Wheat germ agglutinin modified mixed micelles overcome the dual barrier of mucus/enterocytes for effective oral absorption of shikonin and gefitinib

Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023;73:17–48.

Article  PubMed  Google Scholar 

Tian X, Gu T, Lee MH, Dong Z. Challenge and countermeasures for EGFR targeted therapy in non-small cell lung cancer. Biochim Biophys Acta Rev Cancer. 2022;1877:188645.

Article  CAS  PubMed  Google Scholar 

Wang C, Zhang Y, Chen W, Wang Y, Xing D. Epidermal growth factor receptor PROTACs as an effective strategy for cancer therapy: a review. Biochim Biophys Acta Rev Cancer. 2023;1878:188927.

Article  CAS  PubMed  Google Scholar 

Wu YL, Zhang L, Kim DW, Liu X, Lee DH, Yang JC, Ahn MJ, Vansteenkiste JF, Su WC, Felip E, Chia V, Glaser S, Pultar P, Zhao S, Peng B, Akimov M, Tan DSW. Phase Ib/II study of Capmatinib (INC280) plus Gefitinib after failure of epidermal growth factor receptor (EGFR) inhibitor therapy in patients with EGFR-Mutated, MET factor-dysregulated non-small-cell lung cancer. J Clin Oncol. 2018;36:3101–9.

Article  CAS  PubMed  Google Scholar 

Dong J, Qin Z, Zhang WD, Cheng G, Yehuda AG, Ashby CR Jr., Chen ZS, Cheng XD, Qin JJ. Medicinal chemistry strategies to discover P-glycoprotein inhibitors: an update. Drug Resist Updat. 2020;49:100681.

Article  PubMed  Google Scholar 

Fan C, Zhang X, Upton Z. Anti-inflammatory effects of shikonin in human periodontal ligament cells. Pharm Biol. 2018;56:415–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao X, Zhu Y, Hu J, Jiang L, Li L, Jia S, Zen K. Shikonin inhibits tumor growth in mice by suppressing pyruvate kinase M2-mediated aerobic glycolysis. Sci Rep. 2018;8:14517.

Article  PubMed  PubMed Central  Google Scholar 

Ai X, Hou X, Feng N. Combination of shikonin and gefitinib reverses drug resistance in human non-small cell lung cancer and its mechanism (in Chinese). China J Chin Materia Med. 2024;49:175–84. https://doi.org/10.19540/j.cnki.cjcmm.20230810.401

Article  Google Scholar 

Shirley M, Keam SJ. Aumolertinib: a review in Non-small Cell Lung Cancer. Drugs. 2022;82:577–84.

Article  CAS  PubMed  Google Scholar 

Biaoxue R, Shuanying Y, Wei L, Wei Z, Zongjuan M. Maintenance therapy of gefitinib for non-small-cell lung cancer after first-line chemotherapy regardless of epidermal growth factor receptor mutation: a review in Chinese patients. Curr Med Res Opin. 2012;28:1699–708.

Article  PubMed  Google Scholar 

Li H, Tong Y, Bai L, Ye L, Zhong L, Duan X, Zhu Y. Lactoferrin functionalized PEG-PLGA nanoparticles of shikonin for brain targeting therapy of glioma. Int J Biol Macromol. 2018;107:204–11.

Article  CAS  PubMed  Google Scholar 

Wang D, Jiang Q, Dong Z, Meng T, Hu F, Wang J, Yuan H. Nanocarriers transport across the gastrointestinal barriers: the contribution to oral bioavailability via blood circulation and lymphatic pathway. Adv Drug Deliv Rev. 2023;203:115130.

Article  CAS  PubMed  Google Scholar 

Ejazi SA, Louisthelmy R, Maisel K. Mechanisms of nanoparticle transport across intestinal tissue: an oral delivery perspective. ACS Nano. 2023;17:13044–61.

Article  CAS  PubMed  Google Scholar 

Alshammari MK, Almomen EY, Alshahrani KF, Altwalah SF, Kamal M, Al-Twallah MF, Alsanad SH, Al-Batti MH, Al-Rasheed FJ, Alsalamah AY, Alhazza MB, Alasmari FA, Abida M, Imran. Nano-enabled strategies for the treatment of lung cancer. Biomedicines: Potential Bottlenecks and Future Perspectives; 2023;11:473.

Google Scholar 

Delorme V, Lichon L, Mahindad H, Hunger S, Laroui N, Daurat M, Godefroy A, Coudane J, Gary-Bobo M, Van Den Berghe H. Reverse poly(epsilon-caprolactone)-g-dextran graft copolymers. Nano-carriers for intracellular uptake of anticancer drugs. Carbohydr Polym. 2020;232:115764.

Article  CAS  PubMed  Google Scholar 

Grimaudo MA, Pescina S, Padula C, Santi P, Concheiro A, Alvarez-Lorenzo C, Nicoli S. Poloxamer 407/TPGS mixed micelles as promising carriers for cyclosporine ocular delivery. Mol Pharm. 2018;15:571–84.

Article  CAS  PubMed  Google Scholar 

Liu Z, Wang H, Bu Y, Wu T, Chen X, Yan H, Lin Q. Fabrication of self-assembled micelles based on amphiphilic oxidized sodium alginate grafted oleoamine derivatives via Schiff base reduction amination reaction for delivery of hydrophobic food active ingredients. Int J Biol Macromol. 2023:128653.

Joy R, Siddiqua H, Sharma S, Raveendran M, John F, Hassan PA, Gawali SL, Raghavan SC. George, block copolymer encapsulation of disarib, an inhibitor of bcl2 for improved chemotherapeutic potential. ACS Omega. 2023;8:40729–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gupta A, Costa AP, Xu X, Lee SL, Cruz CN, Bao Q, Burgess DJ. Formulation and characterization of curcumin loaded polymeric micelles produced via continuous processing. Int J Pharm. 2020;583:119340.

Article  CAS  PubMed  Google Scholar 

Stevens KC, Marras AE, Campagna TR, Ting JM, Tirrell MV. Effect of charged block length mismatch on double diblock polyelectrolyte complex micelle cores. Macromolecules. 2023;56:5557–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fritz HF, Ortiz AC, Velaga SP, Morales JO. Preparation of a novel lipid-core micelle using a low-energy emulsification method. Drug Deliv Transl Res. 2018;8:1807–14.

Article  CAS  PubMed  Google Scholar 

Zhou Y, Yang L, Yan Z, Deng X, Zhang J. Preparation and characterization of uricase in uricase-catalase liposomes prepared using borate buffer. Nan Fang Yi Ke Da Xue Bao. 2015;35:268–71.

CAS  Google Scholar 

Hou X, Cao B, He Y, Guo T, Li Z, Liu Y, Zhang Y, Feng N. Improved self-assembled micelles based on supercritical fluid technology as a novel oral delivery system for enhancing germacrone oral bioavailability. Int J Pharm. 2019;569:118586.

Article  CAS  PubMed  Google Scholar 

Kotta S, Aldawsari HM, Badr-Eldin SM, Nair AB, Yt K. Progress in polymeric micelles for drug delivery applications. Pharmaceutics. 2022;14.

Kim TI, Kim TG, Lim DH, Kim SB, Park SM, Lim HJ, Kim HJ, Ki KS, Kwon EG, Kim YJ, Mayakrishnan V. The effect of nanoemulsified methionine and cysteine on the in vitro expression of casein in bovine mammary epithelial cells. Asian-Australas J Anim Sci. 2019;32:257–64.

Article  CAS  PubMed  Google Scholar 

Fan Z, Wu J, Fang X, Sha X. A new function of vitamin E-TPGS in the intestinal lymphatic transport of lipophilic drugs: enhancing the secretion of chylomicrons. Int J Pharm. 2013;445:141–7.

Article  CAS  PubMed  Google Scholar 

Chiu HI, Lim V. Wheat germ agglutinin-conjugated disulfide cross-linked alginate nanoparticles as a docetaxel carrier for colon cancer therapy. Int J Nanomed. 2021;16:2995–3020.

Article  Google Scholar 

Liu Y, Xie X, Hou X, Shen J, Shi J, Chen H, He Y, Wang Z, Feng N. Functional oral nanoparticles for delivering silibinin and cryptotanshinone against breast cancer lung metastasis. J Nanobiotechnol. 2020;18:83.

Article  CAS  Google Scholar 

Liu Y, Liu J, Liang J, Zhang M, Li Z, Wang Z, Dang B, Feng N. Mucosal transfer of wheat germ agglutinin modified lipid-polymer hybrid nanoparticles for oral delivery of oridonin. Nanomedicine. 2017;13:2219–29.

Article  CAS  PubMed  Google Scholar 

Akkus ZB, Nazir I, Jalil A, Tribus M, Bernkop-Schnurch A. Zeta potential changing polyphosphate nanoparticles: a promising approach to overcome the mucus and epithelial barrier. Mol Pharm. 2019;16:2817–25.

Article  CAS  PubMed  Google Scholar 

Raghu G, Berk M, Campochiaro PA, Jaeschke H, Marenzi G, Richeldi L, Wen FQ, Nicoletti F, Calverley PMA. The multifaceted therapeutic role of N-Acetylcysteine (NAC) in disorders characterized by oxidative stress. Curr Neuropharmacol. 2021;19:1202–24.

CAS  PubMed  PubMed Central  Google Scholar 

Trindade IC, Pound-Lana G, Pereira DGS, de Oliveira LAM, Andrade MS, Vilela JMC, Postacchini BB, Mosqueira VCF. Mechanisms of interaction of biodegradable polyester nanocapsules with non-phagocytic cells. Eur J Pharm Sci. 2018;124:89–104.

Article  CAS  PubMed  Google Scholar 

Wang CM, Fernez MT, Woolston BM, Carrier RL. Native gastrointestinal mucus: critical features and techniques for studying interactions with drugs, drug carriers, and bacteria. Adv Drug Deliv Rev. 2023;200:114966.

Article  CAS 

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