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Evaluation of Phenylalanine Substitution on the Antimicrobial Properties of Histatin 8 against Wild-Type and Antibiotic-Resistant
Evaluation of Phenylalanine Substitution on the Antimicrobial Properties of Histatin 8 against Wild-Type and Antibiotic-Resistant
The unregulated and inappropriate use of antibiotics triggered the rapid spread of antimicrobial resistance in pathogenic ...
Changes in the Expression Landscape of HER2-Negative Breast Cancer under the Influence of Anthracycline-Containing Neoadjuvant Chemotherapy Regimens
Changes in the Expression Landscape of HER2-Negative Breast Cancer under the Influence of Anthracycline-Containing Neoadjuvant Chemotherapy Regimens
Currently, several treatment options are available for patients with HER2 breast cancer; however, there is no gold standar...
Study on the Mechanisms of Antifibrotic Action of Soluble Proteins of Human Mesenchymal Stromal Cell Secretome
Study on the Mechanisms of Antifibrotic Action of Soluble Proteins of Human Mesenchymal Stromal Cell Secretome
Multipotent mesenchymal stromal cells (MSCs) are key regulators of tissue healing after injury. Acting in a paracrine mann...
The Influence of Elevated Concentrations of Secretory IgA on the Level of Immunocompetent Cells, Cytokines, Reagins, Circulating Immune Complexes, and C-Reactive Protein in the Blood of Practically Healthy Residents of Murmansk Oblast
The Influence of Elevated Concentrations of Secretory IgA on the Level of Immunocompetent Cells, Cytokines, Reagins, Circulating Immune Complexes, and C-Reactive Protein in the Blood of Practically Healthy Residents of Murmansk Oblast
A total of 104 (77 women and 27 men) practically healthy residents of the city of Apatity, Murmansk oblast, aged 21–...
Peculiarities of General and Mucosal Immunity in Urban Residents of Murmansk Oblast
Peculiarities of General and Mucosal Immunity in Urban Residents of Murmansk Oblast
The state of general and mucosal immunity was studied in 103 permanently living and working residents of Apatity town, Mur...
Improving the Functional and Antibacterial Properties of an Endoprosthetic Mesh Using Atomic Layer Deposition Technology
Improving the Functional and Antibacterial Properties of an Endoprosthetic Mesh Using Atomic Layer Deposition Technology
Over the past few decades, abdominal wall hernias of various locations have attracted close attention from surgeons in var...
Saliva Glucose Determination by Biosensor: Method Comparison to Chemiluminescence Immunoassay
Saliva Glucose Determination by Biosensor: Method Comparison to Chemiluminescence Immunoassay
The noninvasive sampling materials and methods have garnered great interest among researchers. Saliva is considered the mo...
Prospects for the Application of Synthetic Zeolites as Components of Wound Coverings and Selective Hemosorbents
Prospects for the Application of Synthetic Zeolites as Components of Wound Coverings and Selective Hemosorbents
The issues of potential applicability of synthetic framework aluminosilicates (zeolites) as components of medical material...
Transcriptome Analysis of Bone Marrow Plasma Cells in Multiple Myeloma Patients before Treatment
Transcriptome Analysis of Bone Marrow Plasma Cells in Multiple Myeloma Patients before Treatment
Multiple myeloma (MM) is a malignant lymphoproliferative disorder associated with accumulation of terminally differentiate...
Thermodynamic and Electrochemical Characteristics of Urine Protein Molecules That Affect the Formation of Stones
Thermodynamic and Electrochemical Characteristics of Urine Protein Molecules That Affect the Formation of Stones
Pathogenetic development of urolithiasis (UL) can be divided chronologically into prestone phase and stone phase. Specific...
Cj0983 and Cj0090 Lipoproteins Contain Potential Linear Peptide Epitopes for Anti- Vaccine Applications
Cj0983 and Cj0090 Lipoproteins Contain Potential Linear Peptide Epitopes for Anti- Vaccine Applications
Campylobacter jejuni, a Gram-negative bacterium, is the major etiologic agent of campylobacteriosis responsible for approx...
Development of a Technology for Producing Therapeutic Peptides Weighting Less Than 5 kDa in a Bacterial Expression System
Development of a Technology for Producing Therapeutic Peptides Weighting Less Than 5 kDa in a Bacterial Expression System
Therapeutic peptides are an interesting class of pharmaceutical compounds that are structurally intermediate between small...
Organotin Complexes—Candidates for Antitumor Agents: Toxicity vs. Pharmaceutical Activity
Organotin Complexes—Candidates for Antitumor Agents: Toxicity vs. Pharmaceutical Activity
Chemotherapy is one of the promising areas for the treatment of cancer. Platinum-based drugs are widely used in clinical p...
Detection of Replication-Competent Adenoviral Particles in the Vector Vaccines Salnavac® and Gam-Covid-Vac® against the New Coronavirus Infection Covid-19
Detection of Replication-Competent Adenoviral Particles in the Vector Vaccines Salnavac® and Gam-Covid-Vac® against the New Coronavirus Infection Covid-19
The 2019–2022 coronavirus pandemic has brought vaccination to the forefront in recent years. As a result, various ap...
Isolation, Identification, and Cytotoxicity of α-Alectoronic and α-Collatolic Acids Isolated from the Lichen
Isolation, Identification, and Cytotoxicity of α-Alectoronic and α-Collatolic Acids Isolated from the Lichen
The results of the study on isolation, purification, and study of the cytotoxicity of α-alectoronic and α-collat...
Variability in the Content of 8-Hydroxy-2-deoxyguanosine as a Marker of Oxidative Stress during Subchronic Intoxication with Pesticides
Variability in the Content of 8-Hydroxy-2-deoxyguanosine as a Marker of Oxidative Stress during Subchronic Intoxication with Pesticides
In this study, a change in the concentration of 8-hydroxy-2-deoxyguanosine (8-OHdG) in the oral fluid and plasma of model ...
Levels of IgG to Food Antigens in Practically Healthy People and with Metabolic Syndrome
Levels of IgG to Food Antigens in Practically Healthy People and with Metabolic Syndrome
The study compared the content of IgG specific to 90 food antigens in practically healthy people and in people with metabo...
Association of 25(OH) Vitamin D with Cardiometabolic Risk Factors in the Age Aspect
Association of 25(OH) Vitamin D with Cardiometabolic Risk Factors in the Age Aspect
Background: This study assessed the association of vitamin D status with the frequency of incidence of metabolic health ri...
Ultrastructure of Mitochondria in Skeletal Muscle Weakened by Sarcopenia during Aging
Ultrastructure of Mitochondria in Skeletal Muscle Weakened by Sarcopenia during Aging
The processes of progressive decrease in muscle mass and weakening of mitochondrial function that occur during aging in sk...
Deep Learning Methods for Binding Site Prediction in Protein Structures
Deep Learning Methods for Binding Site Prediction in Protein Structures
This work is an overview of deep machine learning methods aimed at predicting binding sites in protein structures. Several...
Calorie Restriction Decreases JAK-STAT Pathway Gene Expression, Tumor Mass and Activity of Glutathione-Dependent Enzymes
Calorie Restriction Decreases JAK-STAT Pathway Gene Expression, Tumor Mass and Activity of Glutathione-Dependent Enzymes
Melanoma is one of the most aggressive types of cancer. Melanoma morbidity is increasing every year and mortality rate is ...
Effect of Autophagy Regulators on FcεRI-Dependent Activation of the RBL-2H3 Cells
Effect of Autophagy Regulators on FcεRI-Dependent Activation of the RBL-2H3 Cells
Mast cells (MCs) are an important population of connective tissue cells that play a key role in the development of allergi...
LINC00654–SOX5 mRNA-miRNA-133a Compose New RNA Panel for Colorectal Cancer (CRC): A Potential Diagnostic Panel for CRC
LINC00654–SOX5 mRNA-miRNA-133a Compose New RNA Panel for Colorectal Cancer (CRC): A Potential Diagnostic Panel for CRC
Many disorders can be accurately diagnosed using ribonucleic acids (RNAs). A panel of RNAs specific to colorectal cancer (...
Exploring the Cause of Survival Disparities in EGFR-Mutated Lung Cancer Subtypes: Unraveling Distinctive Genomic and Phenotypic Features of 19Del and L858R Mutation Subtypes
Exploring the Cause of Survival Disparities in EGFR-Mutated Lung Cancer Subtypes: Unraveling Distinctive Genomic and Phenotypic Features of 19Del and L858R Mutation Subtypes
Different efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) has been observed between lun...
CUL5 Is Involved in Proteasome-Degradation of BiP in Breast Cancer Cells
CUL5 Is Involved in Proteasome-Degradation of BiP in Breast Cancer Cells
The E3 ubiquitin ligase Cullin 5 (CUL5) has been linked to a variety of cell biological functions, such as developmental p...
Construction of Expression Vectors for Efficient Production of Recombinant Proteins in E. coli for the Development of Therapeutic Drugs
Construction of Expression Vectors for Efficient Production of Recombinant Proteins in E. coli for the Development of Therapeutic Drugs
When developing vaccines and immunotherapeutic and enzymatic drugs, it is usually necessary to obtain a functional protein...
The Effects of Pretreatment with Atorvastatin, Fenofibrate, or Both Drugs in a Mouse Model of Acute Lipemia Induced by the General Lipase Inhibitor Poloxamer 407
The Effects of Pretreatment with Atorvastatin, Fenofibrate, or Both Drugs in a Mouse Model of Acute Lipemia Induced by the General Lipase Inhibitor Poloxamer 407
Dyslipidemia is a well-known risk factor for the development of cardiovascular diseases and atherosclerosis. The effects o...
The Role of Arachidonic Acid Metabolizing Cytochromes P450 in the Control of Cardiovascular Functions
The Role of Arachidonic Acid Metabolizing Cytochromes P450 in the Control of Cardiovascular Functions
Arachidonic acid (AA) is widely distributed in many organs and can be metabolized in several ways into small lipid molecul...
Effects of Various Poly(A) Tails on Luciferase Expression
Effects of Various Poly(A) Tails on Luciferase Expression
Synthesis of RNA by in vitro transcription has many applications in the production of vaccines, anticancer and gene therap...
Investigating Non-Covalent Interactions of Human Serum Albumin with Doxorubicin and Folic Acid
Investigating Non-Covalent Interactions of Human Serum Albumin with Doxorubicin and Folic Acid
The development of effective delivery systems for antitumor drugs with increased specificity and controlled release is one...
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