Albasher G, Maashi N, Alfarraj S et al (2020) Perinatal exposure to tartrazine triggers oxidative stress and neurobehavioral alterations in mice offspring. Antioxidants 9:53. https://doi.org/10.3390/antiox9010053

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arnold LE, Lofthouse N, Hurt E (2012) Artificial food colors and attention-deficit/hyperactivity symptoms: conclusions to dye for. Neurotherapeutics 9:599–609. https://doi.org/10.1007/s13311-012-0133-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Asif Ahmed M, Al-Khalifa AS, Al-Nouri DM, El-din MFS (2021) Dietary intake of artificial food color additives containing food products by school-going children. Saudi J Biol Sci 28:27–34. https://doi.org/10.1016/j.sjbs.2020.08.025

Article  CAS  PubMed  Google Scholar 

Bakthavachalu P, Kannan SM, Qoronfleh MW (2020) Food color and autism: a meta-analysis. Adv Neurobiol 24:481–504. https://doi.org/10.1007/978-3-030-30402-7_15

Article  PubMed  Google Scholar 

Bangasser DA, Cuarenta A (2021) Sex differences in anxiety and depression: circuits and mechanisms. Nat Rev Neurosci 22:674–684. https://doi.org/10.1038/s41583-021-00513-0

Article  CAS  PubMed  Google Scholar 

Barciela P, Perez-Vazquez A, Prieto MA (2023) Azo dyes in the food industry: features, classification, toxicity, alternatives, and regulation. Food Chem Toxicol 178:113935. https://doi.org/10.1016/j.fct.2023.113935

Article  CAS  PubMed  Google Scholar 

Brazilian Health Regulatory Agency. Power BI Report. https://app.powerbi.com/view?r=eyJrIjoiZmQ2ZDBjNTItMDFmMi00MmM5LWE4Y2QtMzBhOGZlYTU4OGUzIiwidCI6ImI2N2FmMjNmLWMzZjMtNGQzNS04MGM3LWI3MDg1ZjVlZGQ4MSJ9&pageName=ReportSection08a3239a66872bb5b7a9. Accessed 24 Jun 2025

Dey S, Nagababu BH (2022) Applications of food color and bio-preservatives in the food and its effect on the human health. Food Chem Adv 1:100019. https://doi.org/10.1016/j.focha.2022.100019

Article  Google Scholar 

Donner NC, Lowry CA (2013) Sex differences in anxiety and emotional behavior. Pflüg Arch - Eur J Physiol 465:601–626. https://doi.org/10.1007/s00424-013-1271-7

Article  CAS  Google Scholar 

EFSA Panel on Food Additives and Nutrient Sources Added to Food (2009) Scientific opinion on the re-evaluation tartrazine (E 102). EFSA J 7:1331. https://doi.org/10.2903/j.efsa.2009.1331

Article  Google Scholar 

Gao Y, Li C, Shen J et al (2011) Effect of food azo dye tartrazine on learning and memory functions in mice and rats, and the possible mechanisms involved. J Food Sci 76:T125–T129. https://doi.org/10.1111/j.1750-3841.2011.02267.x

Article  CAS  PubMed  Google Scholar 

Haridevamuthu B, Murugan R, Seenivasan B et al (2024) Synthetic azo-dye, tartrazine induces neurodevelopmental toxicity via mitochondria-mediated apoptosis in zebrafish embryos. J Hazard Mater 461:132524. https://doi.org/10.1016/j.jhazmat.2023.132524

Article  CAS  PubMed  Google Scholar 

Huang L, Xiao D, Sun H et al (2022) Behavioral tests for evaluating the characteristics of brain diseases in rodent models: optimal choices for improved outcomes (review). Mol Med Rep 25:1–1. https://doi.org/10.3892/mmr.2022.12699

Article  CAS  Google Scholar 

Komada M, Takao K, Miyakawa T (2008) Elevated plus maze for mice. J Vis Exp JoVE 1088. https://doi.org/10.3791/1088

König J (2015) 2 - Food colour additives of synthetic origin. In: Scotter MJ (ed) Colour Additives for Foods and Beverages. Woodhead Publishing, Oxford, pp 35–60

Chapter  Google Scholar 

Kraeuter A-K, Guest PC, Sarnyai Z (2019) The elevated plus maze test for measuring anxiety-like behavior in rodents. In: Guest PC (ed) Pre-clinical models: techniques and protocols. Springer, New York, NY, pp 69–74

Lakens D (2013) Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Front Psychol 4:863. https://doi.org/10.3389/fpsyg.2013.00863

Article  PubMed  PubMed Central  Google Scholar 

Lipskikh OI, Korotkova EI, Khristunova YeP et al (2018) Sensors for voltammetric determination of food azo dyes - a critical review. Electrochim Acta 260:974–985. https://doi.org/10.1016/j.electacta.2017.12.027

Article  CAS  Google Scholar 

Lueptow LM (2017) Novel object recognition test for the investigation of learning and memory in mice. J Vis Exp JoVE 55718. https://doi.org/10.3791/55718

Miller MD, Steinmaus C, Golub MS et al (2022) Potential impacts of synthetic food dyes on activity and attention in children: a review of the human and animal evidence. Environ Health 21:45. https://doi.org/10.1186/s12940-022-00849-9

Article  PubMed  PubMed Central  Google Scholar 

Monisha B, Sridharan R, Kumar PS et al (2023) Sensing of azo toxic dyes using nanomaterials and its health effects - a review. Chemosphere 313:137614. https://doi.org/10.1016/j.chemosphere.2022.137614

Article  CAS  PubMed  Google Scholar 

Rafati A, Nourzei N, Karbalay-Doust S, Noorafshan A (2017) Using vitamin E to prevent the impairment in behavioral test, cell loss and dendrite changes in medial prefrontal cortex induced by tartrazine in rats. Acta Histochem 119:172–180. https://doi.org/10.1016/j.acthis.2017.01.004

Article  CAS  PubMed  Google Scholar 

Ramos-Souza C, Bandoni DH, Bragotto APA, De Rosso VV (2023) Risk assessment of azo dyes as food additives: revision and discussion of data gaps toward their improvement. Compr Rev Food Sci Food Saf 22:380–407. https://doi.org/10.1111/1541-4337.13072

Article  PubMed  Google Scholar 

Rovina K, Siddiquee S, Shaarani SM (2017) A review of extraction and analytical methods for the determination of tartrazine (E 102) in foodstuffs. Crit Rev Anal Chem 47:309–324. https://doi.org/10.1080/10408347.2017.1287558

Article  CAS  PubMed  Google Scholar 

Seibenhener ML, Wooten MC (2015) Use of the open field maze to measure locomotor and anxiety-like behavior in mice. J Vis Exp JoVE 52434. https://doi.org/10.3791/52434

Şensoy E (2024a) Determination of the effects of sunset yellow on mouse liver and pancreas using histological methods. Toxicol Res. https://doi.org/10.1093/toxres/tfae070

Article  Google Scholar 

Şensoy E (2024b) Comparison of the effect of sunset yellow on the stomach and small intestine of developmental period of mice. Heliyon 10:e31998. https://doi.org/10.1016/j.heliyon.2024.e31998

Article  PubMed  PubMed Central  Google Scholar 

Şensoy E (2025) The potential histopathological effect of sunset yellow FCF on lungs and hearts of developing mice. Br Food J 127:1495–1508. https://doi.org/10.1108/BFJ-06-2024-0580

Article  Google Scholar 

Şensoy E, Güneş E (2024) Determination of the effect of sunset yellow on the morphological parameters of male mice during the development period. Food Chem Toxicol 188:114653. https://doi.org/10.1016/j.fct.2024.114653

Article  CAS  PubMed  Google Scholar 

Sharma M, Sharma S, Alkhanjaf AAM et al (2025) Microbial fuel cells for azo dye degradation: a perspective review. J Ind Eng Chem 142:45–67. https://doi.org/10.1016/j.jiec.2024.07.031

Article  CAS  Google Scholar 

Wopara I, Modo EU, Adebayo OG et al (2021) Anxiogenic and memory impairment effect of food color exposure: upregulation of oxido-neuroinflammatory markers and acetyl-cholinestrase activity in the prefrontal cortex and hippocampus. Heliyon 7:e06378. https://doi.org/10.1016/j.heliyon.2021.e06378

Article  PubMed  PubMed Central  Google Scholar 

World Health Organization. Evaluation of certain food additives: eighty-second report of the Joint FAO/WHO Expert Committee on Food Additives. https://www.who.int/publications/i/item/9789241210003. Accessed 24 Jun 2025