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Rudolf Virchow and the discovery of the Müller cell
Rudolf Virchow and the discovery of the Müller cell
Albrecht von Graefe (1828–1870) studied medicine in Berlin and one of his teachers wa...
Histologic Dataset of Normal and Atypical Mitotic Figures on Human Breast Cancer (AMi-Br)
Histologic Dataset of Normal and Atypical Mitotic Figures on Human Breast Cancer (AMi-Br)
Assessment of the density of mitotic figures (MFs) in histologic tumor sections is an important prognostic marker for many...
Embedding radical prostatectomy specimens: selective with regular cassettes or complete with large cassettes
Embedding radical prostatectomy specimens: selective with regular cassettes or complete with large cassettes
Bernhardt M, Hommerding O, Kreft T et al (2024) Prospective selective embedding of radical prostatectomy specimens is not ...
FGFR3::TACC3 fusions in head and neck carcinomas: a study of nine cases highlighting phenotypic heterogeneity, frequent HPV association, and a morphologically distinct subset in favor of a putative entity
FGFR3::TACC3 fusions in head and neck carcinomas: a study of nine cases highlighting phenotypic heterogeneity, frequent HPV association, and a morphologically distinct subset in favor of a putative entity
The FGFR3::TACC3 fusion has been reported in subsets of diverse cancers including urothelial and squamous cell carcinomas ...
S100 and CD34 positive spindle cell tumors of the uterine cervix with EGFR mutation: a hitherto unrecognized neoplasm phenotypically and epigenetically overlapping with “NTRK-rearranged spindle cell neoplasms” of the uterus
S100 and CD34 positive spindle cell tumors of the uterine cervix with EGFR mutation: a hitherto unrecognized neoplasm phenotypically and epigenetically overlapping with “NTRK-rearranged spindle cell neoplasms” of the uterus
NTRK-rearranged spindle cell neoplasm represents an emerging entity included in the latest 5th edition of WHO classificati...
Tumor budding in pre-neoadjuvant biopsy and post-neoadjuvant resection specimens is associated with poor prognosis in intrahepatic cholangiocarcinoma—a cohort study of 147 cases by modified ITBCC criteria
Tumor budding in pre-neoadjuvant biopsy and post-neoadjuvant resection specimens is associated with poor prognosis in intrahepatic cholangiocarcinoma—a cohort study of 147 cases by modified ITBCC criteria
Tumor budding (TB) has been associated with poor survival in a variety of cancers including intrahepatic cholangiocarcinom...
Diagnostic utility of ESR1 mutation detection in liquid biopsy of metastatic breast cancer patients
Diagnostic utility of ESR1 mutation detection in liquid biopsy of metastatic breast cancer patients
Molecular analysis of circulating cell-free DNA (cfDNA) extracted from peripheral blood plasma samples of metastatic breas...
Uterine mesenchymal tumours harboring the KAT6B/A::KANSL1 gene fusion represent a distinct type of uterine sarcoma based on DNA methylation profiles
Uterine mesenchymal tumours harboring the KAT6B/A::KANSL1 gene fusion represent a distinct type of uterine sarcoma based on DNA methylation profiles
Uterine mesenchymal tumours harboring KAT6B/A::KANSL1 gene fusions typically exhibit histological and immunophenotypic ove...
Relationships between tumor CD147 expression, tumor-infiltrating lymphocytes, and oncostatin M in hepatocellular carcinoma
Relationships between tumor CD147 expression, tumor-infiltrating lymphocytes, and oncostatin M in hepatocellular carcinoma
In hepatocellular carcinoma (HCC), CD147 expression contributes to tumor malignancy; however, its relationship with the tu...
Primary central nervous system diffuse large B-cell lymphoma with MYC and BCL2 rearrangements associated with deep brain stimulation device
Primary central nervous system diffuse large B-cell lymphoma with MYC and BCL2 rearrangements associated with deep brain stimulation device
Author notesKirill A. Lyapichev and Sri Bharathi Kavuri contributed equally to this work.Authors and AffiliationsDepartmen...
Malignant epithelioid neoplasm with GLI1 gene rearrangement (PANX3::GLI1 transcript) and MDM2 gene amplification
Malignant epithelioid neoplasm with GLI1 gene rearrangement (PANX3::GLI1 transcript) and MDM2 gene amplification
We hereby report the case of an epithelioid neoplasm arising from pterygopalatine fossa in a 13-year-old child harboring P...
Apocrine variant of intraductal carcinoma of the parotid gland with sebaceous-like differentiation: expanding morphological and molecular spectrum of an enigmatic entity
Apocrine variant of intraductal carcinoma of the parotid gland with sebaceous-like differentiation: expanding morphological and molecular spectrum of an enigmatic entity
Delgado R, Klimstra D (1996) Albores-Saavedra J. Low grade salivary duct carcinoma. A distinctive variant with a low grade...
Exploratory evidence maps for the WHO Classification of Tumours 5th edition for lung and thymus tumors
Exploratory evidence maps for the WHO Classification of Tumours 5th edition for lung and thymus tumors
The WHO Classification of Tumours (WCT) guides cancer diagnosis, treatment, and research. However, research evidence in pa...
Integrating single cell and bulk RNA sequencing data identifies RBM17 as a novel response biomarker for immunotherapy in bladder cancer
Integrating single cell and bulk RNA sequencing data identifies RBM17 as a novel response biomarker for immunotherapy in bladder cancer
Checkpoint inhibitors (CPIs) have been widely applied in the treatment of patients with bladder cancer (BLCA). However, th...
A morphological and immunohistochemical study of ductal carcinoma in situ, invasive breast carcinoma of no special type, and mucinous carcinoma of the breast in comparison with solid papillary carcinoma regarding neuroendocrine marker expression
A morphological and immunohistochemical study of ductal carcinoma in situ, invasive breast carcinoma of no special type, and mucinous carcinoma of the breast in comparison with solid papillary carcinoma regarding neuroendocrine marker expression
The exact relationship between solid papillary carcinoma (SPC) and invasive breast carcinoma of no special type (IBC-NST) ...
Renal epithelioid angiomyolipomas overexpress TFE3 and the TFE3-regulated gene TRIM63 in the absence of TFE3 rearrangement
Renal epithelioid angiomyolipomas overexpress TFE3 and the TFE3-regulated gene TRIM63 in the absence of TFE3 rearrangement
Angiomyolipoma (AML) is a neoplasm within the perivascular epithelioid cell tumor family that occurs somewhat frequently i...
Müllerian clear cell carcinoma arising from rectal endometriosis with pericolonic lymph node metastasis
Müllerian clear cell carcinoma arising from rectal endometriosis with pericolonic lymph node metastasis
Heaps JM, Nieberg RK, Berek JS (1990) Malignant neoplasms arising in endometriosis. Obstet Gynecol 75(6):1023–1028CAS  ...
Immunohistochemical analysis of tumor budding in stage II colon cancer: exploring zero budding as a prognostic marker
Immunohistochemical analysis of tumor budding in stage II colon cancer: exploring zero budding as a prognostic marker
Tumor budding, a biomarker traditionally evaluated using hematoxylin and eosin (H&E) staining, has gained recognit...
Neuroendocrine neoplasms of the breast: a review of literature
Neuroendocrine neoplasms of the breast: a review of literature
Primary neuroendocrine neoplasms (NENs) of the breast are characterized by neuroendocrine architectural and cytological fe...
Pediatric thyroid-like follicular renal cell carcinoma—a post-neuroblastoma case with comprehensive genomic profiling data
Pediatric thyroid-like follicular renal cell carcinoma—a post-neuroblastoma case with comprehensive genomic profiling data
Thyroid-like follicular renal cell carcinoma (TLFRCC), an emerging subtype of renal cell carcinoma, presents diagnostic ch...
Contemporary review of papillary renal cell carcinoma—current state and future directions
Contemporary review of papillary renal cell carcinoma—current state and future directions
Historically, papillary renal cell carcinoma (PRCC) was divided into two types, type 1 and type 2, based solely on morphol...
Giant cell carcinoma of the urinary bladder
Giant cell carcinoma of the urinary bladder
We present the clinicopathological features of 23 cases of the giant cell subtype of urothelial carcinoma, a rare subtype ...
Correction to: Practical guidelines of the EOTTD for pathological and genetic diagnosis of hydatidiform moles
Correction to: Practical guidelines of the EOTTD for pathological and genetic diagnosis of hydatidiform moles
Department of Pathology, Cancer Biology & Epigenetics Group, Research Center of IPO Porto (CI-IPOP) / RISE@ CI-IPOP (H...
Ovarian endometrioid carcinoma with a sex cord-like pattern: a morphological, immunohistochemical, and molecular analysis
Ovarian endometrioid carcinoma with a sex cord-like pattern: a morphological, immunohistochemical, and molecular analysis
Sex cord-like endometrioid carcinoma (SCLEC) is an uncommon entity which may constitute a diagnostic challenge. This study...
Mutational, immune microenvironment, and clinicopathological profiles of diffuse large B-cell lymphoma and follicular lymphoma with BCL6 rearrangement
Mutational, immune microenvironment, and clinicopathological profiles of diffuse large B-cell lymphoma and follicular lymphoma with BCL6 rearrangement
BCL6-rearrangement (BCL6-R) is associated with a favorable prognosis of follicular lymphoma (FL), but the mechanism is unk...
Flanagan’s condensed protocol for neurodegenerative diseases. Implementation in a clinical autopsy setting with partial supervision of a neuropathologist
Flanagan’s condensed protocol for neurodegenerative diseases. Implementation in a clinical autopsy setting with partial supervision of a neuropathologist
The Condensed Protocol (CP) was originally developed for the evaluation of Alzheimer’s Disease (AD) and other neurod...
Clinicopathological analysis of thyroid carcinomas with the RET and NTRK fusion genes: characterization for genetic analysis
Clinicopathological analysis of thyroid carcinomas with the RET and NTRK fusion genes: characterization for genetic analysis
Thyroid carcinomas exhibit various genetic alterations, including the RET and NTRK fusion genes that are targets for molec...
Predominance of T-bet-positive Th1 cells in infiltrating T-lymphocytes in most of active arteritis lesions of giant cell arteritis
Predominance of T-bet-positive Th1 cells in infiltrating T-lymphocytes in most of active arteritis lesions of giant cell arteritis
Immunological mechanisms through the activation of CD4-positive T-cells have been assumed to be involved in the pathogenes...
Epidermodysplasia verruciformis–associated eccrine neoplasm: a rare entity with distinctive clinical and histopathologic features
Epidermodysplasia verruciformis–associated eccrine neoplasm: a rare entity with distinctive clinical and histopathologic features
Most tumors are caused by inherited or acquired genetic changes. However, a subset of tumors is driven by viral infection ...
The diagnostic utility of cytology specimen in a case of EWSR1::NFATC2 sarcoma
The diagnostic utility of cytology specimen in a case of EWSR1::NFATC2 sarcoma
EWSR1::NFATC2 sarcoma, a rare round cell sarcoma constituting the majority of EWSR1::non-ETS sarcomas, has recently been d...
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