Atta AA, Ibrahim WW, Mohamed AF, Abdelkader NF (2023) Microglia polarization in nociplastic pain: mechanisms and perspectives. Inflammopharmacology 31:1053–1067
Article CAS PubMed PubMed Central Google Scholar
Attal N, Bouhassira D, Colvin L (2023) Advances and challenges in neuropathic pain: a narrative review and future directions. Br J Anaesth 131:79–92
Chen G, Zhang YQ, Qadri YJ, Serhan CN, Ji RR (2018) Microglia in Pain: detrimental and protective roles in Pathogenesis and Resolution of Pain. Neuron 100:1292–1311
Article CAS PubMed PubMed Central Google Scholar
Dominguez E, Mauborgne A, Mallet J, Desclaux M, Pohl M (2010) SOCS3-mediated blockade of JAK/STAT3 signaling pathway reveals its major contribution to spinal cord neuroinflammation and mechanical allodynia after peripheral nerve injury. J Neurosci 30:5754–5766
Article CAS PubMed PubMed Central Google Scholar
Duan F, Wang X, Wang H, Wang Y, Zhang Y, Chen J, Zhu X, Chen B (2022) GDF11 ameliorates severe acute pancreatitis through modulating macrophage M1 and M2 polarization by targeting the TGFbetaR1/SMAD-2 pathway. Int Immunopharmacol 108:108777
Article CAS PubMed Google Scholar
Guo J, Tang X, Deng P, Hui H, Chen B, An J, Zhang G, Shi K, Wang J, He Y, Hao D, Yang H (2024) Interleukin-4 from curcumin-activated OECs emerges as a central modulator for increasing M2 polarization of microglia/macrophage in OEC anti-inflammatory activity for functional repair of spinal cord injury. Cell Commun Signal 22:162
Article CAS PubMed PubMed Central Google Scholar
He Y, Yao X, Taylor N, Bai Y, Lovenberg T, Bhattacharya A (2018) RNA sequencing analysis reveals quiescent microglia isolation methods from postnatal mouse brains and limitations of BV2 cells. J Neuroinflammation 15:153
Article PubMed PubMed Central Google Scholar
Hu X, Du L, Liu S, Lan Z, Zang K, Feng J, Zhao Y, Yang X, Xie Z, Wang PL, Ver Heul AM, Chen L, Samineni VK, Wang YQ, Lavine KJ, Gereau RWt, Wu GF, Hu H (2023) A TRPV4-dependent neuroimmune axis in the spinal cord promotes neuropathic pain. J Clin Invest 133. https://doi.org/10.1172/JCI161507
Inoue K, Tsuda M (2018) Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential. Nat Rev Neurosci 19:138–152
Article CAS PubMed Google Scholar
Jiang BC, Ding TY, Guo CY, Bai XH, Cao DL, Wu XB, Sha WL, Jiang M, Wu LJ, Gao YJ (2022) NFAT1 orchestrates spinal microglial transcription and promotes microglial proliferation via c-MYC contributing to nerve Injury-Induced Neuropathic Pain. Adv Sci (Weinh) 9:e2201300
Kohno K, Shirasaka R, Yoshihara K, Mikuriya S, Tanaka K, Takanami K, Inoue K, Sakamoto H, Ohkawa Y, Masuda T, Tsuda M (2022) A spinal microglia population involved in remitting and relapsing neuropathic pain. Science 376:86–90
Article CAS PubMed Google Scholar
Lai LYS, Gracie NP, Gowripalan A, Howell LM, Newsome TP (2022) SMAD proteins: mediators of diverse outcomes during infection. Eur J Cell Biol 101:151204
Article CAS PubMed Google Scholar
Li W, Wang W, Liu L, Qu R, Chen X, Qiu C, Li J, Hayball J, Liu L, Chen J, Wang X, Pan X, Zhao Y (2019) GDF11 antagonizes TNF-alpha-induced inflammation and protects against the development of inflammatory arthritis in mice. FASEB J 33:3317–3329
Article CAS PubMed Google Scholar
Li H, Wang P, Tang L, Sun J, Zhang Y, Luo W, Luo C, Hu Z, Yang L (2021) Distinct Polarization Dynamics of Microglia and infiltrating macrophages: a novel mechanism of spinal cord Ischemia/Reperfusion Injury. J Inflamm Res 14:5227–5239
Article CAS PubMed PubMed Central Google Scholar
Li J, Wei Y, Zhou J, Zou H, Ma L, Liu C, Xiao Z, Liu X, Tan X, Yu T, Cao S (2022) Activation of locus coeruleus-spinal cord noradrenergic neurons alleviates neuropathic pain in mice via reducing neuroinflammation from astrocytes and microglia in spinal dorsal horn. J Neuroinflammation 19:123
Article CAS PubMed PubMed Central Google Scholar
Li X, Shi H, Zhang D, Jing B, Chen Z, Zheng Y, Chang S, Gao L, Zhao G (2023) Paeonol alleviates neuropathic pain by modulating microglial M1 and M2 polarization via the RhoA/p38MAPK signaling pathway. CNS Neurosci Ther 29:2666–2679
Article CAS PubMed PubMed Central Google Scholar
Li F, Sun X, Sun K, Kong F, Jiang X, Kong Q (2024) Lupenone improves motor dysfunction in spinal cord injury mice through inhibiting the inflammasome activation and pyroptosis in microglia via the nuclear factor kappa B pathway. Neural Regeneration Res 19:1802–1811
Liu Q, Zhang Y, Liu S, Liu Y, Yang X, Liu G, Shimizu T, Ikenaka K, Fan K, Ma J (2019) Cathepsin C promotes microglia M1 polarization and aggravates neuroinflammation via activation of ca(2+)-dependent PKC/p38MAPK/NF-kappaB pathway. J Neuroinflammation 16:10
Article PubMed PubMed Central Google Scholar
Liu W, Rong Y, Wang J, Zhou Z, Ge X, Ji C, Jiang D, Gong F, Li L, Chen J, Zhao S, Kong F, Gu C, Fan J, Cai W (2020) Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 polarization. J Neuroinflammation 17:47
Article CAS PubMed PubMed Central Google Scholar
Long Y, Li XQ, Deng J, Ye QB, Li D, Ma Y, Wu YY, Hu Y, He XF, Wen J, Shi A, Yu S, Shen L, Ye Z, Zheng C, Li N (2024) Modulating the polarization phenotype of microglia - a valuable strategy for central nervous system diseases. Ageing Res Rev 93:102160
Lu B, Zhong J, Pan J, Yuan X, Ren M, Jiang L, Yang Y, Zhang G, Liu D, Zhang C (2019) Gdf11 gene transfer prevents high fat diet-induced obesity and improves metabolic homeostasis in obese and STZ-induced diabetic mice. J Translational Med 17. https://doi.org/10.1186/s12967-019-02166-1
Machelak W, Szczepaniak A, Jacenik D, Zielinska M (2023) The role of GDF11 during inflammation - an overview. Life Sci 322:121650
Article CAS PubMed Google Scholar
Mai CL, Tan Z, Xu YN, Zhang JJ, Huang ZH, Wang D, Zhang H, Gui WS, Zhang J, Lin ZJ, Meng YT, Wei X, Jie YT, Grace PM, Wu LJ, Zhou LJ, Liu XG (2021) CXCL12-mediated monocyte transmigration into brain perivascular space leads to neuroinflammation and memory deficit in neuropathic pain. Theranostics 11:1059–1078
Article CAS PubMed PubMed Central Google Scholar
Mei W, Zhu B, Shu Y, Liang Y, Lin M, He M, Luo H, Ye J (2021) GDF11 protects against glucotoxicity-induced mice retinal microvascular endothelial cell dysfunction and diabetic retinopathy disease. Mol Cell Endocrinol 537. https://doi.org/10.1016/j.mce.2021.111422
Moigneu C, Abdellaoui S, Ramos-Brossier M, Pfaffenseller B, Wollenhaupt-Aguiar B, de Azevedo Cardoso T, Camus C, Chiche A, Kuperwasser N, Azevedo da Silva R, Pedrotti Moreira F, Li H, Oury F, Kapczinski F, Lledo PM, Katsimpardi L (2023) Systemic GDF11 attenuates depression-like phenotype in aged mice via stimulation of neuronal autophagy. Nat Aging 3:213–228
Article CAS PubMed PubMed Central Google Scholar
Orhurhu MS, Chu R, Claus L, Roberts J, Salisu B, Urits I, Orhurhu E, Viswanath O, Kaye AD, Kaye AJ, Orhurhu V (2020) Neuropathic Pain and Sickle Cell Disease: a review of Pharmacologic Management. Curr Pain Headache Rep 24:52
Peng J, Wang K, Xiang W, Li Y, Hao Y, Guan Y (2019) Rosiglitazone polarizes microglia and protects against pilocarpine-induced status epilepticus. CNS Neurosci Ther 25:1363–1372
Article CAS PubMed PubMed Central Google Scholar
Schmid AB, Tampin B, Baron R, Finnerup NB, Hansson P, Hietaharju A, Konstantinou K, Lin CC, Markman J, Price C, Smith BH, Slater H (2023) Recommendations for terminology and the identification of neuropathic pain in people with spine-related leg pain. Outcomes from the NeuPSIG working group. Pain 164:1693–1704
Article PubMed PubMed Central Google Scholar
Su HH, Yen JC, Liao JM, Wang YH, Liu PH, MacDonald IJ, Tsai CF, Chen YH, Huang SS (2021) In situ slow-release recombinant growth differentiation factor 11 exhibits therapeutic efficacy in ischemic stroke. Biomed Pharmacother 144:112290
Article CAS PubMed Google Scholar
Tozaki-Saitoh H, Tsuda M (2019) Microglia-neuron interactions in the models of neuropathic pain. Biochem Pharmacol 169:113614
Comments (0)