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Ginkgo biloba Leaf Polysaccharide Induces Autophagy and Modulates the Expression of Apoptosis Markers in Hepatocellular Carcinoma Cells
Ginkgo biloba Leaf Polysaccharide Induces Autophagy and Modulates the Expression of Apoptosis Markers in Hepatocellular Carcinoma Cells
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and poses a severe threat to human health. Gink...
Human eRF1 Translation Regulation
Human eRF1 Translation Regulation
Eukaryotic translation release factor eRF1 is an important cellular protein that plays a key role in translation terminati...
Silencing of the S-Phase Kinase-Associated Protein 2 Gene (SKP2) Inhibits Proliferation and Migration of Hepatocellular Carcinoma Cells
Silencing of the S-Phase Kinase-Associated Protein 2 Gene (SKP2) Inhibits Proliferation and Migration of Hepatocellular Carcinoma Cells
SKP2 gene is an independent prognostic factor in some diseases and a potential oncogene. The molecular mechanism underlyin...
Triosephosphate Isomerase Inhibition by Resveratrol: A New Mechanism of Anti-Glycolysis in Breast Cancer
Triosephosphate Isomerase Inhibition by Resveratrol: A New Mechanism of Anti-Glycolysis in Breast Cancer
Breast cancer cells undergo a process of reprogramming their metabolism for rapid growth and proliferation. One of the mos...
New Epigenetic Markers of Age-Dependent Changes in the Cardiovascular System
New Epigenetic Markers of Age-Dependent Changes in the Cardiovascular System
Cardiovascular diseases remain a predominant global cause of mortality, with a noteworthy rise in the risk of morbidity wi...
Structure and Function of the Transglutaminase Cluster in the Basal Metazoan Halisarca dujardinii (Sponge)
Structure and Function of the Transglutaminase Cluster in the Basal Metazoan Halisarca dujardinii (Sponge)
Transglutaminases are enzymes that carry out post-translational modifications of proteins and participate in the regulatio...
Spatial Organization of Chromatin of the KLF5 Gene Promoter Region in Pancreatic Ductal Adenocarcinoma Cells
Spatial Organization of Chromatin of the KLF5 Gene Promoter Region in Pancreatic Ductal Adenocarcinoma Cells
Pancreatic Ductal AdenoCarcinoma (PDAC) is characterized by a poor prognosis and is poorly amenable to modern therapies. A...
GRIP1 is Involved in the Interaction of Vimentin Filaments with Focal Adhesions in Endothelial Cells
GRIP1 is Involved in the Interaction of Vimentin Filaments with Focal Adhesions in Endothelial Cells
Vimentin intermediate filaments are dynamic structures that are able to move in cytoplasm owing to activity of the motor p...
Multi-Omic Rejuvenation: A New Strategy for Lifespan Extension
Multi-Omic Rejuvenation: A New Strategy for Lifespan Extension
Various age-related disorders accumulate during aging, causing a decline in tissue and organ function, raising the risk of...
Inactivation of Type 3 Fimbriae Increases Adhesion of Klebsiella oxytoca to Lung Epithelial Cells
Inactivation of Type 3 Fimbriae Increases Adhesion of Klebsiella oxytoca to Lung Epithelial Cells
Klebsiella oxytoca is a causative agent of various community-acquired and nosocomial infections, including urinary tract i...
Point Mutations V546E and D547H of the RBM-B Motif Do Not Affect the Binding of PrimPol to RPA and DNA
Point Mutations V546E and D547H of the RBM-B Motif Do Not Affect the Binding of PrimPol to RPA and DNA
The human primase-polymerase PrimPol is a key participant of the mechanism of DNA synthesis restart during replication for...
Redox Status and Protein Glutathionylation in Binase-Treated HPV16-Positive SiHa Carcinoma Cells
Redox Status and Protein Glutathionylation in Binase-Treated HPV16-Positive SiHa Carcinoma Cells
Human papillomavirus type 16 (HPV16) belongs to viruses of the high-risk type and is associated by overexpression of E6 an...
Search for Transposable Element Insertions and Chromosomal Rearrangements That Change Gene Expression in D. melanogaster Strains with Impaired Transposition Control of gypsy Retrotransposon
Search for Transposable Element Insertions and Chromosomal Rearrangements That Change Gene Expression in D. melanogaster Strains with Impaired Transposition Control of gypsy Retrotransposon
Transposable elements (TEs) increase the frequency of spontaneous mutations in the genome and are capable of altering the ...
Expression of Long Noncoding RNAs and Protein-Coding Genes Involved in Oxidative Stress and Cell Senescence in Patients with Chronic Obstructive Pulmonary Disease
Expression of Long Noncoding RNAs and Protein-Coding Genes Involved in Oxidative Stress and Cell Senescence in Patients with Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a multifactorial heterogeneous chronic inflammatory respiratory disease. T...
Methylation of Selected CpG-Sites of the Gene CSF1 as a Factor in Regulation of Its Expression and a Marker of Human Biological Aging
Methylation of Selected CpG-Sites of the Gene CSF1 as a Factor in Regulation of Its Expression and a Marker of Human Biological Aging
Abstract—Age-associated transformation of methylation patterns is considered to be an important predictor of human b...
p62: Intersection of Antioxidant Defense and Autophagy Pathways
p62: Intersection of Antioxidant Defense and Autophagy Pathways
Numerous regulatory cascades link the cell response to oxidative stress and the mechanisms that maintain homeostasis and c...
Recombinant VLP Vaccines Synthesized in Plant Expression Systems: Current Updates and Prospects
Recombinant VLP Vaccines Synthesized in Plant Expression Systems: Current Updates and Prospects
The development and creation of a new generation vaccines based on recombinant proteins that assemble into virus-like part...
Methylation of Long Noncoding RNA Genes SNHG6, SNHG12, and TINCR in Ovarian Cancer
Methylation of Long Noncoding RNA Genes SNHG6, SNHG12, and TINCR in Ovarian Cancer
Ovarian cancer (OC) develops asymptomatically and escapes diagnosis until advanced stages, the feature contributing to a h...
Participation of Proteins of the CPSF Complex in Polyadenylation of Transcripts Read by RNA Polymerase III from SINEs
Participation of Proteins of the CPSF Complex in Polyadenylation of Transcripts Read by RNA Polymerase III from SINEs
SINEs are mobile genetic elements of multicellular eukaryotes that arose during evolution from various tRNAs, as well as f...
Synthesis of a Bisbenzoxazole Analogue of Hoechst 33258 as a Potential GC-Selective DNA Ligand
Synthesis of a Bisbenzoxazole Analogue of Hoechst 33258 as a Potential GC-Selective DNA Ligand
Using a computer modeling approach, we proposed a structure for a potential GC-specific DNA ligand, which could form a com...
Study of the Gut Transcriptomic Response in Drosophila melanogaster with Knockdown of Gagr, Domesticated gag Gene of Errantiviruses
Study of the Gut Transcriptomic Response in Drosophila melanogaster with Knockdown of Gagr, Domesticated gag Gene of Errantiviruses
As a result of molecular domestication of the gag gene of errantiviruses, the Gagr gene was formed in the genome of Drosop...
Development of Biological Microchips on an Aluminum Support with Cells Made of Brush Polymers
Development of Biological Microchips on an Aluminum Support with Cells Made of Brush Polymers
A method has been developed for manufacturing biological microchips on an aluminum substrate with hydrophilic cells from b...
DNA Methylation Profiling in Aneurysm and Comorbid Atherosclerosis of the Ascending Aorta
DNA Methylation Profiling in Aneurysm and Comorbid Atherosclerosis of the Ascending Aorta
Atherosclerosis and aneurysm of the aorta are relatively common pathological conditions that remain asymptomatic for a lon...
ArdA Protein Specificity against Type I Restriction–Modification Systems
ArdA Protein Specificity against Type I Restriction–Modification Systems
The ArdA DNA-mimic antirestriction proteins inhibit type I restriction−modification (RMI) systems by binding instead...
Small Non-Coding sRNA53 Modulates the Quorum Sensing System to Enhance Drug Resistance in Escherichia coli Exposed to Heavy Ion and X-ray Irradiation
Small Non-Coding sRNA53 Modulates the Quorum Sensing System to Enhance Drug Resistance in Escherichia coli Exposed to Heavy Ion and X-ray Irradiation
Small non-coding RNAs (sRNAs, also called sncRNAs) known as gene expression regulatory factors are capable of modulating m...
Melatonin Enhances the Effect of ABT-737 in Acute Monocytic Leukemia THP-1 Cells
Melatonin Enhances the Effect of ABT-737 in Acute Monocytic Leukemia THP-1 Cells
Melatonin (N-acetyl-5-methoxytryptamine, MEL) is a hormone synthesized by the pineal gland. Due to its oncostatic effect, ...
A Group of New Hypermethylated Long Non-Coding RNA Genes Associated with the Development and Progression of Breast Cancer
A Group of New Hypermethylated Long Non-Coding RNA Genes Associated with the Development and Progression of Breast Cancer
Abstract—Breast cancer is the most common type of cancer among women. The study of the mechanisms of metastasis, the...
Photochemical Processes of Cell DNA Damage by UV Radiation of Various Wavelengths: Biological Consequences
Photochemical Processes of Cell DNA Damage by UV Radiation of Various Wavelengths: Biological Consequences
Photochemical reactions in cell DNA are induced in various organisms by solar UV radiation and may lead to a series of bio...
Stochastic Packaging of Cas Proteins into Exosomes
Stochastic Packaging of Cas Proteins into Exosomes
Abstract—CRISPR/Cas systems are perspective molecular tools for targeted manipulation with genetic materials, such a...
Genome Stability of Bacillus velezensis after Two-Year Exposure in Open Space
Genome Stability of Bacillus velezensis after Two-Year Exposure in Open Space
Abstract—Spore-forming bacteria have a unique resistance to negative environmental conditions, including aggressive ...
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