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The Drosophila ribonucleoprotein Clueless is required for ribosome biogenesis in vivo
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Absence of the dolichol synthesis gene DHRSX leads to N-glycosylation defects in Lec5 and Lec9 Chinese hamster ovary cells
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Versican binds collagen via its G3 domain and regulates the organization and mechanics of collagenous matrices
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Downregulation of PIK3IP1/TrIP on T cells is controlled by TCR signal strength, PKC, and metalloprotease-mediated cleavage
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2-Hydroxylation is a chemical switch linking fatty acids to glucose-stimulated insulin secretion
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A peptide derived from the amino terminus of leptin improves glucose metabolism and energy homeostasis in myotubes and db/db mice
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‘GGFGGQ’ repeats in Hfq of Acinetobacter baumannii are essential for nutrient utilization and virulence
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Identification of a staphylococcal dipeptidase involved in the production of human body odor
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The activity of the ribonucleotide monophosphatase UmpH is controlled by interaction with the GlnK signaling protein in Escherichia coli
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Suppressed ORAI1-STIM1-dependent Ca2+ entry by protein kinase C isoforms regulating platelet procoagulant activity
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Molecular determinants of neuropeptide-mediated activation mechanisms in tachykinin NK1 and NK2 receptors
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The crystal structure of Grindelia robusta 7,13-copalyl diphosphate synthase reveals active site features controlling catalytic specificity
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Molecular insights into the structure and function of the Staphylococcus aureus fatty acid kinase
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Crystal structures of cables formed by the acetylated and unacetylated forms of the Schizosaccharomyces pombe tropomyosin ortholog TpmCdc8
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Characterization of atypical BAR domain-containing proteins coded by Toxoplasma gondii
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Complex sporulation-specific expression of transcription termination factor Rho highlights its involvement in Bacillus subtilis cell differentiation
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Distinct chemical structures inhibit the CEMIP hyaluronidase and promote oligodendrocyte progenitor cell maturation
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TFEB agonist clomiphene citrate activates the autophagy-lysosomal pathway and ameliorates Alzheimer's disease symptoms in mice
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Phosphorylation regulates the chromatin remodeler SMARCAD1 in nucleosome binding, ATP hydrolysis, and histone exchange
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PARP14 is a writer, reader, and eraser of mono-ADP-ribosylation
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Stabilization of interdomain interactions in G protein α subunits as a determinant of Gαi subtype signaling specificity
Stabilization of interdomain interactions in G protein α subunits as a determinant of Gαi subtype signaling specificity
Keywordsheterotrimeric G proteinG protein–coupled receptordomain interactionseffector couplingproximity labelingmass spect...
Engineering a human P2X2 receptor with altered ligand selectivity in yeast
Engineering a human P2X2 receptor with altered ligand selectivity in yeast
Journal of Biological ChemistryAuthor links open overlay panel, , , , , , , , , P2X receptors are a family of ligand gated...
Structure-function analysis of plant G-protein regulatory mechanisms identifies key Gα-RGS protein interactions
Structure-function analysis of plant G-protein regulatory mechanisms identifies key Gα-RGS protein interactions
KeywordsGα proteinRGSplantriceactivation/deactivationstructureSelaginella moellendorffiAbbreviationsAtGPA1Arabidopsis thal...
Dynamics-driven allosteric stimulation of diguanylate cyclase activity in a red light-regulated phytochrome
Dynamics-driven allosteric stimulation of diguanylate cyclase activity in a red light-regulated phytochrome
Journal of Biological ChemistryAuthor links open overlay panel, , Sensor-effector proteins integrate information from diff...
Structures of LIG1 provide a mechanistic basis for understanding a lack of sugar discrimination against a ribonucleotide at the 3'-end of nick DNA
Structures of LIG1 provide a mechanistic basis for understanding a lack of sugar discrimination against a ribonucleotide at the 3'-end of nick DNA
Journal of Biological ChemistryAuthor links open overlay panel, , , Human DNA ligase 1 (LIG1) is the main replicative liga...
Structural insight into the ZFAND1–p97 interaction involved in stress granule clearance
Structural insight into the ZFAND1–p97 interaction involved in stress granule clearance
KeywordsZFAND1p97stress granuleubiquitin-proteasome systemzinc fingerubiquitin-like domainNMR spectroscopycryo-EMX-ray cry...
The structures of salt-inducible kinase 3 in complex with inhibitors reveal determinants for binding and selectivity
The structures of salt-inducible kinase 3 in complex with inhibitors reveal determinants for binding and selectivity
Keywordssalt-inducible kinaseisoform selectivitycrystallization chaperonesAMPK related kinasedrug designcrystal structurep...
Emergence of two distinct spatial folds in a pair of plant virus proteins encoded by nested genes
Emergence of two distinct spatial folds in a pair of plant virus proteins encoded by nested genes
Keywordsgenome evolutionmovement proteinsoverlapping reading framesvirus genomesconvergent evolution of protein structuret...
Mimicking kidney flow shear efficiently induces aggregation of LECT2, a protein involved in renal amyloidosis
Mimicking kidney flow shear efficiently induces aggregation of LECT2, a protein involved in renal amyloidosis
Journal of Biological ChemistryAuthor links open overlay panel, , , , , , Aggregation of leukocyte cell-derived chemotaxin...
Bacterial stigmasterol degradation involving radical flavin delta-24 desaturase and molybdenum-dependent C26 hydroxylase
Bacterial stigmasterol degradation involving radical flavin delta-24 desaturase and molybdenum-dependent C26 hydroxylase
Journal of Biological ChemistryAuthor links open overlay panel, , , , , , , , , Sterols are ubiquitous membrane constituen...
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