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APEX1-STAT3 signaling mediates the force-coordinated endothelial regeneration
APEX1-STAT3 signaling mediates the force-coordinated endothelial regeneration
Endothelial regeneration is critical for maintaining vascular homeostasis and inhibiting neointimal formation during vascu...
Wnt signaling - using the bloodstream to send a message
Wnt signaling - using the bloodstream to send a message
Wnt signaling is one of the cell’s most complex and important signal transduction pathways. This pathway, which is d...
Deep learning in chromatin organization: from super-resolution microscopy to clinical applications
Deep learning in chromatin organization: from super-resolution microscopy to clinical applications
The 3D organization of the genome plays a critical role in regulating gene expression, maintaining cellular identity, and ...
Loss of synaptic Munc13-1 underlies neurotransmission abnormalities in spinal muscular atrophy
Loss of synaptic Munc13-1 underlies neurotransmission abnormalities in spinal muscular atrophy
Spinal muscular atrophy (SMA) is a devastating neurodegenerative disease characterized by degeneration of spinal motoneuro...
sTLR9 on maternal Circulating immune cells as a negative regulatory phenotype during pregnancy
sTLR9 on maternal Circulating immune cells as a negative regulatory phenotype during pregnancy
TLR9 is an intracellular receptor that can also be localized to the cell surface, called sTLR9. sTLR9 is thought to have a...
Molecular components of the FPR2/ALX pathway participate in astrocyte-neuron resolution responses to afford maneb-induced toxicity
Molecular components of the FPR2/ALX pathway participate in astrocyte-neuron resolution responses to afford maneb-induced toxicity
Environmental toxicants such as maneb (MB), a dithiocarbamate pesticide, trigger progressive neuronal death, probably due ...
Modeling of kidney allograft rejection using hiPSC-derived kidney organoids and HLA-mismatched PBMCs: an co-culture system
Modeling of kidney allograft rejection using hiPSC-derived kidney organoids and HLA-mismatched PBMCs: an co-culture system
The aim of this study is to establish an in vitro co-culture system to model allograft rejection using kidney organoids sy...
A key spectral tuning site of UV-sensitive vertebrate non-visual opsin Opn5
A key spectral tuning site of UV-sensitive vertebrate non-visual opsin Opn5
Opsins are photoreceptive proteins responsible for visual and non-visual photoreceptions in animals. In general, vertebrat...
The transcriptional regulation of NUPR1 expression by MYC is implicated in the regulation of ferroptosis in human spermatogonial stem cells
The transcriptional regulation of NUPR1 expression by MYC is implicated in the regulation of ferroptosis in human spermatogonial stem cells
Non-obstructive azoospermia (NOA) is a leading cause of male infertility, characterized by impaired spermatogenesis. Recen...
pVHL regulates protein stability of the TCF/LEF transcription factor family via ubiquitin-independent proteasomal degradation
pVHL regulates protein stability of the TCF/LEF transcription factor family via ubiquitin-independent proteasomal degradation
The Wnt/β-catenin signaling pathway plays key roles in development and adult tissue homeostasis by controlling cell p...
Rhapontigenin attenuates neurodegeneration in a parkinson’s disease model by downregulating mtDNA-cGAS-STING-NF-κB-mediated neuroinflammation via PINK1/DRP1-dependent microglial mitophagy
Rhapontigenin attenuates neurodegeneration in a parkinson’s disease model by downregulating mtDNA-cGAS-STING-NF-κB-mediated neuroinflammation via PINK1/DRP1-dependent microglial mitophagy
Microglial activation-induced neuroinflammation and impaired neuronal mitophagy are recognized as pivotal pathogeneses in ...
Linc01271 promotes lipid synthesis and MASLD/MASH progression via miR-149-3p/RAB35 axis
Linc01271 promotes lipid synthesis and MASLD/MASH progression via miR-149-3p/RAB35 axis
Metabolic associated steatohepatitis (MASH) is a severe form of metabolic dysfunction-associated steatotic liver disease (...
Bending the boundaries: the many facets of endophilin-As from membrane dynamics to disease
Bending the boundaries: the many facets of endophilin-As from membrane dynamics to disease
The endophilin-A proteins (EndoAs) are Bin/Amphiphysin/Rvs (BAR) domain proteins with key roles in both clathrin-mediated ...
Synergistic combination of orally available safe-in-man pleconaril, AG7404, and mindeudesivir inhibits enterovirus infections in human cell and organoid cultures
Synergistic combination of orally available safe-in-man pleconaril, AG7404, and mindeudesivir inhibits enterovirus infections in human cell and organoid cultures
Enteroviruses can infect various human organs, causing diseases such as meningitis, the common cold, hand-foot-and-mouth d...
PARP12-mediated ADP-ribosylation contributes to breast cancer cell fate by regulating AKT activation and DNA-damage response
PARP12-mediated ADP-ribosylation contributes to breast cancer cell fate by regulating AKT activation and DNA-damage response
Breast cancer represents the primary cause of death of women under 65 in developed countries, due to the acquisition of mu...
CFAP65 is essential for C2a projection integrity in axonemes: implications for organ-specific ciliary dysfunction and infertility
CFAP65 is essential for C2a projection integrity in axonemes: implications for organ-specific ciliary dysfunction and infertility
Defects in motile cilia and flagella lead to motile ciliopathies, including primary ciliary dyskinesia (PCD), which manife...
Calcium-binding protein CALU-1 is essential for proper collagen formation in Caenorhabditis elegans
Calcium-binding protein CALU-1 is essential for proper collagen formation in Caenorhabditis elegans
Collagen, a major component of the extracellular matrix, is crucial for the structural integrity of the Caenorhabditis ele...
M6A -mediated lncRNA SCIRT stability promotes NSCLC progression through binding to SFPQ and activating the PI3K/Akt pathway
M6A -mediated lncRNA SCIRT stability promotes NSCLC progression through binding to SFPQ and activating the PI3K/Akt pathway
Non-small cell lung cancer (NSCLC) has emerged as one of the most prevalent malignancies worldwide. N6-methyladenosine (m6...
NFAT5 exacerbates β-cell ferroptosis by suppressing the transcription of PRDX2 in obese type 2 diabetes mellitus
NFAT5 exacerbates β-cell ferroptosis by suppressing the transcription of PRDX2 in obese type 2 diabetes mellitus
Pancreatic β-cell damage is a critical pathological mechanism in the progression of obese type 2 diabetes mellitus (T...
From smog to scarred hearts: unmasking the detrimental impact of air pollution on myocardial ischemia–reperfusion injury
From smog to scarred hearts: unmasking the detrimental impact of air pollution on myocardial ischemia–reperfusion injury
Air pollution is a global environmental health hazard associated with elevated cardiovascular morbidity and mortality. Eme...
Ebastine-mediated destabilization of E3 ligase MKRN1 protects against metabolic dysfunction-associated steatohepatitis
Ebastine-mediated destabilization of E3 ligase MKRN1 protects against metabolic dysfunction-associated steatohepatitis
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic condition encompassing metabolic dysfunction...
D-Serine disrupts Cbln1 and GluD1 interaction and affects Cbln1-dependent synaptic effects and nocifensive responses in the central amygdala
D-Serine disrupts Cbln1 and GluD1 interaction and affects Cbln1-dependent synaptic effects and nocifensive responses in the central amygdala
Ionotropic glutamate receptors (iGluRs) mediate fast excitatory neurotransmission in the nervous system. In addition to NM...
Innate and adaptive immunity in neurodegenerative disease
Innate and adaptive immunity in neurodegenerative disease
Neurodegenerative diseases (NDs) are a group of neurological disorders characterized by the progressive loss of s...
Dnajc5b contributes to male fertility by maintaining the mitochondrial functions and autophagic homeostasis during spermiogenesis
Dnajc5b contributes to male fertility by maintaining the mitochondrial functions and autophagic homeostasis during spermiogenesis
DnaJ heat shock protein family member C5 beta (DNAJC5B), also known as cysteine-string protein beta, exhibits a prominent ...
Measurement of serum 1,5-AG provides insights for diabetes management and the anti-viral immune response
Measurement of serum 1,5-AG provides insights for diabetes management and the anti-viral immune response
Achieving an in-range glycated haemoglobin (HbA1c) is essential for managing diabetes mellitus (DM). However, this paramet...
Ketogenic diet induces an inflammatory reactive astrocytes phenotype reducing glioma growth
Ketogenic diet induces an inflammatory reactive astrocytes phenotype reducing glioma growth
The use of a ketogenic diet (KD) in glioma is currently tested as an adjuvant treatment in standard chemotherapy regimens....
SLPI controls neutrophil migration abilities and impacts neutrophil skin infiltration in experimental psoriasis
SLPI controls neutrophil migration abilities and impacts neutrophil skin infiltration in experimental psoriasis
Skin infiltration by neutrophils is a hallmark of the chronic inflammatory skin disease psoriasis, yet the mechanisms unde...
Enhanced secretion of the amyotrophic lateral sclerosis ALS-associated misfolded TDP-43 mediated by the ER-ubiquitin specific peptidase USP19
Enhanced secretion of the amyotrophic lateral sclerosis ALS-associated misfolded TDP-43 mediated by the ER-ubiquitin specific peptidase USP19
Proteinopathies, such as amyotrophic lateral sclerosis (ALS), are marked by the accumulation of misfolded proteins that di...
Antiviral strategies against influenza virus: an update on approved and innovative therapeutic approaches
Antiviral strategies against influenza virus: an update on approved and innovative therapeutic approaches
Influenza viruses still represent a great concern for Public Health by causing yearly seasonal epidemics and occasionally ...
The immune sensitivity caused by DUSP11, an RNA 5′-end maturation phosphatase, is adjusted by a human non-coding RNA, nc886
The immune sensitivity caused by DUSP11, an RNA 5′-end maturation phosphatase, is adjusted by a human non-coding RNA, nc886
All cellular transcripts initially have a tri-phosphate (PPP) group at the 5′-end, recognized as a pathogen-associat...
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