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Thymic Stromal Lymphopoietin (TSLP): Evidence in Respiratory Epithelial-driven Diseases Including Chronic Rhinosinusitis with Nasal Polyps
Thymic Stromal Lymphopoietin (TSLP): Evidence in Respiratory Epithelial-driven Diseases Including Chronic Rhinosinusitis with Nasal Polyps
Thymic stromal lymphopoietin (TSLP) is increasingly recognized for its pivotal role in the pathogenesis of various epithel...
Effects of Food Processing on Allergenicity
Effects of Food Processing on Allergenicity
There is an increasing awareness among clinicians that industrial and household food processing methods can increase or de...
Parosmia: Pathophysiology and Management
Parosmia: Pathophysiology and Management
Parosmia is a qualitative olfactory disorder in which there is a mismatch between the memory of an odor and the actual exp...
The Impact of the Indoor Environment on Childhood Asthma
The Impact of the Indoor Environment on Childhood Asthma
This manuscript reviews the impact of important indoor environmental exposures on pediatric asthma, with a focus on recent...
Hypersensitivity Reactions to Anticonvulsants
Hypersensitivity Reactions to Anticonvulsants
Antiepileptics are the mainstay of treatment for seizure management. Immediate and delayed hypersensitivity reactions asso...
Effect of Dupilumab in CRSwNP Sinonasal Outcomes from Real Life Studies: A Systematic Review with Meta-analysis
Effect of Dupilumab in CRSwNP Sinonasal Outcomes from Real Life Studies: A Systematic Review with Meta-analysis
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a debilitating inflammatory condition that significantly impacts qual...
Hyper IgE Syndrome: Bridging the Gap Between Immunodeficiency, Atopy, and Allergic Diseases
Hyper IgE Syndrome: Bridging the Gap Between Immunodeficiency, Atopy, and Allergic Diseases
It seeks to answer key questions about the molecular and cellular mechanisms underlying Hyper IgE Syndrome (HIES), the gen...
T Cell Exhaustion in Allergic Diseases and Allergen Immunotherapy: A Novel Biomarker?
T Cell Exhaustion in Allergic Diseases and Allergen Immunotherapy: A Novel Biomarker?
This review explores the emerging role of T cell exhaustion in allergic diseases and allergen immunotherapy (AIT). It aims...
Climate Change and the Future of Allergies and Asthma
Climate Change and the Future of Allergies and Asthma
Climate change affects global temperature, meteorological variables, plant aerobiology, air pollution exposure and a host ...
Managing Chronic Urticaria in Children: An Update
Managing Chronic Urticaria in Children: An Update
To provide an update and new insights into the management of pediatric patients with chronic urticaria. Chronic urticaria ...
Occupational Respiratory Allergy to Flour in the Modern Era
Occupational Respiratory Allergy to Flour in the Modern Era
A comprehensive literature review was conducted in order to identify and summarize recent research on IgE-mediated occupat...
Pediatric Systemic Autoinflammatory Disorders: An Overview
Pediatric Systemic Autoinflammatory Disorders: An Overview
Systemic autoinflammatory disorders (SAIDs) are a group of diseases that are characterized by recurrent or persistent unpr...
Metabolomics in Childhood Asthma – a Promising Tool to Meet Various Clinical Needs
Metabolomics in Childhood Asthma – a Promising Tool to Meet Various Clinical Needs
The aim of our review is to summarize the available literature where metabolomics was used in studies on childhood asthma,...
Oral Janus Kinase Inhibitors in Pediatric Atopic Dermatitis
Oral Janus Kinase Inhibitors in Pediatric Atopic Dermatitis
To analyze the efficacy and safety of Janus kinase inhibitors (JAKi) in the treatment of pediatric AD. Adolescents with mo...
Impact of Enolase in Allergic Disease
Impact of Enolase in Allergic Disease
There is growing evidence that enolase is involved in allergy. This manuscript reviews the impact of enolase in allergic d...
Childhood-Onset Systemic Lupus Erythematosus (cSLE): An International Perspective
Childhood-Onset Systemic Lupus Erythematosus (cSLE): An International Perspective
Childhood-onset systemic lupus erythematosus (cSLE) is a severe and potentially life-threatening chronic autoimmune diseas...
Cephalosporin Allergy: Updates on Diagnostic Testing
Cephalosporin Allergy: Updates on Diagnostic Testing
Cephalosporins are one of the most prescribed antibiotics worldwide and are implicated in a wide range of hypersensitivity...
Mechanisms of Bone Morphogenetic Protein 2 in Respiratory Diseases
Mechanisms of Bone Morphogenetic Protein 2 in Respiratory Diseases
Bone morphogenetic protein 2 (BMP2) belongs to the transforming growth factor-β (TGF-β) superfamily and plays an...
Extent of Endoscopic Sinus Surgery in Chronic Rhinosinusitis: A Systematic Review and Meta-Analysis
Extent of Endoscopic Sinus Surgery in Chronic Rhinosinusitis: A Systematic Review and Meta-Analysis
There is an incomplete understanding regarding the extent of endoscopic sinus surgery (ESS) in managing chronic rhinosinus...
Epidemiology and the Growing Epidemic of Food Allergy in Children and Adults Across the Globe
Epidemiology and the Growing Epidemic of Food Allergy in Children and Adults Across the Globe
Food allergies are immune-mediated, complex disorders, which are the source of increasing health concern worldwide. The go...
Multidisciplinary Decision-Making—ITAlian Consensus After Two Years of Real Practice on the Management of Severe Uncontrolled CRSwNP by Biologics (ITACA Study)
Multidisciplinary Decision-Making—ITAlian Consensus After Two Years of Real Practice on the Management of Severe Uncontrolled CRSwNP by Biologics (ITACA Study)
We aimed to reach an Italian multidisciplinary consensus on some crucial aspects of treatment decision making in CRSwNP, f...
Reversible Elevation of Tryptase Over the Individual's Baseline: Why is It the Best Biomarker for Severe Systemic Mast Cell Activation and MCAS?
Reversible Elevation of Tryptase Over the Individual's Baseline: Why is It the Best Biomarker for Severe Systemic Mast Cell Activation and MCAS?
Mast cell (MC) activation syndromes (MCAS) are conditions defined by recurrent episodes of severe systemic anaphylaxis or ...
Precautionary Allergen Labeling: Avoidance for All?
Precautionary Allergen Labeling: Avoidance for All?
Precautionary allergen labeling (PAL) suggests the risk of unintended allergen presence (UAP) in food but is unregulated i...
The Natural History and Risk Factors for the Development of Food Allergies in Children and Adults
The Natural History and Risk Factors for the Development of Food Allergies in Children and Adults
This narrative review explores food allergy prevalence and natural history stratified by life stages, especially in contex...
Recent Insights into the Environmental Determinants of Childhood Asthma
Recent Insights into the Environmental Determinants of Childhood Asthma
Ubiquitous environmental exposures, including ambient air pollutants, are linked to the development and severity of childh...
What the SARS-CoV-2 Pandemic Has Taught Us About Immunosuppression, Vaccinations, and Immune Dysregulation: The Rheumatology Experience
What the SARS-CoV-2 Pandemic Has Taught Us About Immunosuppression, Vaccinations, and Immune Dysregulation: The Rheumatology Experience
This review reflects on the impact of the COVID-19 pandemic on the field of rheumatology, emphasizing resulting insights r...
Type 2 and Non-type 2 Inflammation in the Upper Airways: Cellular and Molecular Alterations in Olfactory Neuroepithelium Cell Populations
Type 2 and Non-type 2 Inflammation in the Upper Airways: Cellular and Molecular Alterations in Olfactory Neuroepithelium Cell Populations
Neurogenesis occurring in the olfactory epithelium is critical to continuously replace olfactory neurons to maintain olfac...
Alpha-Tryptase as a Risk-Modifying Factor for Mast Cell–Mediated Reactions
Alpha-Tryptase as a Risk-Modifying Factor for Mast Cell–Mediated Reactions
To provide an overview on the current understanding of genetic variability in human tryptases and summarize the literature...
Fungal Sensitization and Human Allergic Disease
Fungal Sensitization and Human Allergic Disease
Fungal sensitizations have been associated with hypersensitivity reactions with variable levels of evidence available to l...
Evaluation and Modification of a Shared Decision-Making Tool for Peanut Allergy Management
Evaluation and Modification of a Shared Decision-Making Tool for Peanut Allergy Management
Based on shared decision-making (SDM) principles, a decision aid was previously developed to help patients, their caregive...
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