Barbier P, Zejneli O, Martinho M, Lasorsa A, Belle V, Smet-Nocca C, Tsvetkov PO, Devred F, Landrieu I (2019) Role of Tau as a Microtubule-Associated protein: structural and functional aspects. Front Aging Neurosci 11:204
Article CAS PubMed PubMed Central Google Scholar
Bartolome F, Carro E, Alquezar C (2022) Oxidative stress in Tauopathies: from cause to Therapy. Antioxid (Basel) 11:1421
Bayer TA (2015) Proteinopathies, a core concept for understanding and ultimately treating degenerative disorders? Eur Neuropsychopharmacol 25:713–724
Article CAS PubMed Google Scholar
Bjorklund G, Aaseth J, Dadar M, Chirumbolo S (2019) Molecular targets in Alzheimer’s Disease. Mol Neurobiol 56:7032–7044
Boban M, Babić Leko M, Miškić T, Hof PR, Šimić G (2019) Human neuroblastoma SH-SY5Y cells treated with okadaic acid express phosphorylated high molecular weight tau-immunoreactive protein species. J Neurosci Methods 319:60–68
Article CAS PubMed Google Scholar
Chang HY, Sang TK, Chiang AS (2018) Untangling the Tauopathy for Alzheimer’s disease and parkinsonism. J Biomed Sci 25:54
Article PubMed PubMed Central Google Scholar
Chen Y, Yu Y (2023) Tau and neuroinflammation in Alzheimer’s disease: interplay mechanisms and clinical translation. J Neuroinflamm 20:165
Clavaguera F, Bolmont T, Crowther RA, Abramowski D, Frank S, Probst A, Fraser G, Stalder AK, Beibel M, Staufenbiel M, Jucker M, Goedert M, Tolnay M (2009) Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol 11:909–913
Article CAS PubMed PubMed Central Google Scholar
Cummings JL, Gonzalez MI, Pritchard MC, May PC, Toledo-Sherman LM, Harris GA (2023) The therapeutic landscape of tauopathies: challenges and prospects. Alzheimers Res Ther 15:168
Article PubMed PubMed Central Google Scholar
del Barrio L, Martín-de-Saavedra MD, Romero A, Parada E, Egea J, Avila J, McIntosh JM, Wonnacott S, López MG (2011) Neurotoxicity Induced by Okadaic Acid in the Human Neuroblastoma SH-SY5Y line can be differentially prevented by α7 and β2* nicotinic stimulation. Toxicol Sci 123:193–205
Eo H, Lee S, Kim SH, Ju IG, Huh E, Lim J, Park S, Oh MS (2022) Petasites japonicus leaf extract inhibits Alzheimer’s-like pathology through suppression of neuroinflammation. Food Funct 13:10811–10822
Article CAS PubMed Google Scholar
Eo H, Kim JH, Im H, Ju IG, Huh E, Pun R, Shin D, Lim Y, Oh MS (2024) 6-Shogaol attenuates natural aging-induced locomotive and cognitive declines through suppression of p75 neurotrophin receptor in vivo. J Funct Foods 113:106025
Gao YL, Wang N, Sun FR, Cao XP, Zhang W, Yu JT (2018) Tau in neurodegenerative disease. Ann Transl Med 6:175
Article PubMed PubMed Central Google Scholar
Giraldo E, Lloret A, Fuchsberger T, Viña J (2014) Aβ and tau toxicities in Alzheimer’s are linked via oxidative stress-induced p38 activation: protective role of vitamin E. Redox Biol 2:873–877
Article CAS PubMed PubMed Central Google Scholar
Glenner GG, Wong CW (1984) Alzheimer’s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 120:885–890
Article CAS PubMed Google Scholar
Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI (1986) Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci U S A 83:4913–4917
Article CAS PubMed PubMed Central Google Scholar
Ju IG, Son SY, Lee S, Im H, Huh E, Eo H, Choi JG, Sohn MW, Yim SV, Kim SY, Kim DH, Lee CH, Oh MS (2023) Protective effects of CCL01 against Abeta-induced neurotoxicity in 5xFAD transgenic mouse model of Alzheimer’s disease. Biomed Pharmacother 158:114105
Article CAS PubMed Google Scholar
Lee JM, Lee JH, Song MK, Kim YJ (2022) NXP032 ameliorates Aging-Induced oxidative stress and cognitive impairment in mice through activation of Nrf2 Signaling. Antioxid (Basel) 11:130
Lee JM, Lee JH, Kim SH, Sim TH, Kim YJ (2023) NXP032 ameliorates cognitive impairment by alleviating the neurovascular aging process in aged mouse brain. Sci Rep 13:8594
Article CAS PubMed PubMed Central Google Scholar
Li X, Feng X, Sun X, Hou N, Han F, Liu Y (2022) Global, regional, and national burden of Alzheimer’s disease and other dementias, 1990–2019. Frontiers in Aging Neuroscience 14
Medeiros R, Baglietto-Vargas D, LaFerla FM (2011) The role of tau in Alzheimer’s disease and related disorders. CNS Neurosci Ther 17:514–524
Article CAS PubMed Google Scholar
Metaxas A, Kempf SJ (2016) Neurofibrillary tangles in Alzheimer’s disease: elucidation of the molecular mechanism by immunohistochemistry and tau protein phospho-proteomics. Neural Regen Res 11:1579–1581
Article CAS PubMed PubMed Central Google Scholar
Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM (2003) Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles: Intracellular Aβ and Synaptic Dysfunction. Neuron 39:409–421
Qiu C, Kivipelto M, von Strauss E (2009) Epidemiology of Alzheimer’s disease: occurrence, determinants, and strategies toward intervention. Dialogues Clin Neurosci 11:111–128
Article PubMed PubMed Central Google Scholar
Salcedo-Tello P, Ortiz-Matamoros A, Arias C (2011) GSK3 function in the brain during development, neuronal plasticity, and Neurodegeneration. Int J Alzheimers Dis 2011:189728
Article PubMed PubMed Central Google Scholar
Takeuchi H, Iba M, Inoue H, Higuchi M, Takao K, Tsukita K, Karatsu Y, Iwamoto Y, Miyakawa T, Suhara T, Trojanowski JQ, Lee VM, Takahashi R (2011) P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating. PLoS ONE 6:e21050
Article CAS PubMed PubMed Central Google Scholar
Walsh DM, Selkoe DJ (2004) Deciphering the molecular basis of memory failure in Alzheimer’s disease. Neuron 44:181–193
Article CAS PubMed Google Scholar
Xu F, He B, Xiao F, Yan T, Bi K, Jia Y, Wang Z (2019) Neuroprotective effects of Spinosin on Recovery of Learning and Memory in a mouse model of Alzheimer’s Disease. Biomol Ther (Seoul) 27:71–77
Article CAS PubMed Google Scholar
Yoshiyama Y, Higuchi M, Zhang B, Huang S-M, Iwata N, Saido Takaomi C, Maeda J, Suhara T, Trojanowski JQ, Lee VMY (2007) Synapse loss and Microglial Activation Precede tangles in a P301S Tauopathy Mouse Model. Neuron 53:337–351
Comments (0)