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Shift from chronic to episodic migraine frequency in a long-term phase 3 study of galcanezumab
Shift from chronic to episodic migraine frequency in a long-term phase 3 study of galcanezumab
Chronic migraine (CM) is a highly disabling form of migraine in which patients have ≥ 15 headache days per mon...
The link between spreading depolarization and innate immunity in the central nervous system
The link between spreading depolarization and innate immunity in the central nervous system
Spreading depolarization (SD) is a complex event that induces significant cellular stress in the central nervous system, l...
Epidemiology of clinically significant migraine in Israel: a retrospective database study
Epidemiology of clinically significant migraine in Israel: a retrospective database study
Epidemiological studies on migraine are valuable for tracking disease trends, identifying risk factors, and informing trea...
Exploring the association between statins use or HMG-CoA reductase inhibition and migraine: a systematic review and meta-analysis
Exploring the association between statins use or HMG-CoA reductase inhibition and migraine: a systematic review and meta-analysis
Statins or 3‑hydroxy‑3‑methyl‑glutarylcoenzyme A (HMG‑CoA) reductase inhibitors are medicati...
Intracranial pressure monitoring in patients with spontaneous onset of orthostatic headache
Intracranial pressure monitoring in patients with spontaneous onset of orthostatic headache
Spontaneous intracranial hypotension (SIH) is a debilitating disorder, with an estimated annual incidence of 3.7 per 100,0...
Differential expression of components of the CGRP-receptor family in human coronary and human middle meningeal arteries: functional implications
Differential expression of components of the CGRP-receptor family in human coronary and human middle meningeal arteries: functional implications
Different responses in human coronary arteries (HCA) and human middle meningeal arteries (HMMA) were observed for some of ...
Disrupted gray matter connectome in vestibular migraine: a combined machine learning and individual-level morphological brain network analysis
Disrupted gray matter connectome in vestibular migraine: a combined machine learning and individual-level morphological brain network analysis
Although gray matter (GM) volume alterations have been extensively documented in previous voxel-based morphometry studies ...
Gender-different effect of Src family kinases antagonism on photophobia and trigeminal ganglion activity
Gender-different effect of Src family kinases antagonism on photophobia and trigeminal ganglion activity
Src family kinases (SFKs) contribute to migraine pathogenesis, yet its role in regulating photophobia behaviour, one of th...
Reduced neurovascular coupling of the visual network in migraine patients with aura as revealed with arterial spin labeling MRI: is there a demand-supply mismatch behind the scenes?
Reduced neurovascular coupling of the visual network in migraine patients with aura as revealed with arterial spin labeling MRI: is there a demand-supply mismatch behind the scenes?
Although neuroimaging investigations have consistently demonstrated that “hyperresponsive” and “hypercon...
Hypersensitivity to BKCa channel opening in persistent post-traumatic headache
Hypersensitivity to BKCa channel opening in persistent post-traumatic headache
Large conductance  calcium-activated potassium (BKCa) channels have been implicated in the neurobiological underp...
Connectivity of the insular subdivisions differentiates posttraumatic headache-associated from nonheadache-associated mild traumatic brain injury: an arterial spin labelling study
Connectivity of the insular subdivisions differentiates posttraumatic headache-associated from nonheadache-associated mild traumatic brain injury: an arterial spin labelling study
The insula is an important part of the posttraumatic headache (PTH) attributed to mild traumatic brain injury (mTBI) neuro...
Connectivity of the insular subdivisions differentiates posttraumatic headache-associated from nonheadache-associated mild traumatic brain injury: an arterial spin labelling study
Connectivity of the insular subdivisions differentiates posttraumatic headache-associated from nonheadache-associated mild traumatic brain injury: an arterial spin labelling study
The insula is an important part of the posttraumatic headache (PTH) attributed to mild traumatic brain injury (mTBI) neuro...
Occurrence of new or more severe headaches following COVID-19 is associated with markers of microglial activation and peripheral sensitization: results from a prospective cohort study
Occurrence of new or more severe headaches following COVID-19 is associated with markers of microglial activation and peripheral sensitization: results from a prospective cohort study
New onset or worsening of a headache disorder substantially contributes to the disease burden of post-COVID-19. Its manage...
Occurrence of new or more severe headaches following COVID-19 is associated with markers of microglial activation and peripheral sensitization: results from a prospective cohort study
Occurrence of new or more severe headaches following COVID-19 is associated with markers of microglial activation and peripheral sensitization: results from a prospective cohort study
New onset or worsening of a headache disorder substantially contributes to the disease burden of post-COVID-19. Its manage...
Exploring potential neuroimaging biomarkers for the response to non-steroidal anti-inflammatory drugs in episodic migraine
Exploring potential neuroimaging biomarkers for the response to non-steroidal anti-inflammatory drugs in episodic migraine
Non-steroidal anti-inflammatory drugs (NSAIDs) are considered first-line medications for acute migraine attacks. However, ...
Mechanosensitive receptors in migraine: a systematic review
Mechanosensitive receptors in migraine: a systematic review
Migraine is a debilitating neurological disorder with pain profile, suggesting exaggerated mechanosensation. Mechanosensit...
Calcitonin gene-related peptide antagonists in pregnancy: a disproportionality analysis in VigiBase®
Calcitonin gene-related peptide antagonists in pregnancy: a disproportionality analysis in VigiBase®
Current evidence on the safety of calcitonin gene–related peptide antagonists (CGRP-A) in pregnancy for the treatmen...
Anti-CGRP antibody galcanezumab modifies the function of the trigeminovascular nocisensor complex in the rat
Anti-CGRP antibody galcanezumab modifies the function of the trigeminovascular nocisensor complex in the rat
Monoclonal antibodies directed against the neuropeptide calcitonin gene-related peptide (CGRP) are effective in the preven...
Compromised trigemino-coerulean coupling in migraine sensitization can be prevented by blocking beta-receptors in the locus coeruleus
Compromised trigemino-coerulean coupling in migraine sensitization can be prevented by blocking beta-receptors in the locus coeruleus
Migraine is a disabling neurological disorder, characterized by recurrent headaches. During migraine attacks, individuals ...
Headaches during pregnancy and the risk of subsequent stroke
Headaches during pregnancy and the risk of subsequent stroke
Primary headache disorder is a known risk factor for stroke in women and usually improves during the first trimester of pr...
What to do with non-responders to CGRP(r) monoclonal antibodies: switch to another or move to gepants?
What to do with non-responders to CGRP(r) monoclonal antibodies: switch to another or move to gepants?
In this editorial we aim to provide potential therapeutic options in patients who do not benefit from treatment with CGRP(...
Competing treatments for migraine: a headache for decision-makers
Competing treatments for migraine: a headache for decision-makers
Migraine is the world’s second most common disabling disorder, affecting 15% of UK adults and costing the UK over &#...
Clinical effectiveness of pharmacological interventions for managing chronic migraine in adults: a systematic review and network meta-analysis
Clinical effectiveness of pharmacological interventions for managing chronic migraine in adults: a systematic review and network meta-analysis
Chronic migraine can be a profoundly disabling disorder that may be treated with preventive medications. However, uncertai...
Mapping brain functional networks topological characteristics in new daily persistent headache: a magnetoencephalography study
Mapping brain functional networks topological characteristics in new daily persistent headache: a magnetoencephalography study
The brain functional network topology in new daily persistent headache (NDPH) is not well understood. In this study, we ai...
Trends in migraine incidence among women of childbearing age from 1990 to 2019 and the prediction for 2030: an analysis of national data in China
Trends in migraine incidence among women of childbearing age from 1990 to 2019 and the prediction for 2030: an analysis of national data in China
Migraine is a primary headache, which has been producing heavy disease burden globally. There is no data on the incidence ...
Long-term effectiveness of eptinezumab in patients with migraine and prior preventive treatment failures: extension of a randomized controlled trial
Long-term effectiveness of eptinezumab in patients with migraine and prior preventive treatment failures: extension of a randomized controlled trial
Eptinezumab demonstrated efficacy in adults with migraine and prior preventive treatment failures in the placebo-controlle...
Long-term effectiveness and tolerability of galcanezumab in patients with migraine excluded from clinical trials: real world evidence of 1055 patients with 1 year follow-up from the Galca-Only registry
Long-term effectiveness and tolerability of galcanezumab in patients with migraine excluded from clinical trials: real world evidence of 1055 patients with 1 year follow-up from the Galca-Only registry
Galcanezumab has shown efficacy and effectiveness in the treatment of episodic and chronic migraine (CM), however, the pop...
Correction: Global, regional, and national epidemiology of migraine and tension-type headache in youths and young adults aged 15–39 years from 1990 to 2019: findings from the global burden of disease study 2019
Correction: Global, regional, and national epidemiology of migraine and tension-type headache in youths and young adults aged 15–39 years from 1990 to 2019: findings from the global burden of disease study 2019
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Progesterone distribution in the trigeminal system and its role to modulate sensory neurotransmission: influence of sex
Progesterone distribution in the trigeminal system and its role to modulate sensory neurotransmission: influence of sex
Women are disproportionately affected by migraine, representing up to 75% of all migraine cases. This discrepancy has been...
One-year prospective real-world assessment of effectiveness and safety of erenumab in migraine prevention: results of the French FHU INOVPAIN registry study
One-year prospective real-world assessment of effectiveness and safety of erenumab in migraine prevention: results of the French FHU INOVPAIN registry study
Randomized clinical trials have demonstrated efficacy and safety of erenumab. The aim of this study is to evaluate the eff...
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