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Engineering mannose-functionalized nanostructured lipid carriers by sequential design using hybrid artificial intelligence tools
Engineering mannose-functionalized nanostructured lipid carriers by sequential design using hybrid artificial intelligence tools
Nanostructured lipid carriers (NLCs) hold significant promise as drug delivery systems (DDS) owing to their small size and...
Plant-derived exosome-like nanoparticles for microRNA delivery in cancer treatment
Plant-derived exosome-like nanoparticles for microRNA delivery in cancer treatment
Plant-derived exosome-like nanoparticles (PELNs) are natural nanocarriers and effective delivery systems for plant microRN...
Microneedle patch with pure drug tips for delivery of liraglutide: pharmacokinetics in rats and minipigs
Microneedle patch with pure drug tips for delivery of liraglutide: pharmacokinetics in rats and minipigs
Transdermal delivery of peptide drugs is almost impossible with conventional penetration enhancers because of epidermal ba...
Cyclodextrins and their potential applications for delivering vitamins, iron, and iodine for improving micronutrient status
Cyclodextrins and their potential applications for delivering vitamins, iron, and iodine for improving micronutrient status
Cyclodextrins (CDs) have been investigated as potential biopolymeric carriers that can form inclusion complexes with numer...
Manufacturing and characterisation of 3D-printed sustained-release Timolol implants for glaucoma treatment
Manufacturing and characterisation of 3D-printed sustained-release Timolol implants for glaucoma treatment
Timolol maleate (TML) is a beta-blocker drug that is commonly used to lower the intraocular pressure in glaucoma. This stu...
Imiquimod nanocrystal-loaded dissolving microneedles prepared by DLP printing
Imiquimod nanocrystal-loaded dissolving microneedles prepared by DLP printing
The utilization of 3D printing– digital light processing (DLP) technique, for the direct fabrication of microneedles...
Anti-lung cancer synergy of low-dose doxorubicin and PD-L1 blocker co-delivered via mild photothermia-responsive black phosphorus
Anti-lung cancer synergy of low-dose doxorubicin and PD-L1 blocker co-delivered via mild photothermia-responsive black phosphorus
We have previously identified a latent interaction mechanism between non-small cell lung cancer cells (NSCLCC) and their a...
Wheat germ agglutinin modified mixed micelles overcome the dual barrier of mucus/enterocytes for effective oral absorption of shikonin and gefitinib
Wheat germ agglutinin modified mixed micelles overcome the dual barrier of mucus/enterocytes for effective oral absorption of shikonin and gefitinib
The combination of shikonin (SKN) and gefitinib (GFB) can reverse the drug resistance of lung cancer cells by affecting en...
Influence of physico-chemical properties of two lipoxin emulsion-loaded hydrogels on pre-polarized macrophages: a comparative analysis
Influence of physico-chemical properties of two lipoxin emulsion-loaded hydrogels on pre-polarized macrophages: a comparative analysis
Inflammation, a crucial defense mechanism, must be rigorously regulated to prevent the onset of chronic inflammation and s...
Quercetin loaded polymeric dissolving microarray patches: fabrication, characterisation and evaluation
Quercetin loaded polymeric dissolving microarray patches: fabrication, characterisation and evaluation
Quercetin, a natural compound, shows promising potential in wound healing by reducing fibrosis, limiting scar formation, a...
Resveratrol nanocrystals based dissolving microneedles with highly efficient for rheumatoid arthritis
Resveratrol nanocrystals based dissolving microneedles with highly efficient for rheumatoid arthritis
Rheumatoid arthritis (RA) is a common immune disease characterized mainly by erosive arthritis with extensive clinical seq...
Advancements in nanoscale delivery systems: optimizing intermolecular interactions for superior drug encapsulation and precision release
Advancements in nanoscale delivery systems: optimizing intermolecular interactions for superior drug encapsulation and precision release
Nanoscale preparations, such as nanoparticles, micelles, and liposomes, are increasingly recognized in pharmaceutical tech...
Multi-functional Chitosan Polymeric Micelles for improving the oral bioavailability of Paclitaxel based on synergistic effect
Multi-functional Chitosan Polymeric Micelles for improving the oral bioavailability of Paclitaxel based on synergistic effect
A novel multi-functional micelle delivery system was developed for enhancing the oral absorption of paclitaxel (PTX). The ...
Human mesenchymal stromal cells-laden crosslinked hyaluronic acid-alginate bioink for 3D bioprinting applications in tissue engineering
Human mesenchymal stromal cells-laden crosslinked hyaluronic acid-alginate bioink for 3D bioprinting applications in tissue engineering
Three-dimensional (3D) bioprinting is considered one of the most advanced tools to build up materials for tissue engineeri...
Perfluorodecalin allows resuspension and prevents sediment solidification of extended-release drug formulations in primary packaging
Perfluorodecalin allows resuspension and prevents sediment solidification of extended-release drug formulations in primary packaging
In this technical note we show with two simple experiments how Perfluorodecalin (PFD), an injectable perfluorocarbon, can ...
High mobility group box 1 cytokine targeted topical delivery of resveratrol embedded nanoemulgel for the management of atopic dermatitis
High mobility group box 1 cytokine targeted topical delivery of resveratrol embedded nanoemulgel for the management of atopic dermatitis
Resveratrol is a polyphenolic compound showing anti-inflammatory activity by inhibition of high mobility group box 1 cytok...
A comprehensive review on doxorubicin: mechanisms, toxicity, clinical trials, combination therapies and nanoformulations in breast cancer
A comprehensive review on doxorubicin: mechanisms, toxicity, clinical trials, combination therapies and nanoformulations in breast cancer
Doxorubicin is a key treatment for breast cancer, but its effectiveness often comes with significant side effects. Its act...
Revolutionizing rheumatoid arthritis therapy: harnessing cytomembrane biomimetic nanoparticles for novel treatment strategies
Revolutionizing rheumatoid arthritis therapy: harnessing cytomembrane biomimetic nanoparticles for novel treatment strategies
Rheumatoid arthritis (RA) is a systemic immune disease with severe implications for joint health. The issue of non-specifi...
Effect of PLGA raw materials on in vitro and in vivo performance of drug-loaded microspheres
Effect of PLGA raw materials on in vitro and in vivo performance of drug-loaded microspheres
Poly(lactide-co-glycolide) and poly(lactic-co-glycolic acids) (PLGAs) play a critical role in the development of commercia...
PLGA-PEI nanoparticle covered with poly(I:C) for personalised cancer immunotherapy
PLGA-PEI nanoparticle covered with poly(I:C) for personalised cancer immunotherapy
Melanoma is the main cause of death among skin cancers and its incidence worldwide has been experiencing an appalling incr...
Liver fibrosis pathologies and potentials of RNA based therapeutics modalities
Liver fibrosis pathologies and potentials of RNA based therapeutics modalities
Liver fibrosis (LF) occurs when the liver tissue responds to injury or inflammation by producing excessive amounts of scar...
Understanding the role of the structure of single-stimuli hybrid systems on their behaviour as platforms for colonic delivery
Understanding the role of the structure of single-stimuli hybrid systems on their behaviour as platforms for colonic delivery
The success of colon-targeted oral hybrid systems relies in the proper control over the release of the entrapped nanostruc...
Enhancing the hypotensive effect of latanoprost by combining synthetic phosphatidylcholine liposomes with hyaluronic acid and osmoprotective agents
Enhancing the hypotensive effect of latanoprost by combining synthetic phosphatidylcholine liposomes with hyaluronic acid and osmoprotective agents
The first line of glaucoma treatment focuses on reducing intraocular pressure (IOP) through the prescription of topical pr...
Natural compounds-based nanomedicines for cancer treatment: Future directions and challenges
Natural compounds-based nanomedicines for cancer treatment: Future directions and challenges
Several efforts have been extensively accomplished for the amelioration of the cancer treatments using different types of ...
Impact of antigen loading in tolerogenic nanoparticles to mitigate Th2-mediated allergic lung inflammation
Impact of antigen loading in tolerogenic nanoparticles to mitigate Th2-mediated allergic lung inflammation
Allergic disease is a major global health concern that imposes significant life-altering and economic burdens on affected ...
Protease-activated CendR peptides targeting tenascin-C: mitigating off-target tissue accumulation
Protease-activated CendR peptides targeting tenascin-C: mitigating off-target tissue accumulation
To achieve precision and selectivity, anticancer compounds and nanoparticles (NPs) can be targeted with affinity ligands t...
Effects of semaglutide-loaded lipid nanocapsules on metabolic dysfunction-associated steatotic liver disease
Effects of semaglutide-loaded lipid nanocapsules on metabolic dysfunction-associated steatotic liver disease
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent chronic liver disease that...
OX26-cojugated gangliosilated liposomes to improve the post-ischemic therapeutic effect of CDP-choline
OX26-cojugated gangliosilated liposomes to improve the post-ischemic therapeutic effect of CDP-choline
Cerebrovascular impairment represents one of the main causes of death worldwide with a mortality rate of 5.5 million per y...
Targeting strategies with lipid vectors for nucleic acid supplementation therapy in Fabry disease: a systematic review
Targeting strategies with lipid vectors for nucleic acid supplementation therapy in Fabry disease: a systematic review
Fabry disease (FD) results from a lack of activity of the lysosomal enzyme α-Galactosidase A (α-Gal A), leading ...
RGD-coated polymeric microbubbles promote ultrasound-mediated drug delivery in an inflamed endothelium-pericyte co-culture model of the blood-brain barrier
RGD-coated polymeric microbubbles promote ultrasound-mediated drug delivery in an inflamed endothelium-pericyte co-culture model of the blood-brain barrier
Drug delivery to central nervous pathologies is compromised by the blood-brain barrier (BBB). A clinically explored strate...
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