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Microparticles Mediate Lipopolysaccharide-induced Inflammation and Chronic Pain in Mouse Model
Microparticles Mediate Lipopolysaccharide-induced Inflammation and Chronic Pain in Mouse Model
Recent evidence highlights microparticles (MPs) as crucial players in intercellular communication among immune cells, yet ...
Schizophrenia Biomarkers: Blood Transcriptome Suggests Two Molecular Subtypes
Schizophrenia Biomarkers: Blood Transcriptome Suggests Two Molecular Subtypes
Schizophrenia is a chronic illness that imposes a significant burden on patients, their families, and the health care syst...
Current Status of Research on Nanomaterials Combined with Mesenchymal Stem Cells for the Treatment of Ischemic Stroke
Current Status of Research on Nanomaterials Combined with Mesenchymal Stem Cells for the Treatment of Ischemic Stroke
Ischemic stroke (IS) is a disease with high mortality and disability rates worldwide and is a serious threat to patient he...
Recent Advances in the miRNA-Mediated Regulation of Neuronal Differentiation and Death
Recent Advances in the miRNA-Mediated Regulation of Neuronal Differentiation and Death
The review aims to focus on the role of miRNA in gene regulation, related to differentiation and apoptosis of neurons, foc...
Differential Expression of GABA Receptor-Related Genes in Alzheimer’s Disease and the Positive Regulatory Role of Aerobic Exercise-From Genetic Screening to D-gal-induced AD-like Pathology Model
Differential Expression of GABA Receptor-Related Genes in Alzheimer’s Disease and the Positive Regulatory Role of Aerobic Exercise-From Genetic Screening to D-gal-induced AD-like Pathology Model
Alzheimer’s disease (AD) is the most common neurodegenerative disorder. The neuropathology of AD appears in the hipp...
The Interplay Between Accumulation of Amyloid-Beta and Tau Proteins, PANoptosis, and Inflammation in Alzheimer’s Disease
The Interplay Between Accumulation of Amyloid-Beta and Tau Proteins, PANoptosis, and Inflammation in Alzheimer’s Disease
Alzheimer’s disease (AD) is a common progressive neurodegenerative disorder, and the vast majority of cases occur in...
IL-6 Promotes Muscle Atrophy by Increasing Ubiquitin–Proteasome Degradation of Muscle Regeneration Factors After Cerebral Infarction in Rats
IL-6 Promotes Muscle Atrophy by Increasing Ubiquitin–Proteasome Degradation of Muscle Regeneration Factors After Cerebral Infarction in Rats
Muscle atrophy in pathological or diseased muscles arises from an imbalance between protein synthesis and degradation. Ele...
NSUN2-Mediated RNA 5-Methylcytosine Modification of PTEN Regulates Cognitive Impairments of Mice with Sleep Deprivation and Autophagy Through PI3K/AKT Signaling
NSUN2-Mediated RNA 5-Methylcytosine Modification of PTEN Regulates Cognitive Impairments of Mice with Sleep Deprivation and Autophagy Through PI3K/AKT Signaling
Sleep deprivation (SD) impairs learning and memory. Investigating the role of epigenetic modifications, such as 5-methylcy...
Neuroprotective Effects of Sodium Nitroprusside on CKD-Induced Cognitive Dysfunction in Rats: Role of CBS and Nrf2/HO-1 Pathway
Neuroprotective Effects of Sodium Nitroprusside on CKD-Induced Cognitive Dysfunction in Rats: Role of CBS and Nrf2/HO-1 Pathway
Chronic kidney disease (CKD) is a conceivable new risk factor for cognitive disorder and dementia. Uremic toxicity, oxidat...
HERC5/ISG15 Enhances Glioblastoma Stemness and Tumor Progression by mediating SERBP1protein stability
HERC5/ISG15 Enhances Glioblastoma Stemness and Tumor Progression by mediating SERBP1protein stability
Glioblastoma (GBM) is the most common malignant brain tumor, and has a low survival rate and a poor prognosis. Intensive s...
Association of IL6 Gene Polymorphisms and Neurological Disorders: Insights from Integrated Bioinformatics and Meta-Analysis
Association of IL6 Gene Polymorphisms and Neurological Disorders: Insights from Integrated Bioinformatics and Meta-Analysis
Interleukin 6 (IL6) is an inflammatory biomarker linked to central and peripheral nervous system diseases. This study comb...
Bacopa monnieri Extract Diminish Hypoxia-Induced Anxiety by Regulating HIF-1α Signaling and Enhancing the Antioxidant Defense System in Hippocampus
Bacopa monnieri Extract Diminish Hypoxia-Induced Anxiety by Regulating HIF-1α Signaling and Enhancing the Antioxidant Defense System in Hippocampus
Hypoxia is a significant stressor, and stabilized hypoxia-inducible factor-1α (HIF-1α) regulates the expression ...
Time of the Day of Traumatic Brain Injury has Minimal Effects on Behavioral and Histological Outcomes in Mice of Both Sexes
Time of the Day of Traumatic Brain Injury has Minimal Effects on Behavioral and Histological Outcomes in Mice of Both Sexes
Transcription of > 50% of the mammalian coding genes follows circadian rhythm in an organ-specific mann...
The Role of Lactic Acid Bacteria in Improving Behavioral Deficits, Serum Levels of Vitamin D3, B12 and Reducing Oxidative Stress and Demyelination in a Cuprizone-induced Demyelination Model of Rat
The Role of Lactic Acid Bacteria in Improving Behavioral Deficits, Serum Levels of Vitamin D3, B12 and Reducing Oxidative Stress and Demyelination in a Cuprizone-induced Demyelination Model of Rat
Multiple sclerosis constitutes a chronic, inflammatory, and demyelinating disorder affecting the central nervous system, w...
Therapeutic Potential of TUBB6 Inhibition for Hematoma Reduction, Microtubule Stabilization, and Neurological Recovery in an In Vivo Model of Intracerebral Hemorrhage
Therapeutic Potential of TUBB6 Inhibition for Hematoma Reduction, Microtubule Stabilization, and Neurological Recovery in an In Vivo Model of Intracerebral Hemorrhage
This in vivo study explored the impact of TUBB6 inhibition in intracerebral hemorrhage (ICH), focusing on its effects on h...
Physical Exercise Inhibits Cognitive Impairment and Memory Loss in Aged Mice, and Enhances Pre- and Post-Synaptic Proteins in the Hippocampus of Young and Aged Mice
Physical Exercise Inhibits Cognitive Impairment and Memory Loss in Aged Mice, and Enhances Pre- and Post-Synaptic Proteins in the Hippocampus of Young and Aged Mice
The aim of this study was to evaluate the effects of swimming in the brain and behavior of young and aged mice. Forty-eigh...
Evaluation of Neuroprotective Effect of Gut Microbe in Parkinson's Disease: An In Silico and In Vivo Approach
Evaluation of Neuroprotective Effect of Gut Microbe in Parkinson's Disease: An In Silico and In Vivo Approach
Parkinson's disease is a progressive neurodegenerative disorder marked by the death of dopaminergic neurons in the sub...
Activation of GPR30 Ameliorates Cerebral Ischemia–Reperfusion Injury by Suppressing Ferroptosis Through Nrf2/GPX4 Signaling Pathway
Activation of GPR30 Ameliorates Cerebral Ischemia–Reperfusion Injury by Suppressing Ferroptosis Through Nrf2/GPX4 Signaling Pathway
The newly identified estrogen receptor, G protein-coupled receptor 30 (GPR30), is prevalent in the brain and has been show...
Exosomal GDNF from Bone Marrow Mesenchymal Stem Cells Moderates Neuropathic Pain in a Rat Model of Chronic Constriction Injury
Exosomal GDNF from Bone Marrow Mesenchymal Stem Cells Moderates Neuropathic Pain in a Rat Model of Chronic Constriction Injury
Both of exosomes derived from mesenchymal stem cells (MSCs) and glial cell line-derived neurotrophic factor (GDNF) show po...
Neuroprotective Effects of VGLUT1 Inhibition in HT22 Cells Overexpressing VGLUT1 Under Oxygen Glucose Deprivation Conditions
Neuroprotective Effects of VGLUT1 Inhibition in HT22 Cells Overexpressing VGLUT1 Under Oxygen Glucose Deprivation Conditions
Glutamate (Glu) is a major excitatory neurotransmitter in the brain, essential for synaptic plasticity, neuronal activity,...
Dysregulated Purinergic Signalling in Fragile X Syndrome Cortical Astrocytes
Dysregulated Purinergic Signalling in Fragile X Syndrome Cortical Astrocytes
The symptoms of fragile X syndrome (FXS), caused by a single gene mutation to Fmr1, have been increasingly linked to disor...
Inhibition of CRMP2 Phosphorylation Suppresses Microglia Activation in the Retina and Optic Nerve and Promotes Optic Nerve Regeneration After Optic Nerve Injury
Inhibition of CRMP2 Phosphorylation Suppresses Microglia Activation in the Retina and Optic Nerve and Promotes Optic Nerve Regeneration After Optic Nerve Injury
As the primary connection between the eye and brain, the optic nerve plays a pivotal role in visual information transmissi...
The Blood-Cerebrospinal Fluid Barrier Dysfunction in Brain Disorders and Stroke: Why, How, What For?
The Blood-Cerebrospinal Fluid Barrier Dysfunction in Brain Disorders and Stroke: Why, How, What For?
Ischemic stroke (IS) results in the interruption of blood flow to the brain, which can cause significant damage. The patho...
Identification of Disulfidptosis-Related Genes in Ischemic Stroke by Combining Single-Cell Sequencing, Machine Learning Algorithms, and In Vitro Experiments
Identification of Disulfidptosis-Related Genes in Ischemic Stroke by Combining Single-Cell Sequencing, Machine Learning Algorithms, and In Vitro Experiments
Ischemic stroke (IS) is a severe neurological disorder with a pathogenesis that remains incompletely understood. Recently,...
Continuous Theta Burst Stimulation Inhibits Oxidative Stress-Induced Inflammation and Autophagy in Hippocampal Neurons by Activating Glutathione Synthesis Pathway, Improving Cognitive Impairment in Sleep-Deprived Mice
Continuous Theta Burst Stimulation Inhibits Oxidative Stress-Induced Inflammation and Autophagy in Hippocampal Neurons by Activating Glutathione Synthesis Pathway, Improving Cognitive Impairment in Sleep-Deprived Mice
Sleep deprivation (SD) has been reported to have a negative impact on cognitive function. Continuous theta burst stimulati...
Clinical Implication of Time of Ischaemic Stroke Among Post-Stroke Survivors from Eastern India: A Circadian Perspective
Clinical Implication of Time of Ischaemic Stroke Among Post-Stroke Survivors from Eastern India: A Circadian Perspective
The circadian variation in stroke occurrence is a well-documented phenomenon. However, the circadian effect on stroke outc...
Circular RNA-GRIN2B Suppresses Neuropathic Pain by Targeting the NF-κB/SLICK Pathway
Circular RNA-GRIN2B Suppresses Neuropathic Pain by Targeting the NF-κB/SLICK Pathway
The role of circular RNAs (circRNAs) in neuropathic pain is linked to the fundamental physiological mechanisms involved. H...
Drug Treatment Attenuates Retinal Ganglion Cell Death by Inhibiting Collapsin Response Mediator Protein 2 Phosphorylation in Mouse Models of Normal Tension Glaucoma
Drug Treatment Attenuates Retinal Ganglion Cell Death by Inhibiting Collapsin Response Mediator Protein 2 Phosphorylation in Mouse Models of Normal Tension Glaucoma
Normal tension glaucoma (NTG) is a progressive neurodegenerative disease in glaucoma families. Typical glaucoma develops b...
The Role of Gut-derived Short-Chain Fatty Acids in Multiple Sclerosis
The Role of Gut-derived Short-Chain Fatty Acids in Multiple Sclerosis
Multiple sclerosis (MS) is a chronic condition affecting the central nervous system (CNS), where the interplay of genetic ...
Lycium Barbarum Polysaccharides Improves Cognitive Functions in ICV-STZ-Induced Alzheimer’s Disease Mice Model by Improving the Synaptic Structural Plasticity and Regulating IRS1/PI3K/AKT Signaling Pathway
Lycium Barbarum Polysaccharides Improves Cognitive Functions in ICV-STZ-Induced Alzheimer’s Disease Mice Model by Improving the Synaptic Structural Plasticity and Regulating IRS1/PI3K/AKT Signaling Pathway
Lycium barbarum polysaccharide (LBP) have a certain curative effect on hypoglycemic and neuroprotective effects, but the s...
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