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Molecular Mechanisms of Perivascular Macrophages in Alzheimer’s Disease: Insights from Single-Cell Sequencing and Mendelian Randomization
Molecular Mechanisms of Perivascular Macrophages in Alzheimer’s Disease: Insights from Single-Cell Sequencing and Mendelian Randomization
Alzheimer’s disease (AD) is a leading cause of dementia characterized by neuroinflammation and immune dysregulation....
Molecular Consequences of a Missense Variant, c.1285G > A, Associated With Syndromic Neurodevelopmental Disorder
Molecular Consequences of a Missense Variant, c.1285G > A, Associated With Syndromic Neurodevelopmental Disorder
PHF21A is a histone reader protein that recognizes unmethylated H3 lysine 4 and binds to DNA through its AT-hook motif. PH...
Inhibition of P2Y6 Receptor-Mediated Microglia Phagocytosis Aggravates Brain Injury in Mice of Intracerebral Hemorrhage
Inhibition of P2Y6 Receptor-Mediated Microglia Phagocytosis Aggravates Brain Injury in Mice of Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a devastating stroke subtype leading to severe sensorimotor dysfunction. Many studies sh...
The Role of Estrogen in Mitochondrial Disease
The Role of Estrogen in Mitochondrial Disease
This review aims to investigate the potential role of estrogen in various mitochondrial diseases, such as Leber’s He...
A Technical Assessment of a Commercial GFAP Lateral Flow Assay to Establish Proof-of-Concept for Use in Traumatic Brain Injury
A Technical Assessment of a Commercial GFAP Lateral Flow Assay to Establish Proof-of-Concept for Use in Traumatic Brain Injury
Glial fibrillary acidic protein (GFAP) is an emerging biomarker for the detection of acute intracranial pathology followin...
Targeting Neuronal Alpha7 Nicotinic Acetylcholine Receptor Upregulation in Age-Related Neurological Disorders
Targeting Neuronal Alpha7 Nicotinic Acetylcholine Receptor Upregulation in Age-Related Neurological Disorders
The multifunctional roles of alpha7 nicotinic acetylcholine receptors (α7nAChRs), ranging from cognitive enhancement,...
MicroRNAs as Diagnostic Biomarkers of Myasthenia Gravis: A Systematic Review and Meta-Analysis
MicroRNAs as Diagnostic Biomarkers of Myasthenia Gravis: A Systematic Review and Meta-Analysis
Myasthenia gravis (MG) is an autoimmune neuromuscular disorder characterized by fluctuating muscle weakness. MicroRNAs (mi...
Sex-Specific Neuropsychiatric Effects of Subanesthetic Ketamine Exposure in Pregnant Mice and Their Offspring
Sex-Specific Neuropsychiatric Effects of Subanesthetic Ketamine Exposure in Pregnant Mice and Their Offspring
Depression during pregnancy is often overlooked and undertreated. Ketamine has been shown to exert prompt and sustained an...
The Crosstalk Between Ferritinophagy and Ferroptosis in Ischemic Stroke: Regulatory Mechanisms and Therapeutic Implications
The Crosstalk Between Ferritinophagy and Ferroptosis in Ischemic Stroke: Regulatory Mechanisms and Therapeutic Implications
Ischemic stroke is a common cerebrovascular disease accompanied by a large number of neuronal death and severe functional ...
Kynurenine Pathway Modulation by Exercise in Multiple Sclerosis: Implications for Neuroprotection and Inflammation
Kynurenine Pathway Modulation by Exercise in Multiple Sclerosis: Implications for Neuroprotection and Inflammation
Multiple Sclerosis (MS) is a chronic, inflammatory, and neurodegenerative disease of the Central Nervous System (CNS) that...
Neural Circuit Mapping and Neurotherapy-Based Strategies
Neural Circuit Mapping and Neurotherapy-Based Strategies
Recent developments in neural circuit mapping and neurotherapy are changing our understanding of the dynamic network struc...
Identification of Novel Scaffolds Against GSK-3 for Targeting Alzheimer’s Disease Through Molecular Modeling Techniques
Identification of Novel Scaffolds Against GSK-3 for Targeting Alzheimer’s Disease Through Molecular Modeling Techniques
Alzheimer’s disease (AD) is one of the most common causes of dementia in elderly populations. A multifactorial and c...
Role of Repressive Histone Lysine Demethylases and Methylases in Susceptibility to Depression Using a Novel Progressive Social Defeat Stress Mouse Model
Role of Repressive Histone Lysine Demethylases and Methylases in Susceptibility to Depression Using a Novel Progressive Social Defeat Stress Mouse Model
Major depressive disorder (MDD) results from repeated and constant exposure to stress over prolonged periods. The highly v...
The Cerebral Lymphatic System: Function, Controversies, and Therapeutic Approaches for Central Nervous System Diseases
The Cerebral Lymphatic System: Function, Controversies, and Therapeutic Approaches for Central Nervous System Diseases
The meninges serve as critical barriers that maintain immune homeostasis in the central nervous system (CNS) and play vita...
Ca Inhibits Reactive Oxygen Species Scavenging in Naked Mole-Rat Cortical Homogenates
Ca Inhibits Reactive Oxygen Species Scavenging in Naked Mole-Rat Cortical Homogenates
Deleterious perturbations in reactive oxygen species (ROS) and calcium (Ca2+) handling are key initiators of cell death in...
TMEM16A Activation Inhibits Autophagy in Dorsal Root Ganglion Cells, Which is Associated with the p38 MAPK/mTOR Pathway
TMEM16A Activation Inhibits Autophagy in Dorsal Root Ganglion Cells, Which is Associated with the p38 MAPK/mTOR Pathway
Transmembrane member 16A (TMEM16A) exhibits a negative correlation with autophagy, though the underlying mechanism remains...
Identification of miRNA-TF Regulatory Pathways Related to Diseases from a Neuroendocrine-Immune Perspective
Identification of miRNA-TF Regulatory Pathways Related to Diseases from a Neuroendocrine-Immune Perspective
The neuroendocrine-immune (NEI) network is fundamental for maintaining body's homeostasis and health. While the roles ...
Exosomal MiRNA Therapy for Central Nervous System Injury Diseases
Exosomal MiRNA Therapy for Central Nervous System Injury Diseases
Central nervous system diseases include central nervous system injury diseases, neurodegenerative diseases, and other cond...
Exploring the Neuroprotective Effects of Rufinamide in a Streptozotocin-Induced Dementia Model
Exploring the Neuroprotective Effects of Rufinamide in a Streptozotocin-Induced Dementia Model
Due to the complex pathophysiology of AD (Alzheimer’s Disease), there are currently no effective clinical treatments...
Single-Cell RNA-Seq Reveals the Pseudo-temporal Dynamic Evolution Characteristics of ADSCs to Neuronal Differentiation
Single-Cell RNA-Seq Reveals the Pseudo-temporal Dynamic Evolution Characteristics of ADSCs to Neuronal Differentiation
Adipose-derived stromal cells (ADSCs) are commonly used in regenerative medicine, but the genetic features of their develo...
Application of Circulating Tumor DNA in the Auxiliary Diagnosis and Prognosis Prediction of Glioma
Application of Circulating Tumor DNA in the Auxiliary Diagnosis and Prognosis Prediction of Glioma
Glioma is the most common primary malignant brain tumor. Despite significant advances in the past decade in understanding ...
Molecular Signaling Pathways of Quercetin in Alzheimer’s Disease: A Promising Arena
Molecular Signaling Pathways of Quercetin in Alzheimer’s Disease: A Promising Arena
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by cognitive impairment and memory deficit. Ev...
Differences in Blood and Cerebrospinal Fluid Between Parkinson’s Disease and Related Diseases
Differences in Blood and Cerebrospinal Fluid Between Parkinson’s Disease and Related Diseases
It is difficult to distinguish Parkinson’s disease (PD) in the early stage from those of various disorders including...
A Focal Traumatic Injury to the Neonatal Rodent Spinal Cord Causes an Immediate and Massive Spreading Depolarization Sustained by Chloride Ions, with Transient Network Dysfunction
A Focal Traumatic Injury to the Neonatal Rodent Spinal Cord Causes an Immediate and Massive Spreading Depolarization Sustained by Chloride Ions, with Transient Network Dysfunction
In clinics, physical injuries to the spinal cord cause a temporary motor areflexia below lesion, known as spinal shock. Th...
Correction: Expression of CGRP in the Trigeminal Ganglion and Its Effect on the Polarization of Macrophages in Rats with Temporomandibular Arthritis
Correction: Expression of CGRP in the Trigeminal Ganglion and Its Effect on the Polarization of Macrophages in Rats with Temporomandibular Arthritis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Correction: Sevoflurane Induces Learning and Memory Impairment in Young Mice Through a Reduction in Neuronal Glucose Transporter 3
Correction: Sevoflurane Induces Learning and Memory Impairment in Young Mice Through a Reduction in Neuronal Glucose Transporter 3
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Genetically Predicted Leucine Level Mediates Association Between CD4/CD8br T Lymphocytes and Insomnia
Genetically Predicted Leucine Level Mediates Association Between CD4/CD8br T Lymphocytes and Insomnia
Immune and metabolic factors play an important role in the onset and development of insomnia. This study aimed to investig...
AMPA Receptors in Synaptic Plasticity, Memory Function, and Brain Diseases
AMPA Receptors in Synaptic Plasticity, Memory Function, and Brain Diseases
Tetrameric AMPA-type ionotropic glutamate receptors are primary transducers of fast excitatory synaptic transmission in th...
Correction: Docosahexaenoic Acid Alleviates Oxidative Stress-Based Apoptosis Via Improving Mitochondrial Dynamics in Early Brain Injury After Subarachnoid Hemorrhage
Correction: Docosahexaenoic Acid Alleviates Oxidative Stress-Based Apoptosis Via Improving Mitochondrial Dynamics in Early Brain Injury After Subarachnoid Hemorrhage
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
Correction: Myosin IIA Regulated Tight Junction in Oxygen Glucose-Deprived Brain Endothelial Cells Via Activation of TLR4/PI3K/Akt/JNK1/2/14-3-3ε/NF-κB/MMP9 Signal Transduction Pathway
Correction: Myosin IIA Regulated Tight Junction in Oxygen Glucose-Deprived Brain Endothelial Cells Via Activation of TLR4/PI3K/Akt/JNK1/2/14-3-3ε/NF-κB/MMP9 Signal Transduction Pathway
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
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