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Evading resistance at the double
Evading resistance at the double
Synthesis and characterization of new macrolones — fusions of two antibiotic classes with distinct bacterial targets...
A multiplex single-cell RNA-Seq pharmacotranscriptomics pipeline for drug discovery
A multiplex single-cell RNA-Seq pharmacotranscriptomics pipeline for drug discovery
The gene-regulatory dynamics governing drug responses in cancer are yet to be fully understood. Here, we report a pipeline...
Carbonic anhydrase inhibition ameliorates tau toxicity via enhanced tau secretion
Carbonic anhydrase inhibition ameliorates tau toxicity via enhanced tau secretion
Tauopathies are neurodegenerative diseases that manifest with intracellular accumulation and aggregation of tau protein. T...
Engineering a xylose fermenting yeast for lignocellulosic ethanol production
Engineering a xylose fermenting yeast for lignocellulosic ethanol production
Lignocellulosic ethanol is produced by yeast fermentation of lignocellulosic hydrolysates generated by chemical pretreatme...
Author Correction: Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis
Yu ImaiPresent address: Department of Biomolecular Innovation, Institute for Biomedical Sciences, Shinshu University, Naga...
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway
These authors contributed equally: Jie Shi, Shangying Wang.Department of Bioengineering, University of California, Berkele...
Spatiotemporal control of subcellular O-GlcNAc signaling using Opto-OGT
Spatiotemporal control of subcellular O-GlcNAc signaling using Opto-OGT
The post-translational modification of intracellular proteins through O-linked β-N-acetylglucosamine (O-GlcNAc) is a ...
Open-ended molecular recording of sequential cellular events into DNA
Open-ended molecular recording of sequential cellular events into DNA
Genetically encoded DNA recorders noninvasively convert transient biological events into durable mutations in a cell’...
Stress it up
AKT is a serine/threonine kinase that is essential for cellular metabolism and proliferation and is overactive in cancer c...
Reeling in microorganisms
The metabolic engineering of microorganisms is an attractive platform for bioremediation and the industrial production of ...
The death gaze of MEDUSA
The death gaze of MEDUSA
Chemogenetic profiling can reveal genetic determinants that coordinate phenotypic responses to therapeutics, along with pr...
Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression
Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression
Telomere dysfunction is intricately linked to the aging process and stands out as a prominent cancer hallmark. Here we dem...
Engineering APOBEC3A deaminase for highly accurate and efficient base editing
Engineering APOBEC3A deaminase for highly accurate and efficient base editing
Cytosine base editors (CBEs) are effective tools for introducing C-to-T base conversions, but their clinical applications ...
LPS gets a fresh trim
LPS gets a fresh trim
Detection of intracellular lipolysaccharide (LPS) activates an immune response initiated by the non-canonical inflammasome...
Peptide vaccines get an OS update
Peptide vaccines get an OS update
Peptide vaccines use antigenic peptide fragments to induce an immune response but are problematic because of the short hal...
Bringing chemistry to medicine to redefine the undruggable
Bringing chemistry to medicine to redefine the undruggable
Chemical approaches, such as those that leverage induced proximity, targeted degradation, synthetic gene regulators or pro...
Biocatalytic cyclization of small macrolactams by a penicillin-binding protein-type thioesterase
Biocatalytic cyclization of small macrolactams by a penicillin-binding protein-type thioesterase
Macrocyclic peptides represent promising scaffolds for chemical tools and potential therapeutics. Synthetic methods for pe...
Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM
Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM
Compact Cas9 nucleases hold great promise for therapeutic applications. Although several compact Cas9 nucleases have been ...
In search of chemical rationales
In search of chemical rationales
Small molecules and drugs are not homogenously distributed across cells, and are instead enriched in distinct subcellular ...
Author Correction: An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity
Authors and AffiliationsDepartment of Chemistry, The University of Chicago, Chicago, IL, USATong Wu, Chang Liu, Siyuan Zou...
Characterizing the metabolomes of phase-separated condensates
Characterizing the metabolomes of phase-separated condensates
Cells contain compartments composed of phase-separated protein condensates. We find that these condensates have a unique c...
Medicine from modified mRNA
Medicine from modified mRNA
As the COVID-19 pandemic rapidly spread around the world, the scientific community desperately searched for therapeutic in...
Survival of the sweetest tooth
The development of multidrug resistance in bacteria is a global public health concern, and the genetic and molecular deter...
Traffic control
Lysosomal degradation of extracellular and membrane proteins can be facilitated by lysosome-targeted chimeras (LYTACs). LY...
RNA-based anti-CRISPRs
RNA-based anti-CRISPRs
Using a type I-F SRU as an example, Camara-Wilpert et al. demonstrate that SRUs inhibit CRISPR–Cas immunity via an RNA-bas...
Metagenomic domain substitution for the high-throughput modification of nonribosomal peptides
Metagenomic domain substitution for the high-throughput modification of nonribosomal peptides
The modular nature of nonribosomal peptide biosynthesis has driven efforts to generate peptide analogs by substituting ami...
Accelerating the design of pili-enabled living materials using an integrative technological workflow
Accelerating the design of pili-enabled living materials using an integrative technological workflow
Bacteria can be programmed to create engineered living materials (ELMs) with self-healing and evolvable functionalities. H...
An allosteric redox switch involved in oxygen protection in a CO2 reductase
An allosteric redox switch involved in oxygen protection in a CO2 reductase
Metal-dependent formate dehydrogenases reduce CO2 with high efficiency and selectivity, but are usually very oxygen sensit...
A single-component, light-assisted uncaging switch for endoproteolytic release
A single-component, light-assisted uncaging switch for endoproteolytic release
Proteases function as pivotal molecular switches, initiating numerous biological events. Notably, potyviral protease, deri...
Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance
Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance
The efficacy of aminoglycoside antibiotics is waning due to the acquisition of diverse resistance mechanisms by bacteria. ...
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