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L-Theanine Effectively Protects Against Copper-Facilitated Dopamine Oxidation: Implication for Relieving Dopamine Overflow-Associated Neurotoxicities
L-Theanine Effectively Protects Against Copper-Facilitated Dopamine Oxidation: Implication for Relieving Dopamine Overflow-Associated Neurotoxicities
Non-physiological disorders release dopamine into extracellular brain fluid to induce neurodegenerative brain diseases. Th...
MicroRNAs as Regulators, Biomarkers, and Therapeutic Targets in Autism Spectrum Disorder
MicroRNAs as Regulators, Biomarkers, and Therapeutic Targets in Autism Spectrum Disorder
The pathogenesis of autism spectrum disorder (ASD) is complex and is mainly influenced by genetic and environmental factor...
Augmentation of Endogenous 2-Arachidonoylglycerol Mitigates Autistic Behaviors of BTBR Mice
Augmentation of Endogenous 2-Arachidonoylglycerol Mitigates Autistic Behaviors of BTBR Mice
The lipid-based endocannabinoid (eCB) system regulates a host of developmental, physiological, and pathological processes ...
Multi-Omics Approach Reveals Genes and Pathways Affected in Miller-Dieker Syndrome
Multi-Omics Approach Reveals Genes and Pathways Affected in Miller-Dieker Syndrome
Miller-Dieker syndrome (MDS) is a rare neurogenetic disorder resulting from a heterozygous deletion of 26 genes in the MDS...
Inter-alpha Inhibitor Proteins Modulate Microvascular Endothelial Components and Cytokines After Exposure to Hypoxia–Ischemia in Neonatal Rats
Inter-alpha Inhibitor Proteins Modulate Microvascular Endothelial Components and Cytokines After Exposure to Hypoxia–Ischemia in Neonatal Rats
Inter-alpha inhibitor proteins (IAIPs) are neuroprotective and attenuate lipopolysaccharide (LPS)-mediated blood–bra...
Ginger Extract Improves Cognitive Dysfunction via Modulation of Gut Microbiota-Derived Short-Chain Fatty Acids in D-Galactose/Ovariectomy-Induced Alzheimer-Like Disease
Ginger Extract Improves Cognitive Dysfunction via Modulation of Gut Microbiota-Derived Short-Chain Fatty Acids in D-Galactose/Ovariectomy-Induced Alzheimer-Like Disease
Alzheimer’s disease (AD) is the most common form of dementia with complex causes and limited treatment options. Rece...
Effect of L-Carnitine Level on the Risk of Neuromyelitis Optica Spectrum Disorders: A Two-Sample Mendelian Randomization Study
Effect of L-Carnitine Level on the Risk of Neuromyelitis Optica Spectrum Disorders: A Two-Sample Mendelian Randomization Study
Previous research has often focused on studying the CNS damage in neuromyelitis optica spectrum disorders (NMOSD), while t...
Alzheimer’s Disease-Derived Outer Membrane Vesicles Exacerbate Cognitive Dysfunction, Modulate the Gut Microbiome, and Increase Neuroinflammation and Amyloid-β Production
Alzheimer’s Disease-Derived Outer Membrane Vesicles Exacerbate Cognitive Dysfunction, Modulate the Gut Microbiome, and Increase Neuroinflammation and Amyloid-β Production
Although our understanding of the molecular biology of Alzheimer’s disease (AD) continues to improve, the etiology o...
Molecular and Behavioral Neuroprotective Effects of Clavulanic Acid and Crocin in Haloperidol-Induced Tardive Dyskinesia in Rats
Molecular and Behavioral Neuroprotective Effects of Clavulanic Acid and Crocin in Haloperidol-Induced Tardive Dyskinesia in Rats
Clavulanic acid (ClvA), a beta-lactamase inhibitor, is being explored for its significant neuroprotective potential. The e...
Caffeic Acid Attenuates Neuronal Apoptosis, Oxidative Stress, and Memory Deficits via Antioxidant Properties in Aging Rats Induced by D-Galactose
Caffeic Acid Attenuates Neuronal Apoptosis, Oxidative Stress, and Memory Deficits via Antioxidant Properties in Aging Rats Induced by D-Galactose
Aging is a main factor related to cognitive deficits. D-Galactose (D-gal), a monosaccharide, increases oxidative stress le...
Copper Mitigates Atrazine-Induced Neurotoxicity in Parkinson’s Disease Models
Copper Mitigates Atrazine-Induced Neurotoxicity in Parkinson’s Disease Models
Atrazine (ATR), one of the most prevalent herbicides used worldwide, has been associated with various environmental health...
Integrated Profiling Identifies Long-Term Molecular Consequences of Prenatal Dexamethasone Treatment in the Rat Brain—Potential Triggers of Depressive Phenotype and Cognitive Impairment
Integrated Profiling Identifies Long-Term Molecular Consequences of Prenatal Dexamethasone Treatment in the Rat Brain—Potential Triggers of Depressive Phenotype and Cognitive Impairment
Prenatal excess of glucocorticoids (GCs) is considered to be one of the highly impacting factors contributing to depressio...
The Impact of the Histone Deacetylase Inhibitor—Sodium Butyrate on Complement-Mediated Synapse Loss in a Rat Model of Neonatal Hypoxia–Ischemia
The Impact of the Histone Deacetylase Inhibitor—Sodium Butyrate on Complement-Mediated Synapse Loss in a Rat Model of Neonatal Hypoxia–Ischemia
Perinatal asphyxia is one of the most important causes of morbidity and mortality in newborns. One of the key pathogenic f...
Alpha‑Asarone Ameliorates Neuronal Injury After Ischemic Stroke and Hemorrhagic Transformation by Attenuating Blood–Brain Barrier Destruction, Promoting Neurogenesis, and Inhibiting Neuroinflammation
Alpha‑Asarone Ameliorates Neuronal Injury After Ischemic Stroke and Hemorrhagic Transformation by Attenuating Blood–Brain Barrier Destruction, Promoting Neurogenesis, and Inhibiting Neuroinflammation
Recombinant tissue-type plasminogen activator (rt-PA), the primary drug for acute ischemic stroke (IS), has a narrow thera...
Parkinson's Disease and the Microbiota-Gut-Brain Axis: Metabolites, Mechanisms, and Innovative Therapeutic Strategies Targeting the Gut Microbiota
Parkinson's Disease and the Microbiota-Gut-Brain Axis: Metabolites, Mechanisms, and Innovative Therapeutic Strategies Targeting the Gut Microbiota
The human gut microbiota is diverse and abundant and plays important roles in regulating health by participating in metabo...
Upregulation of C1QC as a Mediator of Blood–Brain Barrier Damage in Type 2 Diabetes Mellitus
Upregulation of C1QC as a Mediator of Blood–Brain Barrier Damage in Type 2 Diabetes Mellitus
The blood–brain barrier (BBB) is a neurovascular structure that safeguards the brain by inhibiting the passage of ha...
Microglia Sing the Prelude of Neuroinflammation-Associated Depression
Microglia Sing the Prelude of Neuroinflammation-Associated Depression
Major depressive disorder (MDD) is a psychiatric condition characterized by sadness and anhedonia and is closely linked to...
Early-Life Stress Influences the Transcriptional Activation of Alpha-2A Adrenergic Receptor and Associated Protein Kinase A Signaling Molecules in the Frontal Cortex of Rats
Early-Life Stress Influences the Transcriptional Activation of Alpha-2A Adrenergic Receptor and Associated Protein Kinase A Signaling Molecules in the Frontal Cortex of Rats
Early life is a highly sensitive period associated with profound changes in brain structure and function. Adverse experien...
Exosomal AFAP1-AS1 Promotes the Growth, Metastasis, and Glycolysis of Pituitary Adenoma by Inhibiting HuR Degradation
Exosomal AFAP1-AS1 Promotes the Growth, Metastasis, and Glycolysis of Pituitary Adenoma by Inhibiting HuR Degradation
Exosomal long noncoding RNAs (lncRNAs), which are highly expressed in tumor-derived exosomes, regulate various cellular be...
Nrf2 Signaling Pathway: Focus on Oxidative Stress in Spinal Cord Injury
Nrf2 Signaling Pathway: Focus on Oxidative Stress in Spinal Cord Injury
Spinal cord injury (SCI) is a serious, disabling injury to the central nervous system that can lead to motor, sensory, and...
Palmatine Ameliorates Motor Deficits and Dopaminergic Neuron Loss by Regulating NLRP3 Inflammasome through Mitophagy in Parkinson's Disease Model Mice
Palmatine Ameliorates Motor Deficits and Dopaminergic Neuron Loss by Regulating NLRP3 Inflammasome through Mitophagy in Parkinson's Disease Model Mice
NLRP3 inflammasomes-mediated proinflammatory response and mitochondrial dysfunction play a critical role in the etiology a...
Alpha-Pinene Decreases the Elevated Levels of Astrogliosis, Pyroptosis, and Autophagy Markers in the Hippocampus Triggered by Kainate in a Rat Model of Temporal Lobe Epilepsy
Alpha-Pinene Decreases the Elevated Levels of Astrogliosis, Pyroptosis, and Autophagy Markers in the Hippocampus Triggered by Kainate in a Rat Model of Temporal Lobe Epilepsy
The development and progression of temporal lobe epilepsy (TLE) are heavily influenced by inflammation, excessive activati...
Insomnia in Parkinson’s Disease: Causes, Consequences, and Therapeutic Approaches
Insomnia in Parkinson’s Disease: Causes, Consequences, and Therapeutic Approaches
Sleep disorders represent prevalent non-motor symptoms in Parkinson’s disease (PD), affecting over 90% of the PD pop...
Recent Insights into the Neurobiology of Alzheimer’s Disease and Advanced Treatment Strategies
Recent Insights into the Neurobiology of Alzheimer’s Disease and Advanced Treatment Strategies
In recent years, significant advancements have been made in understanding Alzheimer’s disease from both neurobiologi...
MicroRNA-128-3p Affects Neuronal Apoptosis and Neurobehavior in Cerebral Palsy Rats by Targeting E3 Ubiquitin-Linking Enzyme Smurf2 and Regulating YY1 Expression
MicroRNA-128-3p Affects Neuronal Apoptosis and Neurobehavior in Cerebral Palsy Rats by Targeting E3 Ubiquitin-Linking Enzyme Smurf2 and Regulating YY1 Expression
This study was dedicated to investigating the effects of microRNA-128-3p (miR-128-3p) on neuronal apoptosis and neurobehav...
The Role of Thrombo-inflammation in Ischemic Stroke: Focus on the Manipulation and Clinical Application
The Role of Thrombo-inflammation in Ischemic Stroke: Focus on the Manipulation and Clinical Application
Stroke leaves a great economic burden due to its high morbidity and mortality. Rapid revascularization of targeted vessel(...
A Complex Interplay Between Melatonin and RORβ: RORβ is Unlikely a Putative Receptor for Melatonin as Revealed by Biophysical Assays
A Complex Interplay Between Melatonin and RORβ: RORβ is Unlikely a Putative Receptor for Melatonin as Revealed by Biophysical Assays
A nuclear retinoic acid receptor (RAR)-related orphan receptor β (RORβ) is strictly expressed in the brain, part...
Rosiglitazone Promotes Oligodendrocyte Development and Myelin Formation of Repeated Neonatal Sevoflurane Exposure via PPARγ Signaling
Rosiglitazone Promotes Oligodendrocyte Development and Myelin Formation of Repeated Neonatal Sevoflurane Exposure via PPARγ Signaling
Sevoflurane is one of the most commonly used general anesthetics for children and infants. Recent research indicates that ...
Role of Microglial Mitophagy in Alleviating Postoperative Cognitive Dysfunction: a Mechanistic Study
Role of Microglial Mitophagy in Alleviating Postoperative Cognitive Dysfunction: a Mechanistic Study
Postoperative cognitive dysfunction (POCD), a common complication following anesthesia and surgery, is influenced by hippo...
Ferroptosis in Cognitive Impairment Associated with Diabetes and Alzheimer’s Disease: Mechanistic Insights and New Therapeutic Opportunities
Ferroptosis in Cognitive Impairment Associated with Diabetes and Alzheimer’s Disease: Mechanistic Insights and New Therapeutic Opportunities
Cognitive impairment associated with diabetes and Alzheimer’s disease has become a major health issue affecting olde...
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