Perillic acid disrupts the specification of germ layers by upregulating the FGF/MAPK pathway

Bottcher RT, Niehrs C (2005) Fibroblast growth factor signaling during early vertebrate development. Endocr Rev 26:63–77

Article  PubMed  Google Scholar 

Bottcher RT, Pollet N, Delius H, Niehrs C (2004) The transmembrane protein XFLRT3 forms a complex with FGF receptors and promotes FGF signalling. Nat Cell Biol 6:38–44

Article  PubMed  Google Scholar 

Cheng QF, Rao PV, Zigler JS Jr (2001) Effect of Perillic acid, a putative isoprenylation inhibitor, on the cultured rat lens. Exp Eye Res 73:239–245

Article  PubMed  Google Scholar 

Cho GS, Park DS, Choi SC, Han JK (2017) Tbx2 regulates anterior neural specification by repressing FGF signaling pathway. Dev Biol 421:183–193

Article  PubMed  Google Scholar 

Cordenonsi M, Montagner M, Adorno M, Zacchigna L, Martello G, Mamidi A, Soligo S, Dupont S, Piccolo S (2007) Integration of TGF-beta and Ras/MAPK signaling through p53 phosphorylation. Science 315:840–843

Article  PubMed  Google Scholar 

Cox WG, Hemmati-Brivanlou A (1995) Caudalization of neural fate by tissue recombination and bFGF. Development 121:4349–4358

Article  PubMed  Google Scholar 

Delaune E, Lemaire P, Kodjabachian L (2005) Neural induction in xenopus requires early FGF signalling in addition to BMP Inhibition. Development 132:299–310

Article  PubMed  Google Scholar 

Dinsmore CJ, Soriano P (2018) MAPK and PI3K signaling: at the crossroads of neural crest development. Dev Biol 444(Suppl 1):S79–S97

Article  PubMed  PubMed Central  Google Scholar 

Dorey K, Amaya E (2010) FGF signalling: diverse roles during early vertebrate embryogenesis. Development 137:3731–3742

Article  PubMed  Google Scholar 

Fletcher RB, Harland RM (2008) The role of FGF signaling in the establishment and maintenance of mesodermal gene expression in xenopus. Dev Dyn 237:1243–1254

Article  PubMed  PubMed Central  Google Scholar 

Fuentealba LC, Eivers E, Ikeda A, Hurtado C, Kuroda H, Pera EM, De Robertis EM (2007) Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal. Cell 131:980–993

Article  PubMed  PubMed Central  Google Scholar 

Geary L, LaBonne C (2018) FGF mediated MAPK and PI3K/Akt signals make distinct contributions to pluripotency and the establishment of neural crest. Elife 7

Harland RM (1991) In situ hybridization: an improved whole-mount method for xenopus embryos. Methods Cell Biol 36:685–695

Article  PubMed  Google Scholar 

Hong CS, Park BY, Saint-Jeannet JP (2008) Fgf8a induces neural crest indirectly through the activation of Wnt8 in the paraxial mesoderm. Development 135:3903–3910

Article  PubMed  Google Scholar 

Hongo I, Okamoto H (2022) FGF/MAPK/Ets signaling in xenopus ectoderm contributes to neural induction and patterning in an autonomous and paracrine manner, respectively. Cells Dev 170:203769

Article  PubMed  Google Scholar 

Hongo I, Kengaku M, Okamoto H (1999) FGF signaling and the anterior neural induction in xenopus. Dev Biol 216:561–581

Article  PubMed  Google Scholar 

Isaacs HV, Pownall ME, Slack JM (1994) eFGF regulates Xbra expression during xenopus gastrulation. EMBO J 13:4469–4481

Article  PubMed  PubMed Central  Google Scholar 

Kumar S, Umair Z, Kumar V, Goutam RS, Park S, Lee U, Kim J (2024) Xbra modulates the activity of linker region phosphorylated Smad1 during xenopus development. Sci Rep 14:8922

Article  PubMed  PubMed Central  Google Scholar 

Launay C, Fromentoux V, Shi DL, Boucaut JC (1996) A truncated FGF receptor blocks neural induction by endogenous xenopus inducers. Development 122:869–880

Article  PubMed  Google Scholar 

Pera EM, Ikeda A, Eivers E, De Robertis EM (2003) Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction. Genes Dev 17:3023–3028

Article  PubMed  PubMed Central  Google Scholar 

Ribisi S Jr., Mariani FV, Aamar E, Lamb TM, Frank D, Harland RM (2000) Ras-mediated FGF signaling is required for the formation of posterior but not anterior neural tissue in xenopus laevis. Dev Biol 227:183–196

Article  PubMed  Google Scholar 

Sapkota G, Alarcon C, Spagnoli FM, Brivanlou AH, Massague J (2007) Balancing BMP signaling through integrated inputs into the Smad1 linker. Mol Cell 25:441–454

Article  PubMed  Google Scholar 

Schohl A, Fagotto F (2002) Beta-catenin, MAPK and Smad signaling during early xenopus development. Development 129:37–52

Article  PubMed  Google Scholar 

Schulte-Merker S, Smith JC (1995) Mesoderm formation in response to brachyury requires FGF signalling. Curr Biol 5:62–67

Article  PubMed  Google Scholar 

Shojaei S, Kiumarsi A, Moghadam AR, Alizadeh J, Marzban H, Ghavami S (2014) Perillyl alcohol (Monoterpene alcohol), Limonene. Enzymes 36:7–32

Article  PubMed  Google Scholar 

Umbhauer M, Penzo-Mendez A, Clavilier L, Boucaut J, Riou J (2000) Signaling specificities of fibroblast growth factor receptors in early xenopus embryo. J Cell Sci 113(Pt 16):2865–2875

Article  PubMed  Google Scholar 

Yeruva L, Pierre KJ, Elegbede A, Wang RC, Carper SW (2007) Perillyl alcohol and Perillic acid induced cell cycle arrest and apoptosis in Non small cell lung cancer cells. Cancer Lett 257:216–226

Article  PubMed  Google Scholar 

Zahn N, James-Zorn C, Ponferrada VG, Adams DS, Grzymkowski J, Buchholz DR, Nascone-Yoder NM, Horb M, Moody SA, Vize PD et al (2022) Normal Table of Xenopus development: a new graphical resource. Development 149

Comments (0)

No login
gif