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A Gut Microbial Metabolite Alleviates Stress-Induced Neurobehavioral Dysfunction in an Alzheimer’s Disease Model
A Gut Microbial Metabolite Alleviates Stress-Induced Neurobehavioral Dysfunction in an Alzheimer’s Disease Model
Chronic psychological stress is a known risk factor for neurodegenerative disorders like Alzheimer’s disease (AD), b...
Leaf miRNAs of Negatively Regulate the Aging-Associated Genes in
Leaf miRNAs of Negatively Regulate the Aging-Associated Genes in
Aging is a physiological process that culminates in cellular senescence, a phenomenon that has significant implications fo...
The Influence of the Probiotics, Ketogenic Diets, and Gut Microbiota on Epilepsy and Epileptic Models: A Comprehensive Review
The Influence of the Probiotics, Ketogenic Diets, and Gut Microbiota on Epilepsy and Epileptic Models: A Comprehensive Review
About one-third of epilepsies are resistant to antiepileptic drugs; thus, uncovering new pathways in the pathophysiology o...
Novel miRNAs, miR-937-3p, miR-4536-3p, and miR-4650-5p, can Modulate Neuronal Differentiation via the Wnt/MAPK Pathway in SH-SY5Y Cells
Novel miRNAs, miR-937-3p, miR-4536-3p, and miR-4650-5p, can Modulate Neuronal Differentiation via the Wnt/MAPK Pathway in SH-SY5Y Cells
MicroRNAs (miRNAs) are small non-coding RNAs that regulate various biological processes, including cell differentiation. D...
Dual Mechanism of Docosahexaenoic acid (DHA) in Alzheimer’s Disease: PAD4 Inhibition and Autophagy Stimulation
Dual Mechanism of Docosahexaenoic acid (DHA) in Alzheimer’s Disease: PAD4 Inhibition and Autophagy Stimulation
Alzheimer’s disease (AD), which affects millions globally, is marked by progressive cognitive decline and neurodegen...
LINC00265 Serves as a Diagnostic and Prognostic Marker for Acute Ischemic Stroke and INHIBITS Disease Progression Through the miR- 155 - 5p/TRIM32 Axis
LINC00265 Serves as a Diagnostic and Prognostic Marker for Acute Ischemic Stroke and INHIBITS Disease Progression Through the miR- 155 - 5p/TRIM32 Axis
Acute ischemic stroke (AIS) is a medical emergency stemming from a reduction in cerebral blood supply, leading to neuronal...
TAT-T407 Mitigates Apoptosis and Cognitive Impairments Following Cerebral Ischemia Through Disruption of TRPV1-CDK5 Interaction
TAT-T407 Mitigates Apoptosis and Cognitive Impairments Following Cerebral Ischemia Through Disruption of TRPV1-CDK5 Interaction
Cerebral ischemia/reperfusion (I/R) injury manifests as progressive motor and cognitive dysfunction, primarily attributed ...
Carnosic Acid Attenuated the Motor Impairment by Bisphenol A is Related to the Regulation of Autophagy Through Parkin in In Vitro and In Vivo
Carnosic Acid Attenuated the Motor Impairment by Bisphenol A is Related to the Regulation of Autophagy Through Parkin in In Vitro and In Vivo
Bisphenol A (BPA) is an endocrine-disrupting compound linked to impairments in motor function and the manifestation of anx...
Long Non-coding RNA CRNDE Promotes the Development of Glioma by Inducing Polarization of M2-Type Macrophages
Long Non-coding RNA CRNDE Promotes the Development of Glioma by Inducing Polarization of M2-Type Macrophages
Glioma is the most common primary malignant brain tumor globally, with a poor prognosis due to its complex interaction wit...
A Ginsenoside Composition Ameliorated Aβ and Tau Aggregation via Autophagy Lysosome Pathway
A Ginsenoside Composition Ameliorated Aβ and Tau Aggregation via Autophagy Lysosome Pathway
Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by the abnormal deposition of amyloid...
Neuron-Derived Extracellular Vesicles: Emerging Regulators in Central Nervous System Disease Progression
Neuron-Derived Extracellular Vesicles: Emerging Regulators in Central Nervous System Disease Progression
The diagnosis and exploration of central nervous system (CNS) diseases remain challenging due to the blood–brain bar...
Evaluation of the Protective Effects of Noscapine on Paraquat-Induced Parkinson's Disease in Rats
Evaluation of the Protective Effects of Noscapine on Paraquat-Induced Parkinson's Disease in Rats
Parkinson's disease (PD) is a degenerative central nervous system disease pathologically attributed to dopaminergic ne...
ERRα Knockout Promotes M2 Microglial Polarization and Inhibits Ferroptosis in Sepsis-Associated Brain Dysfunction
ERRα Knockout Promotes M2 Microglial Polarization and Inhibits Ferroptosis in Sepsis-Associated Brain Dysfunction
Sepsis-associated brain dysfunction (SABD) is a critical neurological complication with high mortality, yet its pathogenes...
Uncovering Potential Susceptibility Genes for Multiple Sclerosis-Induced Neuropathic Bladder: A Mendelian Randomization Analysis
Uncovering Potential Susceptibility Genes for Multiple Sclerosis-Induced Neuropathic Bladder: A Mendelian Randomization Analysis
Despite lacking a genetic explanation for the causal link between multiple sclerosis (MS) and neuropathic bladder (NPB), o...
Role and Relationship Between Homocysteine and HS in Ischemic Stroke
Role and Relationship Between Homocysteine and HS in Ischemic Stroke
Homocysteine (Hcy), a sulfur-containing amino acid, is an important intermediate product of methionine metabolism. Hcy can...
Advancements in Stem Cell Research for Effective Therapies Against Alzheimer’s Disease: Current Investigation and Future Insight
Advancements in Stem Cell Research for Effective Therapies Against Alzheimer’s Disease: Current Investigation and Future Insight
Alzheimer’s disease (AD) is the most prevalent cause of dementia in the elderly, affecting approximately 50 million ...
Identifying Immune Response Protein Biomarkers in Parkinson’s-Related Cognitive Impairment and Depression
Identifying Immune Response Protein Biomarkers in Parkinson’s-Related Cognitive Impairment and Depression
A distinct immune microenvironment may develop in patients with Parkinson’s disease (PD), influenced by the severity...
L-Theanine Effectively Protects Against Copper-Facilitated Dopamine Oxidation: Implication for Relieving Dopamine Overflow-Associated Neurotoxicities
L-Theanine Effectively Protects Against Copper-Facilitated Dopamine Oxidation: Implication for Relieving Dopamine Overflow-Associated Neurotoxicities
Non-physiological disorders release dopamine into extracellular brain fluid to induce neurodegenerative brain diseases. Th...
MicroRNAs as Regulators, Biomarkers, and Therapeutic Targets in Autism Spectrum Disorder
MicroRNAs as Regulators, Biomarkers, and Therapeutic Targets in Autism Spectrum Disorder
The pathogenesis of autism spectrum disorder (ASD) is complex and is mainly influenced by genetic and environmental factor...
Augmentation of Endogenous 2-Arachidonoylglycerol Mitigates Autistic Behaviors of BTBR Mice
Augmentation of Endogenous 2-Arachidonoylglycerol Mitigates Autistic Behaviors of BTBR Mice
The lipid-based endocannabinoid (eCB) system regulates a host of developmental, physiological, and pathological processes ...
Multi-Omics Approach Reveals Genes and Pathways Affected in Miller-Dieker Syndrome
Multi-Omics Approach Reveals Genes and Pathways Affected in Miller-Dieker Syndrome
Miller-Dieker syndrome (MDS) is a rare neurogenetic disorder resulting from a heterozygous deletion of 26 genes in the MDS...
Inter-alpha Inhibitor Proteins Modulate Microvascular Endothelial Components and Cytokines After Exposure to Hypoxia–Ischemia in Neonatal Rats
Inter-alpha Inhibitor Proteins Modulate Microvascular Endothelial Components and Cytokines After Exposure to Hypoxia–Ischemia in Neonatal Rats
Inter-alpha inhibitor proteins (IAIPs) are neuroprotective and attenuate lipopolysaccharide (LPS)-mediated blood–bra...
Ginger Extract Improves Cognitive Dysfunction via Modulation of Gut Microbiota-Derived Short-Chain Fatty Acids in D-Galactose/Ovariectomy-Induced Alzheimer-Like Disease
Ginger Extract Improves Cognitive Dysfunction via Modulation of Gut Microbiota-Derived Short-Chain Fatty Acids in D-Galactose/Ovariectomy-Induced Alzheimer-Like Disease
Alzheimer’s disease (AD) is the most common form of dementia with complex causes and limited treatment options. Rece...
Effect of L-Carnitine Level on the Risk of Neuromyelitis Optica Spectrum Disorders: A Two-Sample Mendelian Randomization Study
Effect of L-Carnitine Level on the Risk of Neuromyelitis Optica Spectrum Disorders: A Two-Sample Mendelian Randomization Study
Previous research has often focused on studying the CNS damage in neuromyelitis optica spectrum disorders (NMOSD), while t...
Alzheimer’s Disease-Derived Outer Membrane Vesicles Exacerbate Cognitive Dysfunction, Modulate the Gut Microbiome, and Increase Neuroinflammation and Amyloid-β Production
Alzheimer’s Disease-Derived Outer Membrane Vesicles Exacerbate Cognitive Dysfunction, Modulate the Gut Microbiome, and Increase Neuroinflammation and Amyloid-β Production
Although our understanding of the molecular biology of Alzheimer’s disease (AD) continues to improve, the etiology o...
Molecular and Behavioral Neuroprotective Effects of Clavulanic Acid and Crocin in Haloperidol-Induced Tardive Dyskinesia in Rats
Molecular and Behavioral Neuroprotective Effects of Clavulanic Acid and Crocin in Haloperidol-Induced Tardive Dyskinesia in Rats
Clavulanic acid (ClvA), a beta-lactamase inhibitor, is being explored for its significant neuroprotective potential. The e...
Caffeic Acid Attenuates Neuronal Apoptosis, Oxidative Stress, and Memory Deficits via Antioxidant Properties in Aging Rats Induced by D-Galactose
Caffeic Acid Attenuates Neuronal Apoptosis, Oxidative Stress, and Memory Deficits via Antioxidant Properties in Aging Rats Induced by D-Galactose
Aging is a main factor related to cognitive deficits. D-Galactose (D-gal), a monosaccharide, increases oxidative stress le...
Copper Mitigates Atrazine-Induced Neurotoxicity in Parkinson’s Disease Models
Copper Mitigates Atrazine-Induced Neurotoxicity in Parkinson’s Disease Models
Atrazine (ATR), one of the most prevalent herbicides used worldwide, has been associated with various environmental health...
Integrated Profiling Identifies Long-Term Molecular Consequences of Prenatal Dexamethasone Treatment in the Rat Brain—Potential Triggers of Depressive Phenotype and Cognitive Impairment
Integrated Profiling Identifies Long-Term Molecular Consequences of Prenatal Dexamethasone Treatment in the Rat Brain—Potential Triggers of Depressive Phenotype and Cognitive Impairment
Prenatal excess of glucocorticoids (GCs) is considered to be one of the highly impacting factors contributing to depressio...
The Impact of the Histone Deacetylase Inhibitor—Sodium Butyrate on Complement-Mediated Synapse Loss in a Rat Model of Neonatal Hypoxia–Ischemia
The Impact of the Histone Deacetylase Inhibitor—Sodium Butyrate on Complement-Mediated Synapse Loss in a Rat Model of Neonatal Hypoxia–Ischemia
Perinatal asphyxia is one of the most important causes of morbidity and mortality in newborns. One of the key pathogenic f...
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