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A randomized trial comparing safety, immunogenicity and efficacy of self-amplifying mRNA and adenovirus-vector COVID-19 vaccines
A randomized trial comparing safety, immunogenicity and efficacy of self-amplifying mRNA and adenovirus-vector COVID-19 vaccines
This phase 3 trial compared safety, tolerability, immunogenicity and efficacy of the self-amplifying mRNA COVID-19 vaccine...
Author Correction: Reply to: mRNA COVID-19 vaccinations are not associated with RVO development 21 days and 12 weeks after vaccination
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
Ad26.RSV.preF completely protects calves from severe respiratory disease induced by bovine RSV challenge
Ad26.RSV.preF completely protects calves from severe respiratory disease induced by bovine RSV challenge
Vaccination with Ad26.RSV.preF, an Adenoviral serotype 26 vector encoding RSV F protein stabilized in its prefusion confor...
Evaluation of one year immunity following rabies post-exposure prophylaxis in dog bite cases
Evaluation of one year immunity following rabies post-exposure prophylaxis in dog bite cases
Rabies remains a global health threat despite being preventable with post-exposure prophylaxis (PEP). This study assessed ...
Modi-2 a vaccine stimulating CD4 responses to homocitrullinated self epitopes as therapy for solid cancers
Modi-2 a vaccine stimulating CD4 responses to homocitrullinated self epitopes as therapy for solid cancers
Stresses within the tumour microenvironment can mediate post-translational modifications of self-proteins. Homocitrullinat...
Mass cytometry reveals cellular correlates of immune response heterogeneity to SARS-CoV-2 vaccination in the elderly
Mass cytometry reveals cellular correlates of immune response heterogeneity to SARS-CoV-2 vaccination in the elderly
Heterogeneity in vaccine response, particularly in vulnerable populations like the elderly, represents a significant publi...
Modeling the persistence of 4CMenB vaccine protection against real world meningococcal B disease in adolescents
Modeling the persistence of 4CMenB vaccine protection against real world meningococcal B disease in adolescents
The efficacy of the four-component 4CMenB vaccine is measured through the serum bactericidal antibody (SBA) assay on four ...
Neutralizing antibodies elicited in macaques recognize V3 residues on altered conformations of HIV-1 Env trimer
Neutralizing antibodies elicited in macaques recognize V3 residues on altered conformations of HIV-1 Env trimer
Eliciting broadly neutralizing antibodies that protect against diverse HIV-1 strains is a primary goal of AIDS vaccine res...
M2e nanovaccines supplemented with recombinant hemagglutinin protect chickens against heterologous HPAI H5N1 challenge
M2e nanovaccines supplemented with recombinant hemagglutinin protect chickens against heterologous HPAI H5N1 challenge
Current poultry vaccines against influenza A viruses target the globular head region of the hemagglutinin (HA1), providing...
Applying causal inference and Bayesian statistics to understanding vaccine safety signals using a simulation study
Applying causal inference and Bayesian statistics to understanding vaccine safety signals using a simulation study
Community perception of vaccine safety influences vaccine uptake. Our objective was to assess current vaccine safety monit...
Progress on the research and development of plague vaccines with a call to action
Progress on the research and development of plague vaccines with a call to action
There is a compelling demand for approved plague vaccines due to the endemicity of Yersinia pestis and its potential for p...
Computationally designed Spike antigens induce neutralising responses against the breadth of SARS-COV-2 variants
Computationally designed Spike antigens induce neutralising responses against the breadth of SARS-COV-2 variants
Updates of SARS-CoV-2 vaccines are required to generate immunity in the population against constantly evolving SARS-CoV-2 ...
WHO International Standards for antibodies to HPV6 HPV11 HPV31 HPV33 HPV45 HPV52 and HPV58
WHO International Standards for antibodies to HPV6 HPV11 HPV31 HPV33 HPV45 HPV52 and HPV58
Previously established World Health Organization (WHO) International Standards (IS) for anti-HPV16 and HPV18 antibodies ar...
Risk benefit analysis to evaluate risk of thromboembolic events after mRNA COVID-19 vaccination and COVID-19
Risk benefit analysis to evaluate risk of thromboembolic events after mRNA COVID-19 vaccination and COVID-19
We compared the risks and benefits of COVID-19 vaccines using a causal pathway analysis to weigh up possible risk factors ...
COVID-19 vaccine refusal is driven by deliberate ignorance and cognitive distortions
COVID-19 vaccine refusal is driven by deliberate ignorance and cognitive distortions
Vaccine hesitancy was a major challenge during the COVID-19 pandemic. A common but sometimes ineffective intervention to r...
Understanding the rationales and information environments for early, late, and nonadopters of the COVID-19 vaccine
Understanding the rationales and information environments for early, late, and nonadopters of the COVID-19 vaccine
Anti-vaccine sentiment during the COVID-19 pandemic grew at an alarming rate, leaving much to understand about the relatio...
FcRn regulates antigen presentation in dendritic cells downstream of DEC205-targeted vaccines
FcRn regulates antigen presentation in dendritic cells downstream of DEC205-targeted vaccines
Dendritic cell (DC)-targeted vaccination is a new mode of antigen delivery that relies on the use of monoclonal antibodies...
Insights into vaccines for elderly individuals: from the impacts of immunosenescence to delivery strategies
Insights into vaccines for elderly individuals: from the impacts of immunosenescence to delivery strategies
Immunosenescence increases the risk and severity of diseases in elderly individuals and leads to impaired vaccine-induced ...
The role of correlates of protection in overcoming barriers to vaccine development and demonstrating efficacy
Vaccine development requires the conduct of clinical trials to generate the necessary safety, quality and efficacy data ne...
Author Correction: Enhanced attenuation of chikungunya vaccines expressing antiviral cytokines
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Strep A: challenges, opportunities, vaccine-based solutions, and economics
This collection of articles focuses on Streptococcus pyogenes (Strep A) vaccine research and innovation, with a focus on e...
Realising the potential of correlates of protection for vaccine development, licensure and use: short summary
Realising the potential of correlates of protection for vaccine development, licensure and use: short summary
On 27–29th of September 2022, Wellcome convened an international multi-stakeholder workshop to discuss the use of Co...
High production of IL-12 by human dendritic cells stimulated with combinations of pattern-recognition receptor agonists
High production of IL-12 by human dendritic cells stimulated with combinations of pattern-recognition receptor agonists
The cytokine IL-12p70 is crucial for T helper 1 (Th1) polarization and the generation of type 1 immunity required to fight...
Author Correction: A Rift Valley fever mRNA vaccine elicits strong immune responses in mice and rhesus macaques
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Healthy ageing: Herpes zoster infection and the role of zoster vaccination
Healthy ageing: Herpes zoster infection and the role of zoster vaccination
Populations are ageing worldwide, with considerable time lived in ill-health, putting upwards pressure on healthcare budge...
BA.5 bivalent booster vaccination enhances neutralization of XBB.1.5, XBB.1.16 and XBB.1.9 variants in patients with lung cancer
BA.5 bivalent booster vaccination enhances neutralization of XBB.1.5, XBB.1.16 and XBB.1.9 variants in patients with lung cancer
This study reports that most patients with NSCLC had a significant increase in the nAb response to the currently circulati...
Ischemic stroke after COVID-19 bivalent vaccine administration in patients aged 65 years and older in the United States
Ischemic stroke after COVID-19 bivalent vaccine administration in patients aged 65 years and older in the United States
The Centers for Disease Control and Prevention announced in January 2023 a potential connection between administration of ...
The effect of dosage on the protective efficacy of whole-sporozoite formulations for immunization against malaria
The effect of dosage on the protective efficacy of whole-sporozoite formulations for immunization against malaria
Immunization with Plasmodium sporozoites, either attenuated or administered under the cover of an antimalarial drug, can i...
Enhancing anti-viral neutralization response to immunization with HIV-1 envelope glycoprotein immunogens
Enhancing anti-viral neutralization response to immunization with HIV-1 envelope glycoprotein immunogens
An effective human immunodeficiency virus type I (HIV-1) vaccine that robustly elicits broadly neutralizing antibodies (bn...
Conjugation of HIV-1 envelope to hepatitis B surface antigen alters vaccine responses in rhesus macaques
Conjugation of HIV-1 envelope to hepatitis B surface antigen alters vaccine responses in rhesus macaques
An effective HIV-1 vaccine remains a critical unmet need for ending the AIDS epidemic. Vaccine trials conducted to date ha...
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