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Proteasome dynamics in response to metabolic changes
Proteasomal protein breakdown is ubiquitin- and ATP-dependentProtein homeostasis describes the equilibrium between protein...
Repeat-dose toxicity of human umbilical cord mesenchymal stem cells via subcutaneous injection in NOG mice
Repeat-dose toxicity of human umbilical cord mesenchymal stem cells via subcutaneous injection in NOG mice
1 IntroductionThe skin, the largest organ of the human body, acts as the primary physiological defense (Eckhart and Zeeuwe...
The BBS/CCT chaperonin complex ensures the localization of the adhesion G protein-coupled receptor ADGRV1 to the base of primary cilia
IntroductionPrimary cilia are antenna-like organelles that can protrude from the cell membrane of most animal cells and re...
Research progress on small extracellular vesicles in diabetic nephropathy
1 IntroductionDKD is the leading cause of CKD in many developed and developing regions (Ogurtsova et al., 2017). DN is the...
Lmx1a is essential for marginal cell differentiation and stria vascularis formation
IntroductionIn mammals, a hearing (cochlea) and balance system (three semicircular canals, utricle, and saccule) are separ...
Mitoregulin, a tiny protein at the crossroads of mitochondrial functioning, stress, and disease
1 IntroductionMitochondria, the powerhouses of the cell, play a central role in responses to several types of stress, incl...
New evidence for T-cadherin in COVID-19 pathogenesis, endothelial dysfunction, and lung fibrosis
1 IntroductionThe pandemic of COVID-19, triggered by coronavirus 2 (SARS-CoV-2), had an enormous impact on the global heal...
Potential role of SIRT1 in cell ferroptosis
1 IntroductionFerroptosis, first identified in 2012, is a unique form of regulated cell death that is distinct from tradit...
Exosomes in cartilage microenvironment regulation and cartilage repair
1 IntroductionOsteoarthritis (OA), recognized as the prevailing joint pathology globally, is distinguished by the degradat...
Pax1a-EphrinB2a pathway in the first pharyngeal pouch controls hyomandibular plate formation by promoting chondrocyte formation in zebrafish
IntroductionThe shape change of the craniofacial skeleton is a driving force of the head shape change during vertebrate ev...
CD44 variant exons induce chemoresistance by modulating cell death pathways
1 IntroductionCancer ranks among the leading causes of death worldwide, claiming approximately 10 million lives in 2022, a...
Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model
IntroductionKawasaki disease (KD) is a medium-vessel vasculitis that primarily affects children less than 5 years of age (...
The multifaceted role of m5C RNA methylation in digestive system tumorigenesis
1 IntroductionRNA modifications have emerged as a pivotal aspect of epigenetics, drawing increasing attention in recent ye...
The vascular microenvironment and its stem cells regulate vascular homeostasis
1 IntroductionHomeostasis refers to a state in which an individual organism maintains a relatively stable internal environ...
A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression
IntroductionCysteine-rich motor neuron 1 (CRIM1; also known cysteine-rich transmembrane BMP regulator 1; Online Mendelian ...
Combining TNF-α silencing with Wnt3a overexpression: a promising gene therapy for particle-induced periprosthetic osteolysis
1 IntroductionTotal joint arthroplasty (TJA) is a cornerstone treatment for end-stage painful joint diseases, yet it is no...
Regulation and functional importance of human periodontal ligament mesenchymal stromal cells with various rates of CD146+ cells
1 IntroductionFor years, mesenchymal stromal cells (MSCs) have been researched as a promising remedy in tissue regeneratio...
Corrigendum: Protective mechanism of luteinizing hormone and follicle-stimulating hormone against nicotine-induced damage of mouse early folliculogenesis
Corrigendum on: Protective Mechanism of Luteinizing Hormone and Follicle-Stimulating Hormone Against Nicotine-Induced Dama...
Association of endometrial thickness with live birth rates among women undergoing fresh IVF, FET, and PGT cycles
IntroductionInfertility is a significant health concern affecting numerous families, and the development of ART has brough...
TF-chRDP: a method for simultaneously capturing transcription factor binding chromatin-associated RNA, DNA and protein
1 IntroductionTranscription factors (TFs) are pivotal regulators of gene expression, orchestrating a wide array of biologi...
The transcription elongation factors Spt4 and Spt5 control neural progenitor proliferation and are implicated in neuronal remodeling during Drosophila mushroom body development
The transcription elongation factors Spt4 and Spt5 control neural progenitor proliferation and are implicated in neuronal remodeling during Drosophila mushroom body development
Spt4 and Spt5 form the DRB sensitivity inducing factor (DSIF) complex that regulates transcription elongation at multiple ...
Vitamin E supplementation prevents obesogenic diet-induced developmental abnormalities in SR-B1 deficient embryos
Vitamin E supplementation prevents obesogenic diet-induced developmental abnormalities in SR-B1 deficient embryos
IntroductionGenetic and environmental factors influence the risk of neural tube defects (NTD), congenital malformations ch...
Asymmetric dimethylarginine induces maladaptive function of the blood-brain barrier
Asymmetric dimethylarginine induces maladaptive function of the blood-brain barrier
Growing body of evidence suggests that cardiovascular risk factor, asymmetric dimethylarginine (ADMA), can be implicated i...
Multiple roles of mitochondrial autophagy receptor FUNDC1 in mitochondrial events and kidney disease
Multiple roles of mitochondrial autophagy receptor FUNDC1 in mitochondrial events and kidney disease
This article reviews the latest research progress on the role of mitochondrial autophagy receptor FUN14 domain containing ...
Advances in different adult stem cell-derived exosomal non-coding RNAs for the treatment of neurological disorders: a narrative review
Advances in different adult stem cell-derived exosomal non-coding RNAs for the treatment of neurological disorders: a narrative review
Neurological disorders are being increasingly recognized as major causes of death and disability around the world. Neurolo...
Kaempferol enhances intestinal repair and inhibits the hyperproliferation of aging intestinal stem cells in Drosophila
Kaempferol enhances intestinal repair and inhibits the hyperproliferation of aging intestinal stem cells in Drosophila
IntroductionIntestinal stem cells (ISCs) are crucial for tissue repair and homeostasis because of their ability to self-re...
DeepO-GlcNAc: a web server for prediction of protein O-GlcNAcylation sites using deep learning combined with attention mechanism
DeepO-GlcNAc: a web server for prediction of protein O-GlcNAcylation sites using deep learning combined with attention mechanism
IntroductionProtein O-GlcNAcylation is a dynamic post-translational modification involved in major cellular processes and ...
Notch signaling regulates pulmonary fibrosis
Notch signaling regulates pulmonary fibrosis
Pulmonary fibrosis is a progressive interstitial lung disease associated with aging. The pathogenesis of pulmonary fibrosi...
Multi-resolution visual Mamba with multi-directional selective mechanism for retinal disease detection
Multi-resolution visual Mamba with multi-directional selective mechanism for retinal disease detection
IntroductionRetinal diseases significantly impact patients’ quality of life and increase social medical costs. Optical coh...
Polysaccharide-based hydrogels for cartilage regeneration
Polysaccharide-based hydrogels for cartilage regeneration
Cartilage defect is one of the common tissue defect clinical diseases and may finally lead to osteoarthritis (OA) which th...
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