Ahangari F, Sood A, Ma B, Takyar S, Schuyler M, Qualls C, Dela Cruz CS, Chupp GL, Lee CG, Elias JA (2015) Chitinase 3-like-1 regulates both visceral fat accumulation and asthma-like Th2 inflammation. Am J Respir Crit Care Med 191:746–757
CAS PubMed PubMed Central Google Scholar
Baran A, Mysliwiec H, Szterling-Jaworowska M, Kiluk P, Swiderska M, Flisiak I (2018) Serum YKL-40 as a potential biomarker of inflammation in psoriasis. J Dermatol Treat 29:19–23
Cho N, Kim YE, Lee Y, Choi DW, Park C, Kim JH, Kim KI, Kim KK (2024) Effect of RNF113A deficiency on oxidative stress-induced NRF2 pathway. Anim Cells Syst (Seoul) 28:261–271
Choi S, Lee HS, Cho N, Kim I, Cheon S, Park C, Kim EM, Kim W, Kim KK (2022) RBFOX2-regulated TEAD1 alternative splicing plays a pivotal role in Hippo-YAP signaling. Nucleic Acids Res 50:8658–8673
CAS PubMed PubMed Central Google Scholar
Choi S, Cho N, Kim EM, Kim KK (2023a) The role of alternative pre-mRNA splicing in cancer progression. Cancer Cell Int 23:249
CAS PubMed PubMed Central Google Scholar
Choi S, Cho N, Kim KK (2023b) The implications of alternative pre-mRNA splicing in cell signal transduction. Exp Mol Med 55:755–766
CAS PubMed PubMed Central Google Scholar
Choi J, Chudziak J, Lee JH (2024) Bi-directional regulation between inflammation and stem cells in the respiratory tract. J Cell Sci 137
Deng Y, Govers C, Ter Beest E, van Dijk AJ, Hettinga K, Wichers HJ (2020) A THP-1 cell line-based exploration of immune responses toward heat-treated BLG. Front Nutr 7:612397
Di Rosa M, Tibullo D, Saccone S, Distefano G, Basile MS, Di Raimondo F, Malaguarnera L (2016) CHI3L1 nuclear localization in monocyte derived dendritic cells. Immunobiology 221:347–356
Doni A, Mantovani A, Bottazzi B, Russo RC (2021) PTX3 regulation of inflammation, hemostatic response, tissue repair, and resolution of fibrosis favors a role in limiting idiopathic pulmonary fibrosis. Front Immunol 12:676702
CAS PubMed PubMed Central Google Scholar
Eurich K, Segawa M, Toei-Shimizu S, Mizoguchi E (2009) Potential role of chitinase 3-like-1 in inflammation-associated carcinogenic changes of epithelial cells. World J Gastroenterol 15:5249–5259
CAS PubMed PubMed Central Google Scholar
He CH, Lee CG, Dela Cruz CS, Lee CM, Zhou Y, Ahangari F, Ma B, Herzog EL, Rosenberg SA, Li Y et al (2013) Chitinase 3-like 1 regulates cellular and tissue responses via IL-13 receptor alpha2. Cell Rep 4:830–841
CAS PubMed PubMed Central Google Scholar
Jung DM, Kim KK, Kim EM (2023) Chloromethylisothiazolinone induces ER stress-induced stress granule formation in human keratinocytes. Anim Cells Syst (Seoul) 27:171–179
Junker N, Johansen JS, Andersen CB, Kristjansen PE (2005) Expression of YKL-40 by peritumoral macrophages in human small cell lung cancer. Lung Cancer 48:223–231
Kzhyshkowska J, Gratchev A, Goerdt S (2007) Human chitinases and chitinase-like proteins as indicators for inflammation and cancer. Biomark Insights 2:128–146
PubMed PubMed Central Google Scholar
Lee JH, Kim SS, Kim IJ, Song SH, Kim YK, In Kim J, Jeon YK, Kim BH, Kwak IS (2012) Clinical implication of plasma and urine YKL-40, as a proinflammatory biomarker, on early stage of nephropathy in type 2 diabetic patients. J Diabetes Complicat 26:308–312
Lee YS, Yu JE, Kim KC, Lee DH, Son DJ, Lee HP, Jung JK, Kim ND, Ham YW, Yun J et al (2022) A small molecule targeting CHI3L1 inhibits lung metastasis by blocking IL-13Ralpha2-mediated JNK-AP-1 signals. Mol Oncol 16:508–526
Mizoguchi E (2006) Chitinase 3-like-1 exacerbates intestinal inflammation by enhancing bacterial adhesion and invasion in colonic epithelial cells. Gastroenterology 130:398–411
Neumann A, Schindler M, Olofsson D, Wilhelmi I, Schurmann A, Heyd F (2019) Genome-wide identification of alternative splicing events that regulate protein transport across the secretory pathway. J Cell Sci 132
Peltonen R, Gramkow MH, Dehlendorff C, Osterlund PJ, Johansen JS, Isoniemi H (2020) Elevated serum YKL-40, IL-6, CRP, CEA, and CA19-9 combined as a prognostic biomarker panel after resection of colorectal liver metastases. PLoS ONE 15:e0236569
CAS PubMed PubMed Central Google Scholar
Rathcke CN, Vestergaard H (2006) YKL-40, a new inflammatory marker with relation to insulin resistance and with a role in endothelial dysfunction and atherosclerosis. Inflamm Res 55:221–227
Suzuki K, Okawa K, Ohkura M, Kanaizumi T, Kobayashi T, Takahashi K, Takei H, Otsuka M, Tabata E, Bauer PO et al (2024) Evolutionary insights into sequence modifications governing chitin recognition and chitinase inactivity in YKL-40 (HC-gp39, CHI3L1). J Biol Chem 300:107365
CAS PubMed PubMed Central Google Scholar
Thom I, Andritzky B, Schuch G, Burkholder I, Edler L, Johansen JS, Bokemeyer C, Schumacher U, Laack E (2010) Elevated pretreatment serum concentration of YKL-40: an independent prognostic biomarker for poor survival in patients with metastatic nonsmall cell lung cancer. Cancer 116:4114–4121
Wang R, Ren C, Gao T (2024) Correction to: SEPDB: a database of secreted proteins. Database (Oxford) 2024
Wu W, Krijgsveld J (2024) Secretome analysis: reading cellular sign language to understand intercellular communication. Mol Cell Proteom 23:100692
Yan C, Ding X, Wu L, Yu M, Qu P, Du H (2013) Stat3 downstream gene product chitinase 3-like 1 is a potential biomarker of inflammation-induced lung cancer in multiple mouse lung tumor models and humans. PLoS ONE 8:e61984
CAS PubMed PubMed Central Google Scholar
Yu JE, Yeo IJ, Son DJ, Yun J, Han SB, Hong JT (2022) Anti-Chi3L1 antibody suppresses lung tumor growth and metastasis through inhibition of M2 polarization. Mol Oncol 16:2214–2234
Zhang Y, Yao X, Zhou H, Wu X, Tian J, Zeng J, Yan L, Duan C, Liu H, Li H et al (2022) OncoSplicing: an updated database for clinically relevant alternative splicing in 33 human cancers. Nucleic Acids Res 50:D1340–D1347
Zhou Y, Peng H, Sun H, Peng X, Tang C, Gan Y, Chen X, Mathur A, Hu B, Slade MD et al (2014) Chitinase 3-like 1 suppresses injury and promotes fibroproliferative responses in mammalian lung fibrosis. Sci Transl Med 6:240ra276
Zhou Y, He CH, Herzog EL, Peng X, Lee CM, Nguyen TH, Gulati M, Gochuico BR, Gahl WA, Slade ML et al (2015) Chitinase 3-like-1 and its receptors in Hermansky–Pudlak syndrome-associated lung disease. J Clin Invest 125:3178–3192
PubMed PubMed Central Google Scholar
Zhou Y, He CH, Yang DS, Nguyen T, Cao Y, Kamle S, Lee CM, Gochuico BR, Gahl WA, Shea BS et al (2018) Galectin-3 interacts with the CHI3L1 axis and contributes to Hermansky–Pudlak syndrome lung disease. J Immunol 200:2140–2153
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