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Direct effects of prolonged TNF-α and IL-6 exposure on neural activity in human iPSC-derived neuron-astrocyte co-cultures
1 Introduction Following recovery from acute SARS-CoV-2 infection, many patients report lingering symptoms including fat...
Glymphatic system: a self-purification circulation in brain
1 CSF-ISF circulation and glymphatic system in brain Cerebrospinal fluid is a kind of clear, colorless fluid, substantial...
Spinal astrocytes involved in the pathogenesis and treatment of neuropathic pain
1 Introduction Neuropathic pain (NP) refers to pain that arises as a direct consequence of a lesion or disease affecting...
Intrinsic retinoic acid synthesis is required for oligodendrocyte progenitor expansion during CNS remyelination
Introduction Multiple sclerosis (MS) is an immune-driven neurodegenerative disease characterized by chronic inflammation,...
Autism spectrum disorder related phenotypes in a mouse model lacking the neuronal actin binding protein profilin 2
1 Introduction Since the last two decades the relevant role of the actin cytoskeleton for the development and function o...
GABAergic integration of transient and persistent neurons in the developing mouse somatosensory cortex
1 Introduction The amino acid γ-amino-butyric-acid (GABA) is a major inhibitory neurotransmitter in the central nervous s...
A dual role for pleiotrophin in modulating inflammation and myelination in the presence of chondroitin sulfate proteoglycans after nervous system injury
1 Introduction Neurons, the fundamental building blocks of the central nervous system (CNS), are specialized cells respo...
Loss of Bmal1 impairs the glutamatergic light input to the SCN in mice
1 Introduction In addition to its important function in image perception, light has a strong influence on a variety of br...
Editorial: Glial cells in homeostasis, neurodevelopment, and repair
to modulate neuroinflammatory processes would be crucial to develop effective therapeutic approaches that balance their be...
Morphology and connectivity of retinal horizontal cells in two avian species
1 Introduction The vertebrate retina contains five classes of neurons: photoreceptors transduce the incoming visual sign...
Anti-neuroinflammatory effects of conjugated linoleic acid isomers, c9,t11 and t10,c12, on activated BV-2 microglial cells
Anti-neuroinflammatory effects of conjugated linoleic acid isomers, c9,t11 and t10,c12, on activated BV-2 microglial cells
Conjugated linoleic acid (CLA) isomers exhibit anti-inflammatory properties within the central nervous system (CNS). This ...
Anatomical and molecular development of the human primary visual cortex
Anatomical and molecular development of the human primary visual cortex
The human primary visual cortex (V1) development is pivotal to understanding cortical maturation and neuroplasticity. Theo...
Noise-induced cochlear synaptopathy in C57BL/6 N mice as a function of trauma strength: ribbons are more vulnerable than postsynapses
Noise-induced cochlear synaptopathy in C57BL/6 N mice as a function of trauma strength: ribbons are more vulnerable than postsynapses
Noise-induced cochlear synaptopathy is characterized by irreversible loss of synapses between inner hair cells (IHCs) and ...
Voltage-gated potassium channels as a potential therapeutic target for the treatment of neurological and psychiatric disorders
Voltage-gated potassium channels as a potential therapeutic target for the treatment of neurological and psychiatric disorders
Voltage-gated potassium channels are a widely distributed subgroup of potassium channels responsible for the efflux of pot...
Ammonium chloride reduces excitatory synaptic transmission onto CA1 pyramidal neurons of mouse organotypic slice cultures
Ammonium chloride reduces excitatory synaptic transmission onto CA1 pyramidal neurons of mouse organotypic slice cultures
Acute liver dysfunction commonly leads to rapid increases in ammonia concentrations in both the serum and the cerebrospina...
A novel KCNC3 gene variant in the voltage-dependent Kv3.3 channel in an atypical form of SCA13 with dominant central vertigo
A novel KCNC3 gene variant in the voltage-dependent Kv3.3 channel in an atypical form of SCA13 with dominant central vertigo
Potassium channel mutations play an important role in neurological diseases, such as spinocerebellar ataxia (SCA). SCA is ...
Loss of C1q alters the auditory brainstem response
Loss of C1q alters the auditory brainstem response
Neural circuits in the auditory brainstem compute interaural time and intensity differences used to determine the location...
Editorial: Neuromodulation technology: advances in optics and acoustics
It is estimated that about 43.3 million people are blind and 295 million with moderate to severe visual impairment worldwi...
Therapeutic potential of mesenchymal stem cell-derived exosomes and miRNAs in neuronal regeneration and rejuvenation in neurological disorders: a mini review
Therapeutic potential of mesenchymal stem cell-derived exosomes and miRNAs in neuronal regeneration and rejuvenation in neurological disorders: a mini review
Mesenchymal stem cells (MSCs) have gained considerable attention in the field of regenerative medicine due to their abilit...
Mathematical models of C-type and N-type inactivating heteromeric voltage gated potassium channels
Mathematical models of C-type and N-type inactivating heteromeric voltage gated potassium channels
Voltage gated potassium channels can be composed of either four identical, or different, pore-forming protein subunits. Wh...
Retraction: Santacruzamate A Ameliorates AD-Like Pathology by Enhancing ER Stress Tolerance Through Regulating the Functions of KDELR and Mia40-ALR in vivo and in vitro
Retraction: Santacruzamate A Ameliorates AD-Like Pathology by Enhancing ER Stress Tolerance Through Regulating the Functio...
The impact of maternal anti-inflammatory drugs on surgical anesthesia-induced neuroinflammation and cognitive impairment in offspring mice
The impact of maternal anti-inflammatory drugs on surgical anesthesia-induced neuroinflammation and cognitive impairment in offspring mice
BackgroundThe impact of maternal surgery combined with general anesthesia on neuroinflammation and the development of lear...
Organoid intelligence for developmental neurotoxicity testing
Organoid intelligence for developmental neurotoxicity testing
The increasing prevalence of neurodevelopmental disorders has highlighted the need for improved testing methods to determi...
Deprivation of visual input alters specific subset of inhibitory neurons and affect thalamic afferent terminals in V1 of rd1 mouse
Deprivation of visual input alters specific subset of inhibitory neurons and affect thalamic afferent terminals in V1 of rd1 mouse
Retinitis Pigmentosa (RP) is a heterogenous group of inherited disorder, and its progression not only affects the retina b...
Alzheimer’s disease induced neurons bearing PSEN1 mutations exhibit reduced excitability
Alzheimer’s disease induced neurons bearing PSEN1 mutations exhibit reduced excitability
Alzheimer’s disease (AD) is a devastating neurodegenerative condition that affects memory and cognition, characterized by ...
Quantitative, real-time imaging of spreading depolarization-associated neuronal ROS production
Quantitative, real-time imaging of spreading depolarization-associated neuronal ROS production
Spreading depolarization (SD) causes a massive neuronal/glial depolarization, disturbs ionic homeostasis and deranges neur...
Manipulation of DHPS activity affects dendritic morphology and expression of synaptic proteins in primary rat cortical neurons
Manipulation of DHPS activity affects dendritic morphology and expression of synaptic proteins in primary rat cortical neurons
Deoxyhypusine synthase (DHPS) catalyzes the initial step of hypusine incorporation into the eukaryotic initiation factor 5...
The role of ferroptosis in neurodegenerative diseases
The role of ferroptosis in neurodegenerative diseases
Ferroptosis represents an iron− and lipid peroxidation (LPO)-mediated form of regulated cell death (RCD). Recent evidence ...
Neuromodulation of inhibitory synaptic transmission in the basolateral amygdala during fear and anxiety
Neuromodulation of inhibitory synaptic transmission in the basolateral amygdala during fear and anxiety
The basolateral amygdala plays pivotal roles in the regulation of fear and anxiety and these processes are profoundly modu...
Unusual morphology of foveal Müller glia in an adult human born pre-term
Unusual morphology of foveal Müller glia in an adult human born pre-term
The fovea of the human retina, a specialization for acute and color vision, features a high concentration of cone photorec...
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