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Editorial Expression of Concern: DCAF12 promotes apoptosis and inhibits NF-κB activation by acting as an endogenous antagonist of IAPs
The Editors-in-Chief are issuing this Editorial Expression of Concern to alert readers that concerns have been raised abou...
Lack of dominant-negative activity for tumor-related ZNRF3 missense mutations at endogenous levels
Lack of dominant-negative activity for tumor-related ZNRF3 missense mutations at endogenous levels
ZNRF3, a negative regulator of β-catenin signaling, removes Wnt receptors from the membrane. Currently, it is unknown...
Identification of novel germline mutations in FUT7 and EXT1 linked with hereditary multiple exostoses
Identification of novel germline mutations in FUT7 and EXT1 linked with hereditary multiple exostoses
Hereditary multiple exostoses (HME) is an autosomal dominant skeletal disorder primarily linked with mutations in Exostosi...
Mitochondrial unfolded protein response-dependent β-catenin signaling promotes neuroendocrine prostate cancer
Mitochondrial unfolded protein response-dependent β-catenin signaling promotes neuroendocrine prostate cancer
The mitochondrial unfolded protein response (UPRmt) maintains mitochondrial quality control and proteostasis under stress ...
PRMT5-regulated splicing of DNA repair genes drives chemoresistance in breast cancer stem cells
PRMT5-regulated splicing of DNA repair genes drives chemoresistance in breast cancer stem cells
Breast cancer stem cells (BCSCs) are a rare cell population that is responsible for tumour initiation, metastasis and chem...
A TBX2-driven signaling switch from androgen receptor to glucocorticoid receptor confers therapeutic resistance in prostate cancer
A TBX2-driven signaling switch from androgen receptor to glucocorticoid receptor confers therapeutic resistance in prostate cancer
Recent studies suggest that glucocorticoid receptor (GR) activation can cause enzalutamide resistance in advanced prostate...
CBL0137 and NKG2A blockade: a novel immuno-oncology combination therapy for Myc-overexpressing triple-negative breast cancers
CBL0137 and NKG2A blockade: a novel immuno-oncology combination therapy for Myc-overexpressing triple-negative breast cancers
The MYC proto-oncogene is upregulated in >60% of triple-negative breast cancers (TNBCs), it can directly promote tu...
Mevalonate kinase inhibits anti-tumor immunity by impairing the tumor cell-intrinsic interferon response in microsatellite instability colorectal cancer
Mevalonate kinase inhibits anti-tumor immunity by impairing the tumor cell-intrinsic interferon response in microsatellite instability colorectal cancer
Insufficient tumor cell-intrinsic interferon response represents a major obstacle in immune checkpoint blockade (ICB) ther...
MYC upstream region orchestrates resistance to PI3K inhibitors in cancer cells through FOXO3a-mediated autophagic adaptation
MYC upstream region orchestrates resistance to PI3K inhibitors in cancer cells through FOXO3a-mediated autophagic adaptation
The MYC oncogene is frequently overexpressed in tumors and inhibition of its translation is considered an attractive thera...
Enhanced anti-cancer efficacy of arginine deaminase expressed by tumor-seeking Salmonella Gallinarum
Enhanced anti-cancer efficacy of arginine deaminase expressed by tumor-seeking Salmonella Gallinarum
Amino acid deprivation, particularly of nonessential amino acids that can be synthesized by normal cells but not by cancer...
Characterisation of APOBEC3B-Mediated RNA editing in breast cancer cells reveals regulatory roles of NEAT1 and MALAT1 lncRNAs
Characterisation of APOBEC3B-Mediated RNA editing in breast cancer cells reveals regulatory roles of NEAT1 and MALAT1 lncRNAs
RNA editing is a crucial post-transcriptional process that influences gene expression and increases the diversity of the p...
Correction: Targeting MERTK on tumour cells and macrophages: a potential intervention for sporadic and NF2-related meningioma and schwannoma tumours
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 ...
Insight into mammary gland development and tumor progression in an E2F5 conditional knockout mouse model
Insight into mammary gland development and tumor progression in an E2F5 conditional knockout mouse model
Development of breast cancer is linked to altered regulation of mammary gland developmental processes. A better understand...
Hypoxic stabilization of RIPOR3 mRNA via METTL3-mediated m6A methylation drives breast cancer progression and metastasis
Hypoxic stabilization of RIPOR3 mRNA via METTL3-mediated m6A methylation drives breast cancer progression and metastasis
Dysregulated N6-methyladenosine (m6A) modification has been associated with breast cancer pathogenesis. Hypoxia which char...
Targeting CircAURKA prevents colorectal cancer progression via enhancing CTNNB1 protein degradation
Targeting CircAURKA prevents colorectal cancer progression via enhancing CTNNB1 protein degradation
Tumor progression of colorectal cancer (CRC) seriously affects patient prognosis. For CRC patients with advanced-stage dis...
USP36 promotes colorectal cancer progression through inhibition of p53 signaling pathway via stabilizing RBM28
USP36 promotes colorectal cancer progression through inhibition of p53 signaling pathway via stabilizing RBM28
Colorectal cancer (CRC) stands as the second most common cause of cancer-related mortality globally and p53, a widely reco...
E7-mediated repression of miR-203 promotes LASP1-dependent proliferation in HPV-positive cervical cancer
E7-mediated repression of miR-203 promotes LASP1-dependent proliferation in HPV-positive cervical cancer
Human papillomaviruses (HPV) are a major cause of malignancy, contributing to ~5% of all human cancers worldwide, includin...
Molecular mechanisms of non-genetic aberrant peptide production in cancer
Molecular mechanisms of non-genetic aberrant peptide production in cancer
The cancer peptidome has long been known to be altered by genetic mutations. However, more recently, non-genetic polypepti...
Bone-metastatic lung adenocarcinoma cells bearing CD74-ROS1 fusion interact with macrophages to promote their dissemination
Bone-metastatic lung adenocarcinoma cells bearing CD74-ROS1 fusion interact with macrophages to promote their dissemination
Approximately 40% of patients with lung adenocarcinoma (LUAD) often develop bone metastases during the course of their dis...
MUC1-C regulates NEAT1 lncRNA expression and paraspeckle formation in cancer progression
MUC1-C regulates NEAT1 lncRNA expression and paraspeckle formation in cancer progression
The MUC1 gene evolved in mammals for adaptation of barrier tissues in response to infections and damage. Paraspeckles are ...
Trans-activating mutations of the pseudokinase ERBB3
Trans-activating mutations of the pseudokinase ERBB3
Genetic changes in the ERBB family of receptor tyrosine kinases serve as oncogenic driver events and predictive biomarkers...
Antitumor activity of Z15-0-2, a bispecific nanobody targeting PD-1 and CTLA-4
Antitumor activity of Z15-0-2, a bispecific nanobody targeting PD-1 and CTLA-4
The combination of programmed cell death protein 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) antibodies has pot...
Correction: Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers
Correction: Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
DRAIC mediates hnRNPA2B1 stability and m6A-modified IGF1R instability to inhibit tumor progression
DRAIC mediates hnRNPA2B1 stability and m6A-modified IGF1R instability to inhibit tumor progression
Type 1 insulin-like growth factor receptor (IGF1R) plays an important role in cancer, however, posttranscriptional regulat...
Correction: Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells
Correction: Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells
Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USAShoumin Zhu, Mohammed Soutto, Zheng Ch...
ROS production by mitochondria: function or dysfunction?
ROS production by mitochondria: function or dysfunction?
In eukaryotic cells, ATP generation is generally viewed as the primary function of mitochondria under normoxic conditions....
The nerve cells in gastrointestinal cancers: from molecular mechanisms to clinical intervention
The nerve cells in gastrointestinal cancers: from molecular mechanisms to clinical intervention
Gastrointestinal (GI) cancer is a formidable malignancy with significant morbidity and mortality rates. Recent studies hav...
ERK hyperactivation serves as a unified mechanism of escape in intrinsic and acquired CDK4/6 inhibitor resistance in acral lentiginous melanoma
ERK hyperactivation serves as a unified mechanism of escape in intrinsic and acquired CDK4/6 inhibitor resistance in acral lentiginous melanoma
Patients with metastatic acral lentiginous melanoma (ALM) suffer worse outcomes relative to patients with other forms of c...
FOXO3a-regulated arginine metabolic plasticity adaptively promotes esophageal cancer proliferation and metastasis
FOXO3a-regulated arginine metabolic plasticity adaptively promotes esophageal cancer proliferation and metastasis
Esophageal squamous cell carcinoma (ESCC) is a common malignant tumor with a poor prognosis due to a lack of early detecti...
MYCN and SNRPD3 cooperate to maintain a balance of alternative splicing events that drives neuroblastoma progression
MYCN and SNRPD3 cooperate to maintain a balance of alternative splicing events that drives neuroblastoma progression
Many of the pro-tumorigenic functions of the oncogene MYCN are attributed to its regulation of global gene expression prog...
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