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Impact of immunological aging on T cell-mediated therapies in older adults with multiple myeloma and lymphoma
The aging immune systemImmunodeficiency, inflammaging, and immunobiographyAge-related changes are present in every organ s...
Integrating binding affinity and tonic signaling enables a rational CAR design for augmented T cell function
BackgroundThe disappointing failure of CAR T cell therapy in solid tumors is attributed to inefficient triggering of T cel...
Novel tri-specific T-cell engager targeting IL-13R{alpha}2 and EGFRvIII provides long-term survival in heterogeneous GBM challenge and promotes antitumor cytotoxicity with patient immune cells
IntroductionGlioblastoma multiforme (GBM) is the most prevalent and lethal form of primary brain cancer in adults, with ov...
Co-evolution of glioma and immune microenvironment
Gliomas are the most common malignant primary brain tumors in adults.1 Recent advances in genomic and molecular subtyping ...
Differential predictive value of resident memory CD8+T cell subpopulations in patients with non-small-cell lung cancer treated by immunotherapy
WHAT IS ALREADY KNOWN ON THIS TOPICA population of resident memory CD8+T lymphocytes (TRM), initially identified by the ma...
Natural lung-tropic TH9 cells: a sharp weapon for established lung metastases
BackgroundDue to the distinctive pulmonary microenvironment, the lungs are frequently identified as a primary site for met...
Durable antitumor response via an oncolytic virus encoding decoy-resistant IL-18
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYBackgroundCytokines produced by...
Mitochondrial metabolic reprogramming of macrophages and T cells enhances CD47 antibody-engineered oncolytic virus antitumor immunity
IntroductionOncolytic virotherapy is an effective tumor immunotherapy that enhances antitumor immune response by lysing tu...
Use of artificial intelligence chatbots in clinical management of immune-related adverse events
Artificial intelligence (AI) is progressing rapidly, with various new technologies emerging. Among these, AI chatbots have...
Targeting IL-33 reprograms the tumor microenvironment and potentiates antitumor response to anti-PD-L1 immunotherapy
IntroductionImmune checkpoint inhibitors (ICIs), especially those targeting programmed cell death protein 1 (PD-1) and the...
Non-invasive multimodal CT deep learning biomarker to predict pathological complete response of non-small cell lung cancer following neoadjuvant immunochemotherapy: a multicenter study
IntroductionLung cancer remains the most lethal malignancy worldwide, characterized by a substantial incidence and mortali...
Loss of Annexin A1 in macrophages restrains efferocytosis and remodels immune microenvironment in pancreatic cancer by activating the cGAS/STING pathway
IntroductionPancreatic cancer is a highly malignant disease that is primarily accounted for by pancreatic ductal adenocarc...
scRNA+ TCR-seq revealed dual TCR T cells antitumor response in the TME of NSCLC
The composition, characteristics and response effects of tumor-infiltrating T cell subsets in the tumor microenvironment (...
Immune isolation-enabled nanoencapsulation of donor T cells: a promising strategy for mitigating GVHD and treating AML in preclinical models
IntroductionAcute myeloid leukemia (AML), a malignancy stemming from alterations in myeloid hematopoietic stem cells, resu...
Durability of response to immune checkpoint blockade following treatment discontinuation and efficacy of rechallenge in advanced Merkel cell carcinoma
WHAT IS ALREADY KNOWN ON THIS TOPICPrior studies have observed that patients with advanced Merkel cell carcinoma (MCC) who...
MHC class I and II-deficient humanized mice are suitable tools to test the long-term antitumor efficacy of immune checkpoint inhibitors and T-cell engagers
IntroductionThe use of preclinical animal models remains a pivotal step in cancer immunotherapy development and is instrum...
Angiotensin receptor blocker attacks armored and cold tumors and boosts immune checkpoint blockade
BackgroundAs an emerging therapy for cancer, immune checkpoint blockade (ICB) has made remarkable achievements, but not al...
Intratumoral CXCL13+ CD160+ CD8+ T cells promote the formation of tertiary lymphoid structures to enhance the efficacy of immunotherapy in advanced gastric cancer
IntroductionGastric cancer is among the most prevalent malignancies worldwide, occupying the fifth position in terms of tu...
Endosialin-positive CAFs promote hepatocellular carcinoma progression by suppressing CD8+ T cell infiltration
IntroductionHepatocellular carcinoma (HCC) is the most common form of liver cancer and the third-leading cause of cancer m...
Jeffrey S Weber, MD, PhD (1952-2024): in memoriam to discovery, friendship and family
Jeffrey S Weber’s passing on 18 August 2024 brought forth a wave of emotions and fond memories for a colleague considered ...
Regression of renal cell carcinoma by T cell receptor-engineered T cells targeting a human endogenous retrovirus
WHAT IS ALREADY KNOWN ON THIS TOPICAdoptive transfer of TCR-engineered T cells is an emerging modality for cancer treatmen...
S100A9 and HMGB1 orchestrate MDSC-mediated immunosuppression in melanoma through TLR4 signaling
WHAT IS ALREADY KNOWN ON THIS TOPICImmunotherapies, particularly immune checkpoint inhibitors (ICI), have been pivotal in ...
Circumventing resistance within the Ewing sarcoma microenvironment by combinatorial innate immunotherapy
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYIntroductionEwing sarcoma (ES) ...
Spatial colocalization and combined survival benefit of natural killer and CD8 T cells despite profound MHC class I loss in non-small cell lung cancer
WHAT IS ALREADY KNOWN ON THIS TOPICMajor histocompatibility complex class I (MHC-I) loss occurs frequently in non-small ce...
Combining toll-like receptor agonists with immune checkpoint blockade affects antitumor vaccine efficacy
BackgroundToll-like receptors (TLRs) are evolutionarily conserved receptors, the largest constituents of the pattern recog...
CCR5 and CCL5 in metastatic colorectal cancer
The C-C motif chemokine receptor and ligand type 5 (CCR5 and CCL5, respectively) axis is a well-described pathway in immun...
Preliminary efficacy and safety of YSCH-01 in patients with advanced solid tumors: an investigator-initiated trial
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CD276 regulates the immune escape of esophageal squamous cell carcinoma through CXCL1-CXCR2 induced NETs
IntroductionEsophageal cancer (EC) is the ninth common cancer and the sixth leading cause of cancer-related mortality.1 2 ...
Gene network-based and ensemble modeling-based selection of tumor-associated antigens with a predicted low risk of tissue damage for targeted immunotherapy
BackgroundTargeted anti-cancer immunotherapy can be directed against neoantigens, arising somatically in an individual, or...
Stealth transgenes enable CAR-T cells to evade host immune responses
WHAT IS ALREADY KNOWN ON THIS TOPICThe immune system of patients develops specific anti-chimeric antigen receptor (CAR) re...
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