RGS2-Related Non-coding Interaction Network Modulates the NF-Kappa B Signaling Pathway in MS Patients: A Systems Biology Investigation

Akshaya RL, Rohini M, He Z, Partridge NC, Selvamurugan N (2022) MiR-4638-3p regulates transforming growth factor-β1-induced activating transcription factor-3 and cell proliferation, invasion, and apoptosis in human breast cancer cells. Int J Biol Macromol 222(Pt B):1974–1982. https://doi.org/10.1016/J.IJBIOMAC.2022.09.286

Article  CAS  PubMed  Google Scholar 

Akshaya RL, Saranya I, Salomi GM, Shanthi P, Ilangovan R, Venkataraman P, Selvamurugan N (2024) In vivo validation of the functional role of MicroRNA-4638-3p in breast cancer bone metastasis. J Cancer Res Clin Oncol. https://doi.org/10.1007/S00432-023-05601-5

Article  PubMed  PubMed Central  Google Scholar 

Aloisi F, Cross AH (2022) Mini-review of Epstein-Barr virus involvement in multiple sclerosis etiology and pathogenesis. J Neuroimmunol. https://doi.org/10.1016/J.JNEUROIM.2022.577935

Article  PubMed  Google Scholar 

Aloisi F, Giovannoni G, Salvetti M (2023) Epstein-Barr virus as a cause of multiple sclerosis: opportunities for prevention and therapy. Lancet Neurol 22(4):338–349. https://doi.org/10.1016/S1474-4422(22)00471-9

Article  PubMed  Google Scholar 

Anger T, Klintworth N, Stumpf C, Daniel WG, Mende U, Garlichs CD (2007) RGS protein specificity towards Gq- and Gi/o-mediated ERK 1/2 and Akt activation, in vitro. J Biochem Mol Biol 40(6):899–910. https://doi.org/10.5483/BMBREP.2007.40.6.899

Article  CAS  PubMed  Google Scholar 

Baecher-Allan C, Kaskow BJ, Weiner HL (2018) Multiple sclerosis: mechanisms and immunotherapy. Neuron 97(4):742–768. https://doi.org/10.1016/J.NEURON.2018.01.021

Article  CAS  PubMed  Google Scholar 

Bao Y, Chen Y, Lin L, Li J, Liu X, Wang G, Li Y, Lin Y, Chen Y, Zhou L, Qi Y, Xie Y, Lin Z, Sun Z, Fan Y, Jiang J, Zhang F, Chen H, Chu J, Huang J, Chen X, Liang H, Liang S, An S (2024) Gutudb: a comprehensive multiomics database for intestinal diseases. iMeta 3(3):e195. https://doi.org/10.1002/imt2.195

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barani A, Fanavari Z, Beikverdi K, Mashhadi B, Parsapour N, Rezaei M, Javid P, Azadeh M (2022) Transcription analysis of the THBS2 gene through regulation by potential non-coding diagnostic biomarkers and oncogenes of gastric cancer in the ECM receptor interaction signaling pathway: integrated systems biology and experimental investigation. https://doi.org/10.21203/RS.3.RS-2285590/V2

Chen EY, Tan CM, Kou Y, Duan Q, Wang Z, Meirelles GV, Clark NR, Ma’ayan A (2013) Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool. BMC Bioinformatics 14. https://doi.org/10.1186/1471-2105-14-128

Chiricosta L, Blando S, D’Angiolini S, Gugliandolo A, Mazzon E (2023) A comprehensive exploration of the transcriptomic landscape in multiple sclerosis: a systematic review. Int J Mol Sci. https://doi.org/10.3390/IJMS24021448

Article  PubMed  PubMed Central  Google Scholar 

Cotsapas C, Mitrovic M, Hafler D (2018) Multiple sclerosis. Handb Clin Neurol 148:723–730. https://doi.org/10.1016/B978-0-444-64076-5.00046-6

Article  PubMed  Google Scholar 

Dastmalchi R, Ghafouri-Fard S, Omrani MD, Mazdeh M, Sayad A, Taheri M (2018) Dysregulation of long non-coding RNA profile in peripheral blood of multiple sclerosis patients. Mult Scler Relat Disord 25:219–226. https://doi.org/10.1016/J.MSARD.2018.07.044

Article  PubMed  Google Scholar 

Dobson R, Giovannoni G (2019) Multiple sclerosis - a review. Eur J Neurol 26(1):27–40. https://doi.org/10.1111/ENE.13819

Article  CAS  PubMed  Google Scholar 

Donyavi MH, Salehi-Mazandarani S, Nikpour P (2022) Comprehensive competitive endogenous RNA network analysis reveals EZH2-related axes and prognostic biomarkers in hepatocellular carcinoma. Iran J Basic Med Sci 25(3):286–294. https://doi.org/10.22038/IJBMS.2022.61570.13623

Article  PubMed  PubMed Central  Google Scholar 

Dusonchet J, Li H, Guillily M, Liu M, Stafa K, Derada Troletti C, Boon JY, Saha S, Glauser L, Mamais A, Citro A, Youmans KL, Liu LQ, Schneider BL, Aebischer P, Yue Z, Bandopadhyay R, Glicksman MA, Moore DJ, Liu LiQun, Collins JJ, Wolozin B (2014) A Parkinson’s disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity. Hum Mol Genet 23(18):4887–4905. https://doi.org/10.1093/HMG/DDU202

Article  CAS  PubMed  PubMed Central  Google Scholar 

Egawa T, Albrecht B, Favier B, Sunshine MJ, Mirchandani K, O’Brien W, Thome M, Littman DR (2003) Requirement for CARMA1 in antigen receptor-induced NF-κB activation and lymphocyte proliferation. Curr Biol 13(14):1252–1258. https://doi.org/10.1016/S0960-9822(03)00491-3

Article  CAS  PubMed  Google Scholar 

Ezzati E, Mosadeshi S, Akbarinia A, Horriat S, Rezaei M, Azadeh M (2022) LINC00520 promotes breast cancer development by low expression as a tumor suppressor and prognostic biomarker by regulating the ESR2 expression level: integrated systems biology bioinformatics and experimental analyses. https://doi.org/10.21203/RS.3.RS-1944462/V1

Francelle L, Galvan L, Brouillet E (2014a) Possible involvement of self-defense mechanisms in the preferential vulnerability of the striatum in Huntington’s disease. Front Cellular Neuroscience 8(SEP):1–13. https://doi.org/10.3389/FNCEL.2014.00295

Article  Google Scholar 

Fukunaga T, Iwakiri J, Ono Y, Hamada M (2019) Lncrrisearch: a web server for lncrna-rna interaction prediction integrated with tissue-specific expression and subcellular localization data. Front Genet 10(MAY):462. https://doi.org/10.3389/FGENE.2019.00462

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gautier L, Cope L, Bolstad BM, Irizarry RA (2004) Affy—analysis of Affymetrix GeneChip data at the probe level. Bioinformatics 20(3):307–315. https://doi.org/10.1093/BIOINFORMATICS/BTG405

Article  CAS  PubMed  Google Scholar 

Genc B, Bozan HR, Genc S, Genc K (2019) Stem cell therapy for multiple sclerosis. Adv Exp Med Biol 1084:145–174. https://doi.org/10.1007/5584_2018_247

Article  CAS  PubMed  Google Scholar 

Gharibi T, Babaloo Z, Hosseini A, Marofi F, Ebrahimi-kalan A, Jahandideh S, Baradaran B (2020) The role of B cells in the immunopathogenesis of multiple sclerosis. Immunology 160(4):325. https://doi.org/10.1111/IMM.13198

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghasemi N, Razavi S, Nikzad E (2017) Multiple sclerosis: pathogenesis, symptoms, diagnoses and cell-based therapy. Cell J 19(1):1–10. https://doi.org/10.22074/CELLJ.2016.4867

Article  PubMed  Google Scholar 

Ghoveud E, Teimuri S, Vatandoost J, Hosseini A, Ghaedi K, Etemadifar M, Nasr Esfahani MH, Megraw TL (2020) Potential biomarker and therapeutic LncRNAs in multiple sclerosis through targeting memory B cells. Neuromol Med 22(1):111–120. https://doi.org/10.1007/S12017-019-08570-6

Article  CAS  Google Scholar 

Dweep H, Sticht C, Pandey P, Gretz N (2011) miRWalk--database: prediction of possible miRNA binding sites by “walking” the genes of three genomes. J Biomed Inform44(5):839–847. https://doi.org/10.1016/J.JBI.2011.05.002

Hara H, Wada T, Bakal C, Kozieradzki I, Suzuki S, Suzuki N, Nghiem M, Griffiths EK, Krawczyk C, Bauer B, D’Acquisto F, Ghosh S, Yeh WC, Baier G, Rottapel R, Penninger JM (2003) The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity 18(6):763–775. https://doi.org/10.1016/S1074-7613(03)00148-1

Article  CAS  PubMed  Google Scholar 

Hosseini A, Teimuri S, Ehsani M, Rasa SMM, Etemadifar M, Nasr Esfahani MH, Megraw TL, Ghaedi K (2019) LncRNAs associated with multiple sclerosis expressed in the Th1 cell lineage. J Cell Physiol 234(12):22153–22162. https://doi.org/10.1002/JCP.28779

Article  CAS  PubMed  Google Scholar 

Jensen LJ, Kuhn M, Stark M, Chaffron S, Creevey C, Muller J, Doerks T, Julien P, Roth A, Simonovic M, Bork P, von Mering C (2009) STRING 8–a global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Res. https://doi.org/10.1093/NAR/GKN760

Article  PubMed  PubMed Central  Google Scholar 

Jernås M, Malmeström C, Axelsson M, Nookaew I, Wadenvik H, Lycke J, Olsson B (2013) Microrna regulate immune pathways in T-cells in multiple sclerosis (MS). BMC Immunol. https://doi.org/10.1186/1471-2172-14-32

Article  PubMed  PubMed Central  Google Scholar 

Kaltschmidt B, Kaltschmidt C (2009) NF-κb in the nervous system. Cold Spring Harb Perspect Biol 1(3):a001271. https://doi.org/10.1101/CSHPERSPECT.A001271

Article  PubMed  PubMed Central  Google Scholar 

Kanehisa M, Goto S (2000) KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28(1):27–30. https://doi.org/10.1093/NAR/28.1.27

Comments (0)

No login
gif