The Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature 487, 330–337 (2012).
Kim, J. C. & Bodmer, W. F. Genomic landscape of colorectal carcinogenesis. J. Cancer Res. Clin. Oncol. 148, 533–545 (2022).
Article CAS PubMed Google Scholar
La Vecchia, S. & Sebastián, C. Metabolic pathways regulating colorectal cancer initiation and progression. Semin. Cell Dev. Biol. 98, 63–70 (2020).
Guinney, J. et al. The consensus molecular subtypes of colorectal cancer. Nat. Med. 21, 1350–1356 (2015).
Article CAS PubMed PubMed Central Google Scholar
Dienstmann, R. et al. Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer. Nat. Rev. Cancer 17, 79–92 (2017).
Article CAS PubMed Google Scholar
Mei, Y. et al. Single-cell analyses reveal suppressive tumor microenvironment of human colorectal cancer. Clin. Transl. Med. 11, e422 (2021).
Article CAS PubMed PubMed Central Google Scholar
Qian, J. et al. A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling. Cell Res. 30, 745–762 (2020).
Article CAS PubMed PubMed Central Google Scholar
Wang, R. et al. Single-cell genomic and transcriptomic landscapes of primary and metastatic colorectal cancer tumors. Genome Med. 14, 93 (2022).
Article PubMed PubMed Central Google Scholar
Zhang, L. et al. Single-cell analyses inform mechanisms of myeloid-targeted therapies in colon cancer. Cell 181, 442–459.e29 (2020).
Article CAS PubMed Google Scholar
Pelka, K. et al. Spatially organized multicellular immune hubs in human colorectal cancer. Cell 184, 4734–4752.e20 (2021).
Article CAS PubMed PubMed Central Google Scholar
Lee, H.-O. et al. Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer. Nat. Genet. 52, 594–603 (2020).
Article CAS PubMed Google Scholar
Elmentaite, R. et al. Cells of the human intestinal tract mapped across space and time. Nature 597, 250–255 (2021).
Article CAS PubMed PubMed Central Google Scholar
James, K. R. et al. Distinct microbial and immune niches of the human colon. Nat. Immunol. 21, 343–353 (2020).
Article CAS PubMed PubMed Central Google Scholar
Boland, B. S. et al. Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses. Sci. Immunol. 5, eabb4432 (2020).
Article CAS PubMed PubMed Central Google Scholar
Smillie, C. S. et al. Intra- and inter-cellular rewiring of the human colon during ulcerative colitis. Cell 178, 714–730.e220 (2019).
Article CAS PubMed PubMed Central Google Scholar
Li, G. et al. Identification of novel population-specific cell subsets in Chinese ulcerative colitis patients using single-cell RNA sequencing. Cell. Mol. Gastroenterol. Hepatol. 12, 99–117 (2021).
Article CAS PubMed PubMed Central Google Scholar
Mitsialis, V. et al. Single-cell analyses of colon and blood reveal distinct immune cell signatures of ulcerative colitis and Crohn’s disease. Gastroenterology 159, 591–608 (2020).
Article CAS PubMed Google Scholar
Becker, W. R. et al. Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer. Nat. Genet. 54, 985–995 (2022).
Article CAS PubMed PubMed Central Google Scholar
Qi, J. et al. Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer. Nat. Commun. 13, 1742 (2022).
Article CAS PubMed PubMed Central Google Scholar
Guo, W. et al. Resolving the difference between left-sided and right-sided colorectal cancer by single-cell sequencing. JCI Insight 7, e152616 (2022).
Article PubMed PubMed Central Google Scholar
Joanito, I. et al. Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer. Nat. Genet. 54, 963–975 (2022).
Article CAS PubMed PubMed Central Google Scholar
Xia, J. et al. Single-cell landscape and clinical outcomes of infiltrating B cells in colorectal cancer. Immunology 168, 135–151 (2023).
Article CAS PubMed Google Scholar
Ozato, Y. et al. Spatial and single-cell transcriptomics decipher the cellular environment containing HLA-G+ cancer cells and SPP1+ macrophages in colorectal cancer. Cell Rep. 42, 111929 (2023).
Article CAS PubMed Google Scholar
Alshetaiwi, H. et al. Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics. Sci. Immunol. 5, eaay6017 (2020).
Article CAS PubMed PubMed Central Google Scholar
Cillo, A. R. et al. Immune landscape of viral- and carcinogen-driven head and neck cancer. Immunity 52, 183–199 (2020).
Article CAS PubMed PubMed Central Google Scholar
Batlle, E. & Massagué, J. Transforming growth factor-β signaling in immunity and cancer. Immunity 50, 924–940 (2019).
Article CAS PubMed PubMed Central Google Scholar
Ishimoto, T. et al. Activation of transforming growth factor β1 signaling in gastric cancer-associated fibroblasts increases their motility, via expression of rhomboid 5 homolog 2, and ability to induce invasiveness of gastric cancer cells. Gastroenterology 153, 191–204 (2017).
Article CAS PubMed Google Scholar
Zhan, T., Rindtorff, N. & Boutros, M. Wnt signaling in cancer. Oncogene 36, 1461–1473 (2017).
Article CAS PubMed Google Scholar
Guo, X. et al. Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing. Nat. Med. 24, 978–985 (2018).
Article CAS PubMed Google Scholar
Zhang, L. et al. Lineage tracking reveals dynamic relationships of T cells in colorectal cancer. Nature 564, 268–272 (2018).
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