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Editorial: Nervous regeneration and functional recovery in the central and peripheral nervous systems: diagnostic methods, gene/cell therapies, and interventions
For instance, Y. Wang et al (https://doi.org/10.3389/fnmol.2024.1400927), used an iridoid rich fraction from Valeriana jat...
Ectopic expression of the cation-chloride cotransporter KCC2 in blood exosomes as a biomarker for functional rehabilitation
Introduction According to the World Health Organization (WHO), traumatic brain injury (TBI) is the leading cause of disa...
The effect of AKT inhibition in α-synuclein-dependent neurodegeneration
Introduction Parkinson’s Disease (PD) is a progressive neurodegenerative disorder marked by the degeneration of dopamine...
Editorial: Latest advances in neuroscience at the 9th Croatian Neuroscience Congress
This Research Topic includes papers which feature exciting findings and state-of-the art methodologies applied in brain re...
Editorial: Spatio-temporal molecular mechanisms regulating synapse function and neural circuit dynamics
processes information, adapts to experiences, and responds to injuries , such as through mechanisms like synaptic plastici...
The emerging role of glycine receptor α2 subunit defects in neurodevelopmental disorders
Introduction Glycine receptors (GlyRs) are recognized as mediators of fast inhibitory synaptic neurotransmission in the ...
Extrinsic and intrinsic control of striatal cholinergic interneuron activity
1 Introduction The striatum is the largest portion of the basal ganglia and provides information required for movement, ...
Deciphering motor dysfunction and microglial activation in mThy1-α-synuclein mice: a comprehensive study of behavioral, gene expression, and methylation changes
Introduction Synucleinopathy disorders refer to a group of complex neurodegenerative diseases, including Parkinson’s dis...
Histone monoaminylation is a novel epigenetic mechanism in psychiatric disorders
Monoamines, basic nitrogenous molecules containing one amine group, include serotonin, adrenaline, noradrenaline, dopamine...
Impaired cerebrospinal fluid circulation and cerebral lymphatic drainage in a rat model of chronic hydrocephalus
1 Introduction The human brain is surrounded by cerebrospinal fluid (CSF), which is primarily produced by the choroid ple...
Multi-omics-based phenotyping of AFG3L2-mutant lymphoblasts determines key factors of a pathophysiological interplay between mitochondrial vulnerability and neurodegeneration in spastic ataxia type 5
Graphical Abstract. Pathophysiological impact of AFG3L2 mutations in SPAX5 as revealed by multi-omics analys...
Astrocyte-secreted factors modulate synaptic protein synthesis as revealed by puromycin labeling of isolated synaptosomes
1 Introduction In the central nervous system (CNS), neuronal connectivity in the brain is accomplished by synaptic conne...
Erratum: Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library
Figure 4: Glycosylation patterns of the KCC2-CTD mutants. (A) Top panel: Western blot analysis of KCC2 polypeptides in the...
Profiling hippocampal neuronal populations reveals unique gene expression mosaics reflective of connectivity-based degeneration in the Ts65Dn mouse model of Down syndrome and Alzheimer’s disease
Introduction Down syndrome (DS), caused by the triplication of human chromosome 21 (HSA21), represents the most common g...
Bioenergetic-related gene expression in the hippocampus predicts internalizing vs. externalizing behavior in an animal model of temperament
1 Introduction Psychiatric disorders can be classified using an internalizing versus externalizing model (Cerdá et al., ...
Editorial: Editors' showcase: neuroplasticity and development
Synaptic plasticity, the ability of neurons to strengthen or weaken their connections in response to activity, is fundamen...
Editorial: Molecular pathology, biomarkers and therapeutics of brain tumor and neurodegenerative disease
Both brain tumors and neurodegenerative diseases are among the most prevalent and devastating disorders affecting the huma...
Editorial: Mechanisms of auditory development, maintenance, damage, and protection
Mechanisms of Auditory Development, Maintenance, Damage, and Protection Auditory perception is fundamental to human experi...
The CB1R of mPFC is involved in anxiety-like behavior induced by 0.8/2.65 GHz dual-frequency electromagnetic radiation
1 Introduction Electromagnetic radiation (EMR) refers to the phenomenon of electromagnetic energy radiating into space in...
Functions of TRPs in retinal tissue in physiological and pathological conditions
Functions of TRPs in retinal tissue in physiological and pathological conditions
1 Introduction The visual system is one of the most important senses, contributing to the defense and survival of animal...
The complexities of salt taste reception: insights into the role of TMC4 in chloride taste detection
The complexities of salt taste reception: insights into the role of TMC4 in chloride taste detection
Introduction Taste is a sensory reception that is widely shared among many species. It receives stimulus from the extern...
Further validation of the association between MAPT haplotype-tagging polymorphisms and Alzheimer’s disease: neuropsychological tests, cerebrospinal fluid biomarkers, and APOE genotype
Further validation of the association between MAPT haplotype-tagging polymorphisms and Alzheimer’s disease: neuropsychological tests, cerebrospinal fluid biomarkers, and APOE genotype
1 Introduction Alzheimer’s disease (AD) is a complex condition influenced by both genetic and environmental factors. Ana...
Molecular determinants of resurgent sodium currents mediated by Navβ4 peptide and A-type FHFs
Molecular determinants of resurgent sodium currents mediated by Navβ4 peptide and A-type FHFs
Introduction Voltage-gated sodium channels (VGSCs) can generate classic sodium current and atypical sodium current named...
Risk factors for poor prognosis in patients with zoster-associated neuralgia who underwent interventional pain management
Risk factors for poor prognosis in patients with zoster-associated neuralgia who underwent interventional pain management
1 Introduction Herpes zoster-associated neuralgia (ZAN) is the most common complication of herpes zoster (HZ) and leads ...
A review of the pathogenesis of epilepsy based on the microbiota-gut-brain-axis theory
A review of the pathogenesis of epilepsy based on the microbiota-gut-brain-axis theory
1 Introduction Epilepsy (Wirrell et al., 2022) is an episodic neurological disorder in which nerve cells in the brain hy...
Cellular signaling pathways in the nervous system activated by various mechanical and electromagnetic stimuli
Cellular signaling pathways in the nervous system activated by various mechanical and electromagnetic stimuli
Introduction The mammalian brain and spinal cord are viscoelastic tissues composed of heterogeneous cell populations, in...
Exploring shared biomarkers and shared pathways in insomnia and atherosclerosis using integrated bioinformatics analysis
Exploring shared biomarkers and shared pathways in insomnia and atherosclerosis using integrated bioinformatics analysis
1 Introduction Insomnia (ISM) is a most common sleep disorder all over the world, which seriously affects people’s quali...
Dynamic micro-optical coherence tomography enables structural and metabolic imaging of the mammalian cochlea
Dynamic micro-optical coherence tomography enables structural and metabolic imaging of the mammalian cochlea
1 Introduction Sensorineural hearing loss (SNHL) is caused by the loss or dysfunction of cochlear hair cells and/or spir...
Inflammation and olfactory loss are associated with at least 139 medical conditions
Inflammation and olfactory loss are associated with at least 139 medical conditions
1 Introduction 1.1 Observations linking olfactory loss and medical conditions: correlation, precedence, and prediction 1....
Inactivity of Stat3 in sensory and non-sensory cells of the mature cochlea
Inactivity of Stat3 in sensory and non-sensory cells of the mature cochlea
1 Introduction The organ of Corti is the receptor organ for hearing located in the cochlea. It consists of various highl...
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