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Xanthoxylin Regulating the Inflammatory Microenvironment After Spinal Cord Injury Through Inhibition of the NF-κB Signaling Pathway
Xanthoxylin Regulating the Inflammatory Microenvironment After Spinal Cord Injury Through Inhibition of the NF-κB Signaling Pathway
Spinal Cord Injury (SCI) is a severe disorder of the central nervous system, typically caused by trauma or disease, which ...
Knockdown of RUNX2 Attenuated A1 Astrocyte Overactivation, Brain Injury, and Cerebral Edema During Ischemic Stroke
Knockdown of RUNX2 Attenuated A1 Astrocyte Overactivation, Brain Injury, and Cerebral Edema During Ischemic Stroke
Although researchers began to unravel the potential significance of Runt-related transcription factor 2 (RUNX2) in some of...
Scopoletin Attenuates Reserpine-Induced Pain-Depression Dyad in Mice via Modulation of Inflammation, Oxidative Stress, and Monoaminergic Pathways
Scopoletin Attenuates Reserpine-Induced Pain-Depression Dyad in Mice via Modulation of Inflammation, Oxidative Stress, and Monoaminergic Pathways
Pain and depression frequently are comorbid and have common mechanisms such as monoamine depletion, inflammation, an...
Dysbiosis and Neurodegeneration in ALS: Unraveling the Gut–Brain Axis
Dysbiosis and Neurodegeneration in ALS: Unraveling the Gut–Brain Axis
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a neurodegenerative disorder marked by t...
Equol as a Multitarget Agent Against Neurodegeneration: Mechanistic Insights into Its Molecular Modulation
Equol as a Multitarget Agent Against Neurodegeneration: Mechanistic Insights into Its Molecular Modulation
Neurodegenerative diseases consist of a group of progressive disorders characterized by the gradual decline in the structu...
Ca-Affinitive and Non-Ca-Affinitive Synaptotagmins in Human Pan-cancer
Ca-Affinitive and Non-Ca-Affinitive Synaptotagmins in Human Pan-cancer
Synaptotagmins (Syts) are a family of crucial Ca2+ sensors for cellular secretions, while half of the Syt isoforms are evo...
Inflammatory Markers and their Relationship with Cognitive Function in Alzheimer’s Disease and Mild Cognitive Impairment. Systematic Review and Meta-Analysis
Inflammatory Markers and their Relationship with Cognitive Function in Alzheimer’s Disease and Mild Cognitive Impairment. Systematic Review and Meta-Analysis
This study estimates the association between blood levels of inflammatory markers and cognitive function in adults with Al...
Exploring Core Genes Involved in Ischemic Stroke and the Therapeutic Potential of Hyperbaric Oxygen: Insights from Transcriptomic Analysis
Exploring Core Genes Involved in Ischemic Stroke and the Therapeutic Potential of Hyperbaric Oxygen: Insights from Transcriptomic Analysis
Ischemic stroke (IS) is a complex neurological disorder caused by reduced cerebral blood flow, typically resulting in tiss...
Platycodin D Attenuates Behavioral Deficits, Amyloid-β Accumulation and Mitochondrial Impairment in AD Models by Inhibiting the cGAS-STING Pathway
Platycodin D Attenuates Behavioral Deficits, Amyloid-β Accumulation and Mitochondrial Impairment in AD Models by Inhibiting the cGAS-STING Pathway
The characteristics of Alzheimer’s disease (AD) include behavioral deficits, amyloid-β (Aβ) accumulation, ...
Phosphocreatine Mitigates Doxorubicin-Induced Neurotoxicity in Rats by Regulating Mitochondrial Function and Apoptosis via the NF-κB/PGC-1α Pathway
Phosphocreatine Mitigates Doxorubicin-Induced Neurotoxicity in Rats by Regulating Mitochondrial Function and Apoptosis via the NF-κB/PGC-1α Pathway
Doxorubicin (DOX) is an effective chemotherapeutic agent, but its clinical utility is limited by its neurotoxic side effec...
Mechanistic Study of Jaceosidin in Regulating Secondary Inflammation After Spinal Cord Injury in Mouse by Inhibiting PKM2 Activity
Mechanistic Study of Jaceosidin in Regulating Secondary Inflammation After Spinal Cord Injury in Mouse by Inhibiting PKM2 Activity
Excessive pro-inflammatory polarization of microglia is a critical driver of secondary inflammation following spinal cord ...
An Enigma of Brain Gasotransmitters: Hydrogen Sulfide and Depression
An Enigma of Brain Gasotransmitters: Hydrogen Sulfide and Depression
Depression is a leading global cause of disability. Emerging evidence highlights glutamatergic dysfunction, particularly i...
A Slower-Progressing TDP-43 rNLS8 Mouse Model for ALS: Implications for Preclinical and Mechanistic Studies
A Slower-Progressing TDP-43 rNLS8 Mouse Model for ALS: Implications for Preclinical and Mechanistic Studies
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised by motor neuron degeneration, muscl...
Neuroprotective Activity of Eriodictyol Against Streptozotocin-Induced Diabetic Peripheral Neuropathy in Wistar Rats by Targeting Wnt/-Catenin Pathway
Neuroprotective Activity of Eriodictyol Against Streptozotocin-Induced Diabetic Peripheral Neuropathy in Wistar Rats by Targeting Wnt/-Catenin Pathway
Long-term hyperglycemia and insulin dysfunction deteriorate peripheral nerve functions, leading to sensory loss, spontaneo...
When Heroes Fall: Reduced Expression of Heat-Resistant Obscure Proteins in Ischemic Stroke
When Heroes Fall: Reduced Expression of Heat-Resistant Obscure Proteins in Ischemic Stroke
The recently discovered family of heat-resistant obscure (Hero) proteins represents a novel class with chaperone-like acti...
Splenomegaly, Spleen Amyloidosis and Neutrophil Infiltration are Present in 3xTg-AD, but not Tg-SwDI Mice
Splenomegaly, Spleen Amyloidosis and Neutrophil Infiltration are Present in 3xTg-AD, but not Tg-SwDI Mice
It is now widely accepted that the development of neurodegenerative diseases depends on and affects many pathological proc...
Engineering the Microbiome: a Novel Approach to Managing Autoimmune Diseases
Engineering the Microbiome: a Novel Approach to Managing Autoimmune Diseases
Autoimmune diseases occur when the immune system mistakenly attacks the body’s own tissues, affecting millions of pe...
Hypertension Induces Cognitive Impairment and Alterations of Acetylcholine Receptor mRNA Expression in the Hippocampus and Cortex of Mice
Hypertension Induces Cognitive Impairment and Alterations of Acetylcholine Receptor mRNA Expression in the Hippocampus and Cortex of Mice
Hypertension is a significant risk factor for cognitive decline and dementia, yet the underlying mechanisms linking hypert...
The Role of Gut Microbiota in Modulating Immune Signaling Pathways in Autoimmune Diseases
The Role of Gut Microbiota in Modulating Immune Signaling Pathways in Autoimmune Diseases
The composition of intestinal microbial communities plays a crucial role in maintaining immune homeostasis, influencing bo...
Fisetin Augments OEC Neuroprotection Through Modulating Neurotrophin/Cytokine Signaling and Activating PI3K/Akt/CREB Pathway in an In Vitro Neurodegenerative Injury
Fisetin Augments OEC Neuroprotection Through Modulating Neurotrophin/Cytokine Signaling and Activating PI3K/Akt/CREB Pathway in an In Vitro Neurodegenerative Injury
The persistence of deleterious substances at lesion sites severely impedes neuronal survival and axonal regeneration follo...
Microparticles Mediate Lipopolysaccharide-induced Inflammation and Chronic Pain in Mouse Model
Microparticles Mediate Lipopolysaccharide-induced Inflammation and Chronic Pain in Mouse Model
Recent evidence highlights microparticles (MPs) as crucial players in intercellular communication among immune cells, yet ...
Schizophrenia Biomarkers: Blood Transcriptome Suggests Two Molecular Subtypes
Schizophrenia Biomarkers: Blood Transcriptome Suggests Two Molecular Subtypes
Schizophrenia is a chronic illness that imposes a significant burden on patients, their families, and the health care syst...
Current Status of Research on Nanomaterials Combined with Mesenchymal Stem Cells for the Treatment of Ischemic Stroke
Current Status of Research on Nanomaterials Combined with Mesenchymal Stem Cells for the Treatment of Ischemic Stroke
Ischemic stroke (IS) is a disease with high mortality and disability rates worldwide and is a serious threat to patient he...
Recent Advances in the miRNA-Mediated Regulation of Neuronal Differentiation and Death
Recent Advances in the miRNA-Mediated Regulation of Neuronal Differentiation and Death
The review aims to focus on the role of miRNA in gene regulation, related to differentiation and apoptosis of neurons, foc...
Differential Expression of GABA Receptor-Related Genes in Alzheimer’s Disease and the Positive Regulatory Role of Aerobic Exercise-From Genetic Screening to D-gal-induced AD-like Pathology Model
Differential Expression of GABA Receptor-Related Genes in Alzheimer’s Disease and the Positive Regulatory Role of Aerobic Exercise-From Genetic Screening to D-gal-induced AD-like Pathology Model
Alzheimer’s disease (AD) is the most common neurodegenerative disorder. The neuropathology of AD appears in the hipp...
The Interplay Between Accumulation of Amyloid-Beta and Tau Proteins, PANoptosis, and Inflammation in Alzheimer’s Disease
The Interplay Between Accumulation of Amyloid-Beta and Tau Proteins, PANoptosis, and Inflammation in Alzheimer’s Disease
Alzheimer’s disease (AD) is a common progressive neurodegenerative disorder, and the vast majority of cases occur in...
IL-6 Promotes Muscle Atrophy by Increasing Ubiquitin–Proteasome Degradation of Muscle Regeneration Factors After Cerebral Infarction in Rats
IL-6 Promotes Muscle Atrophy by Increasing Ubiquitin–Proteasome Degradation of Muscle Regeneration Factors After Cerebral Infarction in Rats
Muscle atrophy in pathological or diseased muscles arises from an imbalance between protein synthesis and degradation. Ele...
NSUN2-Mediated RNA 5-Methylcytosine Modification of PTEN Regulates Cognitive Impairments of Mice with Sleep Deprivation and Autophagy Through PI3K/AKT Signaling
NSUN2-Mediated RNA 5-Methylcytosine Modification of PTEN Regulates Cognitive Impairments of Mice with Sleep Deprivation and Autophagy Through PI3K/AKT Signaling
Sleep deprivation (SD) impairs learning and memory. Investigating the role of epigenetic modifications, such as 5-methylcy...
Neuroprotective Effects of Sodium Nitroprusside on CKD-Induced Cognitive Dysfunction in Rats: Role of CBS and Nrf2/HO-1 Pathway
Neuroprotective Effects of Sodium Nitroprusside on CKD-Induced Cognitive Dysfunction in Rats: Role of CBS and Nrf2/HO-1 Pathway
Chronic kidney disease (CKD) is a conceivable new risk factor for cognitive disorder and dementia. Uremic toxicity, oxidat...
HERC5/ISG15 Enhances Glioblastoma Stemness and Tumor Progression by mediating SERBP1protein stability
HERC5/ISG15 Enhances Glioblastoma Stemness and Tumor Progression by mediating SERBP1protein stability
Glioblastoma (GBM) is the most common malignant brain tumor, and has a low survival rate and a poor prognosis. Intensive s...
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