SCI Abstract

search
+
Safety, pharmacokinetics, and dosimetry of 177Lu-AB-3PRGD2 in patients with advanced integrin αvβ3-positive tumors: a first-in-human study
Update your browser to view ScienceDirect. ...
Induction of Cyp2e1 contributes to asparaginase-induced hepatocyte sensitization to lipotoxicity
Update your browser to view ScienceDirect. ...
Reversing metabolic reprogramming by CPT1 inhibition with etomoxir promotes cardiomyocyte proliferation and heart regeneration via DUSP1 ADP-ribosylation-mediated p38 MAPK phosphorylation
Update your browser to view ScienceDirect. ...
Thio-ProTide strategy: A novel H2S donor–drug conjugate (DDC) alleviates hepatic injury via innate lysosomal targeting
Update your browser to view ScienceDirect. ...
A microfluidic coculture model for mapping signaling perturbations and precise drug screening against macrophage-mediated dynamic myocardial injury
Update your browser to view ScienceDirect. ...
The applications and advances of artificial intelligence in drug regulation: A global perspective
Update your browser to view ScienceDirect. ...
Neuronal activities drive brain waste clearance through the glymphatic system
Update your browser to view ScienceDirect. ...
Synergistic metabolic modulation of fibroblast-like synoviocytes via targeted dual prodrug nanoparticles to mitigate rheumatoid arthritis
Update your browser to view ScienceDirect. ...
Cocrystal pleomorphism-inspired drug nanoassembly for pulmonary-endothelium targeting and pulmonary hypertension treatment
Update your browser to view ScienceDirect. ...
Gut microbiota-derived tryptophan metabolites regulated by Wuji Wan to attenuate colitis through AhR signaling activation
Update your browser to view ScienceDirect. ...
Nanomaterials evoke pyroptosis boosting cancer immunotherapy
Update your browser to view ScienceDirect. ...
Size-transformable nanotherapeutics for cancer therapy
Update your browser to view ScienceDirect. ...
The PGAM5–NEK7 interaction is a therapeutic target for NLRP3 inflammasome activation in colitis
Update your browser to view ScienceDirect. ...
Dual activation of GCGR/GLP1R signaling ameliorates intestinal fibrosis via metabolic regulation of histone H3K9 lactylation in epithelial cells
Update your browser to view ScienceDirect. ...
Comprehensive investigation of multiple targets in the development of newer drugs for the Alzheimer’s disease
Update your browser to view ScienceDirect. ...
Facilitation of mucosal healing by estrogen receptor β in ulcerative colitis through suppression of branched-chain amino acid transport and subsequent triggering of autophagy in colonic epithelial cells
Update your browser to view ScienceDirect. ...
Cerebral endothelial 3-mercaptopyruvate sulfurtransferase improves ischemia-induced cognitive impairment via interacting with protein phosphatase 2A
Update your browser to view ScienceDirect. ...
YOD1 regulates microglial homeostasis by deubiquitinating MYH9 to promote the pathogenesis of Alzheimer’s disease
Update your browser to view ScienceDirect. ...
Drofenine as a Kv2.1 inhibitor alleviated AD-like pathology in mice through Aβ/Kv2.1/microglial NLRP3/neuronal Tau axis
Update your browser to view ScienceDirect. ...
Silencing excessive stress response of neurons — a new approach to treat neurodegeneration diseases
Update your browser to view ScienceDirect. ...
Antitumor activity and low gastrointestinal toxicity of a novel selective inhibitor of nuclear export, SZJK-0421, in multiple myeloma
Antitumor activity and low gastrointestinal toxicity of a novel selective inhibitor of nuclear export, SZJK-0421, in multiple myeloma
Multiple myelomaSelective inhibitorNuclear exportCytotoxicityGastrointestinal toxicity© 2024 The Authors. Published by Els...
Lipid-nanoparticle-enabled nucleic acid therapeutics for liver disorders
Lipid-nanoparticle-enabled nucleic acid therapeutics for liver disorders
Available online 22 April 2024Author links open overlay panel, , , , , , AbstractInherited genetic disorders of the liver ...
Mechanical regulation of lipid and sugar absorption by Piezo1 in enterocytes
Mechanical regulation of lipid and sugar absorption by Piezo1 in enterocytes
Piezo1DGAT2SGLT1Lipid metabolismObesityMechanical sensingIntestinal lipid absorptionIntestinal glucose absorption© 2024 Th...
Commentary: The central lymphatic drainage in pharmacological, surgical and physical therapies of Alzheimer's disease
Commentary: The central lymphatic drainage in pharmacological, surgical and physical therapies of Alzheimer's disease
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, an...
Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis
Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis
multiple myelomaPhenylalanineAmino acid metabolismNutrient deprivationCancer therapyEndoplasmic reticulum stressATF3Apopto...
Enhancing immunotherapy efficacy against MHC-I deficient triple-negative breast cancer using LCL161-loaded macrophage membrane-decorated nanoparticles
Enhancing immunotherapy efficacy against MHC-I deficient triple-negative breast cancer using LCL161-loaded macrophage membrane-decorated nanoparticles
MHC-I deficiencyMacrophageCD47ImmunotherapyTriple-negative breast cancerPhagocytosisImmune checkpointInnate immunity© 2024...
PIM1–HDAC2 axis modulates intestinal homeostasis through epigenetic modification
PIM1–HDAC2 axis modulates intestinal homeostasis through epigenetic modification
Available online 24 April 2024Author links open overlay panel, , , , , , , , , , , , , , AbstractThe mucosal barrier is cr...
KHK-A promotes fructose-dependent colorectal cancer liver metastasis by facilitating the phosphorylation and translocation of PKM2
KHK-A promotes fructose-dependent colorectal cancer liver metastasis by facilitating the phosphorylation and translocation of PKM2
Available online 24 April 2024Author links open overlay panel, , , , , , , , , AbstractExcessive fructose diet is closely ...
Inhibition of xanthine oxidase alleviated pancreatic necrosis via HIF-1α-regulated LDHA and NLRP3 signaling pathway in acute pancreatitis
Inhibition of xanthine oxidase alleviated pancreatic necrosis via HIF-1α-regulated LDHA and NLRP3 signaling pathway in acute pancreatitis
Xanthine oxidase inhibitormulti-omicsHIF-1αnecrotizing acute pancreatitislactatetherapeutic targetNLRP3metabolic flux© 202...
LncRNA ZFPM2-AS1 promotes phyllodes tumor progression by binding to CDC42 and inhibiting STAT1 activation
LncRNA ZFPM2-AS1 promotes phyllodes tumor progression by binding to CDC42 and inhibiting STAT1 activation
LncRNAPhyllodes tumorZFPM2-AS1Cell division cycle 42Activated cdc42 kinase 1Signal transducer and activator of transcripti...
Load More
format_indent_increase