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Memantine/Rosuvastatin Therapy Abrogates Cognitive and Hippocampal Injury in an Experimental Model of Alzheimer's Disease in Rats: Role of TGF-β1/Smad Signaling Pathway and Amyloid-β Clearance
Memantine/Rosuvastatin Therapy Abrogates Cognitive and Hippocampal Injury in an Experimental Model of Alzheimer's Disease in Rats: Role of TGF-β1/Smad Signaling Pathway and Amyloid-β Clearance
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder of complex pathogenesis and multiple interac...
Empagliflozin Mitigates PTZ-Induced Seizures in Rats: Modulating Npas4 and CREB-BDNF Signaling Pathway
Empagliflozin Mitigates PTZ-Induced Seizures in Rats: Modulating Npas4 and CREB-BDNF Signaling Pathway
Empagliflozin (EMPA) is one of the sodium/glucose cotransporter 2 (SGLT2) inhibitors that has been recently approved for t...
Ghrelin Induces Ferroptosis Resistance and M2 Polarization of Microglia to Alleviate Neuroinflammation and Cognitive Impairment in Alzheimer’s Disease
Ghrelin Induces Ferroptosis Resistance and M2 Polarization of Microglia to Alleviate Neuroinflammation and Cognitive Impairment in Alzheimer’s Disease
Microglial polarization and ferroptosis are important pathological features in Alzheimer’s disease (AD). Ghrelin, a ...
LncRNA NEAT1, an Important Biomarker Involved in the Pathological and Physiological Processes of Parkinson's Disease
LncRNA NEAT1, an Important Biomarker Involved in the Pathological and Physiological Processes of Parkinson's Disease
Parkinson's disease (PD) is a complex progressive neurodegenerative disorder and the pathogenesis and treatment method...
The High-Affinity IL-2 Receptor Affects White Matter Damage after Cerebral Ischemia by Regulating CD8 + T Lymphocyte Differentiation
The High-Affinity IL-2 Receptor Affects White Matter Damage after Cerebral Ischemia by Regulating CD8 + T Lymphocyte Differentiation
IL-2/IL-2R inhibition improved the prognosis of ischemic stroke by regulating T cells, while the respective contribution o...
Modulation of Intestinal Inflammation and Protection of Dopaminergic Neurons in Parkinson’s Disease Mice through a Probiotic Formulation Targeting NLRP3 Inflammasome
Modulation of Intestinal Inflammation and Protection of Dopaminergic Neurons in Parkinson’s Disease Mice through a Probiotic Formulation Targeting NLRP3 Inflammasome
Emerging evidence highlights the significance of peripheral inflammation in the pathogenesis of Parkinson’s disease ...
A Comparative Study of Nanoconjugates of a Synthetic and a Natural Drug Against T2DM-Induced Cognitive Dysfunction
A Comparative Study of Nanoconjugates of a Synthetic and a Natural Drug Against T2DM-Induced Cognitive Dysfunction
Type II Diabetes Mellitus (T2DM) is one of the risk factors for the development of dementia leading to cognitive dysfuncti...
NXP032 Improves Memory Impairment Through Suppression of Tauopathy in PS19 Mice and Attenuates Okadaic Acid-Induced Tauopathy in SH-SY5Y Cells
NXP032 Improves Memory Impairment Through Suppression of Tauopathy in PS19 Mice and Attenuates Okadaic Acid-Induced Tauopathy in SH-SY5Y Cells
Tauopathy is widely observed in multiple neurodegenerative diseases such as Alzheimer’s disease (AD) and characteriz...
The Effects of Cannabinoids on Ischemic Stroke-Associated Neuroinflammation: A Systematic Review
The Effects of Cannabinoids on Ischemic Stroke-Associated Neuroinflammation: A Systematic Review
Stroke represents a significant burden on global health and the economy, with high mortality rates, disability, and recurr...
A New Perspective on Mechanisms of Neurodegeneration in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis: the Early and Critical Role of Platelets in Neuro/Axonal Loss
A New Perspective on Mechanisms of Neurodegeneration in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis: the Early and Critical Role of Platelets in Neuro/Axonal Loss
Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disorder, with limited treatment options. This diseas...
PKR Inhibition Prevents Neuroinflammation and Rescues Depressive-Like Behaviors via BDNF/TrkB Signaling
PKR Inhibition Prevents Neuroinflammation and Rescues Depressive-Like Behaviors via BDNF/TrkB Signaling
PKR, a kinase implicated in inflammation, accumulates in the brain, but its role in neuroinflammation-related depression i...
Rebalancing Immune Interactions within the Brain-Spleen Axis Mitigates Neuroinflammation in an Aging Mouse Model of Alzheimer’s Disease
Rebalancing Immune Interactions within the Brain-Spleen Axis Mitigates Neuroinflammation in an Aging Mouse Model of Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common cause of dementia worldwide, characterized by accumulation of amyloid-&#...
Proteomic Analysis of Chronic Binge Alcohol-Induced Hippocampal and Anterior Cingulate Cortex Neuroadaptations in Simian Immunodeficiency Virus (SIV)-Infected Female Rhesus Macaques
Proteomic Analysis of Chronic Binge Alcohol-Induced Hippocampal and Anterior Cingulate Cortex Neuroadaptations in Simian Immunodeficiency Virus (SIV)-Infected Female Rhesus Macaques
Human immunodeficiency virus (HIV) infection produces neurological comorbidities including HIV-associated neurocognitive d...
Reduction of Neuroinflammation as a Common Mechanism of Action of Anorexigenic and Orexigenic Peptide Analogues in the Triple Transgenic Mouse Model of Alzheimer´s Disease
Reduction of Neuroinflammation as a Common Mechanism of Action of Anorexigenic and Orexigenic Peptide Analogues in the Triple Transgenic Mouse Model of Alzheimer´s Disease
Alzheimer’s disease (AD) is the most common form of dementia. Characterized by progressive neurodegeneration, AD typ...
Treg Upregulation by Treadmill Training Accelerates Myelin Repair Post-Ischemia
Treg Upregulation by Treadmill Training Accelerates Myelin Repair Post-Ischemia
Regulatory T (Treg) cells contribute to white matter repair following ischemic stroke, but their limited availability in c...
GDF11 Mitigates Neuropathic Pain via Regulation of Microglial Polarization and Neuroinflammation through TGF-βR1/SMAD2/NF-κB Pathway in Male Mice
GDF11 Mitigates Neuropathic Pain via Regulation of Microglial Polarization and Neuroinflammation through TGF-βR1/SMAD2/NF-κB Pathway in Male Mice
Spinal microglial activation and the polarization towards the M1 phenotype are implicated in the pathological process of n...
Loganic Acid Alleviates the Olfactory-Brain NLRP3 Inflammasome Activation and Rescues Dopaminergic Neurons in Experimental Models of Parkinson’s Disease
Loganic Acid Alleviates the Olfactory-Brain NLRP3 Inflammasome Activation and Rescues Dopaminergic Neurons in Experimental Models of Parkinson’s Disease
The NLRP3 inflammasome signaling cascade activation is a significant contributor to the initiation and progression of Park...
Pharmacological Depletion of Microglia Protects Against Alcohol-Induced Corticolimbic Neurodegeneration During Intoxication in Male Rats
Pharmacological Depletion of Microglia Protects Against Alcohol-Induced Corticolimbic Neurodegeneration During Intoxication in Male Rats
Excessive alcohol use damages the brain, especially corticolimbic regions such as the hippocampus and rhinal cortices, lea...
Vinpocetine and Attenuated Rotenone-Induced Parkinson’s Disease and Restored Dopamine Synthesis in Rats through Modulation of Oxidative Stress, Neuroinflammation, and Lewy Bodies Inclusion
Vinpocetine and Attenuated Rotenone-Induced Parkinson’s Disease and Restored Dopamine Synthesis in Rats through Modulation of Oxidative Stress, Neuroinflammation, and Lewy Bodies Inclusion
Parkinson’s disease (PD) is the main neurodegenerative disorder affecting motor activity, there are different pathop...
A Comprehensive Review on Utilizing Human Brain Organoids to Study Neuroinflammation in Neurological Disorders
A Comprehensive Review on Utilizing Human Brain Organoids to Study Neuroinflammation in Neurological Disorders
Most current information about neurological disorders and diseases is derived from direct patient and animal studies. Howe...
Recombinant Interleukin − 2 2 Immunotherapy Ameliorates Inflammation and Promotes the Release of Monoamine Neurotransmitters in the Gut-Brain Axis of Schistosoma mansoni-Infected Mice
Recombinant Interleukin − 2 2 Immunotherapy Ameliorates Inflammation and Promotes the Release of Monoamine Neurotransmitters in the Gut-Brain Axis of Schistosoma mansoni-Infected Mice
Recombinant interleukin-22 (rIL-22) has been reported as a protective agent in murine models of diseases driven by epithel...
Repetitive Administration of Low-Dose Lipopolysaccharide Improves Repeated Social Defeat Stress-Induced Behavioral Abnormalities and Aberrant Immune Response
Repetitive Administration of Low-Dose Lipopolysaccharide Improves Repeated Social Defeat Stress-Induced Behavioral Abnormalities and Aberrant Immune Response
Repetitive exposure of innate immune cells to a subthreshold dosage of endotoxin components may modulate inflammatory resp...
Canagliflozin Mitigated Cognitive Impairment in Streptozotocin-Induced Sporadic Alzheimer’s Disease in Mice: Role of AMPK/SIRT-1 Signaling Pathway in Modulating Neuroinflammation
Canagliflozin Mitigated Cognitive Impairment in Streptozotocin-Induced Sporadic Alzheimer’s Disease in Mice: Role of AMPK/SIRT-1 Signaling Pathway in Modulating Neuroinflammation
Sporadic Alzheimer’s disease (SAD) represents a major health concern especially among elderly. Noteworthy, neuroinfl...
Investigations on the Ability of the Insular Cortex to Process Peripheral Immunosuppression
Investigations on the Ability of the Insular Cortex to Process Peripheral Immunosuppression
The brain and immune system communicate through complex bidirectional pathways, but the specificity by which the brain per...
Nrf1 Reduces COX-2 Expression and Maintains Cellular Homeostasis After Cerebral Ischemia/Reperfusion By Targeting IL-6/TNF-α Protein Production
Nrf1 Reduces COX-2 Expression and Maintains Cellular Homeostasis After Cerebral Ischemia/Reperfusion By Targeting IL-6/TNF-α Protein Production
Neuroinflammation has been considered involved in the process of cerebral ischemia–reperfusion injury (CIRI). Transc...
Correction: FTY720 Inhibits MPP+-Induced Microglial Activation by Affecting NLRP3 Inflammasome Activation
Correction: FTY720 Inhibits MPP+-Induced Microglial Activation by Affecting NLRP3 Inflammasome Activation
Department of Immunology, Nanjing Medical University, 101 Longmian Avenue, Nanjing, JS, 211166, ChinaShu Yao, Longjun Li, ...
Intestinal Akkermansia muciniphila is Beneficial to Functional Recovery Following Ischemic Stroke
Intestinal Akkermansia muciniphila is Beneficial to Functional Recovery Following Ischemic Stroke
Recent studies have demonstrated the interaction between gut microbiota and brain on ischemic stroke, but the roles of gut...
Hyperalgesic Effect Evoked by il-16 and its Participation in Inflammatory Hypernociception in Mice
Hyperalgesic Effect Evoked by il-16 and its Participation in Inflammatory Hypernociception in Mice
The systemic administration of interleukin-16 (IL-16, 3–30 ng/kg) induced thermal hyperalgesia in mice, tha...
The Antidepressant- and Anxiolytic-Like Effects of the Phosphodiesterase Type-5 Inhibitor Tadalafil are Associated with the Modulation of the Gut-Brain Axis During CNS Autoimmunity
The Antidepressant- and Anxiolytic-Like Effects of the Phosphodiesterase Type-5 Inhibitor Tadalafil are Associated with the Modulation of the Gut-Brain Axis During CNS Autoimmunity
Multiple Sclerosis (MS) is a debilitating disease that severely affects the central nervous system (CNS). Apart from neuro...
Sigma-1 Receptors Control Neuropathic Pain and Peripheral Neuroinflammation After Nerve Injury in Female Mice: A Transcriptomic Study
Sigma-1 Receptors Control Neuropathic Pain and Peripheral Neuroinflammation After Nerve Injury in Female Mice: A Transcriptomic Study
The mechanisms for neuropathic pain amelioration by sigma-1 receptor inhibition are not fully understood. We studied genom...
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