA, et al. Melatonin-loaded nanocarriers: new horizons for therapeutic applications. Molecules. 2021;26(12):3562.

Article  PubMed  PubMed Central  Google Scholar 

Divanbeigi N et al. Improving the anticancer efficiency of doxorubicin by Luteolin nanoemulsion: in vitro study. Nanomed J, 2023. 10(1).

Moghaddam FA et al. Effect of thymoquinone-loaded lipid–polymer nanoparticles as an oral delivery system on anticancer efficiency of doxorubicin. J Nanostructure Chem, 2021: pp. 1–12.

Azmana M, et al. A review on chitosan and chitosan-based bionanocomposites: promising material for combatting global issues and its applications. Int J Biol Macromol. 2021;185:832–48.

Article  CAS  PubMed  Google Scholar 

Kamath RP, Sunil D. Nano-chitosan particles in anticancer drug delivery: an up-to-date review. Mini-Rev Med Chem. 2017;17(15):1457–87.

Article  CAS  PubMed  Google Scholar 

Reshad RAI, Jishan TA, Chowdhury NN. Chitosan and its broad applications: A brief review. Available at SSRN 3842055, 2021.

Parveen S, et al. Lipid polymer hybrid nanoparticles as potent vehicles for drug delivery in cancer therapeutics. Med Drug Discovery. 2023;20:100165.

Article  CAS  Google Scholar 

Karati D, et al. A review on lipid-polymer hybrid nanocarriers in cancer. J Drug Deliv Sci Technol. 2024. https://doi.org/10.1016/j.jddst.2024.105827.

Majeed A et al. A narrative review on lipid-polymer hybrid nanoparticles for geriatric oncology: advancing drug delivery in the aging population. Aging Adv, 2025: p. 104103.

Teixeira M, Carbone C, Souto E. Beyond liposomes: recent advances on lipid based nanostructures for poorly soluble/poorly permeable drug delivery. Prog Lipid Res. 2017;68:1–11.

Article  CAS  PubMed  Google Scholar 

Ma Q, et al. Self-assembled chitosan/phospholipid nanoparticles: from fundamentals to preparation for advanced drug delivery. Drug Deliv. 2020;27(1):200–15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yeligar V, et al. Development and validation of UV spectrophotometric method for simultaneous Estimation of melatonin and Quercetin in liposome formulation. Int J Innov Sci Res Technol. 2017;2(6):189–94.

Google Scholar 

Najib Ullah SNM, et al. Bedaquiline-loaded solid lipid nanoparticles drug delivery in the management of non-small-cell lung cancer (NSCLC). Pharmaceuticals. 2023;16(9):1309.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karthikeyan P, Meenakshi S. Fabrication of hybrid chitosan encapsulated magnetic-kaolin beads for adsorption of phosphate and nitrate ions from aqueous solutions. Int J Biol Macromol. 2021;168:750–9.

Article  CAS  PubMed  Google Scholar 

Farrokhi F, et al. Structural and thermal properties of nanofibrillated whey protein isolate in the glassy state. LWT. 2018;95:274–81.

Article  CAS  Google Scholar 

Selmani A, et al. Simulated gastrointestinal fluids impact the stability of polymer-functionalized selenium nanoparticles: physicochemical aspects. Int J Nanomedicine. 2024. https://doi.org/10.2147/IJN.S483253.

Sousa Ribeiro IR, et al. Flowing through gastrointestinal barriers with model nanoparticles: from complex fluids to model human intestinal epithelium permeation. ACS Appl Mater Interfaces. 2023;15(30):36025–35.

Article  CAS  PubMed  Google Scholar 

Valdes SA, et al. Effect of a solid lipid nanoparticle formulation on the bioavailability of 4-(N)-docosahexaenoyl 2′, 2′-difluorodeoxycytidine after oral administration. AAPS PharmSciTech. 2020;21:1–8.

Article  Google Scholar 

Fakhraei F, et al. Formulation and in vivo evaluation of Perovskia abrotanoides kar. essential oil nanoemulsion incorporated chitosan gel as a novel paradigm in promoting wound healing. Environ Technol Innov. 2025;37:104001.

Article  CAS  Google Scholar 

Abbas G, et al. Nanoparticles of thiolated chitosan for controlled delivery of moxifloxacin: in-vitro and in-vivo evaluation. J King Saud Univ. 2022;34(7):102218.

Article  Google Scholar 

Rezaei M, et al. Biodistribution of carbon quantum dots derived from caccinia macranthera extract via 99mTechnetium radiolabelling in rats. Inorg Chem Commun. 2025;175:114165.

Article  CAS  Google Scholar 

Afsharzadeh M, et al. PEG‐PLA nanoparticles decorated with small‐molecule PSMA ligand for targeted delivery of Galbanic acid and docetaxel to prostate cancer cells. J Cell Physiol. 2020;235(5):4618–30.

Article  CAS  PubMed  Google Scholar 

Nikkhah E, et al. Suppressive effects of dental pulp stem cells and its conditioned medium on development and migration of colorectal cancer cells through MAPKinase pathways. Iran J Basic Med Sci. 2021;24(9):1292.

PubMed