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The heat of the battle: inflammation’s role in prostate cancer development and inflammation-targeted therapies
The heat of the battle: inflammation’s role in prostate cancer development and inflammation-targeted therapies
In prostate cancer (PC), chronic inflammation silently guides disease progression, playing a significant role. As a major ...
Comparative transcriptomic analysis of primary endometrial cancer and bone metastatic cancer: metastasis-associated genes and abnormal cell cycle regulation
Comparative transcriptomic analysis of primary endometrial cancer and bone metastatic cancer: metastasis-associated genes and abnormal cell cycle regulation
Endometrial cancer (EC) is the most common tumor of the female reproductive system. Its incidence is rising worldwide. Bon...
New insights into Notch signaling as a crucial pathway of pancreatic cancer stem cell behavior by chrysin-polylactic acid-based nanocomposite
New insights into Notch signaling as a crucial pathway of pancreatic cancer stem cell behavior by chrysin-polylactic acid-based nanocomposite
Pancreatic cancer is an extremely deadly illness for which there are few reliable treatments. Recent research indicates th...
Analysing DNA methylation and transcriptomic signatures to predict prostate cancer recurrence risk
Analysing DNA methylation and transcriptomic signatures to predict prostate cancer recurrence risk
Prostate cancer (PCa) remains a significant global health challenge, with approximately 1.6 million new cases and 366,000 ...
Development of a prognostic model based on four genes related to exhausted CD8+ T cell in triple-negative breast cancer patients: a comprehensive analysis integrating scRNA-seq and bulk RNA-seq
Development of a prognostic model based on four genes related to exhausted CD8+ T cell in triple-negative breast cancer patients: a comprehensive analysis integrating scRNA-seq and bulk RNA-seq
Low immune infiltration is closely associated with poor clinical results and an unfavorable response to therapy in triple-...
Prognostic value of FCER1G expression and M2 macrophage infiltration in esophageal squamous cell carcinoma
Prognostic value of FCER1G expression and M2 macrophage infiltration in esophageal squamous cell carcinoma
FCER1G as an immune-associated protein, which belongs to the immunoglobulin superfamily and is involved in mediat...
Unraveling the heterogeneity of WHO grade 4 gliomas: insights from clinical, imaging, and molecular characterization
Unraveling the heterogeneity of WHO grade 4 gliomas: insights from clinical, imaging, and molecular characterization
The 2021 WHO classification of central nervous system tumors introduced molecular criteria to stratify Grade 4 gliomas, wh...
Evolving prognostic paradigms in lung adenocarcinoma with brain metastases: a web-based predictive model enhanced by machine learning
Evolving prognostic paradigms in lung adenocarcinoma with brain metastases: a web-based predictive model enhanced by machine learning
Patients with lung adenocarcinoma (LUAD) who develop brain metastases (BM) face significantly poor prognoses. A well-craft...
Integrative prognostic modeling of ovarian cancer: incorporating genetic, clinical, and immunological markers
Integrative prognostic modeling of ovarian cancer: incorporating genetic, clinical, and immunological markers
Ovarian cancer has a high mortality rate, primarily due to late diagnosis and complex pathogenesis. This study develops an...
Key oncogenes and candidate drugs for hepatitis-B-driven hepatocellular carcinoma progression
Key oncogenes and candidate drugs for hepatitis-B-driven hepatocellular carcinoma progression
This study aimed to uncover the key hepatitis-B (HB)-related liver cancer (LC) promoting genes, and clarity their interrel...
Cancer-associated fibroblast-derived COL17A1 promotes gemcitabine resistance and tumorigenesis in pancreatic cancer cells by interacting with ACTN4
Cancer-associated fibroblast-derived COL17A1 promotes gemcitabine resistance and tumorigenesis in pancreatic cancer cells by interacting with ACTN4
Cancer-associated fibroblasts (CAFs) are key components of tumor microenvironment and have been identified to be involved ...
Circadian rhythm related genes signature in glioma for drug resistance prediction: a comprehensive analysis integrating transcriptomics and machine learning
Circadian rhythm related genes signature in glioma for drug resistance prediction: a comprehensive analysis integrating transcriptomics and machine learning
Gliomas, 24% of all primary brain tumors, have diverse histology and poor survival rates, with about 70% recurring due to ...
Causal associations between dietary habits and liver cancer risk: a two-sample Mendelian randomization study
Causal associations between dietary habits and liver cancer risk: a two-sample Mendelian randomization study
Liver cancer is among the most prevalent cancers worldwide and is the second leading cause of cancer-related death. Epidem...
Harnessing nanoparticles for reshaping tumor immune microenvironment of hepatocellular carcinoma
Harnessing nanoparticles for reshaping tumor immune microenvironment of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most prevalent cancers, characterized by high morbidity and mortality rates. ...
SLC7A11 is a potential therapeutic target and prognostic biomarker correlated with immune cell infiltration in cervical cancer
SLC7A11 is a potential therapeutic target and prognostic biomarker correlated with immune cell infiltration in cervical cancer
SLC7A11 is importantly in both ferroptosis and disulfidptosis which participated in human development and homeostasis. By ...
Increased nuclear expression of DNA damage inducible transcript 4 can serve as a potential prognostic biomarker in patients with gliomas: a study based on data mining and experimental tools
Increased nuclear expression of DNA damage inducible transcript 4 can serve as a potential prognostic biomarker in patients with gliomas: a study based on data mining and experimental tools
DNA damage-inducible transcript 4 (DDIT4), induced under cellular stress conditions, has been implicated in malignancies d...
Long non-coding RNA involved in the carcinogenesis of human female cancer - a comprehensive review
Long non-coding RNA involved in the carcinogenesis of human female cancer - a comprehensive review
Recent years have seen an increase in our understanding of lncRNA and their role in various disease states. lncRNA molecul...
A new signature associated with anoikis predicts the outcome and immune infiltration in nasopharyngeal carcinoma
A new signature associated with anoikis predicts the outcome and immune infiltration in nasopharyngeal carcinoma
Previous studies have confirmed the phenomenon of anoikis resistance in nasopharyngeal carcinoma (NPC). Nevertheless, the ...
SPECC1 as a pan-cancer biomarker: unraveling its role in drug sensitivity and resistance mechanisms
SPECC1 as a pan-cancer biomarker: unraveling its role in drug sensitivity and resistance mechanisms
Previous studies have shown a relationship between SPECC1 and the prognosis of breast cancer, indicating a potential funct...
Keratin-15 high expression links with lymph node metastasis and poor survival prognosis in epithelial ovarian cancer patients
Keratin-15 high expression links with lymph node metastasis and poor survival prognosis in epithelial ovarian cancer patients
Keratin-15 (KRT15) involves in the progression and owns prognostic values in several solid cancers, whose clinical role in...
AURKA inhibition shows promise as a therapeutic strategy for ARID1A-mutant colorectal cancer
AURKA inhibition shows promise as a therapeutic strategy for ARID1A-mutant colorectal cancer
Mutations in ARID1A frequently occur in colorectal cancer (CRC) cells. However, there are currently no clinical treatment ...
MicroRNA-34a negatively regulates Netrin1 and mediates MEK/ERK pathway to regulate chemosensitivity of gastric cancer cells
MicroRNA-34a negatively regulates Netrin1 and mediates MEK/ERK pathway to regulate chemosensitivity of gastric cancer cells
To explore the mechanism of action of MicroRNAs-34a (miR-34a) and Eurite growth guiding factor 1 (Netrin1) in cisplatin re...
First reported advanced pancreatic cancer with hyperprogression treated with PD-1 blockade combined with chemotherapy: a case report and literature review
First reported advanced pancreatic cancer with hyperprogression treated with PD-1 blockade combined with chemotherapy: a case report and literature review
Pancreatic cancer is among the most immune-resistant tumor types due to its unique tumor microenvironment and low cancer i...
Title of the article: diagnostic markers for odontogenic tumors: an insight: a review
Title of the article: diagnostic markers for odontogenic tumors: an insight: a review
Odontogenic tumors are a group of tumors that originate from the tissues associated with tooth development and are classif...
The co-expression of Crohn’s disease and colon cancer network was analyzed by bioinformatics-CXCL1 tumour microenvironment and prognosis-related gene CXCL1
The co-expression of Crohn’s disease and colon cancer network was analyzed by bioinformatics-CXCL1 tumour microenvironment and prognosis-related gene CXCL1
This study aimed to investigate the molecular links and mechanisms between Crohn’s disease (CD) and colorectal cance...
Current insights and future directions of Li-Fraumeni syndrome
Current insights and future directions of Li-Fraumeni syndrome
Li-Fraumeni syndrome is a rare yet serious hereditary cancer predisposition syndrome, marked by a significant early-life i...
Advances in the role of membrane-bound transcription factors in carcinogenesis and therapy
Advances in the role of membrane-bound transcription factors in carcinogenesis and therapy
Protein shuttling between the cytoplasm and nucleus is a unique phenomenon in eukaryotic organisms, integral to various ce...
Reconstruction of cancer marker analysis with holistic anatomical precision implicates heterogeneity development during breast tumor progression
Reconstruction of cancer marker analysis with holistic anatomical precision implicates heterogeneity development during breast tumor progression
Biomarkers are not only of significant importance for cancer diagnosis and selection of treatment plans but also recently ...
Expression of CLDN1 and EGFR in PTC
Expression of CLDN1 and EGFR in PTC
Papillary thyroid carcinoma (PTC) involves complex genetic mechanisms, notably involving CLDN1 and EGFR. This study invest...
Comprehensive pan-cancer analysis of FUTs family as prognostic and immunity markers based on multi-omics data
Comprehensive pan-cancer analysis of FUTs family as prognostic and immunity markers based on multi-omics data
The dysregulation of fucosyltransferases (FUTs) contributes to alterations in fucosylated epitope expression, which serve ...
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