Salivary Circadian Gene Expression as a Molecular Indicator of Early Cognitive Impairment in Shift Workers: A Cross-Sectional Study of 300 Adults

Alfonsi V, Scarpelli S, D’Atri A, Stella G, De Gennaro L (2020) Later school start time: the impact of sleep on academic performance and health in the adolescent population. Int J Environ Res Public Health 17(7):2574. https://doi.org/10.3390/ijerph17072574

Article  PubMed  PubMed Central  Google Scholar 

Barger LK, Rajaratnam SMW, Wang W, O’Brien CS, Lockley SW, Czeisler CA (2014) Common sleep disorders increase risk of motor vehicle crashes and adverse health outcomes in firefighters. J Clin Sleep Med 11(3):233–240. https://doi.org/10.5664/jcsm.4470

Article  Google Scholar 

Buxton OM, Cain SW, O’Connor SP, Porter JH, Duffy JF, Wang W, Czeisler CA, Shea SA (2012) Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption. Sci Transl Med 4(129):129ra43. https://doi.org/10.1126/scitranslmed.3003200

Article  PubMed  PubMed Central  Google Scholar 

Choi SH, Park KW, Na DL, Han SH, Cheong HK, Kim DK, ... & Lee JH (2016) The validity of the MoCA and MMSE for the screening of dementia in a Korean population. Alzheimer Disease and Associated Disorders, 30(2), 124–130. https://doi.org/10.1097/WAD.0000000000000110

Coogan AN, Baird AL, Popa-Wagner A, Thome J (2016) Circadian rhythms and attention deficit hyperactivity disorder: the what, the when and the why. Prog Neuropsychopharmacol Biol Psychiatry 67:74–81. https://doi.org/10.1016/j.pnpbp.2016.01.006

Czeisler CA, & Buxton OM (2011) The human circadian timing system and sleep–wake regulation. In M. H. Kryger, T. Roth, & W. C. Dement (Eds.), Principles and Practice of Sleep Medicine (5th ed., pp. 402–419). Elsevier Saunders.

Gan Y, Yang C, Tong X, Sun H, Cong Y, Yin X, Li L, Cao S, Dong X, Gong Y, Shi O, Deng J, Bi H, Lu Z (2015) Shift work and diabetes mellitus: a meta-analysis of observational studies. Occup Environ Med 72(1):72–78. https://doi.org/10.1136/oemed-2014-102150

Article  PubMed  Google Scholar 

Gooley JJ, Chamberlain K, Smith KA, Khalsa SB, Rajaratnam SM, Van Reen E, Zeitzer JM, Czeisler CA, Lockley SW (2011) Exposure to room light before bedtime suppresses melatonin onset and shortens melatonin duration in humans. J Clin Endocrinol Metab 96(3):E463–472. https://doi.org/10.1210/jc.2010-2098

International Labour Organization. (2019). Working time and work organization: shift work and health. Geneva: ILO. Retrieved from https://www.ilo.org/global/topics/non-standard-employment/WCMS_534826/lang--en/index.htm

James SM, Honn KA, Gaddameedhi S, Van Dongen HPA (2017) Shift work: disrupted circadian rhythms and sleep—implications for health and well-being. Curr Sleep Med Rep 3(2):104–112. https://doi.org/10.1007/s40675-017-0071-6

Article  PubMed  PubMed Central  Google Scholar 

Kecklund G, Axelsson J (2016) Health consequences of shift work and insufficient sleep. BMJ 355:i5210. https://doi.org/10.1136/bmj.i5210

Article  PubMed  Google Scholar 

Kirsten H, Al-Hasani H, Ibrahim M, Becker M, Tröger C, Thiery J, Kratzsch J (2021) Salivary gene expression profiles reflect circadian rhythmicity and alterations associated with shift work. Sci Rep 11:22486. https://doi.org/10.1038/s41598-021-01557-6

Article  Google Scholar 

Kondratova AA, Kondratov RV (2012) The circadian clock and pathology of the ageing brain. Nat Rev Neurosci 13(5):325–335. https://doi.org/10.1038/nrn3208

Article  PubMed  PubMed Central  CAS  Google Scholar 

Leng Y, Musiek ES, Hu K, Cappuccio FP, Yaffe K (2019) Association between circadian rhythms and neurodegenerative diseases. Lancet Neurol 18(3):307–318. https://doi.org/10.1016/S1474-4422(18)30461-7

Leone V, Gibbons SM, Martinez K, Hutchison AL, Huang EY, Cham CM, Gibbons S, Hutchison A, Huang E, Cham C, Pierre J, Heneghan A, Nadimpalli A, Hubert N, Zale E, Wang Y, Huang Y, Theriault B, Dinner A, Musch M, Kudsk K, Prendergast B, Gilbert J, Chang E, Chang EB (2015) Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism. Cell Host Microbe 17(5):681–689. https://doi.org/10.1016/j.chom.2015.03.006

Article  PubMed  PubMed Central  CAS  Google Scholar 

Logan RW, McClung CA (2019) Rhythms of life: circadian disruption and brain disorders across the lifespan. Nat Rev Neurosci 20(1):49–65. https://doi.org/10.1038/s41583-018-0088-y

Article  PubMed  PubMed Central  CAS  Google Scholar 

Logan RW, Hasler BP, Forbes EE, Franzen PL, Torregrossa MM, Huang YH, Buysse DJ (2022) Impact of sleep and circadian rhythms on addiction vulnerability in adolescents. Biol Psychiat 91(1):29–40. https://doi.org/10.1016/j.biopsych.2021.06.008

Article  CAS  Google Scholar 

Marquié JC, Tucker P, Folkard S, Gentil C, Ansiau D (2015) Chronic effects of shift work on cognition: findings from the VISAT longitudinal study. Occup Environ Med 72(4):258–264. https://doi.org/10.1136/oemed-2013-101993

Article  PubMed  Google Scholar 

McEwen BS, Karatsoreos IN (2015) Sleep deprivation and circadian disruption: stress, allostasis, and allostatic load. Sleep Med Clin 10(1):1–10. https://doi.org/10.1016/j.jsmc.2014.11.007

Article  PubMed  PubMed Central  Google Scholar 

Musiek ES, Xiong DD, Holtzman DM (2013) Sleep, circadian rhythms, and the pathogenesis of Alzheimer disease. Exp Mol Med 47(3):e148. https://doi.org/10.1038/emm.2013.121

Article  CAS  Google Scholar 

Nasreddine ZS, Phillips NA, Bédirian V, Charbonneau S, Whitehead V, Collin I, Cummings JL, Chertkow H (2005) The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 53(4):695–699. https://doi.org/10.1111/j.1532-5415.2005.53221.x

Article  PubMed  Google Scholar 

Ostheim P, Tichý A, Sirak I, Davidkova M, Stastna MM, Kultova G, Paunesku T, Woloschak G, Majewski M, Port M, Abend M (2020) Overcoming challenges in human saliva gene expression measurements. Sci Rep 10(1):11147. https://doi.org/10.1038/s41598-020-67825-6

Article  PubMed  PubMed Central  CAS  Google Scholar 

Partch CL, Green CB, Takahashi JS (2014) Molecular architecture of the mammalian circadian clock. Trends Cell Biol 24(2):90–99. https://doi.org/10.1016/j.tcb.2013.07.002

Article  PubMed  CAS  Google Scholar 

Patke A, Young MW, Axelrod S (2020) Molecular mechanisms and physiological importance of circadian rhythms. Nat Rev Mol Cell Biol 21(2):67–84. https://doi.org/10.1038/s41580-019-0179-2

Article  PubMed  CAS  Google Scholar 

Pfaffe T, Cooper-White J, Beyerlein P, Kostner K, Punyadeera C (2011) Diagnostic potential of saliva: current state and future applications. Clin Chem 57(5):675–687. https://doi.org/10.1373/clinchem.2010.153767

Article  PubMed  CAS  Google Scholar 

Quintana M, Palicki O, Lucchi G, Ducoroy P, Chambon C, Salles C, Morzel M (2009) Inter-individual variability of protein patterns in saliva of healthy adults. J Proteomics 72(5):822–830. https://doi.org/10.1016/j.jprot.2009.05.004

Article  PubMed  CAS  Google Scholar 

Rajaratnam SMW, Howard ME, Grunstein RR (2013) Sleep loss and circadian disruption in shift work: health burden and management. Med J Aust 199(8 Suppl):S11–S15. https://doi.org/10.5694/mja13.10561

Article  PubMed  Google Scholar 

Ramanathan C, Xu H, Khan SK, Shen Y, Gitis PJ, Welsh DK, Liu AC (2014) Cell type–specific functions of period genes revealed by novel adipocyte and hepatocyte circadian clock models. PLoS Genet 10(4):e1004244. https://doi.org/10.1371/journal.pgen.1004244

Article  PubMed  PubMed Central  CAS  Google Scholar 

Vetter C, Fischer D, Matera JL, Roenneberg T (2015) Aligning work and circadian time in shift workers improves sleep and reduces circadian disruption. Curr Biol 25(7):907–911. https://doi.org/10.1016/j.cub.2015.01.064

Wang X, Yu S, Hou Y, Li Q, Yang L, Wang Y (2021) Circadian rhythm disorders in neurodegenerative diseases: mechanisms and potential therapeutic targets. Front Pharmacol 12:682545. https://doi.org/10.3389/fphar.2021.682545

Article  Google Scholar 

Wright KP, McHill AW, Birks BR, Griffin BR, Rusterholz T, Chinoy ED (2013) Entrainment of the human circadian clock to the natural light–dark cycle. Curr Biol 23(16):1554–1558. https://doi.org/10.1016/j.cub.2013.06.039

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wu G, Ruben MD, Francey LJ, Smith DF, Sherrill JD, Oblong JE, ... & Hogenesch JB (2020) A population-based gene expression signature of molecular circadian rhythmicity in normal human skin. Nature Communications, 11, 4891. https://doi.org/10.1038/s41467-020-18715-1

Zhao W, Wang Y, Yuan J, Wu Y, Gao Y (2021) Altered brain functional connectivity in shift workers: a resting-state fMRI study. Front Neurol 12:667905. https://doi.org/10.3389/fneur.2021.667905

Article  Google Scholar 

Comments (0)

No login
gif