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The role of trimethoprim/sulfamethoxazole in preventing opportunistic infections in systemic lupus erythematosus patients receiving low-level immunosuppressive treatment: an open-label, randomized, controlled trial
The role of trimethoprim/sulfamethoxazole in preventing opportunistic infections in systemic lupus erythematosus patients receiving low-level immunosuppressive treatment: an open-label, randomized, controlled trial
Objective: Systemic lupus erythematosus (SLE) patients receiving immunosuppressive therapy are at risk for opportunistic i...
SASS6 promotes tumor proliferation and is associated with TP53 and immune infiltration in lung adenocarcinoma
SASS6 promotes tumor proliferation and is associated with TP53 and immune infiltration in lung adenocarcinoma
The most common type of non-small cell lung cancer is lung adenocarcinoma (LUAD), which is characterized by high morbidity...
CXCL13: a common target for immune-mediated inflammatory diseases
CXCL13: a common target for immune-mediated inflammatory diseases
CXCL13 is a chemokine that plays an important role in the regulation and development of secondary lymphoid organs. CXCL13 ...
Influence of recipient KRAS gene rs712 polymorphisms on the overall survival rate of hepatocellular carcinoma after hepatic transplantation
Influence of recipient KRAS gene rs712 polymorphisms on the overall survival rate of hepatocellular carcinoma after hepatic transplantation
Hepatocellular carcinoma (HCC) recurrence appears commonly after liver transplantation (LT), and it severely affected the ...
Risk of subsequent primary cancers in bladder cancer survivors
Risk of subsequent primary cancers in bladder cancer survivors
We aimed to investigate the risk of bladder cancer (BCa) survivors developing or dying from 15 specific-subsequent primary...
Genetics, diet, microbiota, and metabolome: partners in crime for colon carcinogenesis
Genetics, diet, microbiota, and metabolome: partners in crime for colon carcinogenesis
Colorectal cancer (CRC) ranks among the most prevalent malignant tumors worldwide, with a multifactorial etiology encompas...
Identifying the prognostic significance of mitophagy-associated genes in multiple myeloma: a novel risk model construction
Identifying the prognostic significance of mitophagy-associated genes in multiple myeloma: a novel risk model construction
Multiple myeloma (MM) is a highly heterogeneous hematological malignancy that is currently incurable. Individualized thera...
GUCA2A dysregulation as a promising biomarker for accurate diagnosis and prognosis of colorectal cancer
GUCA2A dysregulation as a promising biomarker for accurate diagnosis and prognosis of colorectal cancer
Colorectal cancer is a leading cause of global mortality and presents a significant barrier to improving life expectancy. ...
Early minimal residual disease eradication in light chain amyloidosis generates deeper and faster cardiac response
Early minimal residual disease eradication in light chain amyloidosis generates deeper and faster cardiac response
Minimal residual disease (MRD) is of growing interest in light chain (AL) amyloidosis and is associated with higher rates ...
Development and validation of a model for predicting who can benefit from multiple TACE in HCC patients
Development and validation of a model for predicting who can benefit from multiple TACE in HCC patients
This study was to develop and validate a model for predicting who can benefit from multiple transcatheter arterial chemoem...
Tumor-immune hybrid cells evade the immune response and potentiate colorectal cancer metastasis through CTLA4
Tumor-immune hybrid cells evade the immune response and potentiate colorectal cancer metastasis through CTLA4
Understanding the metastatic cascade is critical for the treatment and prevention of cancer-related death. Within a tumor,...
Analysis of METTL14 expression in pancreatic cancer and adjacent tissues and its prognostic value for patient outcomes
Analysis of METTL14 expression in pancreatic cancer and adjacent tissues and its prognostic value for patient outcomes
This study aims to analyze the differential expression of METTL14 in pancreatic cancer (PC) tissues and adjacent normal ti...
A systematic review and meta-analysis of the endothelial-immune candidate biomarker endoglin in rheumatic diseases
A systematic review and meta-analysis of the endothelial-immune candidate biomarker endoglin in rheumatic diseases
Existing challenges in accurately diagnosing various rheumatic diseases (RDs) have stimulated the search for novel biomark...
Clinical characteristics and prognosis analysis of pseudomonas aeruginosa bloodstream infection in adults: a retrospective study
Clinical characteristics and prognosis analysis of pseudomonas aeruginosa bloodstream infection in adults: a retrospective study
Pseudomonas aeruginosa bloodstream infections (PA BSIs) in adults, especially those complicated by sepsis, are associated ...
Chronobiological disruptions: unravelling the interplay of shift work, circadian rhythms, and vascular health in the context of stroke risk
Chronobiological disruptions: unravelling the interplay of shift work, circadian rhythms, and vascular health in the context of stroke risk
Shift work, particularly night shifts, disrupts circadian rhythms and increases stroke risk. This manuscript explores the ...
Current biological implications and clinical relevance of metastatic circulating tumor cells
Current biological implications and clinical relevance of metastatic circulating tumor cells
Metastatic disease and cancer recurrence are the primary causes of cancer-related deaths. Circulating tumor cells (CTCs) a...
The prognostic implications and oncogenic role of NSUN5 in clear cell renal cell carcinoma
The prognostic implications and oncogenic role of NSUN5 in clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC), a predominant form of urinary malignancy, requires the identification of reliable...
Development of hepatocellular carcinoma organoid model recapitulating HIF-1A metabolic signature
Development of hepatocellular carcinoma organoid model recapitulating HIF-1A metabolic signature
Hypoxia is one of the main hallmarks of hepatocellular carcinoma (HCC) resulting from improper oxygenation and insufficien...
Extracellular vesicles miR-574-5p and miR-181a-5p as prognostic markers in NSCLC patients treated with nivolumab
Extracellular vesicles miR-574-5p and miR-181a-5p as prognostic markers in NSCLC patients treated with nivolumab
Immune checkpoint inhibitors (ICIs) have revolutionized the management of advanced non-small cell lung cancer (NSCLC), alt...
The impact of magnesium biotinate and arginine silicate complexes on metabolic dysfunctions, antioxidant activity, inflammation, and neuromodulation in high-fat diet-fed rats
The impact of magnesium biotinate and arginine silicate complexes on metabolic dysfunctions, antioxidant activity, inflammation, and neuromodulation in high-fat diet-fed rats
Biotin and arginine play crucial roles in lipid metabolism and may offer promising interventions against obesity. This stu...
Risk and mediation analyses of hemoglobin glycation index and survival prognosis in patients with sepsis
Risk and mediation analyses of hemoglobin glycation index and survival prognosis in patients with sepsis
An increasing number of studies have reported the close relation of the hemoglobin glycation index (HGI) with metabolism, ...
Effect of immunogenetics polymorphism and expression on direct-acting antiviral drug response in chronic hepatitis C
Effect of immunogenetics polymorphism and expression on direct-acting antiviral drug response in chronic hepatitis C
The prevalence of HCV infection in Egypt has decreased following the introduction of direct-acting antiviral therapy. Howe...
Real-world experience with CDK4/6 inhibitors in hormone receptor-positive metastatic and recurrent breast cancer: findings from an Asian population
Real-world experience with CDK4/6 inhibitors in hormone receptor-positive metastatic and recurrent breast cancer: findings from an Asian population
Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy have demonstrated significant clinical be...
Abatacept versus tumor necrosis factor inhibitors on mortality and medical utilizations in the treatment of rheumatoid arthritis associated interstitial lung disease: a large-scale real-world retrospective cohort study
Abatacept versus tumor necrosis factor inhibitors on mortality and medical utilizations in the treatment of rheumatoid arthritis associated interstitial lung disease: a large-scale real-world retrospective cohort study
Rheumatoid arthritis is a chronic inflammatory disease, and interstitial lung disease is one of the important extra-articu...
The value of perforator flap reconstruction in painful soft tissue calcifications
The value of perforator flap reconstruction in painful soft tissue calcifications
Soft tissue calcifications frequently cause debilitating pain and functional impairments, considerably affecting patients&...
The burden of hyperkalaemia on hospital healthcare resources
The burden of hyperkalaemia on hospital healthcare resources
Hyperkalaemia is associated with prolonged hospital admission and worse mortality. Hyperkalaemia may also necessitate clin...
Exploring the crosstalk molecular mechanisms between IgA nephropathy and Sjögren’s syndrome based on comprehensive bioinformatics and immunohistochemical analyses
Exploring the crosstalk molecular mechanisms between IgA nephropathy and Sjögren’s syndrome based on comprehensive bioinformatics and immunohistochemical analyses
IgA nephropathy (IgAN) and Sjogren's syndrome (SS) are two autoimmune diseases with undetermined etiology and related ...
The role of BUD31 in clear cell renal cell carcinoma: prognostic significance, alternative splicing, and tumor immune environment
The role of BUD31 in clear cell renal cell carcinoma: prognostic significance, alternative splicing, and tumor immune environment
BUD31, a splicing factor, is linked to various cancers. This study examines BUD31's expression, prognostic value, muta...
Integrative single-cell and bulk transcriptome analyses identify a distinct pro-tumor macrophage signature that has a major prognostic impact on glioblastomas
Integrative single-cell and bulk transcriptome analyses identify a distinct pro-tumor macrophage signature that has a major prognostic impact on glioblastomas
Glioblastoma (GBM) is a highly heterogeneous disease with poor clinical outcomes. To comprehensively dissect the molecular...
Strategies for treating the cold tumors of cholangiocarcinoma: core concepts and future directions
Strategies for treating the cold tumors of cholangiocarcinoma: core concepts and future directions
Cholangiocarcinoma (CCA) is a rare type of digestive tract cancer originating from the epithelial cells of the liver and b...
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