Vasan S, Padhy RK (2023) Tardive dyskinesia. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK448207
Caroff SN (2020) Recent advances in the pharmacology of tardive dyskinesia. Clin Psychopharmacol Neurosci 18(4):493
Article PubMed PubMed Central CAS Google Scholar
Waln O, Jankovic J (2013) An update on tardive dyskinesia: from phenomenology to treatment. Tremor Other Hyperkinet Mov (N Y) 3. https://doi.org/10.7916/D88P5Z71
Kapur S, Zipursky R, Jones C, Remington G, Houle S (2000) Relationship between dopamine D2 occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia. Am J Psychiatry 157(4):514–520
Article PubMed CAS Google Scholar
Silvestri S, Seeman MV, Negrete JC, Houle S, Shammi CM, Remington GJ, Kapur S, Zipursky RB, et al (2000) Increased dopamine D2 receptor binding after long-term treatment with antipsychotics in humans: a clinical PET study. Psychopharmacology 152(2):174–180. https://doi.org/10.1007/s002130000532
Article PubMed CAS Google Scholar
Kapur S, Remington G, Jones C, Wilson A, DaSilva J, Houle S, Zipursky R (1996) High levels of dopamine D2 receptor occupancy with low-dose haloperidol treatment: a PET study. Am J Psychiatry 153(7):948–950
Article PubMed CAS Google Scholar
Turrone P, Remington G, Kapur S, Nobrega JN (2003) The relationship between dopamine D2 receptor occupancy and the vacuous chewing movement syndrome in rats. Psychopharmacology 165(2):166–171. https://doi.org/10.1007/s00213-002-1259-z
Article PubMed CAS Google Scholar
Turrone P, Remington G, Kapur S, Nobrega JN (2003) Differential effects of within-day continuous vs. transient dopamine D2 receptor occupancy in the development of vacuous chewing movements (VCMs) in rats. Neuropsychopharmacol 28 (8):1433–1439. https://doi.org/10.1038/sj.npp.1300233
Turrone P, Remington G, Nobrega JN (2002) The vacuous chewing movement (VCM) model of tardive dyskinesia revisited: is there a relationship to dopamine D2 receptor occupancy? Neurosci Biobehav Rev 26(3):361–380
Article PubMed CAS Google Scholar
Aringhieri S, Carli M, Kolachalam S, Verdesca V, Cini E, Rossi M, McCormick PJ, Corsini GU et al (2018) Molecular targets of atypical antipsychotics: from mechanism of action to clinical differences. Pharmacol Ther 192:20–41
Article PubMed CAS Google Scholar
Seeman P (2002) Atypical antipsychotics: mechanism of action. Can J Psychiatry 47(1):27–38
Arana GW (2000) An overview of side effects caused by typical antipsychotics. J Clin Psychiatry 61(4):5–13
Tsai G, Goff DC, Chang RW, Flood J, Baer L, Coyle JT (1998) Markers of glutamatergic neurotransmission and oxidative stress associated with tardive dyskinesia. Am J Psychiatry 155(9):1207–1213. https://doi.org/10.1176/ajp.155.9.1207
Article PubMed CAS Google Scholar
Lohr JB, Kuczenski R, Niculescu AB (2003) Oxidative mechanisms and tardive dyskinesia. CNS Drugs 17(1):47–62. https://doi.org/10.2165/00023210-200317010-00004
Article PubMed CAS Google Scholar
Cho CH, Lee HJ (2013) Oxidative stress and tardive dyskinesia: pharmacogenetic evidence. Prog Neuropsychopharmacol Biol Psychiatry 46:207–213. https://doi.org/10.1016/j.pnpbp.2012.10.018
Article PubMed CAS Google Scholar
Galili-Mosberg R, Gil-Ad I, Weizman A, Melamed E, Offen D (2000) Haloperidol–induced neurotoxicity–possible implications for tardive dyskinesia. J Neural Transm 107(4):479–490
Bishnoi M, Chopra K, Kulkarni SK (2008) Activation of striatal inflammatory mediators and caspase-3 is central to haloperidol-induced orofacial dyskinesia. Eur J Pharmacol 590(1–3):241–245
Article PubMed CAS Google Scholar
Bishnoi M, Chopra K, Kulkarni SK (2008) Differential striatal levels of TNF-α, NFκB p65 subunit and dopamine with chronic typical and atypical neuroleptic treatment: role in orofacial dyskinesia. Prog Neuropsychopharmacol Biol Psychiatry 32(6):1473–1478
Article PubMed CAS Google Scholar
Jiang Q, Zhang X, Lu X, Li Y, Lu C, Chi J, Ma Y, Shi X et al (2023) Genetic susceptibility to tardive dyskinesia and cognitive impairments in Chinese Han schizophrenia: role of oxidative stress-related and adenosine receptor genes. Neuropsychiatr DisTreat 19:2499–2509
Tsermpini EE, Redenšek S, Dolžan V (2022) Genetic factors associated with tardive dyskinesia: from pre-clinical models to clinical studies. Front Pharmacol 12:834129
Article PubMed PubMed Central Google Scholar
Casey D (1990) Tardive dyskinesia. Western J Med 153(5):535
Loonen AJ (2023) Putative role of immune reactions in the mechanism of tardive dyskinesia. Brain, Behavior, Immunity-Health 33:100687
Article PubMed PubMed Central CAS Google Scholar
Wu Q, Yuan F, Zhang S, Liu W, Miao Q, Zheng X, Lu S, Hou K (2022) Correlation of blood biochemical markers with tardive dyskinesia in schizophrenic patients. Dis Markers 1:1767989
Osacka J, Kiss A, Pirnik Z (2022) Possible involvement of apoptosis in the antipsychotics side effects: a mini-review. Clin Exp Pharmacol Physiol 49(8):836–847
Article PubMed CAS Google Scholar
Li N, Li Y, Yu T, Gou M, Chen W, Wang X, Tong J, Chen S et al (2024) Immunosenescence-related T cell phenotypes and white matter in schizophrenia patients with tardive dyskinesia. Schizophr Res 269:36–47
Article PubMed CAS Google Scholar
Takeuchi H, Mori Y, Tsutsumi Y (2022) Pathophysiology, prognosis and treatment of tardive dyskinesia. Therapeutic Adv Psychopharmacol 12:20451253221117310
Ali Z, Roque A, El-Mallakh RS (2020) A unifying theory for the pathoetiologic mechanism of tardive dyskinesia. Med Hypotheses 140:109682
Article PubMed CAS Google Scholar
Yttri EA, Dudman JT (2016) Opponent and bidirectional control of movement velocity in the basal ganglia. Nature 533(7603):402–406
Article PubMed PubMed Central CAS Google Scholar
Barbera G, Liang B, Zhang L, Gerfen CR, Culurciello E, Chen R, Li Y, Lin D-T (2016) Spatially compact neural clusters in the dorsal striatum encode locomotion relevant information. Neuron 92(1):202–213
Article PubMed PubMed Central CAS Google Scholar
Margolese HC, Chouinard G, Kolivakis TT, Beauclair L, Miller R (2005) Tardive dyskinesia in the era of typical and atypical antipsychotics Part 1.: pathophysiology and mechanisms of induction. Can J Psychiatry 50(9):541–547. https://doi.org/10.1177/070674370505000907
Casey DE (2000) Tardive dyskinesia: pathophysiology and animal models. J Clin Psychiatry 61(Suppl 4):5–9
Sulzer D, Cragg SJ, Rice ME (2016) Striatal dopamine neurotransmission: regulation of release and uptake. Basal ganglia 6(3):123–148
Article PubMed PubMed Central Google Scholar
Tritsch NX, Sabatini BL (2012) Dopaminergic modulation of synaptic transmission in cortex and striatum. Neuron 76(1):33–50
Article PubMed PubMed Central CAS Google Scholar
Lovinger DM (2010) Neurotransmitter roles in synaptic modulation, plasticity and learning in the dorsal striatum. Neuropharmacology 58(7):951–961
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