Xu S, Shi Q, Li B et al (2020) High MTHFR promoter methylation levels in men confer protection against ischemic stroke. Bosnian J Basic Med Sci Udruzenje Basicnih Mediciniskih Znanosti 20:477–486

CAS  Google Scholar 

Fu Y, Wang X, Kong W (2018) Hyperhomocysteinaemia and vascular injury: advances in mechanisms and drug targets. Br J Pharmacol 175:1173–1189

Article  CAS  PubMed  Google Scholar 

Maksimova MY, Ivanov AV, Virus ED et al (2021) Impact of glutathione on acute ischemic stroke severity and outcome: possible role of aminothiols redox status. Redox Rep 26:117–123

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang J, Gu J, Huang Y, Fang Y, Lin J (2021) The association between serine hydroxymethyl transferase 1 gene hypermethylation and ischemic stroke. Bosnian J Basic Med Sci Udruzenje Basicnih Mediciniskih Znanosti 21:454–460

CAS  Google Scholar 

Kaplan P, Tatarkova Z, Sivonova MK, Racay P, Lehotsky J (2020) Homocysteine and mitochondria in cardiovascular and cerebrovascular systems. Int J Mol Sci 21:7698

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang Q, He GW (2019) Imbalance of homocysteine and H(2)S: significance, mechanisms, and therapeutic promise in vascular injury. Oxid Med Cell Longev 2019:7629673

Article  PubMed  PubMed Central  Google Scholar 

Ding Y, Fang F, Liu X et al (2024) H(2)S regulates the phenotypic transformation of astrocytes following cerebral ischemia/reperfusion via inhibiting the RhoA/ROCK pathway. Mol Neurobiol 61:3179–3197

Article  CAS  PubMed  Google Scholar 

Abe K, Kimura H (1996) The possible role of hydrogen sulfide as an endogenous neuromodulator. J Neurosci 16:1066–1071

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan J, Du J, Zhang Z et al (2022) The protective effects of hydrogen sulfide new donor methyl S-(4-fluorobenzyl)-N-(3,4,5-trimethoxybenzoyl)-l-cysteinate on the ischemic stroke. Molecules 27

Wen JY, Zhang J, Chen S et al (2021) Endothelium-derived hydrogen sulfide acts as a hyperpolarizing factor and exerts neuroprotective effects via activation of large-conductance Ca(2+) -activated K(+) channels. Br J Pharmacol 178:4155–4175

Article  CAS  PubMed  Google Scholar 

Wei X, Zhang B, Cheng L et al (2015) Hydrogen sulfide induces neuroprotection against experimental stroke in rats by down-regulation of AQP4 via activating PKC. Brain Res 1622:292–299

Article  CAS  PubMed  Google Scholar 

Lehotsky J, Tothova B, Kovalska M et al (2016) Role of homocysteine in the ischemic stroke and development of ischemic tolerance. Front Neurosci 10:538

Article  PubMed  PubMed Central  Google Scholar 

Majumder A, Singh M, George AK, Homme RP, Laha A, Tyagi SC (2019) Remote ischemic conditioning as a cytoprotective strategy in vasculopathies during hyperhomocysteinemia: an emerging research perspective. J Cell Biochem 120:77–92

Article  CAS  PubMed  Google Scholar 

Blom HJ (2000) Consequences of homocysteine export and oxidation in the vascular system. Semin Thromb Hemost 26:227–232

Article  CAS  PubMed  Google Scholar 

Jiao F, Zhao Y, Limbu SM et al (2023) Cyhexatin causes developmental toxic effects by disrupting endocrine system and inducing behavioral inhibition, apoptosis and DNA hypomethylation in zebrafish (Danio rerio) larvae. Chemosphere 339:139769

Article  CAS  PubMed  Google Scholar 

Wan C, Zong RY, Chen XS (2022) The new mechanism of cognitive decline induced by hypertension: high homocysteine-mediated aberrant DNA methylation. Front Cardiovasc Med 9:928701

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang D, Hong X, Wang J et al (2021) Estradiol-17beta inhibits homocysteine mediated damage by promoting H(2) S production via upregulating CBS and CSE expression in human umbilical vein endothelial cells. J Cell Biochem 122:915–925

Article  CAS  PubMed  Google Scholar 

Sonal YAE, Yang X, Shou W (2023) Collective production of hydrogen sulfide gas enables budding yeast lacking MET17 to overcome their metabolic defect. PLoS Biol 21:e3002439

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jakubowski H, Perla-Kajan J, Finnell RH et al (2009) Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice. FASEB J 23:1721–1727

Article  CAS  PubMed  PubMed Central  Google Scholar 

Giuffre A, Vicente JB (2018) Hydrogen sulfide biochemistry and interplay with other gaseous mediators in mammalian physiology. Oxid Med Cell Longev 2018:6290931

Article  PubMed  PubMed Central  Google Scholar 

Zhang F, Chen S, Wen JY, Chen ZW (2020) 3-Mercaptopyruvate sulfurtransferase/hydrogen sulfide protects cerebral endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury via mitoprotection and inhibition of the RhoA/ROCK pathway. Am J Physiol Cell Physiol 319:C720–C733

Article  CAS  PubMed  Google Scholar 

Handy DE, Loscalzo J (2003) Homocysteine and atherothrombosis: diagnosis and treatment. Curr Atheroscler Rep 5:276–283

Article  PubMed  Google Scholar 

Li JJ, Li Q, Du HP et al (2015) Homocysteine triggers inflammatory responses in macrophages through inhibiting CSE-H2S signaling via DNA Hypermethylation of CSE promoter. Int J Mol Sci 16:12560–12577

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li MH, Tang JP, Zhang P et al (2014) Disturbance of endogenous hydrogen sulfide generation and endoplasmic reticulum stress in hippocampus are involved in homocysteine-induced defect in learning and memory of rats. Behav Brain Res 262:35–41

Article  CAS  PubMed  Google Scholar 

Tang XQ, Shen XT, Huang YE et al (2011) Inhibition of endogenous hydrogen sulfide generation is associated with homocysteine-induced neurotoxicity: role of ERK1/2 activation. J Mol Neurosci 45:60–67

Article  CAS  PubMed  Google Scholar 

Chiku T, Padovani D, Zhu W, Singh S, Vitvitsky V, Banerjee R (2009) H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia. J Biol Chem 284:11601–11612

Article  CAS  PubMed  PubMed Central  Google Scholar 

Palleschi S, De Angelis S, Rossi B et al (2008) Homocysteinemia correlates with plasma thiol redox status in patients with end-stage renal disease. Nephron: Clin Pract 108:c106-112

CAS  PubMed  Google Scholar 

Chang L, Geng B, Yu F et al (2008) Hydrogen sulfide inhibits myocardial injury induced by homocysteine in rats. Amino Acids 34:573–585

Article  CAS  PubMed  Google Scholar 

Parsanathan R, Jain SK (2018) Hydrogen sulfide increases glutathione biosynthesis, and glucose uptake and utilisation in C(2)C(12) mouse myotubes. Free Radic Res 52:288–303

Article  CAS  PubMed  PubMed Central  Google Scholar 

Giustarini D, Tazzari V, Bassanini I, Rossi R, Sparatore A (2018) The new H(2)S-releasing compound ACS94 exerts protective effects through the modulation of thiol homoeostasis. J Enzyme Inhib Med Chem 33:1392–1404

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tyagi N, Moshal KS, Sen U et al (2009) H2S protects against methionine-induced oxidative stress in brain endothelial cells. Antioxid Redox Signal 11:25–33

Article  CAS  PubMed  PubMed Central