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Epigenetic Regulation of OLIG2 in Glioblastoma: Mechanisms and Therapeutic Targets to Combat Treatment Resistance
Epigenetic Regulation of OLIG2 in Glioblastoma: Mechanisms and Therapeutic Targets to Combat Treatment Resistance
Glioblastoma (GBM) represents one of the most aggressive brain tumors with a poor prognosis despite decades of research. E...
Loss of COL20A1 in Schwann Cells Alters Regeneration of the Neuromuscular Junction and Locomotor Activity in Mice
Loss of COL20A1 in Schwann Cells Alters Regeneration of the Neuromuscular Junction and Locomotor Activity in Mice
Collagen type XX alpha 1 (COL20A1) was recently found to be highly concentrated in perisynaptic Schwann cells (PSCs), the ...
Ketogenic Diet Mitigates Age-Related Cognitive Decline and Neuroinflammation in Rats, While Antibiotics Exacerbate Brain Health Risks
Ketogenic Diet Mitigates Age-Related Cognitive Decline and Neuroinflammation in Rats, While Antibiotics Exacerbate Brain Health Risks
The ketogenic diet (KD), a high-fat, low-carbohydrate regimen, has been shown to exert neuroprotective effects in various ...
Exploring Ciliary Mechanisms in the Causation of Hydrocephalus in Humans—Similarities and Differences from Animal Models
Exploring Ciliary Mechanisms in the Causation of Hydrocephalus in Humans—Similarities and Differences from Animal Models
Hydrocephalus is a condition defined by excessive cerebrospinal fluid (CSF) relative to the brain volume. Congenital and i...
Serum Metabolomic Profiling in Possible Early-Stage Multiple Sclerosis: A Targeted H-NMR Comparison of OCB Type 1 and Type 2 Patterns
Serum Metabolomic Profiling in Possible Early-Stage Multiple Sclerosis: A Targeted H-NMR Comparison of OCB Type 1 and Type 2 Patterns
Oligoclonal band (OCB) analysis in cerebrospinal fluid (CSF) remains a cornerstone for the early diagnosis of multiple scl...
Antiepileptic and Neuroprotective Biochemical Actions of Sabinene Prevent the Development of Pentylenetetrazol-Induced Seizures and Neuropsychiatric Comorbidities in Mice
Antiepileptic and Neuroprotective Biochemical Actions of Sabinene Prevent the Development of Pentylenetetrazol-Induced Seizures and Neuropsychiatric Comorbidities in Mice
Epilepsy is a long-term neurological disorder that leads to disability with neuropsychiatric comorbidities. Studies have s...
Cognitive and Behavioral Effects of Chronic Tartrazine Use in vivo: An Assessment Within and Above the Acceptable Daily Intake
Cognitive and Behavioral Effects of Chronic Tartrazine Use in vivo: An Assessment Within and Above the Acceptable Daily Intake
The use of dyes is a common practice in several industrial sectors to increase the attractiveness of the merchandise. Tart...
Correction: Urolithin A Enhances Tight Junction Protein Expression in Endothelial Cells Cultured In Vitro via Pink1-Parkin-Mediated Mitophagy in Irradiated Astrocytes
Correction: Urolithin A Enhances Tight Junction Protein Expression in Endothelial Cells Cultured In Vitro via Pink1-Parkin-Mediated Mitophagy in Irradiated Astrocytes
Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, No.58 Zhongshan Road 2, Guangzhou, 510080,...
Integrin CD11b Alleviates Cerebral Ischemia/Reperfusion Injury via a Mechanism Involving Microglia/Macrophage Polarization
Integrin CD11b Alleviates Cerebral Ischemia/Reperfusion Injury via a Mechanism Involving Microglia/Macrophage Polarization
The polarization of microglia/macrophages is crucial for maintaining the neuroinflammatory response during cerebral ischem...
Salivary Circadian Gene Expression as a Molecular Indicator of Early Cognitive Impairment in Shift Workers: A Cross-Sectional Study of 300 Adults
Salivary Circadian Gene Expression as a Molecular Indicator of Early Cognitive Impairment in Shift Workers: A Cross-Sectional Study of 300 Adults
This cross-sectional study explored the potential utility of salivary circadian gene expression as a non-invasive biomarke...
Therapeutic Potential of products derived from for Alzheimer’s Disease Treatment
Therapeutic Potential of products derived from for Alzheimer’s Disease Treatment
AD is a neurodegenerative disorder and is associated with the presence of amyloid-β plaques and neurofibrillary tangl...
RGS2-Related Non-coding Interaction Network Modulates the NF-Kappa B Signaling Pathway in MS Patients: A Systems Biology Investigation
RGS2-Related Non-coding Interaction Network Modulates the NF-Kappa B Signaling Pathway in MS Patients: A Systems Biology Investigation
Multiple sclerosis (MS) is the most common chronic inflammatory disease affecting the brain and spinal cord, with approxim...
miR-146A and miR-146B Promoter Methylation and Common Sequence Variations Are Not Likely to Be Involved in Autism Spectrum Disorder
miR-146A and miR-146B Promoter Methylation and Common Sequence Variations Are Not Likely to Be Involved in Autism Spectrum Disorder
One of the well-studied epigenetic regulators is miRNA (miRNA) which plays critical roles in gene regulation and has been ...
Comprehensive in Silico Reclassification of MECP2 Variants of Uncertain Significance in Rett Syndrome: Performance Evaluation and Structural Analysis
Comprehensive in Silico Reclassification of MECP2 Variants of Uncertain Significance in Rett Syndrome: Performance Evaluation and Structural Analysis
Rett syndrome (RTT) is a severe neurodevelopmental disorder primarily caused by missense variants in the MECP2 gene. Howev...
Iron and Ferritin Dyshomeostasis Intersect with Sex, Age, and Disease Severity in Amyotrophic Lateral Sclerosis
Iron and Ferritin Dyshomeostasis Intersect with Sex, Age, and Disease Severity in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, characterized by progressive loss of motor neuro...
The Impact of Glutamatergic Excitotoxicity on the Differentiation of Cerebellar Neural Stem Cells
The Impact of Glutamatergic Excitotoxicity on the Differentiation of Cerebellar Neural Stem Cells
The adult cerebellum retains a small Sox2/prominin-1 NSC pool whose fate is shaped by developmental cues and the glutamate...
Higher Serum Aspartate May be Associated with Better Cognitive Function as Mediated by Reduced Aβ Accumulation in Frontal and Temporal Lobes in Mild Cognitive Impairment
Higher Serum Aspartate May be Associated with Better Cognitive Function as Mediated by Reduced Aβ Accumulation in Frontal and Temporal Lobes in Mild Cognitive Impairment
Aspartate, a key excitatory neurotransmitter, has shown conflicting links to cognitive disorders like Alzheimer’s di...
Spinocerebellar Ataxia Type 1 (SCA1) Cell Models Display Widespread Mitochondrial and Extra-Nuclear Alterations
Spinocerebellar Ataxia Type 1 (SCA1) Cell Models Display Widespread Mitochondrial and Extra-Nuclear Alterations
Ataxin-1 (ATXN1) is a nuclear-cytoplasmic shuttling protein, which, when expanded in its polyglutamine coding stretch, cau...
Regulation of Hippocamposeptal Synaptic Transmission by GABABRs Is Altered in 5XFAD Mice in a Sex- and Age-Dependent Manner
Regulation of Hippocamposeptal Synaptic Transmission by GABABRs Is Altered in 5XFAD Mice in a Sex- and Age-Dependent Manner
Hippocamposeptal (HS) neurons send GABAergic projections from the hippocampus to the medial septum/diagonal band of Broca ...
Sedative Effects of Daidzin, Possibly Through the GABAA Receptor Interaction Pathway: In Vivo Approach with Molecular Dynamic Simulations
Sedative Effects of Daidzin, Possibly Through the GABAA Receptor Interaction Pathway: In Vivo Approach with Molecular Dynamic Simulations
The soy isoflavone daidzin (DZN) has been considered a hopeful bioactive compound having diverse biological activities, in...
REV-ERBα Mitigates Astrocyte Activation and Protects Dopaminergic Neurons from Damage
REV-ERBα Mitigates Astrocyte Activation and Protects Dopaminergic Neurons from Damage
Parkinson’s disease (PD) is characterized by astrocyte activation and disruptions in circadian rhythm. Within the as...
Sex-Specific ADNP/NAP (Davunetide) Regulation of Cocaine-Induced Plasticity
Sex-Specific ADNP/NAP (Davunetide) Regulation of Cocaine-Induced Plasticity
Cocaine use disorder (CUD) is a chronic neuropsychiatric disorder estimated to effect 1–3% of the population. Activi...
Involvement of CXCL10 rs4256246, CXCR4 rs2228014, CCR2 rs1799864 and CXCL16 rs2277680 in the Predisposition to Schizophrenia
Involvement of CXCL10 rs4256246, CXCR4 rs2228014, CCR2 rs1799864 and CXCL16 rs2277680 in the Predisposition to Schizophrenia
Chemokine ligands and their receptors have acquired less attention than pro- and anti-inflammatory cytokines in schizophre...
Identification and Validation of Endoplasmic Reticulum Stress-Related Gene in Traumatic Brain Injury
Identification and Validation of Endoplasmic Reticulum Stress-Related Gene in Traumatic Brain Injury
Endoplasmic reticulum stress (ERS) plays an essential role in the development of traumatic brain injury (TBI). We aimed to...
An early Transcriptomic Investigation in Adult Patients with Spinal Muscular Atrophy Under Treatment with Nusinersen
An early Transcriptomic Investigation in Adult Patients with Spinal Muscular Atrophy Under Treatment with Nusinersen
Spinal muscular atrophy (SMA) is a rare degenerative disorder with loss of motor neurons caused by mutations in the SMN1 g...
The Role of Thioredoxin System in Shank3 Mouse Model of Autism
The Role of Thioredoxin System in Shank3 Mouse Model of Autism
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by difficulties in social interactio...
Genomic Validation in the UK Biobank Cohort Suggests a Role of C8B and MFG-E8 in the Pathogenesis of Trigeminal Neuralgia
Genomic Validation in the UK Biobank Cohort Suggests a Role of C8B and MFG-E8 in the Pathogenesis of Trigeminal Neuralgia
Trigeminal neuralgia (TN) is a severe facial pain disease of uncertain pathophysiology and unclear genetic background. Alt...
Investigating the Genetic Association of 40 Biochemical Indicators with Parkinson’s Disease
Investigating the Genetic Association of 40 Biochemical Indicators with Parkinson’s Disease
The mechanisms of Parkinson’s disease (PD) are not fully understood, which hinders the development of effective ther...
Clinical and Molecular Profiles of a Cohort of Egyptian Patients with Collagen VI-Related Dystrophy
Clinical and Molecular Profiles of a Cohort of Egyptian Patients with Collagen VI-Related Dystrophy
Collagen VI-related dystrophies (COL6-RD) display a wide spectrum of disease severity and genetic variability ranging from...
Identification of Pathogenic Missense Mutations of NF1 Using Computational Approaches
Identification of Pathogenic Missense Mutations of NF1 Using Computational Approaches
Neurofibromatosis type 1 (NF1) is a prevalent autosomal dominant disorder caused by mutations in the NF1 gene, leading to ...
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