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Neuronal BAG3 attenuates tau hyperphosphorylation, synaptic dysfunction, and cognitive deficits induced by traumatic brain injury via the regulation of autophagy-lysosome pathway
Neuronal BAG3 attenuates tau hyperphosphorylation, synaptic dysfunction, and cognitive deficits induced by traumatic brain injury via the regulation of autophagy-lysosome pathway
Growing evidence supports that early- or middle-life traumatic brain injury (TBI) is a risk factor for developing Alzheime...
Neuropathological spectrum of anti-IgLON5 disease and stages of brainstem tau pathology: updated neuropathological research criteria of the disease-related tauopathy
Neuropathological spectrum of anti-IgLON5 disease and stages of brainstem tau pathology: updated neuropathological research criteria of the disease-related tauopathy
Anti-IgLON5 disease is a unique condition that bridges autoimmunity and neurodegeneration. Since its initial description 1...
MYB/MYBL1-altered gliomas frequently harbor truncations and non-productive fusions in the MYB and MYBL1 genes
MYB/MYBL1-altered gliomas frequently harbor truncations and non-productive fusions in the MYB and MYBL1 genes
Astrocytomas that harbor recurrent genomic alterations in MYB or MYBL1 are a group of Pediatric-type diffuse low-grade gli...
Hypothesis-based investigation of known AD risk variants reveals the genetic underpinnings of neuropathological lesions observed in Alzheimer’s-type dementia
Hypothesis-based investigation of known AD risk variants reveals the genetic underpinnings of neuropathological lesions observed in Alzheimer’s-type dementia
Alzheimer’s disease (AD) is the leading cause of dementia worldwide. Besides neurofibrillary tangles and amyloid bet...
Cryo-EM structure of a natural prion: chronic wasting disease fibrils from deer
Cryo-EM structure of a natural prion: chronic wasting disease fibrils from deer
Chronic wasting disease (CWD) is a widely distributed prion disease of cervids with implications for wildlife conservation...
Autoantibodies to BACE1 promote Aβ accumulation and neurodegeneration in Alzheimer’s disease
Autoantibodies to BACE1 promote Aβ accumulation and neurodegeneration in Alzheimer’s disease
The profile of autoantibodies is dysregulated in patients with Alzheimer’s disease (AD). Autoantibodies to beta-site...
Effects of brain microRNAs in cognitive trajectory and Alzheimer’s disease
Effects of brain microRNAs in cognitive trajectory and Alzheimer’s disease
microRNAs (miRNAs) have a broad influence on gene expression; however, we have limited insights into their contribution to...
Comprehensive mapping of synaptic vesicle protein 2A (SV2A) in health and neurodegenerative diseases: a comparative analysis with synaptophysin and ground truth for PET-imaging interpretation
Comprehensive mapping of synaptic vesicle protein 2A (SV2A) in health and neurodegenerative diseases: a comparative analysis with synaptophysin and ground truth for PET-imaging interpretation
Synaptic dysfunction and loss are central to neurodegenerative diseases and correlate with cognitive decline. Synaptic Ves...
TMEM106B amyloid filaments in the Biondi bodies of ependymal cells
TMEM106B amyloid filaments in the Biondi bodies of ependymal cells
Biondi bodies are filamentous amyloid inclusions of unknown composition in ependymal cells of the choroid plexuses, ependy...
Compartment-specific small non-coding RNA changes and nucleolar defects in human mesial temporal lobe epilepsy
Compartment-specific small non-coding RNA changes and nucleolar defects in human mesial temporal lobe epilepsy
Mesial temporal lobe epilepsy (mTLE) is a debilitating disease characterized by recurrent seizures originating from tempor...
No sex difference in the extent of acute mechanical blood–brain barrier disruption after experimental concussion
No sex difference in the extent of acute mechanical blood–brain barrier disruption after experimental concussion
Authors and AffiliationsDepartment of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, 3320 S...
The microglial translocator protein (TSPO) in Alzheimer’s disease reflects a phagocytic phenotype
The microglial translocator protein (TSPO) in Alzheimer’s disease reflects a phagocytic phenotype
Translocator protein (TSPO) is a mitochondrial protein expressed by microglia, ligands for which are used as a marker of n...
Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia
Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia
Mutations in ITM2B cause familial British, Danish, Chinese, and Korean dementias. In familial British dementia (FBD), a mu...
Pure LATE-NC: Frequency, clinical impact, and the importance of considering APOE genotype when assessing this and other subtypes of non-Alzheimer’s pathologies
Pure LATE-NC: Frequency, clinical impact, and the importance of considering APOE genotype when assessing this and other subtypes of non-Alzheimer’s pathologies
Pure limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes (pure LATE-NC) is a term used to describ...
Unsuccessful transmissions of atypical genetic Creutzfeldt–Jakob disease (PRNP p.T183A-129M) in transgenic mice
Unsuccessful transmissions of atypical genetic Creutzfeldt–Jakob disease (PRNP p.T183A-129M) in transgenic mice
Aguilar-Calvo P, Callender JA, Sigurdson CJ (2021) Short and sweet: How glycans impact prion conversion, cofactor interact...
Genome-wide methylation profiling differentiates benign from aggressive and metastatic pituitary neuroendocrine tumors
Genome-wide methylation profiling differentiates benign from aggressive and metastatic pituitary neuroendocrine tumors
Aggressive pituitary neuroendocrine tumors (PitNETs)/adenomas are characterized by progressive growth despite surgery and ...
Neuronal and oligodendroglial, but not astroglial, tau translates to in vivo tau PET signals in individuals with primary tauopathies
Neuronal and oligodendroglial, but not astroglial, tau translates to in vivo tau PET signals in individuals with primary tauopathies
Tau PET has attracted increasing interest as an imaging biomarker for 4-repeat (4R)-tauopathy progressive supranuclear pal...
Pathologic and clinical correlates of region-specific brain GFAP in Alzheimer’s disease
Pathologic and clinical correlates of region-specific brain GFAP in Alzheimer’s disease
Plasma glial fibrillary acidic protein (GFAP) is an emerging biomarker of Alzheimer’s disease (AD), with higher bloo...
A new subtype of diffuse midline glioma, H3 K27 and BRAF/FGFR1 co-altered: a clinico-radiological and histomolecular characterisation
A new subtype of diffuse midline glioma, H3 K27 and BRAF/FGFR1 co-altered: a clinico-radiological and histomolecular characterisation
Diffuse midline gliomas (DMG) H3 K27-altered are incurable grade 4 gliomas and represent a major challenge in neuro-oncolo...
G2C4 targeting antisense oligonucleotides potently mitigate TDP-43 dysfunction in human C9orf72 ALS/FTD induced pluripotent stem cell derived neurons
G2C4 targeting antisense oligonucleotides potently mitigate TDP-43 dysfunction in human C9orf72 ALS/FTD induced pluripotent stem cell derived neurons
The G4C2 repeat expansion in the C9orf72 gene is the most common genetic cause of Amyotrophic Lateral Sclerosis and Fronto...
Microglia activation in periplaque white matter in multiple sclerosis depends on age and lesion type, but does not correlate with oligodendroglial loss
Microglia activation in periplaque white matter in multiple sclerosis depends on age and lesion type, but does not correlate with oligodendroglial loss
Multiple sclerosis (MS) is the most frequent inflammatory and demyelinating disease of the CNS. The disease course in MS i...
The neuropathology of intimate partner violence
The neuropathology of intimate partner violence
Lifelong brain health consequences of traumatic brain injury (TBI) include the risk of neurodegenerative disease. Up to on...
Independent prognostic impact of DNA methylation class and chromosome 1p loss in WHO grade 2 and 3 meningioma undergoing adjuvant high-dose radiotherapy: comprehensive molecular analysis of EORTC 22042–26042
Independent prognostic impact of DNA methylation class and chromosome 1p loss in WHO grade 2 and 3 meningioma undergoing adjuvant high-dose radiotherapy: comprehensive molecular analysis of EORTC 22042–26042
In the recent 2021 CNS5 WHO classification, molecular alterations were introduced int...
PLAG1 fusions extend the spectrum of PLAG(L)-altered CNS tumors
PLAG1 fusions extend the spectrum of PLAG(L)-altered CNS tumors
Department of Neuropathology, GHU Paris-Psychiatrie et Neurosciences, Sainte-Anne Hospital, 1, Rue Cabanis, 75014, Paris, ...
Risk of chronic traumatic encephalopathy in rugby union is associated with length of playing career
Risk of chronic traumatic encephalopathy in rugby union is associated with length of playing career
School of Psychology and Neuroscience, University of Glasgow, Glasgow, G12 8QQ, UKWilliam Stewart, Shannon Gilchrist &...
Clinical, genomic, and epigenomic analyses of H3K27M-mutant diffuse midline glioma long-term survivors reveal a distinct group of tumors with MAPK pathway alterations
Clinical, genomic, and epigenomic analyses of H3K27M-mutant diffuse midline glioma long-term survivors reveal a distinct group of tumors with MAPK pathway alterations
Department of Pediatrics, Michigan Medicine, Ann Arbor, MI, USAHolly J. Roberts, Sunjong Ji, Rodrigo Cartaxo, Santhosh A. ...
CDKN2A/B mutations and allele-specific alterations stratify survival outcomes in IDH-mutant astrocytomas
CDKN2A/B mutations and allele-specific alterations stratify survival outcomes in IDH-mutant astrocytomas
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Histopathologic brain age estimation via multiple instance learning
Histopathologic brain age estimation via multiple instance learning
Understanding age acceleration, the discordance between biological and chronological age, in the brain can reveal mechanis...
Somatic mosaic SOX10 indel mutations underlie a form of segmental schwannomatosis
Somatic mosaic SOX10 indel mutations underlie a form of segmental schwannomatosis
Bahuau M, Vidaud D, Jenkins RB, Bièche I, Kimmel DW, Assouline B et al (1998) Germ-line deletion involving the INK4 locus ...
Senescent fibro-adipogenic progenitors are potential drivers of pathology in inclusion body myositis
Senescent fibro-adipogenic progenitors are potential drivers of pathology in inclusion body myositis
Inclusion body myositis (IBM) is unique across the spectrum of idiopathic inflammatory myopathies (IIM) due to its distinc...
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