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Looking Beyond the Surface: Olutasidenib and Ivosidenib for Treatment of mIDH1 Acute Myeloid Leukemia
Looking Beyond the Surface: Olutasidenib and Ivosidenib for Treatment of mIDH1 Acute Myeloid Leukemia
Mutations in isocitrate dehydrogenase-1 (IDH1) are recurrent in several malignancies and prevalent in acute myeloid leukem...
An Update on the Management of Rectal Neuroendocrine Neoplasms
An Update on the Management of Rectal Neuroendocrine Neoplasms
Rectal neuroendocrine neoplasms (NENs) are increasing in incidence. Most lesions are low grade, well-differentiated neuroe...
Respiratory Depression Associated with Opioids: A Narrative Review
Respiratory Depression Associated with Opioids: A Narrative Review
All opioids have a risk of causing respiratory depression and reduced cerebral circulation. Fentanyl has the greatest risk...
Current Drug Resistance Mechanisms and Treatment Options in Gastrointestinal Stromal Tumors: Summary and Update
Current Drug Resistance Mechanisms and Treatment Options in Gastrointestinal Stromal Tumors: Summary and Update
Gastrointestinal stromal tumor (GIST) is characterized by well-defined oncogenes. Despite the significant improvement in t...
Tarlatamab-dlle: A New Hope for Patients with Extensive-Stage Small-Cell Lung Cancer
Tarlatamab-dlle: A New Hope for Patients with Extensive-Stage Small-Cell Lung Cancer
Lung cancer is expected to contribute to about 0.234 million new cases and about 0.125 million mortalities in the United S...
Updates in Treatment of HER2-positive Metastatic Breast Cancer
Updates in Treatment of HER2-positive Metastatic Breast Cancer
The therapeutic landscape for HER2-positive metastatic breast cancer has exploded in the last two decades following the in...
New Therapeutic Targets in RAS Wild-type Pancreatic Cancer
New Therapeutic Targets in RAS Wild-type Pancreatic Cancer
The landscape of treatment of advanced PDAC is witnessing significant changes. This is in part due to the advent of molecu...
Molecular Secrets Revealed: How Diabetes may be Paving the Way for Leukemia
Molecular Secrets Revealed: How Diabetes may be Paving the Way for Leukemia
Type 2 Diabetes Mellitus (T2DM) and leukemia are two major global health concerns, both contributing significantly to morb...
“When Less is More”: Paradigm Shifts in Radiation Treatment for Early-Stage Breast Cancer
“When Less is More”: Paradigm Shifts in Radiation Treatment for Early-Stage Breast Cancer
Recent advancements in the treatment of early-stage breast cancer have significantly shifted the radiotherapy landscape. T...
From Subtypes to Solutions: Integrating CMS Classification with Precision Therapeutics in Colorectal Cancer
From Subtypes to Solutions: Integrating CMS Classification with Precision Therapeutics in Colorectal Cancer
The biological heterogeneity of colorectal cancer makes its molecular characteristics essential for therapeutic decision-m...
Treatment Options for IDH-Mutant Malignant Gliomas
Treatment Options for IDH-Mutant Malignant Gliomas
As the peak incidence of isocitrate dehydrogenase (IDH)-mutant gliomas is amongst young adults, there is a need to balance...
A Review of Current and Future Antibody Drug Conjugates in Breast Cancer
A Review of Current and Future Antibody Drug Conjugates in Breast Cancer
Antibody–drug conjugates (ADCs) are a novel class of anti-cancer agents that have changed the standard of care for p...
Unveiling the Potential of Cyclin-Dependent Kinases 4 and 6 Inhibitors Beyond Progression in Hormone Receptor Positive/Human Epidermal Growth Factor Negative Advanced Breast Cancer – A Clinical Review
Unveiling the Potential of Cyclin-Dependent Kinases 4 and 6 Inhibitors Beyond Progression in Hormone Receptor Positive/Human Epidermal Growth Factor Negative Advanced Breast Cancer – A Clinical Review
Cyclin-dependent kinases 4 and 6 inhibitors (CDK4/6i) have revolutionized the management of hormone receptor-positive (HR&...
Who Should Receive Immunotherapy for Advanced Gastroesophageal Cancer?
Who Should Receive Immunotherapy for Advanced Gastroesophageal Cancer?
This paper shines a light on the exciting progress being made in using immunotherapy to treat advanced gastroesophageal ca...
Pioneering the Way: The Revolutionary Potential of Antibody–Drug Conjugates in NSCLC
Pioneering the Way: The Revolutionary Potential of Antibody–Drug Conjugates in NSCLC
Despite targeted therapy and immunotherapy being recognized as established frontline treatments for advanced non-small cel...
Role of Metastasis-Directed Therapy in Genitourinary Cancers
Role of Metastasis-Directed Therapy in Genitourinary Cancers
The treatment of oligometastatic genitourinary cancers is a rapidly advancing field with ablative radiotherapy as one of t...
Post-Radiotherapy Dysphagia in Head and Neck Cancer: Current Management by Speech-Language Pathologists
Post-Radiotherapy Dysphagia in Head and Neck Cancer: Current Management by Speech-Language Pathologists
Dysphagia, difficulty in eating and drinking, remains the most common side effect of radiotherapy treatment for head and n...
Immunotherapy for Brain Tumors: Where We Have Been, and Where Do We Go From Here?
Immunotherapy for Brain Tumors: Where We Have Been, and Where Do We Go From Here?
Immunotherapy for glioblastoma (GBM) remains an intensive area of investigation. Given the seismic impact of cancer immuno...
Precision Cardio-oncology: Update on Omics-Based Diagnostic Methods
Precision Cardio-oncology: Update on Omics-Based Diagnostic Methods
Cardio-oncology is an emerging interdisciplinary field dedicated to the early detection and treatment of adverse cardiovas...
Circulating Tumor DNA in Diffuse Large B-Cell Lymphoma: from Bench to Bedside?
Circulating Tumor DNA in Diffuse Large B-Cell Lymphoma: from Bench to Bedside?
Diffuse large B-cell lymphoma (DLBCL) is a curable disease with variable outcomes due to underlying heterogeneous clinical...
HER2-Positive Metastatic Colorectal Cancer
HER2-Positive Metastatic Colorectal Cancer
Targeted treatment strategies are available for human epidermal growth factor receptor 2 (HER2)–positive (amplified ...
Emerging DNA Methylome Targets in FLT3-ITD-Positive Acute Myeloid Leukemia: Combination Therapy with Clinically Approved FLT3 Inhibitors
Emerging DNA Methylome Targets in FLT3-ITD-Positive Acute Myeloid Leukemia: Combination Therapy with Clinically Approved FLT3 Inhibitors
The internal tandem duplication (ITD) mutation of the FMS-like receptor tyrosine kinase 3 (FLT3-ITD) is the most common mu...
Genetic Predisposition to Sarcoma: What Should Clinicians Know?
Genetic Predisposition to Sarcoma: What Should Clinicians Know?
Pathogenic germline variants in the setting of several associated cancer predisposition syndromes (CPS) may lead to the de...
Neoadjuvant Photodynamic Therapy: An Updated Therapeutic Approach for Non-Melanoma Skin Cancers
Neoadjuvant Photodynamic Therapy: An Updated Therapeutic Approach for Non-Melanoma Skin Cancers
Non-melanoma skin cancers (NMSCs) are the most common malignancy and surgical excision is considered treatment of choice f...
Current status of Complementary and Alternative Medicine Interventions in the Management of Pancreatic Cancer – An Overview
Current status of Complementary and Alternative Medicine Interventions in the Management of Pancreatic Cancer – An Overview
Pancreatic cancer (PC) remains the deadliest cancer worldwide. Most patients are diagnosed at the advanced or metastatic s...
Cardiovascular Adverse Events of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia: Clinical Relevance, Impact on Outcome, Preventive Measures and Treatment Strategies
Cardiovascular Adverse Events of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia: Clinical Relevance, Impact on Outcome, Preventive Measures and Treatment Strategies
The introduction of TKIs into the therapeutic armamentarium of CML has changed the disease paradigm, increasing long-term ...
The Quest for Circulating Biomarkers in Neuroendocrine Neoplasms: a Clinical Perspective
The Quest for Circulating Biomarkers in Neuroendocrine Neoplasms: a Clinical Perspective
Given the considerable heterogeneity in neuroendocrine neoplasms (NENs), it appears unlikely that a sole biomarker exists ...
Updates in Management of Malignant Pleural Mesothelioma
Updates in Management of Malignant Pleural Mesothelioma
Malignant pleural mesothelioma (MPM) is an aggressive asbestos-associated thoracic malignancy that is usually incurable. A...
The Evolving Treatment Landscape of Medullary Thyroid Cancer
The Evolving Treatment Landscape of Medullary Thyroid Cancer
Genetic assessment is crucial to address the correct treatment for advanced medullary thyroid cancer (MTC). Multi tyrosine...
Application of Engineered Dendritic Cell Vaccines in Cancer Immunotherapy: Challenges and Opportunities
Application of Engineered Dendritic Cell Vaccines in Cancer Immunotherapy: Challenges and Opportunities
The primary objective of this study is to evaluate the effectiveness of cancer vaccines containing genetically modified de...
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