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NOTUM-mediated stem cell competition in CRC
In this Journal Club. Gupta and Das discuss a study demonstrating how Apc-deficient intestinal stem cells (ISCs) gain a co...
How cancer reduces motivation
How cancer reduces motivation
In addition to its physical symptoms, cancer cachexia — a severe wasting syndrome — also leads to fatigue, apa...
Ageing lipids map melanoma’s journey
Ageing lipids map melanoma’s journey
Melanoma exhibits distinct patterns of organ-specific spread. Now, Gurung et al. find that age-based variations in stromal...
Reply to ‘Heterogeneity of TP53 mutations necessitates differentiation with p53-rescue therapies’
Peuget, S., Zhou, X. & Selivanova, G. Translating p53-based therapies for cancer into the clinic. Nat. Rev. Cancer 24,...
Heterogeneity of TP53 mutations necessitates differentiation with p53-rescue therapies
Heterogeneity of TP53 mutations necessitates differentiation with p53-rescue therapies
We read with interest the Review by Peuget et al. (Peuget, S., Zhou, X. & Selivanova, G. Translating p53-based therapi...
Recent advances in therapeutic cancer vaccines
Recent advances in therapeutic cancer vaccines
The success of cancer prevention vaccines targeting cancer-causing viruses has drastically reduced cancer mortality worldw...
Revisiting the TGFβ paradox: insights from HPV-driven cancer and the DNA damage response
Revisiting the TGFβ paradox: insights from HPV-driven cancer and the DNA damage response
The transforming growth factor-β (TGFβ) paradox refers to the well-established role of TGFβ in suppressing ...
Gender and sex interactions are intrinsic components of cancer phenotypes
Gender and sex interactions are intrinsic components of cancer phenotypes
Sex is a significant determinant of cancer incidence and outcome. The effects of sexual differentiation on normal and canc...
Midkine crisis fuels age-related tumorigenesis
Midkine crisis fuels age-related tumorigenesis
Ageing is a well-accepted risk factor for developing cancer. Yan et al. used a preclinical rat model to study the mechanis...
Characterization of the B cell receptor repertoire in melanoma
In this Journal Club, Chae and Chung discuss a study characterizing the differentiation and maturation of both tumour-resi...
Author Correction: The importance of 3D fibre architecture in cancer and implications for biomaterial model design
Authors and AffiliationsSchool of Veterinary Medicine & Science, Sutton Bonington Campus, University of Nottingham, Le...
Developing multiple EGFR-mutant lung cancers
Developing multiple EGFR-mutant lung cancers
The occurrence of multiple independent tumours in patients with EGFR-mutant lung cancer was unexplained. A recent study in...
Fanconi anaemia pathway induces chromosome shattering
Fanconi anaemia pathway induces chromosome shattering
Engel et al. conducted a genetic screen in which they identified the Fanconi anaemia (FA) pathway as a driver of chromothr...
Genetic and epigenetic bases of long-term adverse effects of childhood cancer therapy
Genetic and epigenetic bases of long-term adverse effects of childhood cancer therapy
Over the past decade, genome-scale molecular profiling of large childhood cancer survivorship cohorts has led to unprecede...
Dedicated centres and multinational platforms to improve patient care and address early-onset cancers
The incidence of early-onset cancers has increased by approximately 80% over the past three decades. These patients have u...
Chromothripsis in cancer
Chromothripsis in cancer
Chromothripsis is a mutational phenomenon in which a single catastrophic event generates extensive rearrangements of one o...
Circular RNA in cancer
Circular RNA in cancer
Over the past decade, circular RNA (circRNA) research has evolved into a bona fide research field shedding light on the fu...
Rational combination of cancer therapies with PD1 axis blockade
Rational combination of cancer therapies with PD1 axis blockade
This poster explores rational combinations of immune checkpoint blockade of the PD1–PDL1 interaction with other ther...
Shared immunosuppressive mechanism between pregnancy and cancer
Shared immunosuppressive mechanism between pregnancy and cancer
Pregnancy involves immune system suppression to protect the fetus, making it a valuable model for understanding cancer imm...
Lactate promotes DNA repair
Lactate promotes DNA repair
In a recent study published in Nature, lactate has been identified as a key player in enhancing DNA repair mechanisms in g...
Publisher Correction: Structural variations in cancer and the 3D genome
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USAFrank Dubois & Rameen BeroukhimDepartment o...
Tertiary lymphoid structures in anticancer immunity
Tertiary lymphoid structures in anticancer immunity
Tertiary lymphoid structures (TLS) are transient ectopic lymphoid aggregates where adaptive antitumour cellular and humora...
Tracing the evolutionary history of breast cancer
In this Journal Club, Koh and Im discuss a study demonstrating the unique evolutionary trajectory of breast cancers harbou...
Integrative medicine in oncology: redefining the standard of care
Integrative medicine incorporated alongside cancer care, referred to as integrative oncology, is an evidence-informed fiel...
Revealing genomic secrets of archival FFPE samples
In this Tools of the Trade article, Kaile Wang describes the development and use of Arc-well, a high-throughput single-cel...
Routes to second cancers
Routes to second cancers
Sánchez-Guixé et al. investigated the possible routes to second malignancies in survivors of paediatric cancer b...
Judith Campisi (1948–2024)
Judith Campisi (1948–2024)
Internationally recognized scientist Judith (Judy) Campisi passed away at her home at the age of 75 o...
Lymphatic vessels in the age of cancer immunotherapy
Lymphatic vessels in the age of cancer immunotherapy
Lymphatic transport maintains homeostatic health and is necessary for immune surveillance, and yet lymphatic growth is oft...
Programming immune escape
Programming immune escape
In a recent study published in Nature, Goto et al. explore mechanisms of immune evasion in early colorectal cancers and ad...
NET-working under stress
NET-working under stress
In this recent study, He et al. establish that chronic stress promotes metastasis through stress-induced formation of neut...
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