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Defining the transcriptional lineages of breast cancer subtypes
Defining the transcriptional lineages of breast cancer subtypes
In this work, we demonstrate the transcriptional networks that link breast cancer subtypes and their cells of origin, and ...
A 3D genome view of colon cancer initiation
A 3D genome view of colon cancer initiation
The early molecular events driving cancer initiation remain elusive, hampering prognostic accuracy. A comparative analysis...
Global loss of promoter–enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis
Global loss of promoter–enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis
Although three-dimensional (3D) genome architecture is crucial for gene regulation, its role in disease remains elusive. W...
Recapitulating the adenoma–carcinoma sequence by selection of four spontaneous oncogenic mutations in mismatch-repair-deficient human colon organoids
Recapitulating the adenoma–carcinoma sequence by selection of four spontaneous oncogenic mutations in mismatch-repair-deficient human colon organoids
Carcinogenesis results from the sequential acquisition of oncogenic mutations that convert normal cells into invasive, met...
Modeling adenoma–carcinoma progression from a single MLH1-knockout cell via colon organoids
Modeling adenoma–carcinoma progression from a single MLH1-knockout cell via colon organoids
Starting from a single MLH1-knockout human colon cell, we modeled the transition of daughter cells and resultant organoids...
The pro-oncogenic noncanonical activity of a RAS•GTP:RanGAP1 complex facilitates nuclear protein export
The pro-oncogenic noncanonical activity of a RAS•GTP:RanGAP1 complex facilitates nuclear protein export
Canonical RAS signaling, including PI3K/AKT- and RAF/MEK-dependent activities, results mainly from RAS•GTP interacti...
Single-cell transcriptomic landscape deciphers olfactory neuroblastoma subtypes and intra-tumoral heterogeneity
Single-cell transcriptomic landscape deciphers olfactory neuroblastoma subtypes and intra-tumoral heterogeneity
Olfactory neuroblastoma (ONB) is a rare malignancy known to originate from the olfactory epithelium. The complex tumor eco...
Transcription and DNA replication collisions lead to large tandem duplications and expose targetable therapeutic vulnerabilities in cancer
Transcription and DNA replication collisions lead to large tandem duplications and expose targetable therapeutic vulnerabilities in cancer
Despite the abundance of somatic structural variations (SVs) in cancer, the underlying molecular mechanisms of their forma...
Enhanced precision in immunotherapy
Enhanced precision in immunotherapy
Recent advancements in targeted immune checkpoint blockade (ICB) therapy have reshaped cancer treatment paradigms. However...
Integrative single-cell analysis of human colorectal cancer reveals patient stratification with distinct immune evasion mechanisms
Integrative single-cell analysis of human colorectal cancer reveals patient stratification with distinct immune evasion mechanisms
The tumor microenvironment (TME) considerably influences colorectal cancer (CRC) progression, therapeutic response and cli...
How tumors hijack macrophages for immune evasion
How tumors hijack macrophages for immune evasion
Resistance of cancers to immune checkpoint blockades is frequently observed. Pancreatic cancer cells are now shown to crea...
Dual inhibition of EGFR and PI3K with a single drug
Dual inhibition of EGFR and PI3K with a single drug
Precision medicine holds immense promise for treating individuals with cancer. A new study unveils MTX-531 — a drug ...
Single-cell atlas defines distinct immune escape mechanisms in colorectal cancer
Single-cell atlas defines distinct immune escape mechanisms in colorectal cancer
An integrative single-cell analysis of the human colorectum reveals tumor-associated cellular alterations and regulatory p...
BRD-810 is a highly selective MCL1 inhibitor with optimized in vivo clearance and robust efficacy in solid and hematological tumor models
BRD-810 is a highly selective MCL1 inhibitor with optimized in vivo clearance and robust efficacy in solid and hematological tumor models
The MCL1 gene is frequently amplified in cancer and codes for the antiapoptotic protein myeloid cell leukemia 1 (MCL1), wh...
A comeback for checkpoint inhibition in multiple myeloma
A comeback for checkpoint inhibition in multiple myeloma
Early trials of immune checkpoint inhibitors (ICIs) in multiple myeloma (MM) showed increased mortality, halting their dev...
Clinical response and pathway-specific correlates following TIGIT–LAG3 blockade in myeloma: the MyCheckpoint randomized clinical trial
Clinical response and pathway-specific correlates following TIGIT–LAG3 blockade in myeloma: the MyCheckpoint randomized clinical trial
Persons with myeloma were randomized to receive an anti-TIGIT (T cell immunoreceptor) or anti-LAG3 (lymphocyte activation ...
Single-cell multiomic dissection of response and resistance to chimeric antigen receptor T cells against BCMA in relapsed multiple myeloma
Single-cell multiomic dissection of response and resistance to chimeric antigen receptor T cells against BCMA in relapsed multiple myeloma
Markers that predict response and resistance to chimeric antigen receptor (CAR) T cells in relapsed/refractory multiple my...
Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis
Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis
The circadian clock regulates daily rhythms of numerous physiological activities through tightly coordinated modulation of...
Autologous HER2-specific CAR T cells after lymphodepletion for advanced sarcoma: a phase 1 trial
Autologous HER2-specific CAR T cells after lymphodepletion for advanced sarcoma: a phase 1 trial
In this prospective, interventional phase 1 study for individuals with advanced sarcoma, we infused autologous HER2-specif...
Using single-cell transcriptomics to predict which tumors will respond to targeted therapy
Using single-cell transcriptomics to predict which tumors will respond to targeted therapy
We performed a proof-of-concept study showing that single-cell RNA sequencing, a method for capturing rich tumor informati...
Sarcoma ecotypes determine immunotherapy benefit
Sarcoma ecotypes determine immunotherapy benefit
Sarcomas are heterogeneous connective tissue tumors that occur at various anatomic sites and are generally difficult to tr...
PRMT9 inhibition sparks immune responses in AML
PRMT9 inhibition sparks immune responses in AML
Arginine methylation is crucial for tumor maintenance. PRMT9 levels are elevated in acute myeloid leukemia, and its inhibi...
Cycling back to folate metabolism in cancer
Cycling back to folate metabolism in cancer
Metabolic changes contribute to cancer initiation and progression through effects on cancer cells, the tumor microenvironm...
Publisher Correction: Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis
Authors and AffiliationsInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Sin...
First, novel and paradigm-shifting
First, novel and paradigm-shifting
In delineating scientific findings, authors should avoid assertions of primacy and novelty, in favor of measured descripti...
A deep dive into transmissible cancer evolution in bivalve mollusks
A deep dive into transmissible cancer evolution in bivalve mollusks
Transmissible cancer affects marine bivalve mollusks worldwide, but how genetic mechanisms influence cancer evolution and ...
Myeloma evades T cell-engaging therapies
Myeloma evades T cell-engaging therapies
Chimeric antigen receptor T cells and T cell-redirecting bispecific antibody therapies are changing the landscape of myelo...
Endothelium directs fat remodeling in cachexia
Endothelium directs fat remodeling in cachexia
Certain cancers disrupt metabolism, leading to the wasting syndrome known as cachexia. How tumor-induced mediators of cach...
Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy
Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy
Dendritic cells (DCs) are antigen-presenting myeloid cells that regulate T cell activation, trafficking and function...
Turning a failing PhD around
Turning a failing PhD around
Charles Swanton obtained a PhD from the Imperial Cancer Research Fund Laboratories (now the Francis Crick Institute) in 19...
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