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Transcriptomic analysis of non-leukemic cell subsets in azacytidine-responsive AML highlights pathways associated with adhesion, platelet aggregation, and angiogenesis in mice and humans
Transcriptomic analysis of non-leukemic cell subsets in azacytidine-responsive AML highlights pathways associated with adhesion, platelet aggregation, and angiogenesis in mice and humans
Hypomethylating agents (HMAs), such as 5-azacytidine (AZA), are valuable treatment options for patients with acute myeloid...
Arctiin, a lignan compound, enhances adipose tissue browning and energy expenditure by activating the adenosine A2A receptor
Arctiin, a lignan compound, enhances adipose tissue browning and energy expenditure by activating the adenosine A2A receptor
The activation of brown adipose tissue (BAT) or the browning of white adipose tissue (WAT) represents a promising therapeu...
Targeting GPR84 to alleviate acute immune-mediated liver injury
Targeting GPR84 to alleviate acute immune-mediated liver injury
GPR84 is a Gi-coupled G-protein-coupled receptor (GPCR) predominantly expressed in immune cells, with its expression upreg...
Comprehensive single-cell transcriptomic reveals different destinies of melanocytes and dynamic changes of immune microenvironment in a psychological stress-induced leukoderma and leukotrichia mouse model
Comprehensive single-cell transcriptomic reveals different destinies of melanocytes and dynamic changes of immune microenvironment in a psychological stress-induced leukoderma and leukotrichia mouse model
Vitiligo is an acquired skin depigmentation disorder often accompanied by leukoderma and leukotrichia. Half of vitiligo pa...
AEOL-induced NRF2 activation and DWORF overexpression mitigate myocardial I/R injury
AEOL-induced NRF2 activation and DWORF overexpression mitigate myocardial I/R injury
The causal relationship between the activation of nuclear factor erythroid 2-related factor 2 (NRF2) and the preservation ...
Hormonal interventions in skin wounds – a mini review
Hormonal interventions in skin wounds – a mini review
The ability to heal from wounds is perhaps the most important biological function that ensures our survival and perpetuati...
Probiotic bacteria-released extracellular vesicles enhance macrophage phagocytosis in polymicrobial sepsis by activating the FPR1/2 pathway
Probiotic bacteria-released extracellular vesicles enhance macrophage phagocytosis in polymicrobial sepsis by activating the FPR1/2 pathway
Sepsis-induced organ failure and high mortality are largely ascribed to the failure of bacterial clearance from the infect...
Machine learning-driven discovery of novel therapeutic targets in diabetic foot ulcers
Machine learning-driven discovery of novel therapeutic targets in diabetic foot ulcers
1. This is the first report identifying SCUBE1 and RNF103-CHMP3 as therapeutic targets for diabetic foot ulcers (DFU). 2. ...
CKS2 induces autophagy-mediated glutathione metabolic reprogramming to facilitate ferroptosis resistance in colon cancer
CKS2 induces autophagy-mediated glutathione metabolic reprogramming to facilitate ferroptosis resistance in colon cancer
Ferroptosis, a form of cell death characterized by lipid peroxidation, plays a crucial role in tumor suppression, offering...
Tetrandrine induces muscle atrophy involving ROS-mediated inhibition of Akt and FoxO3
Tetrandrine induces muscle atrophy involving ROS-mediated inhibition of Akt and FoxO3
Tetrandrine (Tet), a well-known drug of calcium channel blocker, has been broadly applied for anti-inflammatory and anti-f...
Single-cell characterisation of tissue homing CD4 + and CD8 + T cell clones in immune-mediated refractory arthritis
Single-cell characterisation of tissue homing CD4 + and CD8 + T cell clones in immune-mediated refractory arthritis
Immune-mediated arthritis is a group of autoinflammatory diseases, where the patient’s own immune system attacks and...
STK16 promoted colorectal cancer progress in a c-MYC signaling-dependent manner
STK16 promoted colorectal cancer progress in a c-MYC signaling-dependent manner
Colorectal cancer standed as a global health challenge, ranking third in cancer incidence and second in cancer-related dea...
The plasma proteome differentiates the multisystem inflammatory syndrome in children (MIS-C) from children with SARS-CoV-2 negative sepsis
The plasma proteome differentiates the multisystem inflammatory syndrome in children (MIS-C) from children with SARS-CoV-2 negative sepsis
The Multi-System Inflammatory Syndrome in Children (MIS-C) can develop several weeks after SARS-CoV-2 infection and requir...
Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production
Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production
The cGAS-STING signaling pathway is an essential section of the natural immune system. In recent years, an increasing numb...
The role of N-methyladenosine modification in acute and chronic kidney diseases
The role of N-methyladenosine modification in acute and chronic kidney diseases
N6-methyladenosine (m6A) modification is a kind of RNA modification in which methylation occurs at the sixth N position in...
FGF21 alleviates endothelial mitochondrial damage and prevents BBB from disruption after intracranial hemorrhage through a mechanism involving SIRT6
FGF21 alleviates endothelial mitochondrial damage and prevents BBB from disruption after intracranial hemorrhage through a mechanism involving SIRT6
Disruption of the BBB is a harmful event after intracranial hemorrhage (ICH), and this disruption contributes to a series ...
β-aminoisobutyrics acid, a metabolite of BCAA, activates the AMPK/Nrf-2 pathway to prevent ferroptosis and ameliorates lung ischemia-reperfusion injury
β-aminoisobutyrics acid, a metabolite of BCAA, activates the AMPK/Nrf-2 pathway to prevent ferroptosis and ameliorates lung ischemia-reperfusion injury
Lung ischemia-reperfusion (I/R) injury is a serious clinical problem without effective treatment. Enhancing branched-chain...
Sustained activation of 12/15 lipoxygenase (12/15 LOX) contributes to impaired renal recovery post ischemic injury in male SHR compared to females
Sustained activation of 12/15 lipoxygenase (12/15 LOX) contributes to impaired renal recovery post ischemic injury in male SHR compared to females
Acute kidney injury (AKI) due to ischemia-reperfusion (IR) is a serious and frequent complication in clinical settings, an...
The linear ANRIL transcript P14AS regulates the NF-κB signaling to promote colon cancer progression
The linear ANRIL transcript P14AS regulates the NF-κB signaling to promote colon cancer progression
The linear long non-coding RNA P14AS has previously been reported to be dysregulated in colon cancer, but the mechanistic ...
IGF2 deficiency promotes liver aging through mitochondrial dysfunction and upregulated CEBPB signaling in d-galactose-induced aging mice
IGF2 deficiency promotes liver aging through mitochondrial dysfunction and upregulated CEBPB signaling in d-galactose-induced aging mice
Liver aging, marked by cellular senescence and low-grade inflammation, heightens susceptibility to chronic liver disease a...
Role of DCLK1/Hippo pathway in type II alveolar epithelial cells differentiation in acute respiratory distress syndrome
Role of DCLK1/Hippo pathway in type II alveolar epithelial cells differentiation in acute respiratory distress syndrome
Delay in type II alveolar epithelial cell (AECII) regeneration has been linked to higher mortality in patients with acute ...
Maresin1 ameliorates MSU crystal-induced inflammation by upregulating Prdx5 expression
Maresin1 ameliorates MSU crystal-induced inflammation by upregulating Prdx5 expression
Maresin1 (MaR1) is a potent lipid mediator that exhibits significant anti-inflammatory activity in the context of several ...
TET2 deficiency promotes anxiety and depression-like behaviors by activating NLRP3/IL-1β pathway in microglia of allergic rhinitis mice
TET2 deficiency promotes anxiety and depression-like behaviors by activating NLRP3/IL-1β pathway in microglia of allergic rhinitis mice
Anxiety and depression-like behaviors in allergic rhinitis (AR) are attracting attention, while the precise mechanism has ...
Performance of the MeltPro TB assay as initial test for diagnosis of pulmonary tuberculosis with drug-resistance detection
Performance of the MeltPro TB assay as initial test for diagnosis of pulmonary tuberculosis with drug-resistance detection
The MeltPro TB assay (MeltPro) is a molecular rapid diagnostic test designed for detecting resistance to antituberculosis ...
PP121, a dual inhibitor of tyrosine and phosphoinositide kinases, relieves airway hyperresponsiveness, mucus hypersecretion and inflammation in a murine asthma model
PP121, a dual inhibitor of tyrosine and phosphoinositide kinases, relieves airway hyperresponsiveness, mucus hypersecretion and inflammation in a murine asthma model
Tyrosine kinase and phosphoinositide kinase pathways play important roles in asthma formation. As a dual tyrosine and phos...
Exosomal circCOL1A1 promotes angiogenesis via recruiting EIF4A3 protein and activating Smad2/3 pathway in colorectal cancer
Exosomal circCOL1A1 promotes angiogenesis via recruiting EIF4A3 protein and activating Smad2/3 pathway in colorectal cancer
Colorectal cancer (CRC) is the third frequently diagnosed cancer with high incidence and mortality rate worldwide. Our pre...
Loss of Krüppel-like factor-10 facilitates the development of chemical-induced liver cancer in mice
Loss of Krüppel-like factor-10 facilitates the development of chemical-induced liver cancer in mice
Krüppel-like factor 10 (KLF10) is involved in a positive feedback loop that regulates transforming growth factor ^...
USP38 exacerbates atrial inflammation, fibrosis, and susceptibility to atrial fibrillation after myocardial infarction in mice
USP38 exacerbates atrial inflammation, fibrosis, and susceptibility to atrial fibrillation after myocardial infarction in mice
Inflammation plays an important role in the pathogenesis of atrial fibrillation (AF) after myocardial infarction (MI). The...
Targeted inhibition of CX3CL1 limits podocytes ferroptosis to ameliorate cisplatin-induced acute kidney injury
Targeted inhibition of CX3CL1 limits podocytes ferroptosis to ameliorate cisplatin-induced acute kidney injury
It is widely acknowledged that cisplatin-induced nephrotoxicity hinders its efficacy during clinical therapy. Effective ph...
B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine
B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine
High doses of oral thiamine improve clinical fatigue scores in patients with quiescent inflammatory bowel disease (IBD) an...
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