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Oral Janus Kinase Inhibitors in Pediatric Atopic Dermatitis
Oral Janus Kinase Inhibitors in Pediatric Atopic Dermatitis
To analyze the efficacy and safety of Janus kinase inhibitors (JAKi) in the treatment of pediatric AD. Adolescents with mo...
Impact of Enolase in Allergic Disease
Impact of Enolase in Allergic Disease
There is growing evidence that enolase is involved in allergy. This manuscript reviews the impact of enolase in allergic d...
Childhood-Onset Systemic Lupus Erythematosus (cSLE): An International Perspective
Childhood-Onset Systemic Lupus Erythematosus (cSLE): An International Perspective
Childhood-onset systemic lupus erythematosus (cSLE) is a severe and potentially life-threatening chronic autoimmune diseas...
Cephalosporin Allergy: Updates on Diagnostic Testing
Cephalosporin Allergy: Updates on Diagnostic Testing
Cephalosporins are one of the most prescribed antibiotics worldwide and are implicated in a wide range of hypersensitivity...
Mechanisms of Bone Morphogenetic Protein 2 in Respiratory Diseases
Mechanisms of Bone Morphogenetic Protein 2 in Respiratory Diseases
Bone morphogenetic protein 2 (BMP2) belongs to the transforming growth factor-β (TGF-β) superfamily and plays an...
Extent of Endoscopic Sinus Surgery in Chronic Rhinosinusitis: A Systematic Review and Meta-Analysis
Extent of Endoscopic Sinus Surgery in Chronic Rhinosinusitis: A Systematic Review and Meta-Analysis
There is an incomplete understanding regarding the extent of endoscopic sinus surgery (ESS) in managing chronic rhinosinus...
Epidemiology and the Growing Epidemic of Food Allergy in Children and Adults Across the Globe
Epidemiology and the Growing Epidemic of Food Allergy in Children and Adults Across the Globe
Food allergies are immune-mediated, complex disorders, which are the source of increasing health concern worldwide. The go...
Multidisciplinary Decision-Making—ITAlian Consensus After Two Years of Real Practice on the Management of Severe Uncontrolled CRSwNP by Biologics (ITACA Study)
Multidisciplinary Decision-Making—ITAlian Consensus After Two Years of Real Practice on the Management of Severe Uncontrolled CRSwNP by Biologics (ITACA Study)
We aimed to reach an Italian multidisciplinary consensus on some crucial aspects of treatment decision making in CRSwNP, f...
Reversible Elevation of Tryptase Over the Individual's Baseline: Why is It the Best Biomarker for Severe Systemic Mast Cell Activation and MCAS?
Reversible Elevation of Tryptase Over the Individual's Baseline: Why is It the Best Biomarker for Severe Systemic Mast Cell Activation and MCAS?
Mast cell (MC) activation syndromes (MCAS) are conditions defined by recurrent episodes of severe systemic anaphylaxis or ...
Precautionary Allergen Labeling: Avoidance for All?
Precautionary Allergen Labeling: Avoidance for All?
Precautionary allergen labeling (PAL) suggests the risk of unintended allergen presence (UAP) in food but is unregulated i...
The Natural History and Risk Factors for the Development of Food Allergies in Children and Adults
The Natural History and Risk Factors for the Development of Food Allergies in Children and Adults
This narrative review explores food allergy prevalence and natural history stratified by life stages, especially in contex...
Recent Insights into the Environmental Determinants of Childhood Asthma
Recent Insights into the Environmental Determinants of Childhood Asthma
Ubiquitous environmental exposures, including ambient air pollutants, are linked to the development and severity of childh...
What the SARS-CoV-2 Pandemic Has Taught Us About Immunosuppression, Vaccinations, and Immune Dysregulation: The Rheumatology Experience
What the SARS-CoV-2 Pandemic Has Taught Us About Immunosuppression, Vaccinations, and Immune Dysregulation: The Rheumatology Experience
This review reflects on the impact of the COVID-19 pandemic on the field of rheumatology, emphasizing resulting insights r...
Type 2 and Non-type 2 Inflammation in the Upper Airways: Cellular and Molecular Alterations in Olfactory Neuroepithelium Cell Populations
Type 2 and Non-type 2 Inflammation in the Upper Airways: Cellular and Molecular Alterations in Olfactory Neuroepithelium Cell Populations
Neurogenesis occurring in the olfactory epithelium is critical to continuously replace olfactory neurons to maintain olfac...
Alpha-Tryptase as a Risk-Modifying Factor for Mast Cell–Mediated Reactions
Alpha-Tryptase as a Risk-Modifying Factor for Mast Cell–Mediated Reactions
To provide an overview on the current understanding of genetic variability in human tryptases and summarize the literature...
Fungal Sensitization and Human Allergic Disease
Fungal Sensitization and Human Allergic Disease
Fungal sensitizations have been associated with hypersensitivity reactions with variable levels of evidence available to l...
Evaluation and Modification of a Shared Decision-Making Tool for Peanut Allergy Management
Evaluation and Modification of a Shared Decision-Making Tool for Peanut Allergy Management
Based on shared decision-making (SDM) principles, a decision aid was previously developed to help patients, their caregive...
Biomarkers of Autoimmune Chronic Spontaneous Urticaria
Biomarkers of Autoimmune Chronic Spontaneous Urticaria
Chronic spontaneous urticaria and chronic inducible urticaria (CSU/CindU) are caused by mast cell and basophil activation ...
The Impact of Ambient and Wildfire Air Pollution on Rhinosinusitis and Olfactory Dysfunction
The Impact of Ambient and Wildfire Air Pollution on Rhinosinusitis and Olfactory Dysfunction
With increasing industrialization, exposure to ambient and wildfire air pollution is projected to increase, necessitating ...
Effects of Endoscopic Sinus Surgery on Olfactory Function
Effects of Endoscopic Sinus Surgery on Olfactory Function
To review the effects of endoscopic sinus surgery and endonasal approaches to the skull base on olfaction. Advancements in...
Type 2 Biomarkers for the Indication and Response to Biologics in CRSwNP
Type 2 Biomarkers for the Indication and Response to Biologics in CRSwNP
Three biologics targeting type 2 inflammation have been approved for the treatment of severe and uncontrolled chronic rhin...
Endoscopic Extended Sinus Surgery for Patients with Severe Chronic Rhinosinusitis with Nasal Polyps, the Choice of Mucoplasty: A Systematic Review
Endoscopic Extended Sinus Surgery for Patients with Severe Chronic Rhinosinusitis with Nasal Polyps, the Choice of Mucoplasty: A Systematic Review
The advances in the knowledge of the molecular basis of the inflammatory response in chronic rhinosinusitis with nasal pol...
Expert Consensus on SABA Use for Asthma Clinical Decision-Making: A Delphi Approach
Expert Consensus on SABA Use for Asthma Clinical Decision-Making: A Delphi Approach
A modified Delphi process was undertaken to provide a US expert-led consensus to guide clinical action on short-acting bet...
Treatments of Epistaxis in Hereditary Hemorrhagic Telangiectasia: Systematic Review and Network Meta-Analysis
Treatments of Epistaxis in Hereditary Hemorrhagic Telangiectasia: Systematic Review and Network Meta-Analysis
To analyze and compare the effects of epistaxis treatments for Hereditary Hemorrhagic Telangiectasia (HHT) patients. Of to...
Neuromyelitis Optica: Pathogenesis Overlap with Other Autoimmune Diseases
Neuromyelitis Optica: Pathogenesis Overlap with Other Autoimmune Diseases
Neuromyelitis optica (NMO) is an auto-immune disease essentially depicted by optic neuritis and transverse myelitis. Per s...
An Emerging Role of Extracellular Traps in Chronic Rhinosinusitis
An Emerging Role of Extracellular Traps in Chronic Rhinosinusitis
Chronic rhinosinusitis (CRS) is a complicated, heterogeneous disease likely caused by inflammatory and infectious factors....
Overview and Current Advances in Dapsone Hypersensitivity Syndrome
Overview and Current Advances in Dapsone Hypersensitivity Syndrome
As a sulfone antibacterial agent, dapsone has been widely used to treat leprosy. Moreover, dapsone is also used in many im...
Allergen Stability in Food Allergy: A Clinician’s Perspective
Allergen Stability in Food Allergy: A Clinician’s Perspective
The globally rising food allergy prevalence is associated with the urgent need for new disease prevention methods, efficie...
Effects of Allergen Exposure and Environmental Risk Factors in Schools on Childhood Asthma
Effects of Allergen Exposure and Environmental Risk Factors in Schools on Childhood Asthma
This review aims to assess the prevalence of common allergen exposures and environmental risk factors for asthma in school...
Omalizumab Treatment in Uncontrolled Asthma and CRSwNP Patients, with Previous Endoscopic Sinus Surgery, to Improve Quality of Life and Endoscopic Outcomes: a Two-Year Real-Life Study
Omalizumab Treatment in Uncontrolled Asthma and CRSwNP Patients, with Previous Endoscopic Sinus Surgery, to Improve Quality of Life and Endoscopic Outcomes: a Two-Year Real-Life Study
Despite molecular underlying advances, limited and divergent data on monoclonal antibodies (mAb) therapy in chron...
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