NFZ o zdrowiu. Astma. Warszawa; 2020. Accessed 15 Feb 2024.

GINA, Global Strategy for Asthma Management and Prevention. 2023. https://ginasthma.org/wp-content/uploads/2023/07/GINA-2023-Full-report-23_07_06-WMS.pdf. Accessed 15 Feb 2024.

Foppiano F, Schaub B. Childhood asthma phenotypes and endotypes: a glance into the mosaic. Mol Cell Pediatr. 2023;10:9. https://doi.org/10.1186/s40348-023-00159-1.

Article  PubMed  PubMed Central  Google Scholar 

Toskala E, Kennedy DW. Asthma risk factors. Int Forum Allergy Rhinol. 2015;5:S11–6. https://doi.org/10.1002/alr.21557.

Article  PubMed  PubMed Central  Google Scholar 

The Global Asthma Report 2022. Int J Tuberc Lung Dis. 2022;26:1–104. https://www.ingentaconnect.com/content/https://doi.org/10.5588/ijtld.22.101. Accessed 22 Feb 2024.

Kuruvilla ME, Lee FE-H, Lee GB. Understanding Asthma Phenotypes, Endotypes, and Mechanisms of Disease. Clin Rev Allergy Immunol. 2019;56:219–33. https://doi.org/10.1007/s12016-018-8712-1.

Article  PubMed  PubMed Central  Google Scholar 

Chang C, Guo Z, He B, Yao W. Metabolic alterations in the sera of Chinese patients with mild persistent asthma: a GC-MS-based metabolomics analysis. Acta Pharmacol Sin. 2015;36:1356–66. https://doi.org/10.1038/aps.2015.102.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Comhair SAA, McDunn J, Bennett C, Fettig J, Erzurum SC, Kalhan SC. Metabolomic Endotype of Asthma. J Immun. 2015;195:643–50. https://doi.org/10.4049/jimmunol.1500736.

Article  PubMed  CAS  Google Scholar 

Saude EJ, Skappak CD, Regush S, Cook K, Ben-Zvi A, Becker A, et al. Metabolomic profiling of asthma: Diagnostic utility of urine nuclear magnetic resonance spectroscopy. J Allergy Clin Immunol. 2011;127:757-764.e6. https://doi.org/10.1016/j.jaci.2010.12.1077.

Article  PubMed  CAS  Google Scholar 

Turi KN, Romick-Rosendale L, Ryckman KK, Hartert TV. A review of metabolomics approaches and their application in identifying causal pathways of childhood asthma. J Allergy Clin Immunol. 2018;141:1191–201. https://doi.org/10.1016/j.jaci.2017.04.021.

Article  PubMed  CAS  Google Scholar 

Nambiar S, Bong How S, Gummer J, Trengove R, Moodley Y. Metabolomics in chronic lung diseases. Respirology. 2020;25:139–48. https://doi.org/10.1111/resp.13530.

Article  PubMed  Google Scholar 

Tyler SR, Bunyavanich S. Leveraging -Omics for Asthma Endotyping. J Allergy Clin Immunol. 2019;144:13–23. https://doi.org/10.1016/j.jaci.2019.05.015.

Article  PubMed  PubMed Central  Google Scholar 

Ferraro VA, Zanconato S, Carraro S. Metabolomics Applied to Pediatric Asthma: What Have We Learnt in the Past 10 Years? Children (Basel). 2023;10:1452. https://doi.org/10.3390/children10091452.

Article  PubMed  Google Scholar 

Kelly RS, Dahlin A, McGeachie MJ, Qiu W, Sordillo J, Wan ES, et al. Asthma Metabolomics and the Potential for Integrative Omics in Research and the Clinic. Chest. 2017;151:262–77. https://doi.org/10.1016/j.chest.2016.10.008.

Article  PubMed  Google Scholar 

Roshan Lal T, Cechinel LR, Freishtat R, Rastogi D. Metabolic Contributions to Pathobiology of Asthma. Metabolites. 2023;13:212. https://doi.org/10.3390/metabo13020212.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kelly RS, Mendez KM, Huang M, Hobbs BD, Clish CB, Gerszten R, et al. Metabo-Endotypes of Asthma Reveal Differences in Lung Function: Discovery and Validation in Two TOPMed Cohorts. Am J Respir Crit Care Med. 2022;205:288–99. https://doi.org/10.1164/rccm.202105-1268OC.

Article  PubMed  CAS  Google Scholar 

Beger RD, Schmidt MA, Kaddurah-Daouk R. Current Concepts in Pharmacometabolomics, Biomarker Discovery, and Precision Medicine. Metabolites. 2020;10:129. https://doi.org/10.3390/metabo10040129.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Snowden S, Dahlén S-E, Wheelock CE. Application of metabolomics approaches to the study of respiratory diseases. Bioanalysis. 2012;4:2265–90. https://doi.org/10.4155/bio.12.218.

Article  PubMed  CAS  Google Scholar 

Cave AJ, Atkinson LL. Asthma in preschool children: a review of the diagnostic challenges. J Am Board Fam Med. 2014;27:538–48. https://doi.org/10.3122/jabfm.2014.04.130276.

Article  PubMed  Google Scholar 

Sol JA, Quindry JC. Application of a Novel Collection of Exhaled Breath Condensate to Exercise Settings. Int J Environ Res Public Health. 2022;19:3948. https://doi.org/10.3390/ijerph19073948.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ntontsi P, Ntzoumanika V, Loukides S, Benaki D, Gkikas E, Mikros E, et al. EBC metabolomics for asthma severity. J Breath Res. 2020;14:036007. https://doi.org/10.1088/1752-7163/ab9220.

Article  PubMed  CAS  Google Scholar 

Psychogios N, Hau DD, Peng J, Guo AC, Mandal R, Bouatra S, et al. The Human Serum Metabolome. PLoS ONE. 2011;6:e16957. https://doi.org/10.1371/journal.pone.0016957.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bederka LH, Sanchez JR, Rebeles J, Araujo PR, Grayson MH, Lai S-C, et al. Sputum analysis by flow cytometry; an effective platform to analyze the lung environment. PLoS ONE. 2022;17:e0272069. https://doi.org/10.1371/journal.pone.0272069.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kelly RS, Sordillo JE, Lasky-Su J, Dahlin A, Perng W, Rifas-Shiman SL, et al. Plasma metabolite profiles in children with current asthma. Clin Exp Allergy. 2018;48:1297–304. https://doi.org/10.1111/cea.13183.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Checkley W, Deza MP, Klawitter J, Romero KM, Klawitter J, Pollard SL, et al. Identifying biomarkers for asthma diagnosis using targeted metabolomics approaches. Respir Med. 2016;121:59–66. https://doi.org/10.1016/j.rmed.2016.10.011.

Article  PubMed  PubMed Central  Google Scholar 

Matysiak J, Klupczynska A, Packi K, Mackowiak-Jakubowska A, Bręborowicz A, Pawlicka O, et al. Alterations in Serum-Free Amino Acid Profiles in Childhood Asthma. Int J Environ Res Public Health. 2020;17:4758. https://doi.org/10.3390/ijerph17134758.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Crestani E, Harb H, Charbonnier L-M, Leirer J, Motsinger-Reif A, Rachid R, et al. Untargeted Metabolomic Profiling Identifies Disease-specific Signatures in Food Allergy and Asthma. J Allergy Clin Immunol. 2020;145:897–906. https://doi.org/10.1016/j.jaci.2019.10.014.

Article  PubMed  CAS  Google Scholar 

Chiu C-Y, Cheng M-L, Chiang M-H, Wang C-J, Tsai M-H, Lin G. Metabolomic Analysis Reveals Distinct Profiles in the Plasma and Urine Associated with IgE Reactions in Childhood Asthma. J Clin Med. 2020;9:887. https://doi.org/10.3390/jcm9030887.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Mattarucchi E, Baraldi E, Guillou C. Metabolomics applied to urine samples in childhood asthma; differentiation between asthma phenotypes and identification of relevant metabolites. Biomed Chromatogr. 2012;26:89–94. https://doi.org/10.1002/bmc.1631.

Article  PubMed  CAS  Google Scholar 

Carraro S, Bozzetto S, Giordano G, El Mazloum D, Stocchero M, Pirillo P, et al. Wheezing preschool children with early-onset asthma reveal a specific metabolomic profile. Pediatr Allergy Immunol. 2018;29:375–82. https://doi.org/10.1111/pai.12879.

Article  PubMed