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The application of organoids in investigating immune evasion in the microenvironment of gastric cancer and screening novel drug candidates
The application of organoids in investigating immune evasion in the microenvironment of gastric cancer and screening novel drug candidates
Gastric cancer (GC) is a prevalent digestive system tumor, the fifth most diagnosed cancer worldwide, and a leading cause ...
Epigenomic disorder and partial EMT impair luminal progenitor integrity in Brca1-associated breast tumorigenesis
Epigenomic disorder and partial EMT impair luminal progenitor integrity in Brca1-associated breast tumorigenesis
In breast cancer related to the BRCA1 mutation, luminal progenitor cells are believed to be the cells of origin, yet how t...
Strategies to overcome tumour relapse caused by antigen escape after CAR T therapy
Strategies to overcome tumour relapse caused by antigen escape after CAR T therapy
Chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of B cell and plasma cell malignancies, an...
Multi‑omics analysis identifies different molecular subtypes with unique outcomes in early-stage poorly differentiated lung adenocarcinoma
Multi‑omics analysis identifies different molecular subtypes with unique outcomes in early-stage poorly differentiated lung adenocarcinoma
Early-stage poorly differentiated lung adenocarcinoma (LUAD) is plagued by a high risk of postoperative recurrence, and it...
Therapy-induced senescence is a transient drug resistance mechanism in breast cancer
Therapy-induced senescence is a transient drug resistance mechanism in breast cancer
Therapy-induced senescence (TIS) is considered a permanent cell cycle arrest following DNA-damaging treatments; however, i...
Variability in non-tumor areas of colorectal cancer patients as revealed by endoscopic intestinal step biopsies
Variability in non-tumor areas of colorectal cancer patients as revealed by endoscopic intestinal step biopsies
A comprehensive endoscopic small and large intestinal untargeted step biopsy procedure was conducted to compare gene expre...
Regulatory T cells in immune checkpoint blockade antitumor therapy
Regulatory T cells in immune checkpoint blockade antitumor therapy
Regulatory T cells (Tregs), an essential component of the human immune system, are a heterogeneous group of T lymphocytes ...
Traditional Chinese medicine in treating upper digestive tract cancers
Traditional Chinese medicine in treating upper digestive tract cancers
Upper digestive tract cancers, such as oral cavity, laryngeal, esophageal, and gastric cancers, account for 10% of cancer ...
The PI3K-AKT-mTOR axis persists as a therapeutic dependency in KRASG12D-driven non-small cell lung cancer
The PI3K-AKT-mTOR axis persists as a therapeutic dependency in KRASG12D-driven non-small cell lung cancer
KRASG12C and KRASG12D inhibitors represent a major translational breakthrough for non-small cell lung cancer (NSCLC) and c...
Cellular mechanisms of combining innate immunity activation with PD-1/PD-L1 blockade in treatment of colorectal cancer
Cellular mechanisms of combining innate immunity activation with PD-1/PD-L1 blockade in treatment of colorectal cancer
PD-1/PD-L1 blockade therapies have displayed extraordinary clinical efficacy for melanoma, renal, bladder and lung cancer;...
Circular RNA ACVR2A promotes the progression of hepatocellular carcinoma through mir-511-5p targeting PI3K-Akt signaling pathway
Circular RNA ACVR2A promotes the progression of hepatocellular carcinoma through mir-511-5p targeting PI3K-Akt signaling pathway
Circular RNA (circRNA) is thought to mediate the occurrence and development of human cancer and usually acts as a tiny RNA...
Essential gene screening identifies the bromodomain-containing protein BRPF1 as a new actionable target for endocrine therapy-resistant breast cancers
Essential gene screening identifies the bromodomain-containing protein BRPF1 as a new actionable target for endocrine therapy-resistant breast cancers
Identifying master epigenetic factors controlling proliferation and survival of cancer cells allows to discover new molecu...
Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation
Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation
Cellular senescence frequently occurs during anti-cancer treatment, and persistent senescent tumor cells (STCs) unfavorabl...
Functional CRISPR screens in T cells reveal new opportunities for cancer immunotherapies
Functional CRISPR screens in T cells reveal new opportunities for cancer immunotherapies
T cells are fundamental components in tumour immunity and cancer immunotherapies, which have made immense strides and revo...
Cancer immunometabolism: advent, challenges, and perspective
Cancer immunometabolism: advent, challenges, and perspective
For decades, great strides have been made in the field of immunometabolism. A plethora of evidence ranging from basic mech...
Tertiary lymphoid structural heterogeneity determines tumour immunity and prospects for clinical application
Tertiary lymphoid structural heterogeneity determines tumour immunity and prospects for clinical application
Tertiary lymphoid structures (TLS) are clusters of immune cells that resemble and function similarly to secondary lymphoid...
Loss of lncRNA LINC01056 leads to sorafenib resistance in HCC
Loss of lncRNA LINC01056 leads to sorafenib resistance in HCC
Sorafenib is a major nonsurgical option for patients with advanced hepatocellular carcinoma (HCC); however, its clinical e...
Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies
Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies
Autophagy is an essential cellular homeostasis pathway initiated by multiple stimuli ranging from nutrient deprivation to ...
Safety and efficacy of a novel anti-CD19 chimeric antigen receptor T cell product targeting a membrane-proximal domain of CD19 with fast on- and off-rates against non-Hodgkin lymphoma: a first-in-human study
Safety and efficacy of a novel anti-CD19 chimeric antigen receptor T cell product targeting a membrane-proximal domain of CD19 with fast on- and off-rates against non-Hodgkin lymphoma: a first-in-human study
Commercial anti-CD19 chimeric antigen receptor T-cell therapies (CART19) are efficacious against advanced B-cell non-Hodgk...
Effects of RNA methylation on Tumor angiogenesis and cancer progression
Effects of RNA methylation on Tumor angiogenesis and cancer progression
Tumor angiogenesis plays vital roles in the growth and metastasis of cancer. RNA methylation is one of the most common mod...
A liquid biopsy signature of circulating extracellular vesicles-derived RNAs predicts response to first line chemotherapy in patients with metastatic colorectal cancer
A liquid biopsy signature of circulating extracellular vesicles-derived RNAs predicts response to first line chemotherapy in patients with metastatic colorectal cancer
Colorectal cancer (CRC) is one of the most threatening tumors in the world, and chemotherapy remains dominant in the treat...
Targeting MHC-I molecules for cancer: function, mechanism, and therapeutic prospects
Targeting MHC-I molecules for cancer: function, mechanism, and therapeutic prospects
The molecules of Major histocompatibility class I (MHC-I) load peptides and present them on the cell surface, which provid...
Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia
Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia
Pharmacologic targeting of chromatin-associated protein complexes has shown significant responses in KMT2A-rearranged (KMT...
hsa_circ_0007919 induces LIG1 transcription by binding to FOXA1/TET1 to enhance the DNA damage response and promote gemcitabine resistance in pancreatic ductal adenocarcinoma
hsa_circ_0007919 induces LIG1 transcription by binding to FOXA1/TET1 to enhance the DNA damage response and promote gemcitabine resistance in pancreatic ductal adenocarcinoma
Circular RNAs (circRNAs) play important roles in the occurrence and development of cancer and chemoresistance. DNA damage ...
Significant CircRNAs in liver cancer stem cell exosomes: mediator of malignant propagation in liver cancer?
Significant CircRNAs in liver cancer stem cell exosomes: mediator of malignant propagation in liver cancer?
Hepatocellular carcinoma (HCC), one of the most prevalent forms of cancer worldwide, presents a significant global healthc...
The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis
The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis
Current research has demonstrated that extracellular vesicles (EVs) and circulating tumor cells (CTCs) are very closely re...
Immunosignatures associated with TP53 status and co-mutations classify prognostically head and neck cancer patients
Immunosignatures associated with TP53 status and co-mutations classify prognostically head and neck cancer patients
Immune checkpoint inhibitors (ICIs) are a therapeutic strategy for various cancers although only a subset of patients resp...
A bispecific Clec9A-PD-L1 targeted type I interferon profoundly reshapes the tumor microenvironment towards an antitumor state
A bispecific Clec9A-PD-L1 targeted type I interferon profoundly reshapes the tumor microenvironment towards an antitumor state
Despite major improvements in immunotherapeutic strategies, the immunosuppressive tumor microenvironment remains a major o...
Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors
Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors
Triple-negative breast cancer (TNBC) is an aggressive subtype that exhibits a high incidence of distant metastases and lac...
The University of Kansas Cancer Center (KUCC), an NCI designated comprehensive cancer center
The University of Kansas Cancer Center (KUCC), an NCI designated comprehensive cancer center
With world-class, transdisciplinary, expertise and technical capabilities in drug discovery and cellular immunotherapeutic...
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