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Gut-first Parkinson’s disease is encoded by gut dysbiome
Gut-first Parkinson’s disease is encoded by gut dysbiome
In Parkinson's patients, intestinal dysbiosis can occur years before clinical diagnosis, implicating the gut and its m...
Repetitive transcranial magnetic stimulation alleviates motor impairment in Parkinson’s disease: association with peripheral inflammatory regulatory T-cells and SYT6
Repetitive transcranial magnetic stimulation alleviates motor impairment in Parkinson’s disease: association with peripheral inflammatory regulatory T-cells and SYT6
Repetitive transcranial magnetic stimulation (rTMS) has been used to treat various neurological disorders. However, the mo...
HDGFL2 cryptic protein: a portal to detection and diagnosis in neurodegenerative disease
HDGFL2 cryptic protein: a portal to detection and diagnosis in neurodegenerative disease
Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, et al. Ubiquitinated TDP-43 in frontotemporal lobar dege...
Proteomic analysis of APOEε4 carriers implicates lipid metabolism, complement and lymphocyte signaling in cognitive resilience
Proteomic analysis of APOEε4 carriers implicates lipid metabolism, complement and lymphocyte signaling in cognitive resilience
Apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late onset Alzheimer’s disease (AD)....
CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals
CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals
This preclinical AD CSF proteome study identified a panel of 12-CSF markers detecting amyloid positivity and clinical prog...
HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases
HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases
This letter demonstrates the potential of novel cryptic proteins resulting from TAR DNA-binding protein 43 (TDP-43) dysfun...
The endotoxin hypothesis of Alzheimer’s disease
The endotoxin hypothesis of Alzheimer’s disease
Lipopolysaccharide (LPS) constitutes much of the surface of Gram-negative bacteria, and if LPS enters the human body or br...
Regulatory T cells limit age-associated retinal inflammation and neurodegeneration
Regulatory T cells limit age-associated retinal inflammation and neurodegeneration
Ageing is the principal risk factor for retinal degenerative diseases, which are the commonest cause of blindness in the d...
An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders
An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders
Induced pluripotent stem cell-derived microglia (iMGL) represent an excellent tool in studying microglial function in heal...
The concept of resilience to Alzheimer’s Disease: current definitions and cellular and molecular mechanisms
The concept of resilience to Alzheimer’s Disease: current definitions and cellular and molecular mechanisms
Some individuals are able to maintain their cognitive abilities despite the presence of significant Alzheimer’s Dise...
MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson’s disease
MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson’s disease
Parkinson’s disease (PD), one of the most devastating neurodegenerative brain disorders, is characterized by the pro...
Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer’s disease model
Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer’s disease model
Alzheimer’s disease (AD) patients exhibit memory disruptions and profound sleep disturbances, including disruption o...
Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease
Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease
Recent genetic studies on Alzheimer’s disease (AD) have brought microglia under the spotlight, as loci associated wi...
Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brains
Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brains
Alpha-synuclein (α-syn) aggregation into proteinaceous intraneuronal inclusions, called Lewy bodies (LBs), is the neu...
Alzheimer’s genes in microglia: a risk worth investigating
Alzheimer’s genes in microglia: a risk worth investigating
Despite expressing many key risk genes, the role of microglia in late-onset Alzheimer’s disease pathophysiology is s...
Donald Lowell Price, M.D. In memoriam
Donald Lowell Price, M.D. In memoriam
Molecu...
Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons
Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons
Progranulin (PGRN) is a lysosomal glycoprotein implicated in various neurodegenerative diseases, including frontotemporal ...
Roles of peripheral lipoproteins and cholesteryl ester transfer protein in the vascular contributions to cognitive impairment and dementia
Roles of peripheral lipoproteins and cholesteryl ester transfer protein in the vascular contributions to cognitive impairment and dementia
This narrative review focuses on the role of cholesteryl ester transfer protein (CETP) and peripheral lipoproteins in the ...
Altered plasma protein profiles in genetic FTD – a GENFI study
Altered plasma protein profiles in genetic FTD – a GENFI study
Plasma biomarkers reflecting the pathology of frontotemporal dementia would add significant value to clinical practice, to...
Correction: Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come
Correction: Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Peptide-based approaches to directly target alpha-synuclein in Parkinson’s disease
Peptide-based approaches to directly target alpha-synuclein in Parkinson’s disease
Peptides and their mimetics are increasingly recognised as drug-like molecules, particularly for intracellular protein-pro...
Simple model systems reveal conserved mechanisms of Alzheimer’s disease and related tauopathies
Simple model systems reveal conserved mechanisms of Alzheimer’s disease and related tauopathies
The lack of effective therapies that slow the progression of Alzheimer’s disease (AD) and related tauopathies highli...
Mitochondrial dysfunction in Parkinson’s disease – a key disease hallmark with therapeutic potential
Mitochondrial dysfunction in Parkinson’s disease – a key disease hallmark with therapeutic potential
Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic Parkinson’s disease (PD)....
α-Synuclein serine129 phosphorylation – the physiology of pathology
α-Synuclein serine129 phosphorylation – the physiology of pathology
The study that found phospho-serine129 in the Parkinson’s-linked protein alpha-synuclein over two decades ago proposed a p...
Regulation of cortical hyperexcitability in amyotrophic lateral sclerosis: focusing on glial mechanisms
Regulation of cortical hyperexcitability in amyotrophic lateral sclerosis: focusing on glial mechanisms
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by the loss of both upper an...
Mechanisms of ARIA: is it time to focus on the unique immune environment of the neurovascular unit?
Mechanisms of ARIA: is it time to focus on the unique immune environment of the neurovascular unit?
Pfeifer M, Boncristiano S, Bondolfi L, Stalder A, Deller T, Staufenbiel M, et al. Cerebral Hemorrhage after passive anti-a...
Correction: Predominant expression of Alzheimer’s disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts
Correction: Predominant expression of Alzheimer’s disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress
Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress
Cerebral amyloid angiopathy (CAA) is a devastating condition common in patients with Alzheimer’s disease but also ob...
Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come
Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come
Jiang Y, Alam JJ, Gomperts SN, Maruff P, Lemstra AW, Germann UA, et al. Preclinical and randomized clinical evaluation of ...
The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer’s disease
The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer’s disease
RNA editing at the Q/R site of GluA2 occurs with ~99% efficiency in the healthy brain, so that the majority of AMPARs cont...
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